1. Skin-blanching is associated with FEV1, allergy, age and gender in asthma families
- Author
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Maarten van den Berge, Eef D. Telenga, Judith M. Vonk, Dirkje S. Postma, Gerard H. Koppelman, Hajo Jongepier, Leslie A. Lange, Science in Healthy Ageing & healthcaRE (SHARE), and Groningen Research Institute for Asthma and COPD (GRIAC)
- Subjects
Budesonide ,Male ,Allergy ,STRESS ,INHALED CORTICOSTEROIDS ,DISEASE ,Norepinephrine uptake ,Cohort Studies ,Forced Expiratory Volume ,Young adult ,Child ,NOREPINEPHRINE UPTAKE ,integumentary system ,Pigmentation ,Age Factors ,SMOOTH-MUSCLE CELLS ,Middle Aged ,Glucocorticosteroids ,GLUCOCORTICOID-RECEPTOR ,Skin-tests ,LUNG-FUNCTION ,Female ,SEX ,medicine.drug ,Cohort study ,Adult ,Pulmonary and Respiratory Medicine ,EXHALED NITRIC-OXIDE ,medicine.medical_specialty ,Adolescent ,Steroid-resistance ,Young Adult ,Sex Factors ,Internal medicine ,medicine ,Hypersensitivity ,Humans ,Family ,Glucocorticoids ,Asthma ,Skin Tests ,business.industry ,Airway obstruction ,medicine.disease ,respiratory tract diseases ,Airway Obstruction ,body regions ,Immunology ,Exhaled nitric oxide ,business ,STEROID SENSITIVITY - Abstract
Background: Inhaled glucocorticosteroids reduce airway inflammation in asthma patients, thereby improving lung function and reducing airway hyperresponsiveness and symptoms. The response to glucocorticosteroids can be measured with the glucocorticosteroid skin-blanching test. We investigated if asthmatics have a lower skin-blanching response to glucocorticosteroids than non-asthmatic subjects and if asthmatics with airway obstruction have lower skin-blanching response than those without obstruction. Finally, we assessed which clinical and inflammatory parameters influence the variability in skin-blanching response.Methods: We evaluated the skin-blanching response to topical budesonide in a large group of 315 well-characterized asthmatics and their relatives (asthma n = 114, healthy n = 140, other = 61)Results: The skin-blanching scores of the asthma probands and their healthy spouses were not significantly different. The skin-blanching score of patients with FEV1 Conclusions: Asthmatics do not have lower skin-blanching response to glucocorticosteroids than healthy subjects. Furthermore, lower skin-blanching response to glucocorticosteroids is associated with lower FEV1, female gender, higher age and the absence of allergy. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
- Published
- 2012