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Chronic pain is typically defined as pain that persists after acute tissue damage and inflammation or as pain that follows a chronic disease process and lasts more than three months. Because of its debilitating impact on the quality of life of patients, recent research aims to investigate the mechanisms behind nociception to discover novel therapeutic agents to alleviate pain. One such target is the neuropeptide calcitonin gene-related peptide (CGRP), which has shown to play an integral role in migraine pathophysiology. Effective treatments of migraines with CGRP antagonists have stimulated our efforts toward checking a possible involvement of CGRP in nonheadache pain conditions such as hypertension, congestive heart failure, Alzheimer's disease, and vascular ischemia. Here, we provide a brief overview of chronic pain, with a particular emphasis on the role of CGRP as a fundamental mediator of nociceptive pain as well as a target for novel therapeutic agents.

Rheumatoid arthritis (RA) is a common inflammatory disease with several implications on health, disability and economy. Conventional treatment for RA centers on anti-inflammatory drugs and specific targeting of tumor necrosis factor  (TNF-) and interleukin 6 (IL-6). Baricitinib is a novel, Food and Drug Administration (FDA) approved, once daily oral drug that is effective in combination with current treatment and results in significantly reduced symptoms with good safety profile. Further studies are required to find rare side effects and evaluate the long term efficacy in disease modulation and patient symptom reduction. This is a comprehensive review of the literature on baricitinib for the treatment of RA. This review provides an update on the pathophysiology, diagnosis and conventional treatment of RA, then proceeds to introduce baricitinib and the data that exists to support or refute its use in RA. The presented study also indicated clinical trials confirming the effectiveness of baricitinib in this indication.

The Muon Spectrometer of the ATLAS Experiment at CERN is composed of Thin Gap Chambers (TGC) and Monitoring Drift Tubes (MDT) technologies. TGCs are arranged in 6 Big Wheels and 2 Small Wheels. Gain stability and efficiency are required to be monitored during the Large Hadron Collider (LHC) operation (runs). A Charge monitoring board is identified as a solution to measure gain and efficiency during runs for the forthcoming High Luminosity upgrade. Specifications and topology are proposed with preliminary results as a demonstration of feasibility.

In the era of high-angular resolution astronomical instrumentation, where long and very long baseline interferometers (constituted by many, $\sim$ 20 or more, telescopes) are expected to work not only in the millimeter and submillimeter domain, but also at near and mid infrared wavelengths (experiments such as the Planet Formation Imager, PFI, see Monnier et al. 2018 for an update on its design); any promising strategy to alleviate the costs of the individual telescopes involved needs to be explored. In a recent collaboration between engineers, experimental physicists and astronomers in Valparaiso, Chile, we are gaining expertise in the production of light carbon fiber polymer reinforced mirrors. The working principle consists in replicating a glass, or other substrate, mandrel surface with the mirrored adequate curvature, surface characteristics and general shape. Once the carbon fiber base has hardened, previous studies have shown that it can be coated (aluminum) using standard coating processes/techniques designed for glass-based mirrors. The resulting surface quality is highly dependent on the temperature and humidity control among other variables. Current efforts are focused on improving the smoothness of the resulting surfaces to meet near/mid infrared specifications, overcoming, among others, possible deteriorations derived from the replication process. In a second step, at the validation and quality control stage, the mirrors are characterized using simple/traditional tools like spherometers (down to micron precision), but also an optical bench with a Shack-Hartman wavefront sensor. This research line is developed in parallel with a more classical glass-based approach, and in both cases we are prototyping at the small scale of few tens of cms. We here present our progress on these two approaches., Comment: 13 pages, SPIE Proceedings Volume 10700, Ground-based and Airborne Telescopes VII; 107003X (2018). Event: SPIE Astronomical Telescopes + Instrumentation, 2018, Austin, Texas, United States

The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates. Light sensitivity is restored when apo-opsin combines with another 11cRAL to form a new visual pigment. Conversion of atRAL to 11cRAL is carried out by enzyme pathways in neighboring cells. Here we show that blue (450-nm) light converts atRAL specifically to 11cRAL through a retinyl-phospholipid intermediate in photoreceptor membranes. The quantum efficiency of this photoconversion is similar to rhodopsin. Photoreceptor membranes synthesize 11cRAL chromophore faster under blue light than in darkness. Live mice regenerate rhodopsin more rapidly in blue light. Finally, whole retinas and isolated cone cells show increased photosensitivity following exposure to blue light. These results indicate that light contributes to visual-pigment renewal in mammalian rods and cones through a non-enzymatic process involving retinyl-phospholipids., It is currently thought that visual pigments in vertebrate photoreceptors are regenerated exclusively through enzymatic cycles. Here the authors show that mammalian photoreceptors also regenerate opsin pigments in light through photoisomerization of N-ret-PE (N-retinylidene-phosphatidylethanolamine.

The novel Hamamatsu Multi Pixel Photon Counter Array S12045(X) is an array of 16 individual MPPCs (3×3 [mm2]) (further in the article MPPC array channel) each with 3600 G-APD (Geiger-mode Avalanche Photodiode) pixels (50×50 [μ m2]). Each MPPC in the array works with its individual reverse bias voltage around 70[V]. We studied the main features of each MPPC array channel for 2800 MPPC arrays at different temperatures. Two measurement systems were built to extract Gain, Breakdown Voltage, Photon Detection Efficiency (PDE), Optical Cross-talk and Dark rate for each MPPC array channel. The article describes the characterization process of MPPC arrays used in GlueX experiment (Jefferson Lab, Hall D). The hardware and the performed data analysis are described, which include new analytical expressions to obtain the number of photoelectrons and Optical Cross-Talk. The dynamical behavior of characterization parameters is presented as well.