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The study was conducted to investigate the modulatory activity of ethanol extract of neem leaf on the essential biochemical parameters of streptozotocin-induced diabetic rats. The 24-hour acute toxicity test of the orally administered ethanol extract was determined using Finney’s method. Diabetes was induced in the rats by a single intraperitoneal dose of 50 mg/kgbw of streptozotocin (STZ). Blood was collected after 28 days of treatment and used for biochemical analysis. Biochemical analysis was done using standard biochemical methods. The acute toxicity study of the ethanol extract reveal that the median lethal dose was 5.0 g/kg body weight. The anti-diabetic study carried out for a period of 28 days showed a significant (p

The Sida corymbosa plant has been used for centuries in traditional medicine in different countries for prevention and treatment of different diseases such as liver and cardiac diseases. This work aimed at investigating if Sida corymbosa ethanolic leaf extract has preventive and therapeutic effects against abnormal serum bilirubin and total protein in Albino rats by carbon tetrachloride (CCl4). This study took place at Nnamdi Azikiwe University, Nnewi Campus, Anambra State. The rats were grouped into those given 5000, 3000 and 1000 mg/kgbw of the extract before and after CCl4 administration from 7 d to 28 d, those injected CCl4 only which stayed from 7 d to 28 d and those without CCl4 and extract. Male Albino rats weighing 170-190 g were used. Injection of CCl4 (0.4 ml/kgbw i.p) was done using olive as vector before and after oral administration of the Sida corymbosa extract. Serum bilirubin was estimated using Powel’s method while serum total protein was estimated using the Biuret method. Results were analyzed statistically using SPSS statistical software version 21. Analysis done so far revealed that serum bilirubin of rats injected CCl4 without extract administration (negative control) was significantly higher (P