1. Nrf2-Mediated Metabolic Reprogramming in Cancer
- Author
-
Wang, Yan-Yang, Chen, Juan, Liu, Xiao-Ming, Zhao, Ren, and Zhe, Hong
- Subjects
0301 basic medicine ,Aging ,NF-E2-Related Factor 2 ,Metabolic reprogramming ,Review Article ,medicine.disease_cause ,digestive system ,environment and public health ,Biochemistry ,Malignant transformation ,03 medical and health sciences ,Neoplasms ,Nrf2 pathway ,medicine ,Animals ,Humans ,lcsh:QH573-671 ,lcsh:Cytology ,business.industry ,Cancer ,Cell Biology ,General Medicine ,respiratory system ,medicine.disease ,Cell Transformation, Neoplastic ,030104 developmental biology ,The Hallmarks of Cancer ,Drug Resistance, Neoplasm ,Cancer metabolism ,Cancer research ,Signal transduction ,business ,Oxidative stress ,Signal Transduction - Abstract
Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of the critical signaling cascades involved in cell defense and survival against oxidative stress. The significance of Nrf2 in cancer metabolism begins to be recognized. In this minireview, we focus on the Nrf2-mediated cancer metabolic reprogramming and intend to highlight the role of Nrf2 in the regulation of malignant transformation, cancer proliferation, and the development of treatment resistance via metabolic adaptations. We hope for the development of noninvasive biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed cancer metabolic reprogramming in the near future.
- Published
- 2018