1. Process Design and Optimization in the Pharmaceutical Industry: A Suzuki-Miyaura Procedure for the Synthesis of Savolitinib
- Author
-
Gareth P. Howell, Michael John Pilling, Andrew Hornby Dobson, Lucie Miller-Potucka, Lauren R. Agnew, Robert J Cox, Brian A. Taylor, Adlington Neil Keith, Aled Williams, William Hicks, Gall Malcolm Allan Young, Andrew D. Campbell, Anna Jawor-Baczynska, Katy Shepherd, Cristina Fernandez Barrat, and Ross Tassone
- Subjects
Drug Industry ,Molecular Structure ,010405 organic chemistry ,Process (engineering) ,business.industry ,Chemistry ,Triazines ,Organic Chemistry ,Process design ,010402 general chemistry ,01 natural sciences ,Manufacturing engineering ,0104 chemical sciences ,High-Throughput Screening Assays ,Drug Design ,Pyrazines ,business ,Drug industry ,Pharmaceutical industry - Abstract
A multidisciplinary approach covering synthetic, physical, and analytical chemistry, high-throughput experimentation and experimental design, process engineering, and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki–Miyaura process. Working against clear criteria and targets, a full process investigation and optimization package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.
- Published
- 2018