Search

Background Epithelial surface disruption in genital psoriatic lesions may manifest as erosions, fissures and/or ulcers, causing pain and significantly impacting a patient's sexual health. Objective To evaluate the impact of erosions, fissures and/or ulcers in genital psoriatic lesions on pain and sexual activity in patients with moderate‐to‐severe genital psoriasis (GenPs) and treatment responses to ixekizumab vs. placebo until Week 12. Methods This post hoc subgroup analysis of patients presenting with and without erosions, fissures and/or ulcers in genital lesions from a phase IIIb multicentre, randomized, double‐blind, placebo‐controlled study (IXORA‐Q; NCT02718898) in 149 adults with moderate‐to‐severe GenPs treated with subcutaneous ixekizumab (80 mg every 2 weeks; n = 75) or placebo (n = 74) evaluated outcomes for clinician‐rated GenPs severity (static Physician's Global Assessment of Genitalia; sPGA‐G) and patient‐reported genital pain and itch (Genital Psoriasis Symptoms Scale; GPSS) and sexual health (Genital Psoriasis Sexual Frequency Questionnaire; GenPs‐SFQ). Results At baseline, 38% (n = 57) of patients presented with genital erosions, fissures and/or ulcers independent of overall body surface area involvement (

Resume Introduction Les anomalies du raphe median peuvent etre detectees lors de l’examen postnatal ou n’apparaissent qu’au cours de l’enfance ou a l’âge adulte. Elles se rencontrent isolement ou peuvent etre associees a des malformations urogenitales parfois severes. Methode Une revue de la litterature a ete realisee en considerant les articles traitant des anomalies du raphe median, repertories sur la base de donnees Medline jusqu’en avril 2015, a l’aide des mots cles « male », « median raphe » et « abnormalities ». Les articles ont ete selectionnes selon leur langue de publication (anglais et francais) et la pertinence par rapport au sujet. Resultats Quarante et un articles relatifs aux anomalies du raphe median ont ete repertories, dont cinq ont ete selectionnes pour leur pertinence. Nous decrivons les anomalies les plus frequentes (hyperpigmentation, deviation, division, kyste, canal et sinus) en precisant les aspects cliniques, les indications des examens complementaires, les risques de malformations urogenitales potentiellement associees et la prise en charge. Discussion Les anomalies du raphe median meritent d’etre connues de l’urologue car elles peuvent constituer un motif de consultation devant la gene fonctionnelle ou esthetique qu’elles occasionnent ou devant l’apparition d’une complication, notamment infectieuse.

Infliximab, a tumour necrosis factor (TNF)-alpha antagonist, has shown striking efficacy in the treatment of chronic inflammatory rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis. However, long-term follow-up studies support that treatment with infliximab is associated with an increased risk of non-Hodgkin lymphoma. So far, few cases of cutaneous lymphoma have been reported in patients receiving TNF-alpha-blocking agents. We report a patient who developed Sezary syndrome 17 months after the onset of infliximab therapy for ankylosing spondylitis. Cutaneous lesions partially remitted following infliximab withdrawal and methotrexate treatment. Although the causal link between infliximab and the emergence of Sezary syndrome is uncertain, the present case raises the need for exhaustive long-term registries of malignancies, including primary cutaneous lymphomas, in patients receiving TNF-alpha-blocking agents.