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According to the analyzed literature, the use of botulinum toxin type A is promising as an auxiliary method for simultaneous or delayed breast reconstruction using a subpectoral silicone implant or tissue expander. This method is safe and simple. Relaxation of the large pectoral muscle both intraoperatively and in the postoperative period reduces the intensity of pain, accelerates the rehabilitation of patients. Botulinum toxin therapy prevents the animation and deformation of the reconstructed breast. The effect after injection of botulinum toxin persists for 6-8 months and for a long time there is no need for analgesic therapy. According to the literature, this technique for reconstructive plastic surgery in patients with breast cancer significantly improves the quality of life of patients by reducing pain, preventing deformation and contraction of the large pectoral muscle. Conclusion. The literature analysis evaluates the effectiveness of botulinum toxin preparations for pain after reconstructive plastic surgery on the breast using a subpectoral space. The possibilities of therapeutic use of botulinum toxin preparations as an analgesic are known, but are little used in practice. This direction is promising. Given the small number of literary publications on this subject, it is necessary to conduct further research in this direction.