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1. A Pilot School-Based Health Center Intervention to Improve Asthma Chronic Care in High-Poverty Schools

Author

Susan B Butler, Jill S. Halterman, Heather Orom, Heather K. Lehman, Lucy C Holmes, Alicia A Supernault-Sarker, Ziqiang Chen, Patricia M Sorrentino, Stacie J. Lampkin, Vanessa Akiki, Denise Piechowski, and Gregory E. Wilding

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, education, Article, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Intervention (counseling), School Nursing, Immunology and Allergy, Medicine, Humans, Child, Students, Poverty, Asthma, School Health Services, Schools, business.industry, High poverty, Health services research, medicine.disease, Health equity, Test (assessment), Asthma chronic, 030228 respiratory system, Family medicine, Child, Preschool, Pediatrics, Perinatology and Child Health, School based, business
Abstract

OBJECTIVE: To test the feasibility and effectiveness of a multifaceted intervention administered through school-based health centers (SBHCs) to improve asthma control for children in high poverty schools with not well controlled asthma. METHODS: Students 4–14 years old with persistent asthma were enrolled from 3 SBHCs. The centers’ advanced practice providers received training on evidence-based asthma guidelines. Students randomized to the intervention received directly observed therapy of their asthma controller medication, medication adjustments as needed by the centers’ providers, and daily self-management support. Students randomized to usual care were referred back to their primary care provider (PCP) for routine asthma care. RESULTS: We enrolled 29 students. Students in the intervention group received their controller medication 92% of days they were in school. Ninety-four percent of follow-up assessments were completed. During the study, 11 of 12 intervention students had a step-up in medication; 2 of 15 usual care students were stepped up by their PCP. Asthma Control Test scores did not differ between groups, although there were significant improvements from baseline to the 7 month follow-up within each group (both p

Published
2021

2. Cost-Effectiveness of an Antibacterial Envelope for Cardiac Implantable Electronic Device Infection Prevention in the US Healthcare System From the WRAP-IT Trial

Author

Charles Kennergren, Jeff D. Lande, Denise M. Sorrentino, David W. Riggio, Steven F. Roark, Brett J. Berman, Swathi Seshadri, Giuseppe Boriani, Jack J Collier, Edmond M. Cronin, Jeanne E. Poole, Bruce L. Wilkoff, Edward J. Schloss, Rudolph F. Evonich, Marc T. Silver, Robert A. Pickett, Hafiza Khan, Daniel R. Lexcen, Khaldoun G. Tarakji, Reece Holbrook, Andrew D. Krahn, Zayd Eldadah, Suneet Mittal, Jose L. Gallastegui, Darius P. Sholevar, and G. Ralph Corey

Subjects
Time Factors, Cost effectiveness, Cost-Benefit Analysis, population, Risk Factors, Absorbable Implants, defibrillators, Multicenter Studies as Topic, Infection control, infections, Randomized Controlled Trials as Topic, education.field_of_study, Anti-Bacterial Agents, Defibrillators, Implantable, incidence, mortality, Models, Economic, Treatment Outcome, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Quality-Adjusted Life Years, Cardiology and Cardiovascular Medicine, Healthcare system, medicine.medical_specialty, Prosthesis-Related Infections, Clinical Decision-Making, Population, Drug Costs, Prosthesis Implantation, Cost Savings, Physiology (medical), medicine, Humans, Cardiac Resynchronization Therapy Devices, education, Intensive care medicine, business.industry, Decision Trees, Original Articles, Antibiotic Prophylaxis, United States, Quality of Life, business, Envelope (motion)
Abstract

Supplemental Digital Content is available in the text., Background: In the WRAP-IT trial (Worldwide Randomized Antibiotic Envelope Infection Prevention), adjunctive use of an absorbable antibacterial envelope resulted in a 40% reduction of major cardiac implantable electronic device infection without increased risk of complication in 6983 patients undergoing cardiac implantable electronic device revision, replacement, upgrade, or initial cardiac resynchronization therapy defibrillator implant. There is limited information on the cost-effectiveness of this strategy. As a prespecified objective, we evaluated antibacterial envelope cost-effectiveness compared with standard-of-care infection prevention strategies in the US healthcare system. Methods: A decision tree model was used to compare costs and outcomes of antibacterial envelope (TYRX) use adjunctive to standard-of-care infection prevention versus standard-of-care alone over a lifelong time horizon. The analysis was performed from an integrated payer-provider network perspective. Infection rates, antibacterial envelope effectiveness, infection treatment costs and patterns, infection-related mortality, and utility estimates were obtained from the WRAP-IT trial. Life expectancy and long-term costs associated with device replacement, follow-up, and healthcare utilization were sourced from the literature. Costs and quality-adjusted life years were discounted at 3%. An upper willingness-to-pay threshold of $150 000 per quality-adjusted life year was used to determine cost-effectiveness, in alignment with the American College of Cardiology/American Heart Association practice guidelines and as supported by the World Health Organization and contemporary literature. Results: The base case incremental cost-effectiveness ratio of the antibacterial envelope compared with standard-of-care was $112 603/quality-adjusted life year. The incremental cost-effectiveness ratio remained lower than the willingness-to-pay threshold in 74% of iterations in the probabilistic sensitivity analysis and was most sensitive to the following model inputs: infection-related mortality, life expectancy, and infection cost. Conclusions: The absorbable antibacterial envelope was associated with a cost-effectiveness ratio below contemporary benchmarks in the WRAP-IT patient population, suggesting that the envelope provides value for the US healthcare system by reducing the incidence of cardiac implantable electronic device infection. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02277990.

Published
2020
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3. LB01 SIX WEEKS OF SOFOSBUVIR/LEDIPASVIR TREATMENT OF ACUTE HEPATITIS C VIRUS GENOTYPE 1 MONOINFECTION: FINAL RESULTS OF THE THE GERMAN HEPNET ACUTE HCV IV STUDY

Author

K. Deterding, C.D. Spinner, E. Schott, T.M. Welzel, G. Gerken, H. Klinker, U. Spengler, J. Wiegand, J. Schulze zur Wiesch, A. Pathil, M. Cornberg, A. Umgelter, C. Zöllner, S. Zeuzem, A. Papkalla, K. Weber, S. Hardtke, H. Leyen, A. Koch, D. Witzendorff, M. Manns, H. Wedemeyer, C.M. Preda, C.P. Popescu, C. Baicus, M. Manuc, R. Voiosu, E. Ceausu, L. Fulger, A. Nisanian, C.S. Pop, A. Oproiu, A. Arezzo, R. Passera, A. Bullano, Y. Mintz, A. KEDAR, L. Boni, E. Cassinotti, R. Rosati, U. Fumagalli, M. Sorrentino, M. Brizzolari, N. Di Lorenzo, A.L. Gaspari, D. Andreone, E. De Stefani, G. Navarra, S. Lazzara, M. Degiuli, K. Shishin, I. Khatkov, I. Kazakov, R. Schrittwieser, T. Carus, A. Corradi, G. Sitzman, A. Lacy, S. Uranues, A. Szold, M.A. Bonino, M. Morino, J. Strömberg, G. Sandblom, R. Coelen, M. Gaspersz, T. Labeur, J. Vugt, S. Dieren, F. Willemssen, C.Y. Nio, J. IJzermans, H.‐J. Klümpen, B. Groot Koerkamp, T. Gulik, R. Sturgess, D. Palmer, J. Trojan, A. Hoffmeister, B. Neu, S. Kasper, A. Dechêne, C. Jürgensen, J. Schirra, R. Jakobs, A. Høgset, L. Finnesand, A.E. Abd Elrazek, S. Saab, T. Salem, M. Abdel‐Aty, B. Hawary, A. Ismail, M. Zayied, M. Alboraie, R. Orenstein, E. Dubberke, C.H. Lee, S. Khanna, G. Hecht, S. Wong, T. Kwong, X. Wang, R.S.Y. Tang, S.C. Ng, J.J.Y. Sung, J. Yu, S. Ott, G.H. Waetzig, A. Rehmann, J. Moltzau‐Anderson, R. Bharti, J.A. Grasis, L. Cassidy, A. Tholey, H. Fickenscher, D. Seegert, P. Rosenstiel, S. Schreiber, T. Mazzawi, G.A. Lied, M. El‐Salhy, O.H. Gilja, J.G. Hatlebakk, T. Hausken, S.T. Witt, O. Bednarska, A. Icenhour, S. Elsenbruch, M. Ström, J.D. Söderholm, M. Engström, E.A. Mayer, Å. Keita, S. Walter, P.K. Kump, P. Wurm, H.P. Gröchenig, H.H. Wenzl, W. Petritsch, B. Halwachs, M. Wagner, V. Stadlbauer‐Köllner, A.J. Eherer, K.M. Hoffmann, A. Deutschmann, G. Reicht, L. Reiter, P. Slawitsch, G. Gorkiewicz, C. Hoegenauer, Y. Zhou, R. Kakuturu, D. Jung, K.K. Jørgensen, I.C. Olsen, G.L. Goll, M. Lorentzen, N. Bolstad, E.A. Haavardsholm, K.E. Lundin, C. Mørk, J. Jahnsen, T.K. Kvien, B.G. Feagan, B.E. Sands, G. Rossiter, X. Li, K. Usiskin, X. Zhan, J.‐F. Colombel, W.J. Sandborn, J. Panés, M. Ferrante, E. Louis, G. D'Haens, D. Franchimont, A. Kaser, O. Dewit, U. Seidler, K.‐J. Kim, M.F. Neurath, P. Scholl, S. Visvanathan, S.J. Padula, I. Herichova, N. Sha, D. Hall, W.O. Böcher, F. Bloemendaal, A. Levin, M. Wildenberg, P. Koelink, S. Verbeek, J. Claassens, B. Mcrae, G. Vidarsson, G.R. Brink, M. Badke, S. Rose‐John, M.E. Spehlmann, L. Peyrin‐Biroulet, J. Gatlin, M. Soloman, D. Unett, H. Al‐Shamma, D. Behan, J. Langhorst, J. Boone, A. Rueffer, G. Dobos, K. Beiderwellen, T. Lauenstein, W.S. Ngu, R. Bevan, Z.P. Tsiamoulos, P. Bassett, Z. Hoare, M. Rutter, N. Totton, T.J. Lee, A.V. Ramadas, J. Silcock, J. Painter, L.J. Neilson, B.P. Saunders, C.J. Rees, A. Schmidt, S. Goelder, H. Messmann, M. Goetz, T. Kratt, A. Meining, M. Birk, J. Delius, M. Albert, J.Y.W. Escher, A. Lau, R. Hoffman, K. Wiest, null Caca, A. Siddiqui, D. Wilson, M. Cangelosi, R. Rameshshanker, P. Wall, K. Cocks, T. Doulton, A. Yusuf, C. Hancock, R. Valori, A. Aravani, J. Rashbass, S. Vernon, E.J.A. Morris, J.H. ‐Choi, D.‐W. Seo, T.J. Song, D.H. Park, S.S. Lee, S.K. Lee, ‐H. Kim, P. Somani, and M. Sharma

Subjects
0301 basic medicine, Ledipasvir, Sofosbuvir, business.industry, Gastroenterology, Virology, Virus, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, chemistry, Genotype, Medicine, 030211 gastroenterology & hepatology, Acute hepatitis C, business, medicine.drug
Published
2016
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4. Correction to: Laparoscopic right hemicolectomy: the SICE (Società Italiana di Chirurgia Endoscopica e Nuove Tecnologie) network prospectivetrial on 1225 cases comparing intra corporeal versus extra corporeal ileo‑colic side‑to‑side anastomosis (Surgical Endoscopy, (2019), 10.1007/s00464-019-07255-2)

Author

M. Sorrentino, A. Alo, G. L. Canu, F. Monari, A. G. Marrosu, E. Soligo, Wanda Petz, A. Gattolin, R. Vicentini, S. Razzi, M. Zago, S. Neri, A. Pisani Ceretti, D. Apa, F. Gatti, A. Donini, F. Medas, D. Cassetti, S. Rubino, R. Lombardi, G. D. DePalma, Alberto Arezzo, G. Soliani, P. Checcacci, G. Concone, Emanuele Botteri, F. Scognamillo, Ferdinando Agresta, Pierluigi Marini, S. Gelati, Luigi Boni, A. Coratti, Andrea Picchetto, G. Guerriero, M. Calgaro, Francesca Pecchini, A. Contine, Andrea Valeri, N. DeManzini, M. Clementi, A. Balani, F. Fidanza, R. Galleano, Carlo Bergamini, A. Brescia, G. Arcuri, Elio Jovine, E. Rosso, A. Oldani, E. Artioli, Nereo Vettoretto, Giuseppe Navarra, G. Sarro, E. Restini, Chiara Morotti, S. Giannessi, F. DeAngelis, M. Degiuli, G. Talamo, G. Alemanno, L. Cafagna, P. Cumbo, V. Violi, S. Targa, Irnerio Angelo Muttillo, A. Martino, M. DeLuca, Elisa Cassinotti, Alessandro Puzziello, S. Sala, Riccardo Rosati, E. Erdas, R. Petri, A. Deserra, A. Gioffre, G. Viola, E. Stratta, Mario Guerrieri, E. Minciotti, Mauro Podda, Giuseppe Spinoglio, F. Borghi, Micaela Piccoli, C. DeNisco, P. Carcoforo, D. Delogu, Giuseppe Resta, P. Corleone, D. Pennisi, Gianfranco Silecchia, E. Opocher, A. Taddei, A. Budassi, Paolo Delrio, A. Meloni, Marco E. Allaix, A. Ambrosi, H. Impellizzeri, N. Portolani, L. Guerriero, G. Ercolani, A. Guariniello, M. Antoniutti, M. Cesari, A. P. Luzzi, M. Izzo, M. Longoni, R. Mazza, C. Benvenuto, S. Gobbi, P. G. Calo, C. Feo, Antonino Agrusa, L. Covotta, L. Presenti, V. Adamo, Gian Luca Baiocchi, E. Osenda, R. Ottonello, Giancarlo D'Ambrosio, F. Roviello, V. Grammatico, G. Moretto, L. Zampino, Valerio Caracino, Giovanni Ferrari, D. Rega, V. Robustelli, Diego Cuccurullo, F. Vasta, Ugo Elmore, R. Campagnacci, Gianfranco Cocorullo, O. Ghazouani, G. Ricci, S. Berti, F. Colombo, Alberto Sartori, S. Scabini, S. Mazzoccato, B. Pirrera, A. Altamura, N. Tartaglia, E. Romairone, G. Baldazzi, Marco Catarci, G. Garulli, Lorenzo Casali, S. Testa, R. Brachet Contul, M. Basti, U. Rivolta, D. Pertile, M. Pavanello, M. Pisano, Marco Milone, A. Verzelli, P. Ubiali, L. Solaini, M. Coppola, G Anania, Massimo Carlini, F. Corcione, P. DePaolis, P. Ciano, M. Santarelli, V. Panebianco, Nicola Perrotta, R. Sechi, M. Rigamonti, G. Lezoche, L. Fabris, C. Lirusso, D. Foschi, G. Canova, P. Soliani, Roberta Gelmini, Stefano Olmi, A. Lucchi, Giorgia Valpiani, L. Pellegrino, Anania, G., Agresta, F., Artioli, E., Rubino, S., Resta, G., Vettoretto, N., Petz, W. L., Bergamini, C., Arezzo, A., Valpiani, G., Morotti, C., Silecchia, G., Adamo, V., Agrusa, A., Alemanno, G., Allaix, M. E., Alo, A., Altamura, A., Ambrosi, A., Antoniutti, M., Apa, D., Arcuri, G., Baiocchi, G. L., Balani, A., Baldazzi, G., Basti, M., Benvenuto, C., Berti, S., Boni, L., Borghi, F., Botteri, E., Brachet Contul, R., Brescia, A., Budassi, A., Cafagna, L., Calgaro, M., Calo, P. G., Campagnacci, R., Canova, G., Canu, G. L., Caracino, V., Carcoforo, P., Carlini, M., Casali, L., Cassetti, D., Cassinotti, E., Catarci, M., Cesari, M., Checcacci, P., Ciano, P., Clementi, M., Cocorullo, G., Colombo, F., Concone, G., Contine, A., Coppola, M., Coratti, A., Corcione, F., Corleone, P., Covotta, L., Cuccurullo, D., Cumbo, P., D'Ambrosio, G., Deangelis, F., Deluca, M., Demanzini, N., Denisco, C., Depalma, G. D., Depaolis, P., Degiuli, M., Delogu, D., Delrio, P., Deserra, A., Donini, A., Elmore, U., Ercolani, G., Erdas, E., Fabris, L., Ferrari, G., Feo, C., Fidanza, F., Foschi, D., Galleano, R., Garulli, G., Gatti, F., Gattolin, A., Gelati, S., Gelmini, R., Ghazouani, O., Gioffre, A., Gobbi, S., Grammatico, V., Guariniello, A., Giannessi, S., Guerrieri, M., Guerriero, L., Guerriero, G., Impellizzeri, H., Izzo, M., Jovine, E., Lezoche, G., Lirusso, C., Lombardi, R., Longoni, M., Lucchi, A., Luzzi, A. P., Marini, P., Marrosu, A. G., Martino, A., Mazza, R., Mazzoccato, S., Medas, F., Meloni, A., Milone, M., Minciotti, E., Monari, F., Moretto, G., Muttillo, I. A., Navarra, G., Neri, S., Oldani, A., Olmi, S., Opocher, E., Osenda, E., Ottonello, R., Panebianco, V., Pavanello, M., Pecchini, F., Pellegrino, L., Pennisi, D., Perrotta, N., Pertile, D., Petri, R., Picchetto, A., Piccoli, M., Pirrera, B., Pisani Ceretti, A., Pisano, M., Podda, M., Portolani, N., Presenti, L., Puzziello, A., Razzi, S., Rega, D., Restini, E., Ricci, G., Rigamonti, M., Rivolta, U., Robustelli, V., Romairone, E., Rosati, R., Rosso, E., Roviello, F., Sala, S., Santarelli, M., Sarro, G., Sartori, A., Scabini, S., Scognamillo, F., Sechi, R., Solaini, L., Soliani, G., Soliani, P., Soligo, E., Sorrentino, M., Spinoglio, G., Stratta, E., Taddei, A., Talamo, G., Targa, S., Tartaglia, N., Testa, S., Ubiali, P., Valeri, A., Vasta, F., Verzelli, A., Vicentini, R., Viola, G., Violi, V., Zago, M., and Zampino, L.

Subjects
medicine.medical_specialty, colon cancer right hemcolectomy, business.industry, medicine, Surgery, business, Side to side anastomosis, Surgical endoscopy, Laparoscopic right hemicolectomy, NO, LS7_4
Abstract

Due to an error in production the members of SICE CoDIG (Colon Dx Italian Group) listed in the Acknowledgments were not tagged correctly as authors in the XML of this article. This listing is presented again here:.

Published
2019

5. EP-1427 Prognostic role of neutrophil-to-lymphocytes ratio in pancreatic cancer

Author

Manuel Conson, M. Tirozzi, I.R. Scognamiglio, J. De Robbio, A. Roscigno, Roberto Pacelli, C. Oliviero, M. Caroprese, M. Sorrentino, E. Scipilliti, M.V. Agbaje Olufemi, F. Piccolo, and A. Farella

Subjects
Oncology, business.industry, Pancreatic cancer, Cancer research, medicine, Radiology, Nuclear Medicine and imaging, Hematology, medicine.disease, business
Published
2019
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6. Design and performance evaluation of drone propellers

Author

G. M. Sorrentino, A. Di Nisio, Anna Maria Lucia Lanzolla, Gregorio Andria, F. Antonacci, G. Pascazio, and M. Spadevecchia

Subjects
Drones, 3D printing, propeller design, performance evaluation, thrust, Computer science, business.industry, 020208 electrical & electronic engineering, Process (computing), Propeller, Mechanical engineering, Thrust, 02 engineering and technology, 021001 nanoscience & nanotechnology, Drone, performance evaluation, Three dimensional printing, 0202 electrical engineering, electronic engineering, information engineering, Fluid dynamics, thrust, 0210 nano-technology, business
Abstract

Drones are nowadays becoming more and more common. This paper presents a way to improve their performance and increase their versatility based on a faster design and development of drone propellers. This process starts with the modeling of the blades and of the hub of the propeller, which are required to meet dimensional specifications. Afterward, an evaluation is performed with fluid dynamics simulation tools which allows one to predict the forces acting on the propeller and, in particular, its thrust. After being realized using 3D printing, the real propeller undergoes tests that are necessary to verify its resistance to the operating forces and speeds. Afterwards, the propeller is subject to other tests to measure the generated thrust and compare it with the one expected from the simulations. Finally, in this paper, a comparison was performed with the thrust produced by other propellers to understand the improvements that can be adopted.

Published
2018

7. Multicentre international trial of laparoscopic lavage for Hinchey III acute diverticulitis (LLO Study)

Author

G A Binda, M A Bonino, G Siri, S Di Saverio, G Rossi, R Nascimbeni, M Sorrentino, A Arezzo, N Vettoretto, R Cirocchi, A Birindelli, S Bertone, R Mentz, M Brizzolari, R Galleano, L Reggiani, A Parisi, A Gemini, A Pascariello, L Boccia, P Capelli, D Pertile, G Baldazzi, D Cassini, G Portale, V Fiscon, C Boselli, P Gervaz, C A Gomes, N Horesh, C Rey Valcárcel, M Battocletti, G Guercioni, V Tonini, F Agresta, P Bisagni, A Crucitti, P Mariani, S Casiraghi, Z Lakkis, Binda, G A, Bonino, M A, Siri, G, Di Saverio, S, Rossi, G, Nascimbeni, R, Sorrentino, M, Arezzo, A, Vettoretto, N, Cirocchi, R, and Tonini, V

Subjects
Male, Reoperation, medicine.medical_specialty, Settore MED/18 - CHIRURGIA GENERALE, Perforation (oil well), Peritonitis, 030230 surgery, law.invention, Diverticulitis, Colonic, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Colonic, law, Colostomy, medicine, Humans, Peritoneal Lavage, Laparoscopy, Retrospective Studies, medicine.diagnostic_test, business.industry, Mortality rate, Retrospective cohort study, Diverticulitis, Middle Aged, medicine.disease, Conversion to Open Surgery, Surgery, diverticulitis, 030220 oncology & carcinogenesis, Acute Disease, Female, business
Abstract

Background Laparoscopic lavage was proposed in the 1990s to treat purulent peritonitis in patients with perforated acute diverticulitis. Prospective randomized trials had mixed results. The aim of this study was to determine the success rate of laparoscopic lavage in sepsis control and to identify a group of patients that could potentially benefit from this treatment. Methods This retrospective multicentre international study included consecutive patients from 24 centres who underwent laparoscopic lavage from 2005 to 2015. Results A total of 404 patients were included, 231 of whom had Hinchey III acute diverticulitis. Sepsis control was achieved in 172 patients (74·5 per cent), and was associated with lower Mannheim Peritonitis Index score and ASA grade, no evidence of free perforation, absence of extensive adhesiolysis and previous episodes of diverticulitis. The operation was immediately converted to open surgery in 19 patients. Among 212 patients who underwent laparoscopic lavage, the morbidity rate was 33·0 per cent; the reoperation rate was 13·7 per cent and the 30-day mortality rate 1·9 per cent. Twenty-one patients required readmission for early complications, of whom 11 underwent further surgery and one died. Of the 172 patients discharged uneventfully after laparoscopic lavage, a recurrent episode of acute diverticulitis was registered in 46 (26·7 per cent), at a mean of 11 (range 2–108) months. Relapse was associated with younger age, female sex and previous episodes of acute diverticulitis. Conclusion Laparoscopic lavage showed a high rate of successful sepsis control in selected patients with perforated Hinchey III acute diverticulitis affected by peritonitis, with low rates of operative mortality, reoperation and stoma formation.

Published
2018

8. Laparoscopic peritoneal lavage for perforated colonic diverticulitis: a definitive treatment? Retrospective analysis of 63 cases

Author

M. Brizzolari, S Bertozzi, M. Sorrentino, D. Malisan, F. Bruschi, S Bernardi, R. Petri, and E. Scarpa

Subjects
Adult, Male, medicine.medical_specialty, Operative Time, Peritonitis, Diverticulitis, Colonic, Recurrence, medicine, Retrospective analysis, Humans, Peritoneal Lavage, Laparoscopy, Aged, Retrospective Studies, Perforated diverticulitis, medicine.diagnostic_test, business.industry, General surgery, Mortality rate, Gastroenterology, Length of Stay, Middle Aged, Diverticulitis, medicine.disease, Colorectal surgery, Surgery, Treatment Outcome, Intestinal Perforation, Female, business, Abdominal surgery
Abstract

The ideal treatment of perforated diverticulitis and the indications for elective colon resection remain controversial. Considering the significant morbidity and mortality rates related to traditional resection, efforts have been made to reduce the invasiveness of surgery in recent decades. Laparoscopic peritoneal lavage has emerged as an effective alternative option. We retrospectively investigated the effectiveness of laparoscopic peritoneal lavage for perforated diverticulitis and the possibility that it could be a definitive treatment.We included patients treated with laparoscopic peritoneal lavage for perforated diverticulitis. The inclusion criteria were all emergency patients with generalized peritonitis due to Hinchey III perforated diverticulitis and some cases of Hinchey II and IV.Sixty-three patients were treated with laparoscopic peritoneal lavage. Six patients (9.5 %) had Hinchey II diverticulitis; 54 patients (85.7 %) had Hinchey III; and three patients (4.8 %) had Hinchey IV. The mean operative time was 87.3 min (±25.4 min), and the overall morbidity rate was 14.3 %. One patient died because of pulmonary embolism, and there were six early reinterventions because of treatment failure. Delayed colon resection was performed in four of the remaining 57 patients (7 %) because of recurrent diverticulitis. In the other 53 patients (93 %), we saw no recurrence of diverticulitis and no intervention was performed after a median follow-up period of 54 months (interquartile range 27-98 months).Laparoscopic peritoneal lavage for perforated diverticulitis can be considered a safe and effective alternative to traditional surgical resection, and using this approach, most elective colon resection might be avoided.

Published
2014
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9. Prognostic value of systemic inflammatory biomarkers in patients with mCRPC treated with abiraterone in pre-docetaxel setting

Author

Elena Verzoni, D. De Lisi, Daniele Santini, M. Sorrentino, Francesco Pantano, Paolo Grassi, G. Procopio, Raffaele Ratta, F. de Braud, Michele Prisciandaro, and R. Montone

Subjects
Oncology, medicine.medical_specialty, business.industry, Hematology, Inflammatory biomarkers, Abiraterone, chemistry.chemical_compound, Docetaxel, chemistry, Internal medicine, medicine, In patient, business, Value (mathematics), medicine.drug
Published
2017

11. Is laparoscopic peritoneal lavage for diverticular peritonitis only a 'bridge' to elective sigmoidectomy? An alternative hypothesis

Author

M. Sorrentino and M. Brizzolari

Subjects
medicine.medical_specialty, business.industry, Contraindications, Gastroenterology, Peritonitis, medicine.disease, Diverticulum, Colon, Colorectal surgery, Surgery, Bridge (graph theory), Sigmoidectomy, Colon, Sigmoid, Elective Surgical Procedures, Medicine, Humans, Laparoscopy, Peritoneal Lavage, business, Colectomy, Abdominal surgery
Published
2015

12. Exercise test mode dependency for ventilatory efficiency in women but not men

Author

Kristin M. Sorrentino, April C. Soriano, Silvia Dorado, Patrick H. Pham, Kara B. Costello, Trisha A. Tyminski, and James A. Davis

Subjects
Adult, Male, medicine.medical_specialty, Physiology, Physical exercise, Respiratory compensation, Sex Factors, Physiology (medical), Internal medicine, Respiration, medicine, Humans, Cycle ergometer, Carbon dioxide output, Treadmill, business.industry, Cardiopulmonary exercise testing, General Medicine, Carbon Dioxide, Exercise Test, Cardiology, Physical therapy, Breathing, Regression Analysis, Female, Pulmonary Ventilation, business
Abstract

Ventilatory efficiency is commonly defined as the level of ventilation V(E) at a given carbon dioxide output (V(CO(2) )). The slope of the V(E) versus V(CO(2) ) relationship and the lowest V(E)/V(CO(2) ) are two ventilatory efficiency indices that can be measured during cardiopulmonary exercise testing (CPET). A possible CPET mode dependency for these indices was evaluated in healthy men and women. Also evaluated was the relationship between these two indices as, in theory, V(E)/V(CO(2) ) falls hyperbolically towards an asymptote that numerically equals the V(E) versus V(CO(2) ) slope at exercise levels below the ones that cause respiratory compensation for metabolic acidosis. Twenty-eight healthy subjects (14 men) underwent treadmill and cycle ergometer CPET on different days. Ventilation and the gas fractions for oxygen and CO(2) were measured with a vacumed metabolic cart. In men, paired t-test analysis failed to find a mode difference for either ventilatory efficiency index but the opposite was true in the women as each woman had higher values for both indices on the treadmill. For men, the lowest V(E)/V(CO(2) ) was larger than the V(E) versus V(CO(2) ) slope by 1.3 on the treadmill and 0.8 on the cycle ergometer. The corresponding values for women were 1.7 and 1.4. We conclude that in healthy subjects, women, but not men, demonstrate a mode dependency for the two ventilatory efficiency indices investigated in this study. Furthermore, our results are consistent with the theoretical expectation that the lowest V(E)/V(CO(2) ) has a numerical value just above the asymptote of the V(E)/V(CO(2) ) versus V(CO(2) ) relationship.

Published
2006
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13. Is ventilatory efficiency dependent on the speed of the exercise test protocol in healthy men and women?

Author

James A. Davis, Silvia Dorado, Kristin M. Sorrentino, Patrick H. Pham, and April C. Soriano

Subjects
Adult, Male, medicine.medical_specialty, Physiology, Physical exercise, Oxygen Consumption, Sex Factors, Physiology (medical), Internal medicine, Respiration, Humans, Medicine, Carbon dioxide output, Exercise, business.industry, Lactate threshold, Cardiopulmonary exercise testing, General Medicine, Carbon Dioxide, Lung disease, Exercise Test, Cardiology, Physical therapy, Breathing, Regression Analysis, Female, Test protocol, Pulmonary Ventilation, business
Abstract

Indices of ventilatory efficiency have proven useful in assessing patients with heart and lung disease. One of these indices is the slope of the ventilation (V(E)) versus carbon dioxide output (VCO(2)) relationship during cardiopulmonary exercise testing (CPET) for work rates where the relationship is linear. However, this relationship is defined not only by the slope but also by the y-intercept. To examine whether this relationship is dependent on the speed of the CPET protocol, 30 healthy subjects (16 males) were administered a rapid CPET with 1-min increment duration (1-min CPET) to the limit of tolerance and a slow CPET with 4-min increment duration (4-min CPET) to the lactate threshold. Ventilation and the gas fractions for oxygen and CO(2) were measured with a Vacumed metabolic cart. The average increment size of both protocols for both sexes was not significantly different (P>0.05). For the males, the mean (SD) slope for the 1- and 4-min CPET was 20.12 (2.61) and 20.37 (2.41), respectively. The corresponding values for the y-intercept were 4..89 (2.08) and 5..10 (2.00) l min(-1). For the females, the mean (SD) slope for the 1- and 4-min CPET was 23.90 (2.38) and 24.16 (2.55), respectively. The corresponding values for the y-intercept were 3.93 (0.39) and 3.77 (0.71) l min(-1). Paired t-test analysis demonstrated for both sexes that the slopes and y-intercepts were not different for the two protocols (P>0.05). The results of this study demonstrate that the V(E) versus VCO(2) relationship is not dependent on the speed of the CPET protocol.

Published
2006
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14. Comparison of stroke volume estimation for non-steady-state and steady-state graded exercise testing

Author

Patrick H. Pham, April C. Soriano, Kristin M. Sorrentino, and James A. Davis

Subjects
Adult, Male, medicine.medical_specialty, Cardiac output, Time Factors, Steady state (electronics), Physiology, Oxygen pulse, Physical exercise, Blood volume, Oxygen Consumption, Sex Factors, Heart Rate, Reference Values, Physiology (medical), Internal medicine, Heart rate, medicine, Humans, business.industry, Stroke Volume, General Medicine, Stroke volume, Surgery, Exercise Test, Cardiology, Breathing, Female, business
Abstract

The stroke volume (SV) during exercise is an important index of the heart's functional capacity. A new method has been developed for the non-invasive estimation of exercise SV (SVex). It requires the determination of the slope for the oxygen uptake versus heart rate relationship in the steady state of graded exercise testing (GXT). The product of the slope and a constant (reciprocal of an assumed value of the arterial oxygen content) equals an estimated value for SVex. It was validated in a previous study using invasive measurements while subjects were performing steady-state GXT. However, currently the most commonly used GXT protocols are non-steady state, e.g. protocols with 1-min increment durations. We tested the hypothesis that SVex is the same for steady-state and non-steady-state GXT. A total of 30 subjects (15 males and 15 females) served as subjects for the study. Each subject performed two GXTs on different days with different increment durations - 1 and 4 min. Ventilation and gas exchange were measured with the Vacumed metabolic cart. For the male subjects, the mean (SD) SVex values for the 1- and 4-min GXTs were 155.4 (39.5) and 134.6 (27.5) ml, respectively. The corresponding values for the female subjects were 151.6 (37.6) and 134.3 (36.4) ml. Paired t-test analysis demonstrated that for both genders the mean SVex for the 1-min GXT was significantly larger than the 4-min GXT mean value (P

Published
2005
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15. Learning from Disappointing Outcomes: An Evaluation of Prevocational Interventions for Methadone Maintenance Patients

Author

Diane M. Sorrentino, Victor Lidz, Scott C. Bunce, and Lenore Robison

Subjects
Adult, Male, Narcotics, Program evaluation, Methadone maintenance, medicine.medical_specialty, Health (social science), medicine.medical_treatment, education, Psychological intervention, Medicine (miscellaneous), law.invention, Randomized controlled trial, law, Humans, Medicine, Psychiatry, Problem Solving, Rehabilitation, business.industry, Public Health, Environmental and Occupational Health, Middle Aged, Opioid-Related Disorders, Vocational Guidance, Clinical trial, Psychiatry and Mental health, Treatment Outcome, Vocational education, Physical therapy, Female, business, Methadone, medicine.drug
Abstract

To increase rates of employment and improve overall rehabilitation in methadone maintenance treatment, three prevocational trainings, Vocational Problem Solving, Job Seekers Workshop, and the two combined, were evaluated as adjunctive services. Between March 1995 and April 1998, subjects in treatment were interviewed at baseline, randomly assigned to one of the trainings, and followed up at 6 and 12 months postbaseline. None of the three models produced significantly greater employment or better overall rehabilitation. Experience from the study suggests that closer integration of prevocational training with treatment, individualizing efforts to meet training needs, and providing support during job-finding and early job-holding might improve program effectiveness.

Published
2004
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17. The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines

Author

Marta Castiglia, Alessandro Perez, Federica Grisafi, Domenica Matranga, G. Scoarughi, M. Sorrentino, Enrico Bronte, A. Di Stefano, L. Castellana, A. Guarini, C. Corso, G. Barbato, Valentina Calò, F. Di Piazza, Antonio Russo, Nadia Barraco, Daniela Massihnia, L. Insalaco, and Angela Listì

Subjects
Oncology, business.industry, Cell culture, Nsclc cell, Cancer research, Medicine, Hematology, business
Published
2017
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18. Use of the McGRATH ® MAC videolaryngoscope in emergencies

Author

P. Lazzaro, S. Notaro, M. Sorrentino, M. Venditto, P. Murino, A. Corcione, G. Rossi, E. Piscitelli, and A. Notaro

Subjects
Anesthesiology and Pain Medicine, business.industry, Medicine, Medical emergency, Critical Care and Intensive Care Medicine, business, medicine.disease
Published
2017
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19. Broad immunomodulating effect of first-line pazopanib in metastatic renal cell carcinoma patients

Author

Darawan Rinchai, R. Montone, Paolo Grassi, L. De Cecco, Agata Cova, Davide Bedognetti, Raffaele Ratta, Giuseppe Procopio, Paola Squarcina, Elena Verzoni, Veronica Huber, M. Sorrentino, Licia Rivoltini, and M. Dugo

Subjects
Pazopanib, Oncology, business.industry, Renal cell carcinoma, First line, Cancer research, Medicine, Hematology, business, medicine.disease, medicine.drug
Published
2017
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21. Abnormal or delayed development of the posterior membranous area of the brain: anatomy, ultrasound diagnosis, natural history and outcome of Blake's pouch cyst in the fetus

Author

M. Sorrentino, Mario Quarantelli, Dario Paladini, G. Sglavo, Carmela Nappi, G. Pastore, Paladini, Dario, Quarantelli, M., Pastore, G., Sorrentino, M., Sglavo, Gabriella, and Nappi, Carmine

Subjects
medicine.medical_specialty, Karyotype, Autopsy, Gestational Age, Cisterna magna, Fourth ventricle, Ultrasonography, Prenatal, Cerebral Ventricles, Pregnancy, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Cyst, Retrospective Studies, Radiological and Ultrasound Technology, business.industry, Cysts, Infant, Newborn, Obstetrics and Gynecology, Gestational age, General Medicine, medicine.disease, Prognosis, Surgery, Reproductive Medicine, Cranial Fossa, Posterior, Cerebellar vermis, Female, Abnormality, business, Trisomy, Dandy-Walker Syndrome
Abstract

Objectives To review the normal and pathological development of the posterior membranous area (PMA) in the fetal brain, to define sonographic criteria with which to diagnose a Blake's pouch cyst (BPC) in the fetus and to review the ultrasound features, associations and outcome of 19 cases of BPC seen at our center over the last 5 years. Methods We conducted a MEDLINE search using the terms ‘Blake's pouch’, with or without ‘fourth ventricle’ or ‘4th ventricle’, with or without ‘roof’ and identified articles describing normal and/or abnormal development of the PMA, whether or not they were cited in the limited clinical literature on BPC. A description of the normal and abnormal development of BPC was derived by collating these articles. The clinical retrospective study included 19 cases of posterior fossa anomalies with a final diagnosis of BPC seen at our institution. The following variables were assessed: referral indication, gestational age at diagnosis, ultrasound and magnetic resonance imaging (MRI) findings, associated anomalies, natural history and pregnancy and neonatal outcome. A transvaginal three-dimensional (3D) ultrasound examination was performed in all cases and 15 cases underwent MRI. To confirm the diagnosis, postnatal MRI, transfontanellar ultrasound or autopsy were available in all cases. Results Among the 19 cases reviewed, referral indications were: suspicion of vermian abnormality in 11 (58%) cases and other non-central nervous system anomaly in eight (42%) cases. Sonographically, all cases showed the following three signs: 1) normal anatomy and size of the vermis; 2) mild/moderate anti-clockwise rotation of the vermis; 3) normal size of the cisterna magna. On 3D ultrasound, the upper wall of the cyst was clearly visible in 11/19 cases, with choroid plexuses on the superolateral margin of the cyst roof. On follow-up, the BPC had disappeared by 24–26 gestational weeks in six of the 11 cases which did not undergo termination of pregnancy (TOP), and remained unaltered until birth in the other five cases. There were associated anomalies in eight (42%) cases, in five of which this consisted of or included congenital heart disease. Karyotype was available in 14 cases, two of which were abnormal (both trisomy 21). Regarding pregnancy outcome, there were eight (42%) TOPs, two (10%) neonatal deaths and nine (48%) survivors. One neonate, in whom the BPC had disappeared by the time of birth, had obstructive hydrocephaly confirmed. Another neonate was diagnosed with Down syndrome after birth. Excluding the Down syndrome baby, neurodevelopmental outcome was normal at the time of writing in all eight cases. Conclusions Based on our analysis of ultrasound features, we propose that for BPC to be diagnosed in a fetus the following three criteria should be fulfilled: 1) normal anatomy and size of the vermis; 2) mild/moderate anti-clockwise rotation of the vermis; 3) normal size of the cisterna magna. Furthermore, we found that BPC can undergo delayed fenestration at 24–26 weeks in more than 50% of cases. Finally, it seems that BPC shows a risk of association with extracardiac anomalies (heart defects in particular) and, to a lesser extent, trisomy 21. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.

Published
2011

22. The semilunar coronally repositioned flap combined with a frenectomy to obtain root coverage over the maxillary central incisors

Author

Dennis P. Tarnow and Jesse M. Sorrentino

Subjects
Adult, Labial Frenum, medicine.medical_specialty, Mucogingival junction, Gingiva, Dentistry, Frenectomy, Surgical Flaps, stomatognathic system, Incisor, medicine, Maxilla, Humans, Maxillary central incisor, Gingival Recession, Tooth Root, Gingival recession, Orthodontics, Wound Healing, business.industry, stomatognathic diseases, Plastic surgery, medicine.anatomical_structure, Treatment Outcome, Coronal plane, Periodontics, Female, medicine.symptom, business, Follow-Up Studies
Abstract

This case report describes a method for coronally repositioning gingiva for root coverage over the maxillary central incisors while simultaneously performing a frenectomy.The patient was a healthy 43-year-old Brazilian female. Her chief complaint pertained to the unesthetic appearance of the gingival recession involving both maxillary central incisors. Intraoral examination revealed a thick biotype with an adequate band of keratinized gingiva, Miller Class I mucogingival defects, and a broad frenum extending beyond the mucogingival junction. The surgical technique used to treat the areas of recession involved making semilunar incisions over the maxillary central incisors that blended into a frenectomy.Complete root coverage was achieved over the maxillary central incisors that initially presented with 2 mm of recession on the facial surface. The residual frenum no longer attached at a point coronal to the mucogingival margin. Small white scars were detectable at the mucogingival junctions above both incisors but were not an esthetic concern because of the patient's moderate smile line.This case report shows the possibility of applying a combined semilunar coronally repositioned flap with a frenectomy in a case in which maxillary central incisors were impinged upon by a broad aberrant frenum, probed/=3 mm, and presented with Miller Class I mucogingival defects. Further controlled investigations are needed to define the efficacy of this surgical technique.

Published
2009

23. Modeling Methodologies for Design and Control of Solid Oxide Fuel Cell APUs

Author

C. Pianese, M. Sorrentino, Abdul Halim Hakim, Pandian Vasant, and Nader Barsoum

Subjects
Flexibility (engineering), Cogeneration, Engineering, Stack (abstract data type), business.industry, Automotive industry, Mechanical engineering, Solid oxide fuel cell, Ranging, Process engineering, business, Modularity, Sizing
Abstract

Among the existing fuel cell technologies, Solid Oxide Fuel Cells (SOFC) are particularly suitable for both stationary and mobile applications, due to their high energy conversion efficiencies, modularity, high fuel flexibility, low emissions and noise. Moreover, the high working temperatures enable their use for efficient cogeneration applications.SOFCs are entering in a pre‐industrial era and a strong interest for designing tools has growth in the last years. Optimal system configuration, components sizing, control and diagnostic system design require computational tools that meet the conflicting needs of accuracy, affordable computational time, limited experimental efforts and flexibility.The paper gives an overview on control‐oriented modeling of SOFC at both single cell and stack level. Such an approach provides useful simulation tools for designing and controlling SOFC‐APUs destined to a wide application area, ranging from automotive to marine and airplane APUs.

Published
2009
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25. Test-retest reliability for two indices of ventilatory efficiency measured during cardiopulmonary exercise testing in healthy men and women

Author

Patrick H. Pham, Erin M. Ninness, Silvia Dorado, Kara B. Costello, James A. Davis, and Kristin M. Sorrentino

Subjects
Male, medicine.medical_specialty, Physiology, Physical exercise, Animal science, Oxygen Consumption, Heart Rate, Physiology (medical), Surveys and Questionnaires, Linear regression, Medicine, Cycle ergometer, Humans, Carbon dioxide output, Exercise, Reliability (statistics), business.industry, Pulmonary Gas Exchange, Healthy subjects, Reproducibility of Results, Cardiopulmonary exercise testing, General Medicine, Carbon Dioxide, Breathing, Physical therapy, Exercise Test, Linear Models, Respiratory Physiological Phenomena, Female, business
Abstract

The level of ventilation (V E ) at a given carbon dioxide output (V CO2 ) determines ventilatory efficiency. During cardiopulmonary exercise testing (CPET), ventilatory efficiency can be measured as the slope of the V E versus V CO2 relationship or the lowest V E /V CO2 . We evaluated the test-retest reliability of these two ventilatory efficiency indices in 29 healthy subjects (14 males). Each subject performed duplicate cycle ergometer tests on different days. Ventilation and the gas fractions for oxygen and CO 2 were measured with a Vacumed metabolic cart. Linear regression analysis of the V E versus V CO2 slope for the duplicate tests in the males, females, and both sexes combined yielded correlation coefficients of 0·822, 0·942, and 0-910, respectively. The corresponding correlation coefficients for the lowest V E / V CO2 were 0·745, 0-929, and 0·884. A comparison of the test-retest correlation coefficients between the two ventilatory efficiency measures for the men, women, and both sexes combined revealed that they were not significantly different and, for a given index, there were no sex differences. The bias (mean of difference scores between tests) and 95% limits of agreement for the V E versus V CO2 slope in the males, females, and both sexes combined were -0·05 ± 2·41, -0-57 ± 1-92, and -0·32 ± 2·20, respectively. The bias and 95% limits of agreement for the lowest V E /V CO2 were very similar with values of 0-06 ± 2-45, -0-22 ± 2-03, and -0·10 ± 2-27. We conclude that the test-retest reliability for the V E versus V CO2 slope and the lowest V E /V CO2 is the same and that there is no sex difference in reliability for either index of ventilatory efficiency.

Published
2006

26. OC08.01: B-flow derived M-mode is a reliable tool to detect diastolic run-off in fetal aortic coarctation

Author

M. Sorrentino, B. Cioffi, Carmela Nappi, G. Sglavo, G. Pastore, and Dario Paladini

Subjects
medicine.medical_specialty, Fetus, Reproductive Medicine, Radiological and Ultrasound Technology, business.industry, Internal medicine, medicine, Diastole, Cardiology, Obstetrics and Gynecology, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2012
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27. OC05.02: The aorta/RV diameter ratio allows to rule out aortic coarctation in cases referred for ventricular disproportion or suspect of coarctation. A multivariate analysis study

Author

M. Sorrentino, Carmela Nappi, G. Sglavo, G. Pastore, and Dario Paladini

Subjects
medicine.medical_specialty, Aorta, Multivariate analysis, Radiological and Ultrasound Technology, business.industry, Obstetrics and Gynecology, General Medicine, Diameter ratio, Reproductive Medicine, Internal medicine, medicine.artery, Cardiology, medicine, Radiology, Nuclear Medicine and imaging, Suspect, business
Published
2011
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28. TREATMENT OF GIANT HYDRONEPHROSIS

Author

M. Sorrentino

Subjects
Adult, Male, Kidney, medicine.medical_specialty, Adolescent, business.industry, Urology, Urography, Hydronephrosis, Ileal Loop, Pyelectasis, Giant hydronephrosis, medicine.anatomical_structure, Ureter, Ileum, medicine, Humans, business
Abstract

SUMMARY First, the concept of giant hydronephrosis is established; this is when there is not a single pyelectasis, but transformation of the kidney into sacs with thin walls. Three different operations are next examined: renal folding, following a personal technique, which gives good results when there is precise indication; total substitution of the ureter with a vesical tubular segment, which has given bad results; and total substitution of the ureter with an ileal loop, which is the method lending itself to most extensive application.

Published
1966
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31. Conclusioni

Author

M Sorrentino

Subjects
PCA3, Oncology, medicine.medical_specialty, Prostatectomy, business.industry, Urology, medicine.medical_treatment, MEDLINE, Cancer, medicine.disease, medicine.anatomical_structure, Prostate, Internal medicine, medicine, business
Published
1965
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32. Symposium III: Endocrinosurgical Treatment in Intersexuality

Author

M. Wernly, F. Hinman, H.J. Dulce, R. Couvelaire, G. Mayor, M. Pavone, B. Courvoisier, M. Sorrentino, R. Defoort, U. Bracci, Mary G. McGeown, F. Sorrentino, T. Greco, G. Jönsson, E. Belt, J. Hellström, H. Baumelou, Gil Vernet, C. Overzier, J.L. Funck-Brentano, R.G. Bunge, J.F. Glenn, J. Mirouze, G. Valle, and J. Money

Subjects
medicine.medical_specialty, business.industry, Urology, medicine, business, Dermatology
Published
1965
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33. Book Reviews / Varia

Author

Hideo Mitsuya, K. Suyama, F. Sorrentino, Svend Hansen, J. Asai, A. Paalanen, R. Überall, K. Hosoe, W. Lutzeyer, M. Sorrentino, and E. Sai

Subjects
business.industry, Urology, Medicine, business, Classics
Published
1962
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34. Symposium I: Endocrinosurgery in the Cancer of the Prostate

Author

F. Hinman, R. Couvelaire, J. Hellström, H. Baumelou, M. Wernly, R. Defoort, M. Sorrentino, U. Bracci, Mary G. McGeown, J. Mirouze, E. Belt, J. Money, H.J. Dulce, F. Sorrentino, G. Jönsson, M. Pavone, B. Courvoisier, Gil Vernet, G. Mayor, T. Greco, R.G. Bunge, J.F. Glenn, J.L. Funck-Brentano, C. Overzier, and G. Valle

Subjects
Gynecology, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Prostate, Urology, Medicine, Cancer, business, medicine.disease
Published
1965
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35. Symposium II: Parathyroidectomy in Renal Lithiasis

Author

G. Mayor, M. Sorrentino, H.J. Dulce, J.F. Glenn, M. Pavone, T. Greco, C. Overzier, G. Valle, Gil Vernet, J.L. Funck-Brentano, Mary G. McGeown, B. Courvoisier, R. Couvelaire, Frank Hinman, R. Defoort, U. Bracci, R.G. Bunge, J. Mirouze, E. Belt, M. Wernly, J. Money, J. Hellström, H. Baumelou, F. Sorrentino, and G. Jönsson

Subjects
Parathyroidectomy, medicine.medical_specialty, business.industry, Urology, medicine.medical_treatment, Renal lithiasis, Medicine, business, Surgery
Published
1965
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36. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

Author

Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, A., Podda, M., Botteri, E., Passera, R., Agresta, F., Arezzo, A., Guerrieri, M., Ortenzi, M., Cavallo, F., Zese, M., Prando, D., Restini, E., Cianci, P., Millo, P., Brachet Contul, R., Serrao, A., Abatini, F., Altomare, D. F., Picciariello, A., Chetta, G., Lattanzio, F., Tonini, V., Gori, A., Jovine, E., Mastrangelo, L., Sartarelli, L., Frena, A., Malpaga, A., Bertelli, F., Pignata, G., Andreuccetti, J., Sanna, S., Lares, B., Sechi, R., Cillara, N., Pisanu, A., Delogu, D., Ciaccio, G., Farulla, M., Casati, M., Laface, L., De Luca, M., Russello, D., Latteri, S., Longoni, M., Masci, E., Vigna, S., Campanile, F. C., Foti, N., Lepiane, P., Balla, A., Cantore, F., Raveglia, V., Borghi, F., Giraudo, G., Verzelli, A., Budassi, A., Patriti, A., Foghetti, D., Montin, U., Amadio, L., Anania, G., Bombardini, C., Fabbri, N., Feo, C., Cianchi, F., Manetti, A., Lucchese, M., Soricelli, E., Ceccarelli, G., Patiti, M., Frascio, M., Stabilini, C., Filauro, M., Barberis, A., Troian, M., Nagliati, C., Campagnacci, R., Maurizi, A., Berti, S., Gennai, A., Marvaso, A., D'Antonio, D., Feo, C. V., Mazzola, L., Selvaggi, F., Carini, S., Costanzo, F., Boccia, L., Pascariello, A., Perrotta, N., Celiento, M., Opocher, E., Giovenzana, M., Stella, M., Ferrara, F., Boni, L., Abate, E., Da Lio, C., Valli, V., Gelmini, R., Serra, F., Piccoli, M., Gozzo, D., Gattolin, A., Sasia, D., Balani, A., Petronio, B., Calo, P. G., Canu, G. L., Contarini, E., Piatto, G., Vettoretto, N., Caprioli, M., Braga, M., Chiappetta, M. 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E., Salzano, A., Tirone, G., Motter, M., Zanus, G., Passuello, N., Massani, M., Tutino, R., Manzini, N., Terranova, S., Merenda, R., Nordio, S., Zonta, S., Lovisetto, F., Guglielmi, A., Campagnaro, T., Amedeo, E., Scollica, M., Amodio, P., Giannotti, D., Olmi, S., Oldani, A., Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D.F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F.C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C.V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P.G., Canu G.L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M.F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M.V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M.M., Zerbinati A., Corso S., Vasino M.C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S.R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D.G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M.F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A.P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M.E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, Alberto, Podda, Mauro, Botteri, Emanuele, Passera, Roberto, Agresta, Ferdinando, Arezzo, Alberto, M Guerrieri, M Ortenzi, F Cavallo, M Zese, D Prando, E Restini, P Cianci, P Millo, R Brachet Contul, A Serrao, F Abatini, D F Altomare, A Picciariello, G Chetta, F Lattanzio, V Tonini, A Gori, E Jovine, L Mastrangelo, L Sartarelli, A Frena, A Malpaga, F Bertelli, G Pignata, J Andreuccetti, S Sanna, B Lares, R Sechi, N Cillara, A Pisanu, D Delogu, G Ciaccio, M Farulla, M Casati, L Laface, M De Luca, D Russello, S Latteri, M Longoni, E Masci, S Vigna, F C Campanile, N Foti, P Lepiane, A Balla, F Cantore, V Raveglia, F Borghi, G Giraudo, A Verzelli, A Budassi, A Patriti, D Foghetti, U Montin, L Amadio, G Anania, C Bombardini, Niccolò Fabbri, Carlo Feo, F Cianchi, A Manetti, M Lucchese, E Soricelli, G Ceccarelli, M Patiti, M Frascio, C Stabilini, M Filauro, A Barberis, M Troian, C Nagliati, R Campagnacci, A Maurizi, S Berti, A Gennai, A Marvaso, D D'Antonio, C V Feo, N Fabbri, L Mazzola, F Selvaggi, S Carini, F Costanzo, L Boccia, A Pascariello, N Perrotta, M Celiento, E Opocher, M Giovenzana, M Stella, F Ferrara, L Boni, E Abate, C Da Lio, V Valli, R Gelmini, F Serra, M Piccoli, D Gozzo, A Gattolin, D Sasia, A Balani, B Petronio, P G Calò, G L Canu, E Contarini, G Piatto, N Vettoretto, M Caprioli, M Braga, M F Chiappetta, P Maida, P Tammaro, G De Palma, M Milone, V Bottino, A Canfora, F Selvaggi, G Bagaglini, A Agrusa, M Barone, A Mirabella, M V Marino, G Gulotta, G Romano, M Sorrentino, S Ferfoglia, V Papagni, S Eramo, C Boselli, M Basti, V Caracino, G Moretto, M Inama, P Capelli, L Conti, A Muratore, M M Cuoghi, A Zerbinati, S Corso, M C Vasino, M Montuori, F Fidanza, A Lucchetta, A Giuliani, G Dinatale, F Zanzi, A Guariniello, S Bonilauri, G Frazzetta, M Garino, C Marafante, A Gioffrè, S R Del Monte, G Sganga, P Fransvea, M Grande, L Siragusa, G Sica, M Paola, D G Passantino, Marco Catani, F Ricci, E Lauro, E Facci, D Parini, M F Armellino, G Argenio, A Porcu, T Perra, P Bordoni, F Fleres, A Parisi, S Rossi, R Saracco, D Bono, T Viora, F Orlando, A Ferrero, A P Fontana, P De Paolis, D Visconti, F Quaglino, F Festa, S Palagi, G Lo Secco, M Morino, M E Allaix, A Salzano, G Tirone, M Motter, G Zanus, N Passuello, M Massani, R Tutino, N Manzini, S Terranova, R Merenda, S Nordio, S Zonta, F Lovisetto, A Guglielmi, T Campagnaro, E Amedeo, M Scollica, P Amodio, D Giannotti, S Olmi, A Oldani, Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, and Oldani, A

Subjects
medicine.medical_specialty, COVID-19 Pandemic, Coronavirus disease 2019 (COVID-19), Endoscopic surgery, NO, Appendectomy, Appendicitis, Machine learning, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Retrospective Studie, Pandemic, medicine, Humans, Appendiciti, Laparoscopy, Pandemics, Retrospective Studies, medicine.diagnostic_test, business.industry, COVID-19 Pandemic, Appendicitis, Appendicectomy, Machine learning, SARS-CoV-2, COVID-19, Length of Stay, medicine.disease, Settore MED/18, Surgery, Italy, 030220 oncology & carcinogenesis, appendicitis, COVID-19 pandemic, machine learning, appendectomy, cohort studies, humans, length of stay, pandemics, postoperative complications, retrospective studies, laparoscopy, 030211 gastroenterology & hepatology, Observational study, Original Article, Postoperative Complication, Appendicectomy, Cohort Studie, business, Complication, Cohort study, Human
Abstract

Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March–April 2019 vs March–April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registration number and date: Research Registry ID 5789, May 7th, 2020

Published
2021

37. Enhancing Polymeric Electrolyte Membrane Fuel Cell Control by Means of the Perturb and Observe Technique

Author

Giovanni Petrone, Ivan Arsie, Giovanni Spagnuolo, Cesare Pianese, Massimo Vitelli, A. Di Domenico, Alessandro Giustiniani, Marco Sorrentino, I., Arsie, A., DI DOMENICO, A., Giustiniani, G., Petrone, C., Pianese, M., Sorrentino, G., Spagnuolo, and Vitelli, Massimo

Subjects
Engineering, Adaptive control, Renewable Energy, Sustainability and the Environment, business.industry, Mechanical Engineering, Feed forward, hill climbing, Energy Engineering and Power Technology, Proton exchange membrane fuel cell, Electrolyte, polymeric electrolyte membrane (PEM) fuel cell, adaptive control, Cathode, Electronic, Optical and Magnetic Materials, law.invention, Stack (abstract data type), Mechanics of Materials, law, Control theory, business, Gas compressor, Hill climbing
Abstract

In this paper, the use of an adaptive technique aimed at controlling a polymeric electrolyte membrane fuel cell is introduced. It is demonstrated that a hill climbing-based method, acting on the compressor speed and/or the cathode back-pressure valve, allows to better take into account the effect of exogenous variables on stack performance. Particularly, the proposed technique has proven to perform better than classical feedforward/feedback approaches when well known aging mechanisms deteriorate cell efficiency. Numerical results based on experimentally derived models confirm the potential of the proposed control method and its intrinsic reliability.

Published
2009
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38. Office operative hysteroscopy: an update of the evidence (2002-2009)

Author

A. Di Spiezio Sardo, F. Sorrentino, Stefano Bettocchi, Marco Guida, Luigi Nappi, M. Spinelli, Carmela Nappi, Di Spiezio Sardo A, Bettocchi S, Spinelli M, Guida M, Sorrentino F, Nappi L, Nappi C., DI SPIEZIO SARDO, Attilio, Bettocchi, S, Spinelli, M, Guida, M, Sorrentino, F, Nappi, L, and Nappi, Carmine

Subjects
medicine.medical_specialty, business.industry, medicine, Obstetrics and Gynecology, Operative hysteroscopy, business, Surgery
Published
2009

39. PEM Fuel Cells Control by means of the Perturb and Observe Technique

Author

Giovanni Petrone, Cesare Pianese, Giovanni Spagnuolo, Massimo Vitelli, Alessandro Giustiniani, Marco Sorrentino, A., Giustiniani, G., Petrone, C., Pianese, M., Sorrentino, G., Spagnuolo, and Vitelli, Massimo

Subjects
Engineering, Reliability (semiconductor), business.industry, Control theory, Control (management), Feed forward, Proton exchange membrane fuel cell, Valve opening, Electrolyte, business, Gas compressor, Control methods
Abstract

In this paper the use of an adaptive technique aimed at controlling a polymeric electrolyte membrane fuel cell is introduced. It is demonstrated that a hill climbing-based method acting on the compressor speed and/or the backpressure valve opening is able to improve the performance of the fuel cell system with respect to those ones obtained by means of classical feed forward control approaches. Moreover, the proposed technique is able to ensure better performances even if well known aging mechanisms deteriorate cell efficiency. Numerical results based on experimentally derived models confirm the potential of the proposed control method and its intrinsic reliability.

Published
2006

40. Association between vitamin D receptor gene polymorphisms and fasting idiopathic hypercalciuria in recurrent stone-forming patients

Author

V. Nunziata, Domenico Rendina, Giuseppe Mossetti, Roberto Viceconti, Vincenzo Guadagno, Pasquale Strazzullo, Giuseppe Manno, Rosaria Castaldo, Mariangela Sorrentino, Rendina, Domenico, Mossetti, Giuseppe, R., Viceconti, M., Sorrentino, R., Castaldo, G., Manno, V., Guadagno, Strazzullo, Pasquale, and Nunziata, Vincenzo

Subjects
Male, Nephrology, Adult, Alleles, Bone Density, blood/chemistry/genetics/urine, Male, Middle Aged, Parathyroid Hormone, DNA Mutational Analysis, administration /&/ dosage, Calcium, Thyrotropin, Calcitriol receptor, Bone Density, Recurrence, Hypercalciuria, blood, Phosphate, biology, Sodium-Restricted, Fasting, Fasting, Diet, Sodium-Restricted, Middle Aged, FokI, blood/urine, DNA Mutational Analysis, Diet, blood/urine, Polymorphism, Parathyroid Hormone, analysis, Calcium, Female, Polymorphism, Restriction Fragment Length, Adult, medicine.medical_specialty, Urology, Dietary, Phosphates, Kidney Calculi, Calcitriol, blood, Internal medicine, medicine, Vitamin D and neurology, Humans, Alleles, Calcifediol, physiology, Calcifediol, Calcium Oxalate, business.industry, urine, Female, Haplotypes, Humans, Kidney Calculi, Haplotype, medicine.disease, genetics/physiology, Recurrence, Thyrotropin, Calcium, Dietary, Endocrinology, blood, Calcium Oxalate, Haplotypes, Restriction Fragment Length, Receptor, biology.protein, blood, Calcitriol, Receptors, Calcitriol, Calcium, Kidney stones, business, Body mass index
Abstract

Objectives To investigate the association between fasting idiopathic hypercalciuria (IHc), defined as IHc in the fasting state associated with normal parathyroid function, and ApaI, BsmI, and FokI polymorphisms of the vitamin D receptor (VDR) gene in 159 hypercalciuric recurrent stone formers. IHc contributes to the formation of calcium kidney stones in more than one half of reported cases. Methods We examined 62 patients with fasting IHc (24 women, mean age 42.8 ± 11.1 years, body mass index 25.7 ± 4.8 kg/m2), 97 patients with absorptive IHc (41 women, mean age 43.5 ± 10.8 years, body mass index 26.1 ± 4.4 kg/m2), and 124 healthy control subjects (52 women, mean age 41.9 ± 10.4 years, body mass index 25.4 ± 5.1 kg/m2) without a history of nephrolithiasis and without IHc. The bone mass density and VDR genotype and haplotype frequencies were determined in the studied populations. Results A reduced bone mass density was observed in fasting IHc patients compared with absorptive IHc patients (P = 0.009) and control subjects (P = 0.006). The prevalence of ApaI and BsmI VDR genotypes and alleles in patients with fasting IHc was significantly different statistically (P

Published
2004

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