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The aim of this study was to explore the application of standardized ultrasonography in the first trimester. A total of 1670 pregnant women who underwent ultrasonography in the first trimester (1706 fetuses) and 2,562 pregnant women who underwent ultrasonography in the second trimester (2637 fetuses) visiting the Second Affiliated Hospital of Nanchang University from January 2016 to December 2018 were included in this prospective study. Standardized ultrasonography was performed on the fetuses and pregnancy outcomes were tracked in abnormal cases. A total of 20 cases of fetal structural abnormalities were detected in the first trimester and the number of pregnant women who chose to induce labor was as high as 15. A total of 41 cases of fetal soft marker abnormalities were detected in the first trimester and most of these markers returned to normal. A total of 113 cases of malformed fetuses were detected in the second trimester. Additionally, those cases that did not undergo standardized ultrasonography in the first trimester were significantly more likely to show fetal abnormalities in the second trimester than those who had standardized ultrasonography in the first trimester. Some fetal malformations, especially some severe ones, can be detected by standardized ultrasonography in the first trimester. However, standardized ultrasonography in the second trimester which was regard as the best period for fetal malformation detection cannot be replaced by the first trimester. It is better to conduct standardized ultrasonography in both first and second trimesters.

This study introduces gait asymmetry measures by comparing the ground reaction force (GRF) features of the left and right limbs. The proposed features were obtained by decomposing the GRF into components of different frequency sub-bands via the wavelet transform. The correlation coefficients between the right and left limb GRF components of the same frequency sub-band were used to characterize the degree of bilateral symmetry. The asymmetry measures were then obtained by subtracting these coefficients from one. To demonstrate the effectiveness of these asymmetry measures, the proposed measures were applied to differentiate the walking patterns of Parkinson's patients and healthy subjects. The results of the statistical analyses found that the patient group has a higher degree of gait asymmetry. By comparing these results with those obtained by conventional asymmetry measures, it was found that the proposed approach can more effectively distinguish the differences between the tested Parkinson's disease patients and the healthy control subjects.

The goal of this study was to investigate the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in primary liver cancer (PLC) and their association with prognosis. Tumor tissue, non-tumor tissue, and blood samples of 75 PLC patients were collected. Blood samples of 20 volunteers were also collected as healthy controls. Real-time quantitative reverse transcription-polymerase chain reaction was used to analyze the mRNA levels of HIF-1α and VEGF in the tissues. Protein expression of HIF-1α and VEGF was analyzed by immunohistochemistry. Enzyme-linked immunosorbent assay was used to detect the expression of HIF-1α and VEGF at the serum level. Univariate tests, multivariate Cox proportional hazards model, and the Student t-test were used to analyze the data. HIF-1α and VEGF showed higher expression in PLC tumor tissue both at the mRNA and protein levels. HIF-1α and VEGF expression was positive in 62.67 and 66.67% of PLC patients, respectively. HIF-1α and VEGF expression was significantly related to tumor stage and lymph nodes and lung metastases (P < 0.05). HIF-1α expression correlated with VEGF expression in PLC (r = 0.665, P < 0.05). Both HIF-1α and VEGF were significantly associated with overall survival (P < 0.05), while HIF-1α was identified as an independent prognostic factor. Both HIF-1α and VEGF, as the predictors of efficacy of TACE and metastasis of PLC, are biomarkers indicating PLC in advanced stage, and implied poor prognosis in patients with PLC. HIF-1α and VEGF could potentially be targets to improve outcomes in PLC.

INTRODUCTION Core muscle provides proximal stability for efficient lower extremity movement. Bad posture is often caused by primary muscle tightness and weakness of its antagonist. Prolong bad posture may weaken the muscle, and lead to back pain. In previous report, paraspinal muscle has been related chronic law back pain. Scoliosis may be caused by the different activation of back extensors. Core muscle training can improve strength and dynamic stabilization, which may be beneficial to scoliosic patient. Back muscle is important in maintaining the stabilization of the trunk. Unilateral spinal extensor activity can improve its strength, mobility, and endurance. For this purpose, we designed three postures and further determined the most effective exercise on back muscle firing .

INTRODUCTION Jogging injuries are primarily caused by overuse that biomechanics factors could play an important role for the detection of runner injury. The impact forces have been implicated as primary causes of running injuries. The impact force during treadmill jogging is hard to collect using force plate in our previous research experience. We use the in-sole plantar pressure system to overcome this problem in the current study.