1. Prognostic role of homeostasis model assessment and oral glucose tolerance test in nondiabetic patients with Bell’s palsy
- Author
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Tuğba Karagöz, Mustafa Sahin, Mehmet Hakan Korkmaz, Erman Cakal, Kemal Keseroğlu, Ali Özdek, Emel Çadalli Tatar, and Ömer Bayır
- Subjects
Blood Glucose ,medicine.medical_specialty ,HOMA-IR index ,prediabetes ,030204 cardiovascular system & hematology ,Gastroenterology ,Article ,Impaired glucose tolerance ,Prediabetic State ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,insulin resistance ,Bell's palsy ,medicine ,Bell Palsy ,Homeostasis ,Humans ,Prediabetes ,0303 health sciences ,Palsy ,030306 microbiology ,business.industry ,Incidence (epidemiology) ,General Medicine ,Bell’s palsy ,Glucose Tolerance Test ,medicine.disease ,Prognosis ,Case-Control Studies ,business - Abstract
Background/aim We aimed to revealthe incidence and predictive role of insulin resistance and distorted oral glucose tolerance test in nondiabetic patients withBell’s Palsy (BP). Materials and methods Eighty-sixpatients with BP and 28 control subjects; all with normal blood glucose levels and no history of diabetes, were enrolled in the study. We investigated insulin resistance (IR) in all subjects, in terms of HOMA-IR greater than 2.7. Sixty-two of the patients also underwent an oral glucose tolerance test (OGTT). Results The mean HOMA-IR value was significantly increased in patients, compared to the control group (3.2 vs 1.6; P < 0.01). IR was detected more in BP patients than in controls (P < 0.05). The patients with higher HOMA-IR values had more severe facial dysfunction at the initial presentation and complete recovery time took longer than the patients with normal HOMA-IR value (75 days vs 42 days; P < 0.05). Following a 2h-OGTT, impaired glucose tolerance and newly diagnosed DM were found in 60% of the patients. Recovery time was significantly longer in prediabetics and newly diagnosed diabetic patients than in patients with normal glycemia (68 days, 52 days, and 32 days, respectively; P < 0.01). Conclusion There is a strong linkage between HOMA-IR value and BP prognosis so HOMA-IR value may have a significant role of predicting BP prognosis at presentation.
- Published
- 2020