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Food quality and safety issues occurred frequently in recent years, which have attracted more and more attention of social and international organizations. Considering the increased quality risk in the food supply chain, many researchers have applied various information technologies to develop real-time risk identification and traceability systems (RITSs) for preferable food safety guarantee. This paper presents an innovative approach by utilizing the deep-stacking network method for hazardous risk identification, which relies on massive multisource data monitored by the Internet of Things timely in the whole food supply chain. The aim of the proposed method is to help managers and operators in food enterprises to find accurate risk levels of food security in advance and to provide regulatory authorities and consumers with potential rules for better decision-making, thereby maintaining the safety and sustainability of food product supply. The verification experiments show that the proposed method has the best performance in terms of prediction accuracy up to 97.62%, meanwhile achieves the appropriate model parameters only up to 211.26 megabytes. Moreover, the case analysis is implemented to illustrate the outperforming performance of the proposed method in risk level identification. It can effectively enhance the RITS ability for assuring food supply chain security and attaining multiple cooperation between regulators, enterprises, and consumers.

Background: Thromboangiitis obliterans (TAO) is a chronic, non-atherosclerotic, progressive inflammatory vascular disease affecting the small- and medium-size arteries and veins of the extremities. Objective: To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO. Methods: Patients with TAO who underwent anticoagulation as the mainstay of treatment were included in this prospective study. Rest pain relief and healing of trophic lesions (as the primary and secondary endpoint) were investigated at Day 14 and after 6 months of follow-up. High sensitivity C-reactive protein (hsCRP), monocyte count, and ankle-brachial index (ABI) were recorded, and the difference was compared before and after 2-week anticoagulation. The Chi-square test was used to compare the difference between anticoagulant and aspirin groups (based on the literature). Results: From 2014 to 2019, 18 patients were included. Only 1 patient with wet gangrene received endo-therapy for a failing stent at the start of treatment. After ~14 days, 12 of 13 (92%) patients showed complete ulcer healing, and 17 of 18 (94%) patients showed complete relief from rest pain. Monocyte-counts and hsCRP levels decreased significantly (p Conclusion: Anticoagulant therapy may alleviate the inflammation and symptoms of TAO.

Summary Recent attempts have been made to direct the sensory neurotisation of free superficial circumflex iliac artery (SCIA) flaps. However, donor nerves enabling sensory recovery are limited. We report our findings in fifteen patients who underwent distal limb defect reconstruction using a sensate SCIA flap, including the lateral cutaneous branch of the subcostal nerve (LCSN), between August 2017 and September 2018. The distance from the anterosuperior iliac spine to the point where the LCSN crossed the iliac crest ranged between 6.5 and 10 cm. The diameter ranged between 1.5 and 4.0 mm. The flap size ranged between 8 × 4 and 13 × 10 cm2. All of the flaps survived uneventfully. Tests of sensory modalities, including the Semmes-Weinstein (SW) touch, vibration, pinprick, temperature and static two-point discrimination (s2PD) tests were applied in nine regions of each flap post-operatively. One or more modalities were present in at least one region at 6 months post-operatively, and the recovery of vibration perception was more consistent than that of SW touch and pinprick perception. The recovery of s2PD was noted in 4 cases over a follow-up period of more than 12 months. A reliable sensate flap with the LCSN can be considered as an attractive option for the sensory reconstruction of distal limb defects of moderate size.

Background Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory malignancy with poor prognosis. It is urgent to identify novel and valid biomarkers to predict the progress and prognosis of PDAC. The S100A family have been identified as being involved in cell proliferation, migration and differentiation progression of various cancer types. However, the expression patterns and prognostic values of S100As in PDAC remain to be analyzed. Methods We investigated the transcriptional expressions, methylation level and prognostic value of S100As in PDAC patients from the Oncomine, GEPIA2, Linkedomics and cBioPortal databases. Real-time PCR was used to detect the expressions of S100A2/4/6/10/14/16 in four pancreatic cancer cell lines and pancreatic cancer tissues from PDAC patients undergoing surgery. To verify the results further, immunohistochemistry was used to measure the expression of S100A2/4/6/10/14/16 in 43 PDAC patients’ tissue samples. The drug relations of S100As were analyzed by using the Drugbank database. Results The results suggested that, the expression levels of S100A2/4/6/10/14/16 were elevated to PDAC tissues than in normal pancreatic tissues, and the promoter methylation levels of S100A S100A2/4/6/10/14/16 in PDAC (n = 10) were lower compared with normal tissue (n = 184) (P Conclusions Taken together, these results suggest that S100A2/4/6/10/14/16 might be served as prognostic biomarkers for survivals of PDAC patients.

Shortened versions of self-reported questionnaires may be used to reduce respondent burden. When shortened screening tools are used, it is desirable to maintain equivalent diagnostic accuracy to full-length forms. This manuscript presents a case study that illustrates how external data and individual participant data meta-analysis can be used to assess the equivalence in diagnostic accuracy between a shortened and full-length form. This case study compares the Patient Health Questionnaire-9 (PHQ-9) and a 4-item shortened version (PHQ-Dep-4) that was previously developed using optimal test assembly methods. Using a large database of 75 primary studies (34,698 participants, 3,392 major depression cases), we evaluated whether the PHQ-Dep-4 cutoff of ≥ 4 maintained equivalent diagnostic accuracy to a PHQ-9 cutoff of ≥ 10. Using this external validation dataset, a PHQ-Dep-4 cutoff of ≥ 4 maximized the sum of sensitivity and specificity, with a sensitivity of 0.88 (95% CI 0.81, 0.93), 0.68 (95% CI 0.56, 0.78), and 0.80 (95% CI 0.73, 0.85) for the semi-structured, fully structured, and MINI reference standard categories, respectively, and a specificity of 0.79 (95% CI 0.74, 0.83), 0.85 (95% CI 0.78, 0.90), and 0.83 (95% CI 0.80, 0.86) for the semi-structured, fully structured, and MINI reference standard categories, respectively. While equivalence with a PHQ-9 cutoff of ≥ 10 was not established, we found the sensitivity of the PHQ-Dep-4 to be non-inferior to that of the PHQ-9, and the specificity of the PHQ-Dep-4 to be marginally smaller than the PHQ-9.

To investigate the proportion and clinical characteristics of obstructive sleep apnea (OSA) in Chinese patients with polycystic ovarian syndrome (PCOS) through home sleep apnea test (HSAT) and to evaluate the reproductive endocrine and metabolic characteristics in these patients. The study was a cross-sectional analysis of infertile PCOS patients who underwent sleep respiratory monitoring between January and December 2019 at Peking University Third Hospital Reproductive Medical Center and respiratory and critical care medicine department. The prevalence of OSA, body mass index (BMI), menstruation, reproductive endocrine, and metabolic characteristics were collected in patients with PCOS. Logistic regression was performed to identify significant relationships among these factors and OSA. Amont 328 patients with PCOS, the prevalence of OSA was 40% (131/328), and six cases (5%) were severe. Univariate analysis showed that BMI and blood pressure were significantly higher in patients with OSA than in those without OSA (P

IntroductionTo investigate the value of carotid cistern drainage in patients with aneurysmal subarachnoid haemorrhage during intracranial aneurysm clipping.Material and methodsPatients with ruptured intracranial aneurysms were included in this study. During the operation, the craniotomy was performed via a pterional approach to separate the Sylvian cistern and carotid cistern. After completing the clipping of the intracranial aneurysm, a drainage tube was placed in the carotid cistern between the ipsilateral internal carotid artery and optic nerve or lateral internal carotid artery, which was led out through the dura mater, cranial flap foramen or gap and scalp, and connected with an external drainage device.ResultsA total of 6 patients with aneurysmal subarachnoid haemorrhage, who required craniotomy for clipping, were enrolled in the study. These patients were given carotid cistern drainage during the operation. Among these 6 patients, 2 had anterior communicating aneurysms, 1 had a posterior communicating aneurysm of the internal carotid artery, 2 had middle cerebral artery furcation aneurysms, and 1 patient had multiple intracranial aneurysms. For the Hunt-Hess score before the operation, 5 patients were in grade II and 1 patient was in grade III. Furthermore, the postoperative drainage was unobstructed, with a daily drainage of 130–290 ml of haemorrhagic cerebrospinal fluid (CSF).ConclusionsThe CSF drainage of the carotid cistern applied in patients with aneurysmal subarachnoid haemorrhage during the craniotomy for clipping can effectively remove the subarachnoid haemorrhage, control the intracranial hypertension, and reduce the incidence of cerebral vasospasm and hydrocephalus.

Fine-grained visual classification tasks often suffer from that the subordinate categories within a basic-level category have low inter-class discrepancy and high intra-class variances, which is still challenging research for traditional deep neural networks (DNNs). However, different models extract local parts’ features in isolation and neglect the inherent correlations and distribution in high-dimensional space, which limit the single model to achieve better accuracy. In this paper, we propose a novel probability fusion decision framework (named as PFDM-Net) for fine-grained visual classification. More specifically, it first employs data-augmented tricks to enlarge the dataset and pretrain the basic VGG19 and ResNet networks on high-quality images datasets to learn common and domain knowledge simultaneously while fine-tuning with professional skill. Next, refined multiple DNNs with transfer learning are applied to design a multi-stream feature extractor, which utilizes the mixture-granularity information to exploit high-dimensionality features for distinguishing interclass discrepancy and tolerating intra-class variances. Finally, a probability fusion module equipped with gating network and probability fusion layer is developed to fuse different components model with Gaussian distribution as a unified probability representation for the ultimate fine-grained recognition. The input of this module is the various features of multi-models and the output is the fused classification probability. The end-to-end implementation of our framework contain an inner loop about the EM algorithm within an outer loop with the gradient back-propagation optimization of the whole network. Experimental results demonstrate the outperforming performance of PFDM-Net with higher classification accuracy on different fine-grained datasets compared with the state-of-the-arts methods. More discussions are provided to indicate the potential applications in combination with other work.

Transplant vasculopathy is one of the major causes of chronic rejection after solid organ transplantation. The pathogenic mechanisms of transplant vasculopathy are still poorly understood. Herein, we summarize current evidence suggesting that activation of the tunica adventitia may be involved in the pathogenesis of transplant vasculopathy. Adventitia is an early responder to various vascular injuries and plays an integral role in eliciting vascular inflammation and remodeling. Accumulation of macrophages in the adventitia promotes the development of vascular remodeling by releasing a variety of paracrine factors that have profound impacts on vascular mural cells. Targeting adventitial macrophages has been shown to be effective for repressing transplantation-induced arterial remodeling in animal models. Adventitia also fosters angiogenesis, and neovascularization of the adventitial layer may facilitate the transport of inflammatory cells through the arterial wall. Further investigations are warranted to clarify whether inhibiting adventitial oxidative stress and/or adventitial neovascularization are better strategies for preventing transplant vasculopathy.

Myocardial ischaemia reperfusion (I/R) injury is one of the leading causes of coronary artery disease-associated morbidity and mortality. While different strategies have been used to limit I/R injuries, cardiac functions often do not recover to the normal level as anticipated. Recent studies have pointed to important roles of long noncoding RNAs (lncRNAs) in the development of myocardial I/R injury. LncRNA is a class of RNA molecules of more than 200 nucleotides in length which are not translated into proteins. I/R causes dysregulation of lncRNA expression in cardiomyocytes, thereby affecting multiple cellular functions including mitochondrial homeostasis, apoptosis, necrosis and autophagy, suggesting that manipulating lncRNAs may be of great potential in counteracting I/R injury-induced myocardial dysfunctions. In this review, we provide an updated summary on our knowledge about contributions of lncRNAs to the development of I/R injury, with an emphasis on the functional links between several well established cardiac lncRNAs and regulation of cellular outcomes post I/R.

It is difficult to select small targets in freehand distal pointing on large displays due to physical fatigue and jitter. Previous research proposed many solutions but not through the semantic meaning of hand behaviors. The purpose of this study is to investigate the hand behaviors, including hand shapes and motions in the Z-dimension between small and large target selections, by means of two controlled experiments. The generated results indicated that the following: (1) when interacting with a large display from a remote distance, users preferred to complete a low-precision task by the whole hand while using the finger in high-precision tasks. As a result, users moved small targets by the index finger gesture while moving large targets by open hand gesture; (2) selection of small targets led to hand stretching which might reduce the interaction distance; (3) the orientation had significant effects on hand motions in the Z-dimension. The relationship between orientation and hand motions in the Z-dimension is similar to a sinusoidal function; (4) mouse-like pointing had much impact on freehand interaction. Based on these results, some design guidelines for freehand interaction and design suggestions for freehand pointing were discussed.

We sought to unravel the role of hydrogen sulfide (H2S) in the development of hypertension in patients with obstructive sleep apnea (OSA). The study sample included 80 patients with OSA and 45 healthy controls. All subjects underwent measurement of blood pressure (BP) and serum H2S level in the morning. Twentynine of the 39 patients with OSA and concomitant hypertension and 23 of the 41 patients with OSA but no concomitant hypertension received continuous positive alveolar pressure (CPAP) therapy for 4 weeks. Twenty-four-hour ambulatory BP and serum H2S were determined before and after CPAP. Respiratory indices including apnea hypopnea index (AHI), lowest oxygen saturation (SaO2), and length of time 0.05). Multivariate linear regression analysis demonstrated that 24h systolic BP and 24h diastolic BP correlated with H2S as well as their changes after CPAP treatment. Reduction in H2S may play a role in the pathogenesis of hypertension in patients with OSA.

Because the plentiful online resources and visualized learning material are not workable for individuals with visual impairment in Chinese, they face a variety of challenges when they learn. To address this issue, a cloud-based Visually Impaired People (VIP) E-learning Platform with the course on Chinese typing method have been implemented, and the competition for visual impairment on typing and searching online information has been organized to promote and investigate their typing performance. This study aims to examine the design, course, and promotion of the VIP platform through the participants' typing performance in the competition based on their feedback annually. The data compared with ones of last year show that the number of competition participants and the users of the platform were increased by 87 users because of the competition and the courses, the typing speed of adult group performed better than that of the last year, and the accuracy rate performance above is 90%. It is higher than normal-sighted people, which indicates that the platform not only attracts more users year by year but reaches out to the visual impairments to take advantage to strengthen their information and searching abilities by self-directed learning on the Internet.

Background:. Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) syndrome are highly prevalent respiratory conditions. Their coexistence is referred to as the overlap syndrome. They are both related to pulmonary hypertension (PH) development. This study investigated the effects of OSA on PH in patients with COPD and the associated factors. Methods:. Consecutive patients with stable COPD were recruited for an observational cross-sectional study from September 2016 to May 2018 at Peking University Third Hospital. In total, 106 patients with COPD were enrolled and performed home portable monitoring and echocardiography. OSA was defined by an apnea hypopnea index (AHI) ≥10 events/h. Based on OSA absence or presence, patients were divided into the COPD with OSA and COPD without OSA groups. Factors affecting pulmonary artery pressure (PAP) and PH were identified using univariate analysis and logistic regression models. Results:. In the 106 patients with COPD, the mean age was 69.52 years, 91.5% were men, and the mean forced expiratory volume in 1 s (FEV1) percentage of predicted was 56.15%. Fifty-six (52.8%) patients with COPD were diagnosed with OSA, and 24 (22.6%) patients with COPD were diagnosed as PH. Compared with COPD without OSA group, the median PAP in COPD with severe OSA group increased by 5 mmHg (36.00 [26.00–50.00] mmHg vs. 31.00 [24.00–34.00] mmHg, P = 0.036). COPD with percent of night-time spent with oxygen saturation below 90% (T90) > 10% group had higher PAP than COPD with T90 ≤ 1% group (36.00 [29.00–50.00)] mmHg vs. 29.00 [25.50–34.00] mmHg, F = 7.889, P = 0.007). Univariate analysis revealed age, FEV1% predicted, T90, and Charlson index had statistically significant effects on PH. Multiple regression analysis showed a significant and independent effect of both FEV1% predicted (odds ratio [OR] = 3.46; 95% confidence interval [CI]: 1.15–10.46; P = 0.028) and AHI (OR = 3.20; 95% CI: 1.09–19.35; P = 0.034) on PH. Conclusions:. Patients with COPD with OSA are more susceptible to PH, which is associated with declining lung function and increased severity of OSA. Thus, nocturnal hypoxemia and OSA in elderly patients with COPD should be identified and treated.

The aim of this report is to present the clinical results of using free chimeric iliac osteocutaneous flaps based on the periosteal branch of the superficial circumflex iliac artery (SCIA) in complex metacarpal reconstructions.Reconstruction using free chimeric iliac osteocutaneous flaps was performed in a series of seven patients who underwent metacarpal reconstruction for complex metacarpal defects between March 2009 and March 2012. The procedure was performed for bone and soft tissue losses associated with posttraumatic infections (four patients) and posttraumatic bone and soft tissue defects (three patients).The skin paddles of the chimeric flaps had a median size of 3 × 7 cm, and the iliac segments had a mean size of 1 × 1 × 3 cm. The median follow-up time was 18 months. All the flaps survived completely with no signs of infection. Osseous union occurred within a mean period of 3 months, and the range of motion achieved for the metacarpal phalangeal joints was 0-80°. The patients were satisfied with the aesthetic outcome.Chimeric iliac osteocutaneous flaps may be a useful alternative for treating complex metacarpal defects because they yield a thinner skin paddle and less bulky bone segment than traditional flaps.

As one crucial component for the latest generation of adaptive optics, tremendous efforts have been put into the development of high performance 20 W class sodium laser guide star laser system. Two such systems, the continuous wave laser by Toptica, and the quasi-continuous pulse laser by TIPC were extensively studied with simulation and field tests. A new type of 20 W class sodium laser, macro–micro pulse laser, is currently being developed by CIOMP. In this paper, we will study its on-sky performance with simulation based on Monte Carlo rate equation method. The predicted coupling efficiency for this laser in the zenith direction in Changchun is 179.73 photons s−1 W−1/(atoms m−2). The variation of coupling efficiency of this type of laser with pointing direction and the effect of D2b repumping are also studied and reported in this paper.

In this paper, a novel semi-supervised segmentation framework based on a spot-divergence supervoxelization of multi-sensor fusion data is proposed for autonomous forest machine (AFMs) applications in complex environments. Given the multi-sensor measuring system, our framework addresses three successive steps: firstly, the relationship of multi-sensor coordinates is jointly calibrated to form higher-dimensional fusion data. Then, spot-divergence supervoxels representing the size-change property are given to produce feature vectors covering comprehensive information of multi-sensors at a time. Finally, the Gaussian density peak clustering is proposed to segment supervoxels into sematic objects in the semi-supervised way, which non-requires parameters preset in manual. It is demonstrated that the proposed framework achieves a balancing act both for supervoxel generation and sematic segmentation. Comparative experiments show that the well performance of segmenting various objects in terms of segmentation accuracy (F-score up to 95.6%) and operation time, which would improve intelligent capability of AFMs.

Cell apoptosis is involved in acute brain injury after aneurysmal subarachnoid hemorrhage (aSAH). The protein cytokeratin-18 (CK-18) is cleaved by the action of caspases during apoptosis, and the resulting fragments are released into the blood as caspase-cleaved CK (CCCK)-18. Our study examined the relationship between circulating CCCK-18 levels and long-term clinical outcomes among aSAH patients.We recruited 128 aSAH patients and 128 controls (matched on age and sex). Serum was collected at admission to the emergency department. Unfavorable outcome was defined as the Glasgow Outcome Score scores of 1-3. After a 6-month follow-up period, outcomes were assessed using a logistic regression analyses. The prognostic predictive values were evaluated according to receiver operating curves analysis.aSAH patients had higher plasma CCCK-18 levels compared to controls (235.1 ± 86.8 U/L vs. 25.6 ± 23.4 U/L, P0.001). CCCK-18 was independently associated with World Federation of Neurological Surgeons (WFNS) scores (t=4.460, P0.001) and modified Fisher scores (t=3.781, P0.001). Furthermore, CCCK-18 levels were markedly higher among patients with an unfavorable outcome and among non-survivors. CCCK-18 was yet identified as an independent prognostic predictor for mortality (odds ratio, 5.769; 95% confidence interval, 1.196-27.832; P=0.029) and unfavorable outcome (odds ratio, 4.909; 95% confidence interval, 1.521-15.838; P=0.008), as well as had similar predictive values for them compared with WFNS scores and modified Fisher scores.High circulating CCCK-18 levels were associated with injury severity and a poor clinical outcome after aSAH and CCCK-18 had the potential to be a good prognostic biomarker for aSAH.

Type 2 diabetes mellitus (T2DM) is a complex and multifactorial disease that is generally characterized by insulin resistance and loss of β-cell function that develops in adulthood. To date, more than 6% of the world's population is affected by T2DM. The main treatments of T2DM are dietary and lifestyle changes. However, only dependent on behaviour modification and oral hypoglycemics, many patients are unable to maintain glycemic control. Emerging evidence indicates that up to 80% of patients with T2DM undergoing Roux-en-Y gastric bypass (RYGB) experience complete remission of their T2DM and the majority of remissions occur almost immediately following the operation. Obestatin is a 23-amino-acid peptide, which is not only thought to suppress food intake and decrease gastric emptying but also found to exert survival effects in pancreatic β cells, increase glucose-stimulated insulin secretion, and reduce insulin resistance and inflammation. In addition, some researchers demonstrated that obestatin is a nutritional marker reflecting body adiposity and insulin resistance. Although results from previous studies were conflicting, the peripheral blood concentrations of obestatin were changed after RYGB. Therefore, regulation of obestatin level may be another mechanism for RYGB-induced remission of T2DM. In this article, we review briefly the effect of RYGB on T2DM in humans and offer an overview of the published data on the effects of RYGB on obestatin level in patients with T2DM. Furthermore, the possible roles of obestatin in the remission of T2DM following RYGB are also reviewed. Copyright © 2015 John Wiley & Sons, Ltd.

Objective Thrombospondin-1 (TSP-1) acts as an anti-angiogenic factor, and its expression in rat brain is upregulated after intracerebral hemorrhage. The current study was designed to investigate the change of plasma TSP-1 levels and assess the prognostic predictive effect of plasma TSP-1 level and it is associated with head trauma severity in the patients with severe traumatic brain injury (STBI). Materials and methods The plasma TSP-1 levels of 134 patients and 134 healthy controls were measured using enzyme-linked immunosorbent assay. The relationships between plasma TSP-1 levels and trauma severity reflected by Glasgow Coma Scale (GCS) scores as well as between plasma TSP-1 levels and short-term and long-term clinical outcomes were analyzed using multivariate analysis. Results Plasma TSP-1 levels were statistically significantly higher in patients than in healthy controls. The multivariate analysis demonstrated close association of TSP-1 with GCS scores and also identified TSP-1 as an independent predictor for 1-week mortality, 6-month mortality, and 6-month unfavorable outcome. Plasma TSP-1 levels had high prognostic predictive value based on receiver operating characteristic curve. The difference between its prognostic predictive value and GCS scores was not statistically significant. Conclusions Plasma TSP-1 levels are elevated and are highly associated with head trauma severity and short-term and long-term outcomes of STBI. TSP-1 may be a good prognostic biomarker of STBI.

Upper extremity lymphedema is the abnormal accumulation of protein-rich interstitial fluid in affected limb due to the insufficient capacity of the lymphatic system after axillary lymph node dissection (ALND) in breast cancer surgery. It is marked by an abnormal increase of tissue proteins, edema, chronic inflammation, and fibrosis. Lymphedema and its related symptoms seriously affect the quality of patient's life. However, lymphedema treatment is difficult and comes with different therapies. In this review, we discussed the anatomical and pathophysiological basis of upper extremity lymphedema. We also analyzed the characteristics and drawbacks of some existing managements and highlighted the importance of adaptive conceptions in treating upper extremity lymphedema.

Background: To evaluate HPV testing by Hybrid Capture II (HCII) in conjunction with cytology in detecting the residual/recurrence disease after treatment of high-grade cervical intraepithelial neoplasia (CIN II-III) with loop electrosurgical excision procedure (LEEP). Materials and Methods: A retrospective review of 158 patients with histologically confirmed CIN II-III who underwent LEEP between January 2011 and October 2012 was conducted. Post-treatment control was scheduled at the 3rd, 6th, 12th and 18th month. All patients were followed up by Pap smear and HR-HPV genotype and viral load testing. Results: Pre-treatment, HR-HPV DNA, was detected in all specimens of the patients. At follow-up, 25 patients were diagnosed as the residual/recurrent disease during the FU visit, among whom, 16 patients with positive margin: 13 patients (52%) with HR-HPV DNA+/ cytology+, 2 patients (8%) with HR-HPV DNA+/cytology-, 1 patient (4%) with cytology+/ HR-HPV DNA-; 9 patients with clean margin - 5 patients (55.6%) with HR-HPV DNA+/cytology+; 2 patients (22.2%) with HR- HPV DNA+/cytology-, 2 patients (22.2%) with cytology+/ HR-HPV DNA-. None of them persisting HR-HPV DNA-/cytology- with positive or negative margin was identified as the residual/recurrent disease. The majority of residual/recurrent disease was detected at the 12th and 18th month FU, and there was almost no difference in the sensitivity and negative predictive value (NPV) between at the 3rd month and the 6th month FU visits. 14 residual/recurrence disease (14/46:30.4%) had pre-treatment high viral load (>5 000 RUL/PC) and 11 (11/112, 9.8%) with pre-treatment low viral load, P

Background This study aimed to explore relevant factors of hemorrhagic contusions following decompressive craniotomy (DC) in traumatic brain injury (TBI) and create an artificial neural network (ANN) prediction model of the risk factors of hemorrhagic contusions. Methods This study analyzed 425 patients with TBI who underwent DC in the Neurosurgery Department of Shaoxing People's Hospital between 2009 and 2014. Patients were divided into two groups according to the first postoperative CT scans: hemorrhage group and non-hemorrhage group. Gender, age, preoperative situations (Initial Rotterdam CT Score, GCS Score, pupillary response, laboratory data and preoperative hematoma), the time gap between trauma and DC, postoperative CT scans, and Glasgow Outcome Scale (GOS) scores were recorded. ANN was used to predict hematoma. Correlation analysis was used to state the relationship between increased hemorrhage volumes and GOS scores. Results The ANN prediction model was established. This model included 11 parameters: initial Rotterdam CT score, GCS score, C-reactive protein, age, the time gap between trauma and DC, pupillary response, platelet count, bone-flap size, glucose level, hernia magnitude and preoperative hematoma volume. The overall predictive accuracy of the model was 73.0%. Conclusions Initial Rotterdam CT scores and GCS scores may predict the risk of expansion contusions following DC. The ANN prediction model has a high accuracy to forecast hemorrhage.

Background As understanding of the blood supply by superficial circumflex iliac artery (SCIA) to the skin and iliac bone has improved and the use of a perforator flap has become accepted, most previous drawbacks of SICA iliac osteocutaneous flaps, such as bulky flap, small diameter, and inadequate blood supply to bone, can now be overcome. Here, the authors present their experience of using such flaps for the reconstruction of complex defects in the foot and ankle with a focus on feasibility and safety. Methods A retrospective review of patients who underwent foot and ankle reconstruction using an SCIA iliac osteocutaneous flap between 2010 and 2015 was performed to assess outcomes. Results Four patients who underwent treatment with SCIA iliac osteocutaneous flaps and eight patients treated with fabricated chimeric iliac osteocutaneous flaps were identified. The iliac segment size ranged from 1 × 3 × 0.7 to 3 × 6 × 1 cm and the skin paddle size ranged from 1 × 4 to 8 × 16 cm. All flaps survived uneventfully except for marginal necrosis in one anterolateral thigh (ALT) flap and one iliac osteocutaneous flap. The median time to bone union was 4 months. All patients were able to walk in normal footwear and none developed significant complications at the donor site. Conclusion The use of free SCIA iliac osteocutaneous and fabricated chimeric iliac osteocutaneous flaps provides an alternative for treating small- and medium-sized bone defects (smaller than 8 cm) along with soft tissue defects in the foot and ankle region.

Brush-cutter would always bring cutting shock in its cutting process, and its not easy to estimate the cutting resistance by usual cutting theory and methods. The present paper emulates real cutting process by using ANSYS/LS-DYNA, and orthogonal anisotropy model was used to symbolize the wood material. The result shows that the cutting tool with a 40 degrees rake is more competent than the ones with 30 degrees and 50 degrees. This result fits common cutting theories, thus the rationality of this research is proved, and a cutting resistance curve is obtained.

Considering the inherent characteristics of incomplete fingerprint: local feature loss and global information distortion, the recognition progress has been mainly restricted by two critical problems: how to precisely extract informative features and still with compact representation of the incomplete fingerprint; and how to effectively measure the similarity between fingerprint images. In this paper, to handle the first problem, both the minutiae and orientation field feature are extracted and then fused to get a more comprehensive feature with scale and rotation invariability. Dealing with the second one, the pattern entropy is introduced to robustly measure the similarity of two incomplete fingerprints. Extensive experiments have been conducted on both those popular fingerprint databases and our extended databases containing more incomplete fingerprints. Meanwhile, thorough performance comparisons have been made with existing approaches. Experimental results show that our approach has more efficient ability especially in incomplete fingerprint recognition, and also performs well in both accuracy and efficiency.

Reconstruction following devastating hand injuries, with amputations of the thumb plus multiple digits, is challenging. Double flap or combined flap transfers may be options in such cases. Between 2012 and 2014, 6 patients underwent hand reconstruction following devastating injuries with amputations of the thumb and multiple digits. Sensate anterolateral thigh free flaps and superficial circumflex iliac artery osteocutaneous flaps were microsurgically fabricated as sequential chimeric flaps. Basic hand function, including pulp-to-palm distance, pinch strength, sensation recovery and modified DASH scores, were evaluated. Anterolateral thigh flaps were used as "piggyback" flaps, and their size ranged from 8 cm × 16 cm to 10 cm × 25 cm. Cutaneous portions of superficial circumflex iliac artery osteocutaneous flaps ranged in size from 4 cm × 5 cm to 7 cm × 15 cm, and bone flap size ranged from 1 cm × 3 cm × 0.8 cm to 1 cm × 4 cm × 1 cm. All of the flaps survived uneventfully. All patients were able to perform basic hand functions after a median follow-up of 1.8 years. Microsurgically fabricated chimeric iliac osteocutaneous flaps may restore basic hand function to some extent. This procedure is an option worth considering for hand reconstruction following devastating injuries in carefully selected patients.

A simple approach to reduce the governing equations for thick honeycomb sandwich panels to a single equation containing only one displacement function is proposed in this article. The variational equations of motion are derived using Hamilton’s principle and by introducing differential operators. The exact solution of the natural frequencies for rectangular honeycomb sandwich panels with all edges simply-supported is obtained and leading to a satisfied agreement with theoretical results. The influence of the ratio of core thickness to face sheet thickness and aspect ratio on the natural frequencies is studied. The analysis results demonstrate that the presence of inertia of rotation will decrease natural frequencies, and the aspect ration changes not only the value of natural frequencies of the sandwich panel but also the mode order.

With the development of new energy industry, the technicians in the area of solar-wind complementary grid-connected power generation are urgently needed. For this reason, the monitoring system of 10kW solar-wind complementary grid-connected power generation was designed. Hardware system includes field device, communication network and monitoring host. Software design includes operation monitoring, application analysis, video surveillance, information issuing. It realizes functions of supervise and control, equipment events and alarm, report forms and print, energy management and forecasting, remote monitoring and so on. This research can be used to demonstrate experimental teaching in high shool and train power enterprise technicians.

The 3-D solid model with the software of Pro/Engineer was established. The computer aided engineering model of car seat with the methods “solid elements” was established. The elasticity of seat with ANSYS was calculated. Compared with the “force—distortion” curve of seat test, we examined the validity of modeling and the definition of materials.

The study aimed to develop simulation models including intracranial aneurysmal and parent vessel geometries, as well as vascular branches, through 3D printing technology. The simulation models focused on the benefits of aneurysmal treatments and clinical education. This prospective study included 13 consecutive patients who suffered from intracranial aneurysms confirmed by digital subtraction angiography (DSA) in the Neurosurgery Department of Shaoxing People's Hospital. The original 3D-DSA image data were extracted through the picture archiving and communication system and imported into Mimics. After reconstructing and transforming to Binary STL format, the simulation models of the hollow vascular tree were printed using 3D devices. The intracranial aneurysm 3D printing simulation model was developed based on DSA to assist neurosurgeons in aneurysmal treatments and residency training. Seven neurosurgical residents and 15 standardization training residents received their simulation model training and gave high assessments for the educational course with the follow-up qualitative questionnaire. 3D printed simulation models based on DSA can perfectly reveal target aneurysms and help neurosurgeons select therapeutic strategies precisely. As an educational tool, the 3D aneurysm vascular simulation model is useful for training residents.

It is known that calpain activation is involved in human traumatic brain injury (TBI) and that calpain inhibition can have neuroprotective effects on both gray matter and white matter injury of TBI models. However, the role of calpain activation in the corpus callosum remains unclear and requires elucidation given its potential clinical relevance. We evaluated the neuroprotective effects of calpain inhibitor MDL-28170 on corpus callosum function and structural destruction using a fluid percussion injury (FPI) model. The therapeutic time window for a single administration of MDL-28170 was up to 4 h post injury in protecting the corpus callosum structural integrity, and up to 30 min in protecting the axonal function evaluated 1 day following injury. When given 30 min prior injury, MDL-28170 showed neuroprotective effects that lasted up to 7 days. However, 30 min post injury administration of the drug afforded neuroprotection only up to 3 days. In contrast, two additional reinforcement injections at 24 and 48 h in addition to 30 min post FPI significantly protected both axonal function and structural integrity that lasted 14 days following FPI. Our data indicated that calpain inhibitor MDL-28170 is an effective neuroprotectant for axonal injury in corpus callosum following FPI with a therapeutic time window up to 4 hours. Although delayed treatment (2 or 4 h post FPI) was effective in protecting the axonal structure, the axons saved may not be as functional as normal fibers. Multiple drug administrations may be necessary for achieving a persisting effectiveness of this compound.

This study assessed the effect of oxygen affinity and molecular weight (MW) of o-raffinose cross-linked hemoglobin based oxygen carriers (HBOCs) on cerebral oxygen delivery and mean arterial blood pressure (MAP) following hemorrhage and resuscitation in rats.Isoflurane anesthetized rats (n = 6-7 per group) underwent 30% hemorrhage and resuscitation with an equivalent volume of one of three different HBOCs: 1) High P50 Poly o-raffinose hemoglobin (Poly OR-Hb, P50 = 70 mmHg); 2) High P50128 Poly OR-Hb (MW128 kDa, P50 = 70 mmHg) and 3) Low P50128 Poly OR-Hb (MW128 kDa, P50 = 11 mmHg). Hippocampal cerebral tissue oxygen tension, regional cerebral blood flow (rCBF), MAP, total hemoglobin concentration and arterial blood gases were measured. Data analysis by two-way ANOVA and post hoc Tukey tests determined significance (P0.05, mean +/- SD).Hippocampal tissue oxygen tension increased in all HBOC groups following resuscitation. The rCBF remained unchanged after HBOC resuscitation in all groups. Following resuscitation, the peak MAP was higher in the High P50 Poly OR-Hb group (152 +/- 13 mmHg) when compared to either the Low or High P50 large MW, (128 kDa) HBOC group (119 +/- 15 mmHg or 127 +/- 18 respectively, P0.05 for both).O-raffinose polymerized HBOC, with or without lower MW components, maintained cerebral tissue oxygen delivery following hemorrhage and resuscitation in rats. The higher MW HBOCs showed a decrease in peak MAP, which did not alter oxygen delivery. No significant effect of oxygen affinity on cerebral tissue oxygen tension or blood flow was observed.

Objective: To compare the mechanical effects of metatarsal deficit and its reconstruction with ilium, fibula and scapula on foot function using three-dimensional (3-D) finite element analysis. Methods: Deficits of the first to the third metatarsal bone and the fourth to the fifth metatarsal bone, and their reconstructions with ilium, fibula and scapula, respectively, were simulated by a 3-D foot model. The peak displacement and the peak stress were defined as indexes to estimate foot function. Results: It was found that foot function was affected primarily by the deficit of the first to the third metatarsal bone. In comparison with the intact healthy foot, the peak displacement and the peak stress of the whole deficit of the first to the third metatarsal bone increased by 215 and 212%, respectively, while those of the half deficit increased by 165 and 205%, respectively. For the whole and the half deficit of the fourth to the fifth metatarsal bone, the values of the two indexes increased by 144 and 109%, and 137 and 103%, respectively. After reconstruction, the results showed that the stress-concentrated regions dispersed relatively, especially in heel, metatarsal heads and reconstructive bone block. The maximum displacement and stress of the deficit rebuilt by ilium were the minimums in comparison with the reconstructions with fibula and scapula. Conclusion: The reconstructed multi-metatarsal deficit can be analysed by finite element method. The ilium was the preferred reparation material for the bone deficit. Copyright © 2006 John Wiley & Sons, Ltd.

In this paper, we develop a lucky imaging system to restore astronomical images through atmosphere turbulence. Our system takes very short exposures, on the order of the atmospheric coherence time. The rapidly changing turbulence leads to a very variable point spread function (PSF), and the variability of the PSF leads to some frames having better quality than the rest. Only the best frames are selected, aligned and co-added to give a final image with much improved angular resolution. Our system mainly consists of five parts: preprocessing, frame selection, image registration, image reconstruction, and image enhancement. Our lucky imaging system has been successfully applied to restore the astronomical images taken by a 1.23m telescope. We have got clear images of moon surface and Jupiter, and our system can be demonstrated to greatly improve the imaging resolution through atmospheric turbulence.

Multi-band IR data of the space object can be used in the fields of object identification and space surveillance. The radiation characteristics of the object can be obtained by analyzing these data. These characteristics include temperature, area, emissivity, absorptivity, reflectivity, and temporal trends. The infrared radiation temperature of the space object is an important characteristic from which the object's working state in orbit can be judged. We apply the method of measuring the spectral distribution of the object and fit the data to the Planck formula to determine the temperature. In order to improve the precision of measuring temperature on the space object, we optimize the centric wavelength and the bandwidth effectively. Also, we use a simple program to implement temperature measurement.

Using a spherical mirror of 400mm diameter and 12mm thickness, active supporting technology of thin mirror is researched. The axial support of the mirror is composed of 12 active supports and 3 fixed supports. The force actuator, which is composed of displacement actuator and force sensor, is installed in the active support. The mirror surface is tested by Zygo interferometer. For calibration, each actuator exerts unit force alone, and the surface variation is tested and taken as the response function of the actuator. The response functions of all actuators compose the stiffness matrix. Then the stiffness matrix is used by damped least square method to determine the correction force of each active support. In order to analyze the correction capability of the active supports, 14 Zernike modes of the mirror surface are generated and tested respectively, and 7 modes are selected for correction. Initially, the RMS error of mirror surface is 1.16λ I(λ =0.6328nm)when all actuators exert the same force. After 5 iterations, the RMS error of mirror surface is reduced to 0.13λ, close to the original surface quality.

The infrared radiation character (temperature and efficiency radiation area) of a space object is an important characteristic, we can judge the state of the object working in orbit by measuring temperature and variety. Due to lower temperature of the object and far distance between the object and the earth, the infrared radiation signal is faintness, therefore temperature and the infrared radiation character is difficult to measure. There are several methods to measure the temperature of the object in theory and each one has its applicability respectively, such as applying Wien Law to compute temperature, based on Stefan-Bolzmann law to compute temperature and utilizing multi-spectrum detector to measure temperature As a whole these methods are based on the hypothesis that the object is a Black-body or the radiance emissivity is constant. In fact, homochromatic radiance of object is not a constant but a function that changes with wavelength. Since the problem that an object whose homochromatic radiance is not a constant which results in temperature can not be computed accurately, we bring forward a method to contrast the luminance of the object at different wavelengths and deduce the relationship among homochromatic radiance and wavelength and the temperature of Black-body, from which we can compute real temperature of object.

Summary Background The authors present their clinical experience and surgical methods of soft-tissue coverage for the finger using a posterior interosseous free flap. Methods Twelve posterior interosseous free flaps, including two dual-paddle flaps, were performed in 12 patients. Indications included: 1) patients with soft-tissue coverage of the dorsum of the finger ( n =4), pulp ( n =1), fingertip and pulp ( n =5), 2) patients subsequent to release of finger and palm contracture ( n =1) and 3) patients subsequent to finger separation ( n =1). The posterior interosseous vessels were ligated below the level at which the motor branch to the extensor carpi ulnaris crossed the vessel superficially. The recipient vessels were the proper digital artery and palmar subcutaneous vein ( n =10), deep branch of the ulnar palm artery ( n =1), superficial branch of the radial palm artery ( n =1) and the vena comitante. The cosmetic appearance of the donor and recipient sites, static two-point discrimination and active total range of motion of the operated finger were evaluated in a follow-up visit. Results All flaps survived completely and all donor sites were closed directly, leaving a linear scar. De-fatting of the flap was carried out in one case in the late postoperative period; all other patients achieved a cosmetically acceptable result. Static two-point discrimination scores averaged 11mm (range: 8–15mm). Postoperatively, seven patients maintained normal flexion and extension of the joint. Two patients who had experienced a fracture and flexor injury recovered near-normal flexion and extension after flexor release; the other patients only recovered partially due to severe preoperative joint stiffness. Preoperatively, the active total range of motion of the operated fingers averaged 187 (range: 20–260). The average active total range of motion of the operated fingers at the last follow-up was 210 (range: 60–260). There was a significant difference between the preoperative and follow-up values ( p =0.042). Conclusions The posterior interosseous free flap may become one valuable option for finger re-surfacing. Avoiding the sacrifice of a main artery of the hand and shorter pedicle can reduce the morbidity and operative time associated with this procedure. In addition, separate regions can be reconstructed with a dual-paddle flap.

This paper proposed an improved decision tree algorithm, ID3+. Through the performance of autonomous backtracking, information gain reduction and surrogate value, our method overcomes some ID3’s disadvantages, such as preference bias and the inability to deal with unknown attribute values. The experimental results show that our method can competitively and efficiently solve the two problems. The first problems often leads to inferior decision trees, while the second limits ID3’s applicability in real-world domains. And the method could be a good start for a more robust decision tree learning system.

INTRODUCTION: Morbidity and mortality associated with allogeneic blood transfusion and the reduced ability of stored blood to transport oxygen supports the development of hemoglobin based oxygen carriers (HBOC). This study assesses the impact of hemorrhage and resuscitation with an HBOC (Hemoglobin raffimer, Hemolink), fresh or stored blood on cerebral tissue oxygen tension (PBrO2) and cerebral blood flow (CBF) in rats.

Background The aim of this study was to determine the health expenses incurred by families with children with autism spectrum disorder (ASD) and those expenses' relation to total household income and expenditures. Methods In this cross-sectional study, health care expenditure data were collected through face-to-face interviews. Expenses included annual costs for clinic visits, medication, behavioral therapy, transportation, and accommodations. Health care costs as a percentage of total household income and expenditures were also determined. The participants included 290 families with ASD children who were treated at the Children Development and Behavior Research Center, Harbin Medical University, China. Results Families with ASD children from urban and rural areas had higher per-capita household expenditures by 60.8% and 74.7%, respectively, compared with provincial statistics for 2007. Behavioral therapy accounted for the largest proportion of health expenses (54.3%) for ASD children. In 19.9% of urban and 38.2% of rural families, health care costs exceeded the total annual household income. Most families (89.3% of urban families; 88.1% of rural families) in that province reported higher health care expenditures than the provincial household average. Conclusion For families with ASD children, the economic burden of health care is substantially higher than the provincial average.