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CNN classifiers using microscopy images to pick up induced pluripotent stem (iPS) cells from a lot of non-iPS cells ware proposed to improves efficiency of human iPS cell production. By selecting iPS-forming cells at early culture stage, it should be more promising to reduce a considerable amount of work. This paper proposes a CNN reprogramming stage classifier trained by respective types (grown into high-, medium, and low-growth status of iPS-like cells) of time-lapse images taken from the completed cell culturing process. These trained CNNs are used to classify a time-lapse image taken in cell culturing as one stage (a number of consecutive frames) of a respective set of trained time-lapse images. The differences between the actual stage with respective classified stages are than calculated to decide which stage of the completed cell this time-step image taken in cell culturing is near to, then to predict the iPS cell growth status that the culturing cells finally grow into. The method achieved the 85% accuracy to predict the growth status of culturing cells two days later, thus can be applicable for early selection suggestion of good iPS-forming cells.

An outbreak of the 2019 novel coronavirus (COVID-19) has been ongoing in China since January 2020. The threat of infection affects the work and life of most of the population and may also damage sleep. This study aims to examine the subjective sleep status and mental health of the population during the peak of the COVID-19 epidemic.The data were collected through an online questionnaire with a sample of 5461 individuals in China from February 5, 2020, to February 23, 2020. Participants were divided into four groups based on their degree of threat from COVID-19: Group 1 was most closely associated with COVID-19, including inpatients diagnosed with COVID-19, first-line hospital workers and first-line management staff; Group 2 included outpatients diagnosed with COVID-19 and patients who developed a fever and visited the hospital; Group 3 included people related to Group 1 or 2, such as their colleagues, relatives, friends and rescuers; and Group 4 was the farthest removed from contact with COVID-19, covering the general public affected by COVID-19 prevention strategies. The Insomnia Severity Index (ISI), Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7) and Acute Stress Disorder Scale (ASDS) were used.Threat degree of COVID-19 (groups) had significant correlations with insomnia, depression, anxiety, and stress (p 0.05, p 0.01). Age, gender, and area (Hubei province or other provinces) had significant correlations with insomnia (p 0.01). A total of 1380 (24.46%) participants were suspected of having major depression based on the PHQ-9. Additionally, 1042 (18.47%) participants were suspected of having generalized anxiety disorder based on the GAD-7. A total of 892 (15.8%) of the participants had Acute Stress Disorder (ASD) according to the ASDS. The prevalence of clinical insomnia during the outbreak was 20.05% (1131) according to the ISI. The factors of satisfaction with the current sleep pattern and how perceptible the symptoms of the current sleep pattern are to other people (p 0.05) and the middle (difficulty staying asleep) and terminal (waking up too early) (p 0.01) factors of the ISI were significantly different across groups. A total of 1129 (20.01%) participants spent more than one hour awake in bed.The results indicated that insomnia is more severe in people who are female, young, living in the epicenter and experiencing a high degree of threat from COVID-19. As prevention and treatment efforts continue with regard to COVID-19, the general public has developed poor sleep hygiene habits, which deserve attention.

Angiosarcoma is a rare soft tissue sarcoma of poor prognosis. A retrospective single-center study was conducted to characterize cutaneous angiosarcoma. Twenty patients were enrolled. The mean age was 76 years and male to female ratio 3:1. Ninety percent had primary angiosarcoma. Scalp was the most commonly involved site. Metastatic disease was noted in 20% when angiosarcoma was diagnosed. Median overall survival time was 20 months. In this single center series, cutaneous angiosarcoma was a disease of early metastasis and poor prognosis. Physician should be aware of vascular lesions on the scalp and face regions especially in male elderly patients. Keywords: Angiosarcoma, Primary cutaneous angiosarcoma, Metastasis, Treatment, Prognosis

This study was designed to compare optical biometry measurements and predicted refraction in cataract patients with high myopia [axial length (AL) ≥26 mm] using OA-2000 and IOL Master 500. Ocular biometry measurements were performed using both biometers before surgery. Uneventful cataract surgery was performed in all patients. Postoperative manifest refraction was obtained 3wk after surgery or later. A total of 67 eyes were examined. The AL, keratometry (K), and anterior chamber depth (ACD) of the two biometers showed excellent agreement. Predicted errors were similar and a strong positive correlation was observed (r=0.909). Out of 21 eyes (31.34%) with unsuccessful AL readings using the IOL Master 500, 20 eyes of them could be measured using OA-2000. Therefore, the biometric parameters measured by the two biometers showed good agreement. However, OA-2000 had a lower AL measurement failure rate.

Fierce competition in today’s rapidly changing economic environment, the company must establish a sound corporate governance mechanism, in order to strengthen its competitiveness; General manager of corporate governance in the primary leader of the company’s response to the business environment of the test must be the general manager of professionalism in order to develop a clear proper management decisions. Empirical results show significant positive impact of the general manager and the longer the term of the higher professional level of corporate performance was. The general manager turnover, part-time situation it’s of having a significant negative impact on company performance.

In addition to genetics and androgens, novel factors could play a role in androgenetic alopecia (AGA). This study aims to investigate the association between plasma leptin level with the risk and severity of AGA in men. Forty-eight subjects were enrolled including 29 AGA and 19 non-AGA subjects. The plasma leptin level was significantly higher in AGA subjects, compared to non-AGA subjects (4.45 vs 2.76 ng/mL, P

Objective To compare the diagnostic characteristics of the evaluation of myometrial invasion (MI) retrospectively between preoperative magnetic resonance imaging (MRI) and intraoperative frozen sections. Design A retrospective study. Setting University hospital. Sample 201 women diagnosed with endometrial carcinoma. Methods All women underwent preoperative MRI and 111 of them also underwent intraoperative frozen section assessment. The final pathological evaluation was used as the definitive diagnosis. Main outcome measures In women who underwent MRI and frozen sections (n = 111), the accuracies of detection of MI and of deep invasion (defined as ≥50% invasion) were compared. Results The accuracy, sensitivity, and specificity of MRI for detection of MI were 65.8, 58.8, and 88.5%, and those in frozen sections were 90.1, 90.6, and 88.5%, respectively. The accuracy and sensitivity of frozen sections were significantly higher (p

To enhance the efficiency of surfing the Internet, an integrated platform for real estate agency-based on service-oriented architecture (SOA) is established. It employs the concept of search engine and loads the information provided previously by each real estate agency to this platform. Due to the different types of data structure from each real estate agency website, the standard format must be defined for integrating the information. In this paper, the standard is defined by XML and is used to integrate heterogeneous database. This standard format includes the data fields that are required by the agency websites. It is processed in the platform which is expandable by receiving information from other sources in the future. In consideration of the copyright regulation, the agents are allowed to login and to share specific information on this platform in order to increase the transaction rate. The system also includes a Google Map engine for GIS service that marks the spatial location as the users send the requests. It helps the users to find the demanded housing information and to retrieve the nearby geographic location in a very short time.

In this work, ZnO nanowires were grown on Si(1 0 0) wafer and sapphire(0 0 1) substrates using metal-organic chemical vapor deposition (MOCVD). The morphology and crystal structure of ZnO nanowires were evaluated by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The wear characteristics of ZnO nanowires were measured using an atomic force microscopy (AFM) apparatus. A steel micro-sphere (radius of 12 μm) was attached to the end of the AFM cantilever and slid against the ZnO nanowires using low normal load. The wear rate of ZnO nanowires was quantified by comparing the geometrical shape of ZnO nanowires before and after the wear test. Also, the adhesive force between the sphere and the nanowires was measured before and after the wear test. The increase of adhesive force is due to the increase in contact surface after the wear test.

Shaft alignment is an important technique during installation and maintenance of a rotating machine. A high-precision laser alignment system has been designed with dual PSDs (Position Sensing Detector) to change traditional manual way of shaft alignment and to make the measurement easier and more accurate. The system is comprised of two small measuring units (laser transmitter and detector) and a PDA (Personal Digital Assistant) with measurement software. The laser alignment system with dual PSDs was improved on a single PSD system, and yields higher measurement accuracy than the previous design, and has been successful for designing and implements actual shaft alignment. In the system, the range of offset measurement is ±4 mm, and the resolution is 1.5 μm, with accuracy being less than 2 μm.

To enhance the efficiency of surfing the Internet, an integrated platform for real estate agency is established based on service-oriented architecture (SOA). It employs the concept of search engine and loads the information provided by each real estate agency to this platform. Due to various types of data structure from each real estate agency website, a unified format must be defined for integrating the information. In this paper, the format is defined by XML and used to integrate heterogeneous database. Also, the format includes the data fields the agency websites required. It is processed in the platform which is expandable by receiving information from other sources in the future. In consideration of the copyright regulation, the agents are allowed to login and to share specific information on this platform in order to increase the transaction rate. The system also includes a Google Map engine for GIS service that marks the spatial location as users send the requests. It helps users to find the demanded housing information and retrieve the nearby geographic location.

Since the advent of computer communication networks, there have been considerable advances in the field of OSI network management. When there are a number-of subsystems operating and manipulating many complex jobs interconnected by a networks, the need for a network management facility is essential. The network management system is based on the ISO standards for OSI management. It is concerned primarily with the management of the communication subsystems in each node connected to an OSI network. The developed system does not attempt to implement all the management functions, but rather shows how the framework can be used to provide these functions. The ISO network management framework, based on the ISO basic reference model, has been defined to provide the means for the communication subsystems in all the nodes connected to a network to be remotely monitored and controlled. The paper describes the concepts development and achievements of our project in the field of OSI network management, which are applied to the project "optical fiber integrated services ring for Shanghai petrochemical complex".

Background Obesity is a risk factor for multiple health problems, but its association with androgenetic alopecia (AGA) remains controversial. Objective We sought to determine the association between body mass index (BMI) and alopecia severity in men with AGA and early-onset AGA. Methods A cross-sectional study was conducted. The medical charts and photographs of men with a clinical diagnosis of AGA were reviewed. Results In all, 189 men were enrolled with a mean age of 30.8 years. In male-pattern AGA (n = 142), men with severe alopecia (grade V-VII) had higher BMI than those with mild to moderate alopecia (grade I-IV) (25.1 vs 22.8 kg/m 2 , P = .01). After multivariate adjustments, the risk for severe alopecia was higher in the overweight or obese (BMI ≥24 kg/m 2 ) subjects with male-pattern AGA (odds ratio 3.52, P P = .03). Limitations Parameters used to evaluate obesity were limited because of the retrospective nature of the study. Conclusions Higher BMI was significantly associated with greater severity of hair loss in men with male-pattern AGA, especially in those with early-onset AGA.

A theory on combined self-phase modulation (SPM) and stimulated Raman scattering (SRS) in optical fibres is given. The theory shows that Raman frequency conversion is not affected by SPM, and the phase shifts of pump and Stokes radiation are proportional to the input pump pulse. The variation of the linewidths Δν1/2 of pump and Stokes pulses against pump peak powerPp is analysed numerically by fast Fourier transformation (FFT). The results show that the SRS has a small effect on the linewidth of pump light whenPp is small, and will saturate the increase in Δν1/2 asPp becomes large. Discussion on output pump pulse shape makes the physical meaning of the variation of Δν1/2 clear.

In the square-wave PFM system for transmission of TV programmes through optical fibres, square-wave PFM pulses are generated at the transmitter with a relatively low centre frequency, whereas double-frequency equal-width narrow pulses are produced in the receiver before the demodulating low-pass filter, at both the rising and falling edges of the transmitted pulses. The use of the frequency-doubling technique in such a system results in narrow transmission bandwidth and high receiver sensitivity, thus prolonging the transmission distance significantly as compared with ordinary PFM. In the experiment, the system is operated at 1.3 μm with multimode fibre having bandwidth 700 MHz km, a laser diode as optical source and a PIN/FET as detector. It can effectively transmit the high-quality broadcast TV programme with accompanying sound channel to a distance of 50.7 km. Experimental results are: receiver sensitivity −40 dB m, weighted SNR for video 59.3 dB, differential gain and differential phase less than 1% and 1°, respectively.