1. The effects of nondigestible fermentable carbohydrates on adults with overweight or obesity: a meta-analysis of randomized controlled trials
- Author
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Xinxia Wang, Zhi Li, Yizhen Wang, Jie Fu, Bocheng Xu, Jinping Cao, and Mingliang Jin
- Subjects
Adult ,medicine.medical_specialty ,Waist ,Carbohydrates ,Medicine (miscellaneous) ,Blood lipids ,Context (language use) ,Overweight ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Obesity ,Randomized Controlled Trials as Topic ,Nutrition and Dietetics ,business.industry ,Body Weight ,medicine.disease ,Blood pressure ,medicine.symptom ,business ,Body mass index - Abstract
Context Nondigestible fermentable carbohydrates (NDFCs) can be fermented by microbiota, thereby yielding metabolites that have a beneficial role in the prevention and treatment of obesity and its complications. However, to our knowledge, no meta-analysis has been conducted to evaluate the effects of NDFCs on obesity. Objective To conduct a meta-analysis of randomized controlled trials (RCTs) to summarize existing evidence on the effects of numerous NDFCs on adiposity and cardiovascular risk factors in adults with overweight or obesity with ≥2 weeks of follow-up. Data Sources The following databases were searched: MEDLINE, Embase, and CINAHL. Data Extraction Seventy-seven RCTs with 4535 participants were identified for meta-analysis from the 3 databases. Data Analysis The findings suggest that increased intake of NDFCs is significantly effective in reducing body mass index by 0.280 kg/m2, weight by 0.501 kg, hip circumference by 0.554 cm, waist circumference by 0.649 cm, systolic blood pressure by 1.725 mmHg, total cholesterol by 0.36 mmol/L, and low-density lipoprotein by 0.385 mmol/L, with evidence of moderate-to-high quality. Conclusion Convincing evidence from meta-analyses of RCTs indicates that increased NDFC intake improves adiposity, blood lipid levels, and systolic blood pressure in people with overweight and obesity.
- Published
- 2021