1. The impact of diabetes mellitus on treatment and outcomes of rheumatoid arthritis at 5-year follow-up: results from a multi-ethnic Asian cohort
- Author
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Andrea Ang, T.Y. Lian, Hwee Siew Howe, Xin Rong Lim, Claire Teo Min-Li, W. G. Law, Paula Permatasari Tjokrosaputro, Mona Manghani, Ee Tzun Koh, Kok Ooi Kong, Teck Choon Tan, Chuanhui Xu, Grace Yin Lai Chan, Justina Wei Lynn Tan, Samuel Lee Shang Ming, Sze-Chin Tan, Mei Yun Yong, Faith Li-Ann Chia, Hiok Hee Chng, L.W. Koh, Rinkoo Dalan, Bernard Yu-Hor Thong, Jess Mung Ee Loh, Angela Li-Huan Chan, Choon Guan Chua, Khai Pang Leong, and Madelynn Tsu-Li Chan
- Subjects
musculoskeletal diseases ,rheumatoid arthritis ,medicine.medical_specialty ,Univariate analysis ,endocrine system diseases ,treatment ,business.industry ,medicine.medical_treatment ,Ethnic group ,Type 2 Diabetes Mellitus ,nutritional and metabolic diseases ,medicine.disease ,outcomes ,Arthroplasty ,Rheumatology ,Rheumatoid arthritis ,Diabetes mellitus ,Internal medicine ,Cohort ,diabetes mellitus ,Medicine ,Functional status ,Original Article ,business ,AcademicSubjects/MED00010 - Abstract
Objectives We evaluated the impact of type 2 diabetes mellitus (T2DM) on RA treatment and outcomes in a longitudinal RA cohort. Methods We analysed data collected in the period 2001–2013 involving 583 RA patients, including demographics, diabetes diagnosis, clinical features, treatment, ACR functional class, HAQ, and quality-of-life measurement using the Short-Form 36. Results Seventy-seven (13.2%) of the RA patients had T2DM. DAS28 was not different in patients with T2DM at 5 years post-RA diagnosis. Fewer T2DM patients received MTX than those without T2DM (51% vs 80%, P < 0.001). Using univariate analysis, T2DM patients were more likely to experience poorer outcomes in terms of ACR functional status (P = 0.009), joint surgery (P = 0.007), knee arthroplasty (P < 0.001) and hospital admissions (P = 0.006). Multivariate regression analyses showed more knee arthroplasty (P = 0.047) in patients with T2DM. Conclusion Fewer patients with T2DM received MTX compared with those without T2DM. Patients with RA and T2DM were at higher risk of knee arthroplasty than RA patients without T2DM.
- Published
- 2021