Search

Your search keyword '"Katelijn M. Blok"' showing total 3 results
Start Over Author "Katelijn M. Blok" Topic business.industry
3 results on '"Katelijn M. Blok"'

1. Pediatric MS patients with a primary progressive-like disease may still have relevant inflammatory activity and may benefit from regular MS treatment

Author

Rinze F. Neuteboom, Arlette L. Bruijstens, Beatrijs H.A. Wokke, Joost Smolders, Katelijn M Blok, Neurology, and Netherlands Institute for Neuroscience (NIN)

Subjects
medicine.medical_specialty, Multiple Sclerosis, Adolescent, business.industry, Multiple sclerosis, Disease progression, MEDLINE, Disease, Multiple Sclerosis, Chronic Progressive, medicine.disease, Primary progressive, Text mining, Neurology, Internal medicine, Disease Progression, medicine, Humans, Neurology (clinical), Child, business
Published
2020

2. Brain-homing CD4+ T cells display glucocorticoid-resistant features in MS

Author

Joost Smolders, Marie-José Melief, Georges M. G. M. Verjans, Helga E. de Vries, Steven C Koetzier, Thierry P P van den Bosch, Annet F Wierenga-Wolf, Marvin M van Luijn, Katelijn M Blok, Jamie van Langelaar, Erik Lubberts, Theodora A Siepman, Kim Pol, Netherlands Institute for Neuroscience (NIN), Immunology, Neurology, Pathology, Medical Microbiology & Infectious Diseases, Virology, Rheumatology, Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Hematology laboratory, and ACS - Microcirculation

Subjects
Adult, CD4-Positive T-Lymphocytes, Male, ATP Binding Cassette Transporter, Subfamily B, Multiple Sclerosis, Drug Resistance, Tissue Banks, C-C chemokine receptor type 6, Immunofluorescence, Article, Proinflammatory cytokine, Young Adult, Multiple Sclerosis, Relapsing-Remitting, Receptors, Glucocorticoid, Natalizumab, Glucocorticoid receptor, medicine, Humans, Immunologic Factors, Glucocorticoids, medicine.diagnostic_test, business.industry, Middle Aged, White Matter, Real-time polymerase chain reaction, Neurology, Immunology, Th17 Cells, Immunohistochemistry, Female, Autopsy, Neurology (clinical), business, Glucocorticoid, medicine.drug
Abstract

ObjectiveTo study whether glucocorticoid (GC) resistance delineates disease-relevant T helper (Th) subsets that home to the CNS of patients with early MS.MethodsThe expression of key determinants of GC sensitivity, multidrug resistance protein 1 (MDR1/ABCB1) and glucocorticoid receptor (GR/NR3C1), was investigated in proinflammatory Th subsets and compared between natalizumab-treated patients with MS and healthy individuals. Blood, CSF, and brain compartments from patients with MS were assessed for the recruitment of GC-resistant Th subsets using fluorescence-activated cell sorting (FACS), quantitative polymerase chain reaction (qPCR), immunohistochemistry, and immunofluorescence.ResultsAn MS-associated Th subset termed Th17.1 showed a distinct GC-resistant phenotype as reflected by high MDR1 and low GR expression. This expression ratio was further elevated in Th17.1 cells that accumulated in the blood of patients with MS treated with natalizumab, a drug that prevents their entry into the CNS. Proinflammatory markers C-C chemokine receptor 6, IL-23R, IFN-γ, and GM-CSF were increased in MDR1-expressing Th17.1 cells. This subset predominated the CSF of patients with early MS, which was not seen in the paired blood or in the CSF from patients with other inflammatory and noninflammatory neurologic disorders. The potential of MDR1-expressing Th17.1 cells to infiltrate brain tissue was confirmed by their presence in MS white matter lesions.ConclusionThis study reveals that GC resistance coincides with preferential CNS recruitment of pathogenic Th17.1 cells, which may hamper the long-term efficacy of GCs in early MS.

Published
2020

3. CT within 6 hours of headache onset to rule out subarachnoid hemorrhage in nonacademic hospitals

Author

Yu Yi M Wong, Freek Verheul, Jorunn Extercatte, Cees C. Tijssen, Jeannette Hofmeijer, Katelijn M. Blok, Laurike Harlaar, Vincent I.H. Kwa, Mervyn D.I. Vergouwen, Charles B. L. M. Majoie, Bertjan Kerklaan, D. Martijn O. Pruissen, Tobien H.C.M.L. Schreuder, Nyika D. Kruyt, Gabriel J.E. Rinkel, Jeroen Hendrikse, Meriam Braaksma, Susanne ten Holter, Michel J M Remmers, Wouter J. Schonewille, P. J. A. M. Brouwers, Clinical Neurophysiology, Faculty of Science and Technology, Neurology, General Practice, Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, Radiology and Nuclear Medicine, Other departments, and Experimental Vascular Medicine

Subjects
Adult, Male, Emergency Medical Services, medicine.medical_specialty, Time Factors, Subarachnoid hemorrhage, Adolescent, Comorbidity, Sensitivity and Specificity, Diagnosis, Differential, Young Adult, Humans, Medicine, Young adult, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, Academic Medical Centers, medicine.diagnostic_test, business.industry, Lumbar puncture, Incidence, Incidence (epidemiology), Headache, Reproducibility of Results, Normal level, Retrospective cohort study, Middle Aged, Subarachnoid Hemorrhage, medicine.disease, Confidence interval, Surgery, nervous system diseases, Causality, Early Diagnosis, IR-98943, Female, Neurology (clinical), Radiology, Tomography, X-Ray Computed, business, METIS-313116
Abstract

OBJECTIVE: To investigate whether staff radiologists working in nonacademic hospitals can adequately rule out subarachnoid hemorrhage (SAH) on head CT METHODS: In a multicenter, retrospective study, we studied a consecutive series of patients presenting with acute headache to 11 nonacademic hospitals. Inclusion criteria were (1) normal level of consciousness without focal deficits, (2) head CT RESULTS: Of 760 included patients, CSF analysis was considered positive for bilirubin in 52 patients (7%). Independent review of these patients' CTs identified one patient (1/52; 2%) with a perimesencephalic nonaneurysmal SAH. Negative predictive value for detection of subarachnoid blood by staff radiologists working in a nonacademic hospital was 99.9% (95% confidence interval 99.3%-100.0%).CONCLUSIONS: Our results support a change of practice wherein a lumbar puncture can be withheld in patients with a head CT scan performed

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results