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With the development of leisure agriculture and consumer behavior, more attention should be paid to consumer experience. Based on the data of 2004 and 2019, this paper makes a comparative analysis on the tourism behavior of leisure agricultural tourists in Xuzhou, studies the process of behavior change, and uses the Heckman two-step model to analyze the impact of tourists' internal characteristics on the consumption behavior of leisure agricultural tourists. The empirical results show that: in the past 15 years, there have been great changes in the way tourists collect information, and the Internet has become the main information collection tool; the evaluation criteria of tourists have basically not changed, but the satisfaction has improved significantly; the gender, age, occupation, education level and family structure of consumers have no significant impact on whether they choose leisure agricultural travel; the income level will have an impact on tourists' behavior Significant impact. The conclusions of the study are as follows: first, the use of Internet information channels to increase publicity; second, aiming at the internal characteristics of tourists, targeted customer precision marketing; third, to promote the supply side structural reform of leisure agriculture and promote the high-quality development of the industry.

Environmental and epigenetic factors often play an important role in polygenic disorders. However, how such factors affect disease-specific tissues at the molecular level remains to be understood. Here, we address this in pulmonary arterial hypertension (PAH). We obtain pulmonary arterial endothelial cells (PAECs) from lungs of patients and controls (n = 19), and perform chromatin, transcriptomic and interaction profiling. Overall, we observe extensive remodeling at active enhancers in PAH PAECs and identify hundreds of differentially active TFs, yet find very little transcriptomic changes in steady-state. We devise a disease-specific enhancer-gene regulatory network and predict that primed enhancers in PAH PAECs are activated by the differentially active TFs, resulting in an aberrant response to endothelial signals, which could lead to disturbed angiogenesis and endothelial-to-mesenchymal-transition. We validate these predictions for a selection of target genes in PAECs stimulated with TGF-β, VEGF or serotonin. Our study highlights the role of chromatin state and enhancers in disease-relevant cell types of PAH., Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes in transcription factor and enhancer activity that suggest an aberrant response to signalling in PAH.

Background: A high rate of metal-on-metal total hip arthroplasty (MoM-THA) has been well-known. The aim of this study was to compare the long-term outcomes of patients who had undergone uncemented or cemented THA(UTHA or CTHA) following initial MoM-THA failure.Methods: Data from 234 patients (234 hips) who were treated with UTHA or CTHA following initial MoM-THA failure during 2007 - 2018 were retrospectively compared. Follow-up occurred 3 months, 6 months, 1 year, 2 years, and then every 1 year after conversion. The mean follow-up was 84.15 months (67 - 101 months). The primary endpoint was the Harris Hip Scores (HHS); secondary endpoint was the incidence of major orthopaedic complications.Results: The HHS demonstrated statistically greater differences in Group CTHA than in Group UTHA 12 months after conversion. From the 12th month after conversion to the final follow-up, CTHA yielded superior functional outcomes than UTHA. Between-group noteworthy differences were observed regarding the rates of re-revision, aseptic loosening, and periprosthetic fracture (10.3% for UTHA vs 2.5% for CTHA, p = 0.015; 16.3% for UTHA vs 5.9% for CTHA, p = 0.011; and 12.0% for UTHA vs 4.2% for CTHA, p = 0.045, respectively). Conclusion: In the setting of revision following initial MoM-THA failure, we found definite evidence of the superiority of CTHA over UTHA in regard to improving functional outcomes and decreasing the incidence of major orthopaedic complications.

This study proposes a novel mathematical model based on excitation system output equations (ESOEs) to evaluate the steady-state performance of the three-phase brushless asynchronous excitation system (BAES) of a wound-field synchronous aircraft starter-generator system. The steady-state performance could be used to evaluate the field current output capabilities of the BAES and provide a reference for the control schema of the BAES. However, the BAES has unknown multivariable non-linear characteristics, which give rise to difficulty in modelling the steady-state performance. Meanwhile, without closed-loop control of the main exciter stator current, the traditional methods fail to efficiently calculate the required excitation voltage and frequency for a desired field current. Steady-state performances are achieved for numerous discrete states with tedious simulations. This study develops the mathematical model of the ESOEs, which can be used to express the non-linear relationships among the main generator field current, main exciter (ME) rotor speed, ME excitation voltage, and frequency. The field current output capabilities could be evaluated in a time-efficient manner by solving these ESOEs. The proposed mathematical model and theoretical findings are verified by experimental results.

Left ventricular (LV) remodeling following myocardial infarction (MI) is an established prognostic factor for adverse cardiovascular events and the leading cause of heart failure. Empirical observations have suggested that Baduanjin exercise, an important component of traditional Chinese Qigong, may exert potential benefits on cardiopulmonary function. However, the impact of a Baduanjin exercise-based cardiac rehabilitation program for patients recovering from a recent MI has yet to be assessed. The aim of this trial is to evaluate the potential role of Baduanjin exercise in preventing the maladaptive progression to adverse LV remodeling in patients post-MI. A total of 110 clinically stable patients following an MI after undergoing successful infarct-related artery reperfusion will be randomly assigned to the Baduanjin exercise group or usual exercise control group. In addition to usual physical activity, participants in the Baduanjin exercise group will participate in a 45 min Baduanjin exercise training session twice a week, for a total of 12 weeks. The primary endpoint will be the percentage change in LV end-diastolic volume index (LVEDVi) assessed using echocardiography from baseline to 6 months. The results of this study may provide novel evidence on the efficacy of Baduanjin exercise therapy in post-MI patients in reversing adverse LV remodeling and improving clinical outcome. Clinical Trials.gov: NCT02693795.

A fiber-coupled displacement measuring interferometer capable of determining of the posture of a reflective surface of a measuring mirror is proposed. The newly constructed instrument combines fiber-coupled displacement and angular measurement technologies. The proposed interferometer has advantages of both the fiber-coupled and the spatially beam-separated interferometer. A portable dual-position sensitive detector (PSD)-based unit within this proposed interferometer measures the parallelism of the two source beams to guide the fiber-coupling adjustment. The portable dual PSD-based unit measures not only the pitch and yaw of the retro-reflector but also measures the posture of the reflective surface. The experimental results of displacement calibration show that the deviations between the proposed interferometer and a reference one, Agilent 5530, at two different common beam directions are both less than ±35 nm, thus verifying the effectiveness of the beam parallelism measurement. The experimental results of angular calibration show that deviations of pitch and yaw with the auto-collimator (as a reference) are less than ±2 arc sec, thus proving the proposed interferometer’s effectiveness for determination of the posture of a reflective surface.

A dual position-sensitive-detector (PSD)-based unit can be used for angular measurements of a multi-degree-of-freedom measurement system and a laser interferometry-based sensing and tracking system. In order to ensure the precision of incident beam direction measurement for a PSD-based unit, model and autoreflection alignment methods for correction of PSD-based unit parameters are proposed. Experimental results demonstrate the deviations between the angular measurements obtained using a dual PSD-based unit and an autocollimator varied by 70″, 20″, and 1″ for three runs of the autoreflection alignment method, respectively, and the model method deviations all varied by 1″ in the 1000″ measurement range for three runs. It is therefore concluded that the model method is more reliable than the autoreflection alignment method for ensuring the accuracy of a dual PSD-based unit.

Travel motivation is a driving force to led tourists, it will drive tourists to meet the needs of social and psychological. In this paper, we will explore the travel motivation based on the ANP method in Xuzhou city, and will draw the appropriate conclusions.

In recent years, Customer Relationship Management (CRM) has become an important business activity during the logistics process. Starting with the content of Customer Relationship Management, this paper introduces the application situation of CRM in logistics enterprises in China, and proposes a number of innovative approaches to CRM.

We propose a minimum variation of solution method to determine the optimal regularization parameter for singular value decomposition for obtaining the initial distribution for a Chahine iterative algorithm used to determine the particle size distribution from photon correlation spectroscopy data. We impose a nonnegativity constraint to make the initial distribution more realistic. The minimum variation of solution is a single constraint method and we show that a better regularization parameter may be obtained by increasing the discrimination between adjacent values.We developed the S-R curve method as a means of determining the modest iterative solution from the Chahine algorithm. The S-R curve method requires a smoothing operator. We have used simulated data to verify our new method and applied it to real data. Both simulated and experimental data show that the method works well and that the first derivative smoothing operator in the S-R curve gives the best results. Refereed/Peer-reviewed