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Situated at the crossroads of three continents, characterized by a unique composition of aging people, featured by a wide range of special problems—psychological, social, cultural, linguistic, and many others—Israel represents a natural laboratory for innovative approaches toward epidemiology, assessment, treatment, organization of services, policy, teaching, training, and research in the field of interdisciplinary psychogeriatrics.

Those working in the field of psychiatry of old age are confronted with growing difficulties in choosing proper therapeutic strategies for Alzheimer’s disease patients. The evaluation of the efficacy of interventional strategies on pathognomonic clinical manifestations belonging to different stages of Alzheimer’s disease remains an intriguing issue of theoretical and practical importance. By overcoming this challenge it will be possible to answer the following three questions: (a) what are the typical stages along the temporal trajectory of Alzheimer’s disease; (b) are there any reliable ways of intervention, e.g. functional rehabilitation according to the stages concept of Alzheimer’s disease; (c) what are the reasons for different progressions of Alzheimer’s disease; and whether there are strategies to delay this process by keeping patients on a definite functional level.