1. Assessment of the embolization effect of temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogels in the rabbit renal artery by CT perfusion and confirmed by macroscopic examination
- Author
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Yanbing Zhao, Zhen Zhang, Kun Qian, Ping Han, Gui-Na Ma, Nanchuan Jiang, Xin Zhang, Hongsen Zhang, Li Han, Yan Chen, Chuansheng Zheng, and Chunyuan Cen
- Subjects
medicine.medical_treatment ,Science ,Nanogels ,Perfusion scanning ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Renal Artery ,medicine.artery ,medicine ,Animals ,Embolization ,Right Renal Artery ,Renal artery ,Kidney ,Multidisciplinary ,business.industry ,Temperature ,Collateral circulation ,Embolization, Therapeutic ,Perfusion ,medicine.anatomical_structure ,Renal blood flow ,Nanoparticles ,Medicine ,Rabbits ,Nuclear medicine ,business ,Tomography, X-Ray Computed ,X-ray tomography ,030217 neurology & neurosurgery - Abstract
Transcatheter embolization is an important treatment method in clinical therapy, and vascular embolization material plays a key role in embolization. The temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) (PIB) nanogel is a novel embolic agent. To evaluate the feasibility of the nanogel as a blood vessel embolization agent, we aimed to assess the effect of embolization with PIB nanogels in the rabbit renal artery by non-invasive computed tomography (CT) perfusion, macroscopic and histological examination. Ten healthy adult Japanese rabbits were used to implement RAE of PIB nanogels in their right kidneys. CT perfusion scans were performed pre- and post-treatment at various time-points (1, 4, 8, and 12 weeks). Two rabbits were euthanized and histologically examined at each time-point, and the remaining rabbits were euthanized at 12 weeks after embolization. The RAE efficacy of the nanogels was further confirmed by macroscopic and histological examination. The renal volume and renal blood flow (BF) of the right kidney were significantly decreased post-treatment compared with those pre-treatment (volume: pre, 9278 ± 1736 mm3; post 1 week, 5155 ± 979 mm3, P 3, P 3, P 3, P P P P P
- Published
- 2021