1. Health-related quality of life in men with osteoporosis: a systematic review and meta-analysis
- Author
-
Jiayi Liu, Ou Wang, Lei Sun, Di‐chen Zhao, Weibo Xia, Yan Jiang, Wenbing Zheng, Bingna Zhou, Hu Jing, Mei Li, and Xiaoping Xing
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,030209 endocrinology & metabolism ,Cochrane Library ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Quality of life ,Diabetes mellitus ,medicine ,Humans ,Hip fracture ,Hip Fractures ,business.industry ,Public health ,Bone fracture ,medicine.disease ,humanities ,030220 oncology & carcinogenesis ,Meta-analysis ,Quality of Life ,Physical therapy ,Spinal Fractures ,business ,Osteoporotic Fractures - Abstract
The increased social and economic burdens make osteoporosis in men an emerging public health issue. However, the quality of life among men with osteoporosis is still unclear. This systematic review and meta-analysis aimed to evaluate the health-related quality of life (HRQoL) among men with osteoporosis or osteoporotic fracture. PubMed, EMBASE, and the Cochrane Library database were systematically searched from inception to May 2021. Studies were included if they used validated questionnaires to measure HRQoL among osteoporotic men. A meta-analysis was performed using a random-effects model or fixed-effects model to calculate the standard mean difference (SMD) or mean difference (MD) with 95% confidential interval (95% CI). 14 studies involving 6338 male participants were chosen for systematic review, of which 10 were included in the meta-analysis. Men with osteoporosis had poorer global HRQoL and multiple dimensions of HRQoL than men without osteoporosis. Hip fracture, vertebral fractures, or wrist fractures dramatically impaired HRQoL of men, and physical function was declined even before hip fracture (SMD = −0.60, 95% CI, −0.82 to −0.39). Femoral and lumbar BMD was positively correlated with HRQoL, and a number of fragility fractures and time since fracture had negative effects on HRQoL. Effective anti-osteoporotic drugs could improve HRQoL of men. The health-related life quality of men was significantly impaired by osteoporosis and fracture of the hip, vertebral, or wrist. We should pay more attention to the diagnosis and treatment of male osteoporosis to improve the life quality of men.
- Published
- 2021