1. Donation-induced iron depletion is significantly associated with low hemoglobin at subsequent donations
- Author
-
Saurabh Zalpuri, Rosa de Groot, Tiffany C. Timmer, Femmeke J. Prinsze, Katja van den Hurk, Epidemiology and Data Science, and Public and occupational health
- Subjects
Male ,Iron ,Immunology ,Physiology ,Blood Donors ,Hemoglobins ,medicine ,Humans ,Immunology and Allergy ,Low hemoglobin ,Whole blood ,biology ,business.industry ,Low ferritin ,Iron Deficiencies ,Hematology ,Iron deficiency ,medicine.disease ,Ferritin ,Cross-Sectional Studies ,Donation ,Ferritins ,biology.protein ,Female ,Hemoglobin ,business ,Iron depletion - Abstract
Background: Blood donation is associated with a loss of hemoglobin (Hb)-bound iron. Hb levels recover relatively fast by using stored iron. However, it takes more time to replenish iron stores, potentially resulting in iron deficiency. Study design: Hb and ferritin levels were measured in 5056 new, first-time, and repeat whole blood donors. We investigated whether increasing numbers of donations are associated with lower ferritin levels. Furthermore, we tested whether low ferritin levels are associated with low-Hb deferral at the subsequent donation attempt by performing logistic regression adjusted for age and stratified by sex. Results: Whereas mean Hb levels are relatively stable, ferritin levels significantly decrease with increasing numbers of donations and were approximately 50% lower for donors with >50 donations compared with those with 2–10 donations. Despite the poor correlation of ferritin and Hb levels, cross-sectional, iron-deficient donors (ferritin
- Published
- 2021