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1. Combination of renoportal anastomosis and inferior mesenteric vein-portal anastomosis in liver transplantation: A new portal reconstruction technique

Author: Jian-Fang Lu, Qi-Yong Li, Yu Yang, Guo-Ling Lin, Min Xiao, Meng-Xia Li, Li Zhuang, and Shusen Zheng
Subjects: medicine.medical_specialty, Hepatology, Portal Vein, business.industry, medicine.medical_treatment, Anastomosis, Surgical, Gastroenterology, Liver transplantation, Anastomosis, Liver Transplantation, Surgery, Mesenteric Veins, Renoportal anastomosis, Humans, Inferior mesenteric vein, Medicine, business, Vascular Surgical Procedures
Published: 2022

2. Vitamin D has an effect on airway inflammation and Th17/Treg balance in asthmatic mice

Author: Yan-Min Xiao, Jing-Guo Ma, Hong-Li Xiao, Lin Zha, and Guang-Ji Wu
Subjects: Male, Medicine (General), Inflammation, vitamin D, airway inflammation, T-Lymphocytes, Regulatory, Flow cytometry, Mice, R5-920, RAR-related orphan receptor gamma, Vitamin D and neurology, Animals, Medicine, Sensitization, Mice, Inbred BALB C, medicine.diagnostic_test, biology, business.industry, NF-kappa B, General Medicine, asthma, Treg, Ovalbumin, medicine.anatomical_structure, Bronchoalveolar lavage, Real-time polymerase chain reaction, Immunology, biology.protein, Th17 Cells, Th17, medicine.symptom, Reactive Oxygen Species, business, Signal Transduction
Abstract: Asthma is regarded as a chronic inflammation of the airway. Research has highlighted the significance of Vitamin D in asthma. This study explored the mechanism of vitamin D on asthma. The asthma mouse model was established by ovalbumin (OVA) sensitization and treated with vitamin D (50 or 100 ng/ml). The morphological changes of the airway were observed by HE staining. The serum IgE contents and MDA, ROS, and SOD expressions in the bronchoalveolar lavage fluid (BALF) were detected by ELISA. The Th17 and Treg cells were detected using flow cytometry. The RORγt and Foxp 3 expressions were detected by Reverse transcription quantitative polymerase chain reaction (RT‐qPCR). IL‐17, IL‐10, and TGF‐β1 expressions were detected using ELISA. The NF‐κB pathway was blocked using the NF‐κB pathway inhibitor, Andrographolide sulfonate. The NF‐κB pathway‐related indexes were detected by western blotting. After blockade of the NF‐κB pathway, the IL‐17, IL‐10, and TGF‐G1 expressions were detected. OVA‐sensitized asthma induced airway remodeling and elevated IgE content in mice, which was downregulated after vitamin D treatment. MDA and ROS were upregulated and SOD was downregulated in asthmatic mice, while vitamin D inverted the changes. Th17/Treg ratio was imbalanced, RORγt and IL‐17 were upregulated, and Foxp 3, IL‐10, and TGF‐β1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF‐κB‐p65 phosphorylation level. After blockade of the NF‐κB pathway, IL‐17 was downregulated and IL‐10 and TGF‐β1 were upregulated. In conclusion, vitamin D rectified the Th17/Treg balance and alleviated airway inflammation by inhibiting the NF‐κB pathway in asthmatic mice.
Published: 2021

3. Oncolytic Activity of Wild-type Newcastle Disease Virus HK84 Against Hepatocellular Carcinoma Associated with Activation of Type I Interferon Signaling

Author: Huachen Zhu, Yi Guan, Yongdong Niu, Jia Wang, Liming Chen, Guoxi Liang, Min Xiao, Jiating Sun, Dongmei Shi, and Hong Lin
Subjects: Hepatology, biology, business.industry, viruses, Wild type, medicine.disease, biology.organism_classification, Virology, Newcastle disease, Virus, Oncolytic virus, Biosafety, Genome editing, Interferon, Hepatocellular carcinoma, medicine, business, medicine.drug
Abstract: Hepatocellular carcinoma (HCC) is listed as one of the most common causes of cancer-related death. Oncolytic therapy has become a promising treatment because of novel immunotherapies and gene editing technology, but biosafety concerns remain the biggest limitation for clinical application. We studied the the antitumor activity and biosafety of the wild-type Newcastle disease virus HK84 strain (NDV/HK84) and 10 other NDV strains.Cell proliferation and apoptosis were determined by cell counting Kit-8 and fluorescein isothiocyanate Annexin V apoptosis assays. Colony formation, wound healing, and a xenograft mouse model were used to evaluateThe cell counting Kit-8 assays of viability found that the oncolytic activity of the NDV strains differed with the multiplicity of infection (MOI). At an MOI of 20, the oncolytic activity of all NDV strains except the DK/JX/21358/08 strain was80%. The oncolytic activities of the NDV/HK84 and DK/JX/8224/04 strains were80% at both MOI=20 and MOI=2. Only NDV/HK84 had80% oncolytic activities at both MOI=20 and MOI=2. We chose NDV/HK84 as the candidate virus to test the oncolytic effect of NDV in HCC in theIntratumor infection with NDV/HK84 strains compared with vehicle controls or positive controls indicated that NDV/HK84 strain specifically inhibited HCC without affecting healthy mice. High-throughput RNA sequencing showed that the oncolytic activity of NDV/HK84 was dependent on the activation of type I interferon signaling.
Published: 2021

4. The Outcomes of Pre-Stenting on Renal and Ureteral Stones: A Meta-Analysis

Author: Yong Wei, Jingruo Yang, Han Chen, Min Xiao, and Yang Pan
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Urology, Urinary system, Significant difference, Flexible ureteroscopy, Meta-analysis, Medicine, Operative time, Ureteroscopic lithotripsy, Ureteroscopy, Major complication, business
Abstract: Background: Pre-stenting (PS) on the outcomes of semirigid and flexible ureteroscopic lithotripsy for a different upper urinary urolithiasis remains controversial. We performed a meta-analysis comparing the outcomes of ureteroscopic lithotripsy between PS and non-PS. Materials and Methods: Randomized, controlled trials and observational studies comparing PS and non-PS were identified from electronic databases. Stone-free rate (SFR), operative time, and complications were compared by qualitative and quantitative syntheses (meta-analyses). Results: Eleven articles were included in this study. Nearly, all of recently published studies exhibited relatively moderate or high quality during quality assessment. PS was more likely to achieve good SFR compared with non-PS (p < 0.00001). The subgroup results indicated that PS improved the SFR for renal stones and the stones dealt by flexible ureteroscopy (p = 0.0002; p < 0.0001, respectively; some ureteral stones were dealt by flexible ureteroscopy). Ureteral stones and the stones dealt by semirigid ureteroscopy were not influenced by PS (p = 0.62; p = 0.90, respectively). PS is equal as non-PS in terms of operative time for renal stones and the renal and ureteral stones dealt by flexible ureteroscopy (p = 0.47; p = 0.05). No significant difference was found in major complications between the 2 groups for total or for the subgroup of renal stones (p = 0.3; p = 0.69). Conclusions: For ureteral stones or the stones dealt by semirigid ureteroscopy, PS does not show any benefits. For renal stones or the stones dealt by flexible ureteroscopy, PS improves the SFR and may be as safe as non-PS.
Published: 2021

5. Addressing interface elimination: Boosting comprehensive performance of all-solid-state Li-S battery

Author: Shuanjin Wang, Wei Liu, Yuezhong Meng, Yuning Li, Shichao Zhang, Min Xiao, Dongmei Han, Li Zhifeng, Jiaxiang Qin, Sheng Huang, and Lei Zhong
Subjects: chemistry.chemical_classification, Battery (electricity), Work (thermodynamics), Materials science, Renewable Energy, Sustainability and the Environment, business.industry, Diffusion, Energy Engineering and Power Technology, 02 engineering and technology, Electrolyte, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Polyelectrolyte, 0104 chemical sciences, Membrane, chemistry, Optoelectronics, General Materials Science, 0210 nano-technology, business, Electrical conductor
Abstract: Eliminating interfacial incompatibility and creating smooth ions/electrons transport at the interfaces of cathode│electrolyte│anode, are keys for the practical application of all-solid-state lithium-sulfur battery (ASSLSB). Here, we report a fully integrated-ASSLSB (i-ASSLSB) whose interfacial resistances are suppressed by the segmental motion of polyethylene oxide in hierarchical polymer electrolyte throughout the whole battery system. The mobility of ethylene oxide segments and strength of polyelectrolyte membranes can be controlled by the cross-linking degree of single-ion conductive polyelectrolyte. Such a i-ASSLSB without distinct interface achieves liquid-state-level lithium-ion diffusion coefficient of 2.4 × 10−12 cm2 s−1 and demonstrates a remarkable capacity up to 1428 mA h g−1 at 0.05 C and 100-cycle stability at 0.1 C. This work promises a valuable technical approach of interface modulation for high-performance all-solid-state lithium-sulfur batteries.
Published: 2021

6. Effect of wrist-ankle acupuncture on propofol dosage in painless bronchoscopy of elderly patients: A randomized controlled trial

Author: Wei HAO(郝巍), Shi-qiang HAN(韩世强), Zhi-xia LU(卢志霞), Li YANG(杨丽), Yan LI(李燕), and Min-xiao LIU(刘敏肖)
Subjects: Bronchoscopist, Lidocaine, medicine.diagnostic_test, business.industry, Vital signs, body regions, Complementary and alternative medicine, Bronchoscopy, Anesthesia, Acupuncture, medicine, Midazolam, business, Propofol, Adverse effect, medicine.drug
Abstract: Objective To observe whether wrist-ankle acupuncture can reduce propofol dosage in painless bronchoscopy of elderly patients or not and its potential effect mechanism. Methods A total of 60 patients undergoing painless bronchoscopy were randomized into a wrist-ankle acupuncture group and a control group, 30 cases in each one. In the wrist-ankle acupuncture group, wrist-ankle acupuncture was received and the needles were retained for 30 min before entering to the operating room. In the control group, no any intervention was provided. The patients in two groups all received venous administration of midazolam, nalorphine and lidocaine and target controlled infusion of propofol. When the patient's consciousness was lost and the eyelash reflex disappeared, bronchoscopy was performed and the propofol dosage was increased accordingly during operation. Propofol dosage, vital signs and occurrence of adverse reactions, bronchoscopist satisfaction, operation time and recovering time were recorded in the patients of two groups. Results Propofol dosage in induction period and the total dosage of propofol in the wrist-ankle acupuncture group were lower than those in the control group, indicating the statistical differences (both P Conclusion In painless bronchoscopy, wrist-ankle acupuncture may effectively reduce propofol dosage, alleviate respiratory suppression, reduce adverse reaction and shorten the recovering time in elderly patients.
Published: 2021

7. Electrical Switching of Optical Gain in Perovskite Semiconductor Nanocrystals

Author: Lan Chen, Tao Yu, Min Xiao, Chunfeng Zhang, Xiaoyong Wang, and Zhengyuan Qin
Subjects: Amplified spontaneous emission, Materials science, Condensed Matter::Other, business.industry, Mechanical Engineering, Exciton, Physics::Optics, Bioengineering, General Chemistry, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Condensed Matter Physics, Laser, Population inversion, law.invention, Condensed Matter::Materials Science, Nanocrystal, law, Electrode, Optoelectronics, General Materials Science, business, Excitation, Perovskite (structure)
Abstract: Perovskite semiconductor nanocrystals are promising for optical amplification and laser applications benefiting from efficient optical gain generation. Nevertheless, the pump threshold is limited by more than one exciton per nanocrystal required to generate population inversion in neutral nanocrystals due to the level degeneracy. Here, we show that by charging nanocrystals with current injection, the level degeneracy can be lifted to generate charged exciton gain with markedly low excitation density. On the basis of the scenario, we have demonstrated electrical switching of amplified spontaneous emission in films of CsPbBr3 nanocrystals sandwiched by two electrodes with over 50% threshold reduction owing to charged excitons. Our work provides an effective approach to electrically modulated optical gain in colloidal perovskite nanocrystals for potential applications in advanced laser and information technology.
Published: 2021

8. Hypertension and the Kidney: Reduced Kidney Mass Is Bad for Both Normotensive and Hypertensive Rats

Author: Rachel T Scarl, Min Xiao, Lee Hebert, Laura Biederman, Sergey V. Brodsky, Iouri Ivanov, Kyle Ware, Anjali A. Satoskar, Vedat O. Yildiz, Jessica Hemminger, and Ajay Medipally
Subjects: medicine.medical_specialty, Original Contributions, medicine.medical_treatment, 030232 urology & nephrology, Urology, Renal function, Blood Pressure, 030204 cardiovascular system & hematology, Kidney, Rats, Inbred WKY, Nephropathy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Rats, Inbred SHR, Internal Medicine, Animals, Medicine, Hematuria, Creatinine, Proteinuria, business.industry, medicine.disease, Nephrectomy, Rats, medicine.anatomical_structure, Blood pressure, chemistry, Hypertension, bcl-Associated Death Protein, medicine.symptom, business, Kidney disease
Abstract: BACKGROUND Hypertension is a leading cause of chronic kidney disease worldwide. Early studies demonstrated the short-term effects of hypertension on kidney function and morphology in ablative nephropathy. The aim of this study was to investigate the long-term consequences of hypertension in 5/6 nephrectomy (5/6NE) model. METHODS Reduction of the kidney mass by 5/6NE was created in spontaneous hypertensive rats (SHR) and genetically similar normotensive Wistar Kyoto (WKY) rats. Blood pressure, serum creatinine (SCr), hematuria, and proteinuria were monitored weekly for 23 weeks. Kidney morphology was assessed at the end of the study. Sham-operated rats from both strains were used as controls. RESULTS Rats with 5/6NE had increased SCr, blood pressure, hematuria, and proteinuria in both SHR and WKY. Even though the SCr levels and blood pressure were greater in 5/6NE SHR as compared with 5/6NE WKY rats, absolute changes from sham-operated rats were not statistically significant between these 2 groups. 5/6NE SHR had earlier onset and higher proteinuria than 5/6NE WKY rats. Hematuria was similar in 5/6NE SHR and 5/6NE WKY rats. However, 5/6NE SHR had enlarged glomeruli, increased interstitial fibrosis, and prominent intimal thickening in the small arteries/arterioles as compared with 5/6NE WKY rats. CONCLUSIONS The long-term severity of kidney injury correlated with higher blood pressure. Reduction of the kidney mass increases SCr, hematuria, proteinuria, and blood pressure in both normotensive and hypertensive rats. Histological assessment provides better information about underlying chronic kidney injury than actual changes in SCr and urinalysis.
Published: 2021

9. A new score including CD43 and CD180: Increased diagnostic value for atypical chronic lymphocytic leukemia

Author: Chunyan Wang, Cheng He, Donghua Zhang, Songya Liu, Xiwen Tong, Zhiqiong Wang, Lifang Huang, Min Xiao, Li Li, Yi Li, and Xia Mao
Subjects: 0301 basic medicine, Cancer Research, Chronic lymphocytic leukemia, Logistic regression, Gastroenterology, 0302 clinical medicine, Immunophenotyping, immune system diseases, hemic and lymphatic diseases, RC254-282, Original Research, CD20, Leukosialin, biology, CD23, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, immunophenotype, Oncology, 030220 oncology & carcinogenesis, CD79 Antigens, medicine.medical_specialty, Lymphoma, B-Cell, Antigens, CD19, Receptors, Antigen, B-Cell, CD5 Antigens, Sensitivity and Specificity, Diagnosis, Differential, 03 medical and health sciences, Antigens, CD, Internal medicine, Biomarkers, Tumor, medicine, Humans, Radiology, Nuclear Medicine and imaging, Glycoproteins, Receiver operating characteristic, Receptors, IgE, business.industry, flow cytometry, Clinical Cancer Research, CD79B, Antigens, CD20, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Logistic Models, 030104 developmental biology, atypical, ROC Curve, biology.protein, chronic lymphocytic leukemia, CD5, business
Abstract: Moreau score has been used to differentiate chronic lymphocytic leukemia (CLL) from other mature B‐cell neoplasms. However, it showed limitations in Asian patients. Therefore, we conducted a new score system replacing CD5 and CD23 with CD43 and CD180 to evaluate its diagnostic value of CLL. 237 untreated samples diagnosed with mature B‐cell neoplasms were collected and were randomly divided into an exploratory and a validation cohort by a 2:1 ratio. The expression of CD5, CD19, CD20, CD23, CD43, CD79b, CD180, CD200, FMC7, and surface immunoglobulin (SmIg) were analyzed among all the samples. A proposed score was developed based on the logistic regression model. The sensitivity and specificity of the proposed score were calculated by ROC curves. CD43/CD180, CD200, FMC7, and CD79b were included in our new CLL score, which showed a sensitivity of 91.8% and a specificity of 83.1%. These results were confirmed in a validation cohort with a sensitivity of 90.5% (p = 0.808) and a specificity of 79.5% (p = 0.639). In CD5 negative or CD23 negative CLL group, the new CLL score displayed improved sensitivity of 79.4% compared to Moreau score and CLLflow score (41.2% and 47.1%, respectively). In atypical CLL group, the new CLL score showed improved sensitivity of 84.2% compared to Moreau score and CLLflow score (61.4% and 64.9%, respectively). This proposed atypical CLL score helped to offer an accurate differentiation of CLL from non‐CLL together with morphological and molecular methods, particularly in Chinese patients with atypical immunophenotype., This study demonstrated the diagnostic value of combination of CD43 and CD180 with CD200, FMC7 and CD79b in CD5‐ or CD23‐ CLL for the first time. How to differentiate atypical CLL from other mature B cell neoplasms poses a problem in the diagnosis of CLL. This study investigated the immunophenotyping data of patients with mature B‐cell malignancies, and developed a new combined score including CD43 and CD180 which could improve the diagnostic value of CLL versus non‐CLL, particularly in atypical CLL.
Published: 2021

10. Customer Information Disclosure and Collateral Loan: Evidence from Chinese Listed Companies

Author: Min Xiao and Xiaohui He
Subjects: Finance, 050208 finance, Boosting (machine learning), Collateral, business.industry, Supply chain, 05 social sciences, Customer information, ComputingMilieux_GENERAL, Loan, 0502 economics and business, Information disclosure, Business, 050207 economics, General Economics, Econometrics and Finance, Capital market
Abstract: How supply chain information can help a company is given considerable attention by academic and practical circles. As boosting in the Chinese capital market, there is a higher demand for loans. Our...
Published: 2021

11. Two-dimensional electronic spectroscopy with active phase Management

Author: Rui Wang, Chunfeng Zhang, Min Xiao, Weida Zhu, and Xiaoyong Wang
Subjects: Quantum optics, Physics, business.industry, Phase (waves), Physics::Optics, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Electron spectroscopy, 0104 chemical sciences, Frequency comb, Interferometry, Optical modulator, Active phase, Excited state, Optoelectronics, Physical and Theoretical Chemistry, 0210 nano-technology, business
Abstract: Two-dimensional electronic spectroscopy (2DES) is a powerful method to probe the coherent electron dynamics in complicated systems. Stabilizing the phase difference of the incident ultrashort pulses is the most challenging part for experimental demonstration of 2DES. Here, we present a tutorial review on the 2DES protocols based on active phase managements which are originally developed for quantum optics experiments. We introduce the 2DES techniques in box and pump-probe geometries with phase stabilization realized by interferometry, and outline the fully collinear 2DES approach with the frequency tagging by acoustic optical modulators and frequency combs. The combination of active phase managements, ultrashort pulses and other spectroscopic methods may open new opportunities to tackle essential challenges related to excited states.
Published: 2021

12. Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial

Author: Min Xiao, Jingjing Xie, Bo Li, Hongling Geng, Xia Qiu, Jianyong Zhang, Ertao Jia, Jiaxin Wei, Xueming Yao, Yubao Jiang, Yanying Zhang, Yuya Xiao, Li Zhong, Wukai Ma, and Xiang Cui
Subjects: Adult, Male, medicine.medical_specialty, Diclofenac, Gout, Placebo, Gout Suppressants, law.invention, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Randomized controlled trial, Interquartile range, law, Internal medicine, medicine, Humans, Single-Blind Method, Pharmacology (medical), 030212 general & internal medicine, AcademicSubjects/MED00360, 030203 arthritis & rheumatology, febuxostat, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Clinical Science, Middle Aged, randomized clinical trial, Symptom Flare Up, medicine.disease, Uric Acid, Clinical trial, Treatment Outcome, Joint pain, Female, Febuxostat, medicine.symptom, business, medicine.drug
Abstract: Objective Our objective was to determine whether initiation of febuxostat during an acute gout flare prolongs the current episode. Methods In this randomized, placebo-controlled, single-blinded, multicentre trial, patients with acute gout flares within 72 h were randomized (1:1) to the placebo and febuxostat (40 mg/day) groups. All patients were administered diclofenac (150 mg/day) for 7 days and then open-labelled on the eighth day. Febuxostat 40 mg daily and diclofenac 75 mg daily were administered from day 8 through 28 for the remission period. The dose of diclofenac was 150 mg/day before remission in both arms, and the original protocol was maintained until remission. The primary outcome was ‘days to resolution’. Results We randomized 140 patients, 70 into each arm. The mean days to resolution was 5.98 days [median 7.00, interquartile range (IQR) 2.45 days] for the placebo and 6.50 days (median 7.00, IQR 3.67 days) for the febuxostat group (P = 0.578). The rate of resolution within 7 days was 84.38% for the placebo group and 76.92% for the febuxostat group (P = 0.284). There were no statistically significant differences in joint pain, swelling, tenderness and erythema scores at days 1, 3, 5 and 7. The mean serum uric acid levels were 507.54 and 362.62 μmol/l for the placebo and febuxostat group, respectively, on day 7 (P = 0.000). The rate of recurrent gout flares was 10.00% for the placebo group and 6.56% for the febuxostat group from day 8 through 28 (P = 0.492). Conclusion Initiation of febuxostat administration during an acute gout flare did not prolong the duration of acute flares. Trial registration Chinese Clinical Trial Registry, http://www.chictr.org.cn/, ChiCTR1800015962
Published: 2021

13. Fabrication of lithium niobate fork grating by laser-writing-induced selective chemical etching

Author: Lei Yang, Yong Zhang, Xiaopeng Hu, Min Xiao, Xueli Hu, Xiaoyi Xu, Xiaomei Lu, Shuo Yan, and Tianxin Wang
Subjects: Fabrication, Materials science, business.industry, Lithium niobate, Grating, Laser, Isotropic etching, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, law.invention, chemistry.chemical_compound, chemistry, law, Fork (system call), Vortex beam, Optoelectronics, Electrical and Electronic Engineering, business, Biotechnology
Abstract: We propose and experimentally demonstrate a laser-writing-induced selective chemical etching (LWISCE) technique for effective micro-fabrication of lithium niobate (LN) crystal. Laser writing of LN crystal produces negative domains and domain walls. Also, it causes local lattice defects, in which the etching rates are significantly increased in comparison to the original LN crystal. In experiment, we use the LWISCE technique to fabricate various fork gratings in an X-cut LN crystal for the generation of vortex beams. In comparison to etching an untreated X-cut LN crystal, the etching rates of the laser-writing-induced boundaries and the central laser-irradiated areas are enhanced by a factor of 26 and 16, respectively. The width and depth of fork grating structure can be precisely controlled by laser writing parameters. Our method provides an efficient mask-free micro-fabrication technique for LN crystal, which can be readily applied to other ferroelectric crystals such as lithium tantalate, potassium titanyl phosphate and barium calcium titanate.
Published: 2021

14. LncRNA PVT1 promotes cells proliferation via PI3K–AKT–mTOR Pathway in gastrointestinal stromal tumor

Author: Wei Ye, Yang Ling, Dong Xiang Zeng, Quan Liang Yang, Min Xiao, and Yan-Zhi Bi
Subjects: Gastrointestinal tract, biology, GiST, business.industry, General Neuroscience, Mesenchymal stem cell, PDGFRA, digestive system diseases, General Biochemistry, Genetics and Molecular Biology, Receptor tyrosine kinase, biology.protein, Cancer research, Medicine, Stromal tumor, General Agricultural and Biological Sciences, business, Protein kinase B, PI3K/AKT/mTOR pathway
Abstract: Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the gastrointestinal tract by activating mutations in the related receptor tyrosine kinases KIT and PDGFRA. Few...
Published: 2021

15. MULTIMODAL 2.5D CONVOLUTIONAL NEURAL NETWORK FOR DIAGNOSIS OF ALZHEIMER'S DISEASE WITH MAGNETIC RESONANCE IMAGING AND POSITRON EMISSION TOMOGRAPHY

Author: and Huazhi Ji, Weiming Lin, Xuyang Zhang, and Min Xiao
Subjects: Radiation, Nuclear magnetic resonance, medicine.diagnostic_test, Positron emission tomography, business.industry, medicine, Magnetic resonance imaging, Electrical and Electronic Engineering, Condensed Matter Physics, business, Convolutional neural network
Published: 2021

16. A practical update on the epidemiology and risk factors for the emergence and mortality of bloodstream infections from real-world data of 3014 hematological malignancy patients receiving chemotherapy

Author: Jingjing Xu, Xue-Qiong Wu, Kangni Lin, Minmin Chen, Shaozhen Chen, Haojie Zhu, Jinhua Ren, Qian Li, Zhang Yuxin, Min Xiao, Zhizhe Chen, Yan-Ling Zeng, Jianda Hu, Ting Yang, Yongquan Chen, Issa Hajji Ally, and Xiaofeng Luo
Subjects: hematological malignancy, medicine.medical_specialty, biology, business.industry, medicine.drug_class, Antibiotics, Neutropenia, medicine.disease, biology.organism_classification, Acinetobacter baumannii, resistance, Stenotrophomonas maltophilia, Antibiotic resistance, risk factor, Oncology, Internal medicine, Epidemiology, Cohort, medicine, Bloodstream infections, Risk factor, business, Research Paper, pathogen
Abstract: Background: Bloodstream infection (BSI) is a common and serious complication after patients with hematologic malignancies (HM) receiving chemotherapy. This study examined real-world data seeking to characterize HM BSI and identify risk factors for BSI emergence and mortality. Methods: We retrospectively analyzed the pathogenic epidemiology, antibiotic resistance, and BSI risk factors in a single-center cohort including 3014 consecutive patients with HM receiving chemotherapy between 2013 and 2016. Results of the pathogenic epidemiology were validated via comparison to available reported data. Results: We found that 725 patients (24.1%) had BSIs. Gram-negative (G-) bacteria represented 64.7% of the 744 isolated pathogenic strains, while Gram-positive (G+) bacteria and fungi accounted for 27.7% and 7.7% of the BSIs, respectively. The most common isolates were Klebsiella pneumoniae (19.2%), and 95.1% of the multidrug-resistant strains (MDR) were extended-spectrum beta-lactamase producing strains. G- bacteria were the main microflora responsible for BSI in our cohort of Chinese HM patients compared to studies in developed countries or in neutropenic children with HM or solid tumors. Multivariate analysis revealed that male sex, age ≥ 45 and < 65 yr, hospital length of stay ≥ 9d, neutropenia ≥ 7d before cultures, ≥ 2 antibiotics, and infections (gastrointestinal, perirectal, or urinary tract) independently predicted BSI emergence. Furthermore, age ≥ 65 yr, neutropenia ≥ 7d before blood cultures, no HM remission, lower white blood cell count, ≥ 3 antibiotics, respiratory infections, and Acinetobacter baumannii and Stenotrophomonas maltophilia BSI were independent predictors of 30-day mortality. Conclusions: G- bacteria were the predominant microflora during the study period and antibiotic resistance levels of the pathogens detected were high, especially for MDR strains. The mortality of BSI patients was high in this large cohort. Close attention should be paid to the risk factors identified here to facilitate timely and effective clinical management of such patients.
Published: 2021

17. Size-Dependent Hot Carrier Dynamics in Perovskite Nanocrystals Revealed by Two-Dimensional Electronic Spectroscopy

Author: Xiaoyong Wang, Buyang Yu, Min Xiao, Zhengkang Qu, Lan Chen, Chunfeng Zhang, and Zhengyuan Qin
Subjects: Materials science, business.industry, Phonon, Relaxation (NMR), 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Electron spectroscopy, 0104 chemical sciences, Semiconductor, Thermalisation, Nanocrystal, Optoelectronics, General Materials Science, Physical and Theoretical Chemistry, 0210 nano-technology, business, Excitation, Perovskite (structure)
Abstract: The lifetimes of hot carriers have been predicted to be prolonged in small nanocrystals with an inter-level spacing larger than phonon energy. Nevertheless, whether such a phonon bottleneck is present in perovskite semiconductor nanocrystals remains highly controversial. Here we report compelling evidence of a phonon bottleneck in CsPbI3 nanocrystals with marked size-dependent relaxation of hot carriers by using broadband two-dimensional electronic spectroscopy (2DES). By combining high resolutions in both the time (
Published: 2020

18. Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer

Author: Weifeng Wang, Xinyu Chen, Jian Wang, Yun Guo, Kai Wang, Samuel J. Klempner, Jiaochun Shi, Min Xiao, Shuang Wang, and Xian-Ling Guo
Subjects: Male, 0301 basic medicine, Oncology, China, Cancer Research, medicine.medical_specialty, Cancer Diagnostics and Molecular Pathology, DNA Copy Number Variations, Receptor, ErbB-2, Colorectal cancer, medicine.disease_cause, Fusion gene, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, ERBB2 amplification, Copy-number variation, Receptor, trkA, Poly-ADP-Ribose Binding Proteins, Indel, neoplasms, Gene, business.industry, Microsatellite instability, DNA Polymerase II, Genomics, Middle Aged, medicine.disease, DNA polymerase ε, Tumor mutational burden, digestive system diseases, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, Cohort, Tropomyosin receptor kinase, Female, Microsatellite Instability, KRAS, Colorectal Neoplasms, business
Abstract: Background The increasing molecular characterization of colorectal cancers (CRCs) has spurred the need to look beyond RAS, BRAF, and microsatellite instability (MSI). Genomic alterations, including ERBB2 amplifications and mutations, POLE mutations, MSI, and NTRK1–3 fusions, have emerged as targets for matched therapies. We sought to study a clinically annotated Chinese cohort of CRC subjected to genomic profiling to explore relative target frequencies. Methods Tumor and matched whole blood were collected from 609 Chinese patients with CRC. Extracted DNA was analyzed for all classes of genomic alterations across 450 cancer‐related genes, including single‐nucleotide variations (SNVs), short and long insertions and deletions (indels), copy number variations, and gene rearrangements. Next‐generation sequencing–based computational algorithms also determined tumor mutational burden and MSI status. Results Alterations in TP53 (76%), APC (72%), and KRAS (46%) were common in Chinese patients with CRC. For the first time, the prevalence of NTRK gene fusion was observed to be around 7% in the MSI‐high CRC cohort. Across the cohort, MSI was found in 9%, ERBB2 amplification in 3%, and POLE pathogenic mutation in 1.5% of patients. Such results mostly parallel frequencies observed in Western patients. However, POLE existed at a higher frequency and was associated with large tumor T‐cell infiltration. Conclusion Comparing to the Western counterparts, POLE mutations were increased in our cohort. The prevalence of NTRK gene fusion was around 7% in the MSI‐high CRC cohort. Increased adoption of molecular profiling in Asian patients is essential for the improvement of therapeutic outcomes. Implications for Practice The increasing use of genomic profiling assays in colorectal cancer (CRC) has allowed for the identification of a higher number of patient subsets benefiting from matched therapies. With an increase in the number of therapies, assays simultaneously evaluating all candidate biomarkers are critical. The results of this study provide an early support for the feasibility and utility of genomic profiling in Chinese patients with CRC., The emergence of precision medicine has identified genomic variants, such as NTRK gene fusion, microsatellite instability (MSI), HER2 amplification, and POLE pathogenic mutation, as potential agonistic biomarkers for immune or targeted therapies. This article examines NTRK, HER2, and POLE in a cohort of Chinese patients with colorectal cancer.
Published: 2020

19. Iron overload as a risk factor for poor graft function following allogeneic hematopoietic stem cell transplantation

Author: Hajji Ally Issa, Kangni Lin, Minmin Chen, Qiuru Chen, Xiaofeng Luo, Min Xiao, Jianda Hu, Zhihong Zheng, Ting Yang, Jinhua Ren, Yongquan Chen, Zhizhe Chen, Jingjing Xu, Qian Li, Haojie Zhu, Yuxin Zhang, Rong Zheng, Xue-Qiong Wu, Peifang Jiang, Yan-Ling Zeng, Yi-Feng Lin, and Shaozhen Chen
Subjects: Male, Iron Overload, medicine.medical_treatment, Hematopoietic stem cell transplantation, Granulocyte, Andrology, Mice, 03 medical and health sciences, 0302 clinical medicine, Megakaryocyte, Risk Factors, Animals, Medicine, Platelet, allogeneic hematopoietic stem cell transplantation, bone marrow microenvironment, lcsh:R5-920, Mice, Inbred BALB C, business.industry, Monocyte, Hematopoietic Stem Cell Transplantation, General Medicine, hematopoietic reconstruction, Mice, Inbred C57BL, Transplantation, Haematopoiesis, medicine.anatomical_structure, poor graft function, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Bone marrow, lcsh:Medicine (General), business
Abstract: Hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Unfortunately, iron overload is a frequent adverse effect of allo‐HSCT and is associated with poor prognosis. In the present study, we investigated hematopoiesis in iron‐overloaded mice and elucidated the effects of iron overload on the bone marrow (BM) microenvironment. Iron‐overloaded BALB/C mice were generated by injecting 20 mg/mL saccharated iron oxide intraperitoneally. Hematoxylin‐eosin staining was performed to evaluate the effects of an iron overload in mice. BM cells obtained from C57BL/6 mice were transplanted into irradiated BALB/C mice (whole‐body irradiation of 4 Gy, twice with a 4‐hours interval) by tail vein injection. Two weeks after allo‐HSCT, the hematopoietic reconstitution capacity was evaluated in recipients by colony‐forming assays. Histopathological examinations showed brown‐stained granular deposits, irregularly arranged lymphocytes in the liver tissues, and blue‐stained blocks in the BM collected from mice received injections of high‐dose saccharated iron oxide (20 mg/mL). Iron‐overloaded mice showed more platelets, higher‐hemoglobin (HGB) concentration, fewer granulocyte‐macrophage colony‐forming units (CFU‐GM), erythrocyte colony‐forming units (CFU‐E), and mixed granulocyte/erythrocyte/monocyte/megakaryocyte colony‐forming units (CFU‐mix) than healthy mice. Iron‐overloaded recipients presented with reduced erythrocytes and HGB concentration in peripheral blood, along with decreased marrow stroma cells, CFU‐GM, CFU‐E, and CFU‐mix relative to healthy recipients. Taken together, our findings demonstrate that iron overload might alter the number of red blood cells after transplantation in mice by destroying the BM microenvironment, thereby affecting the recovery of BM hematopoietic function.
Published: 2020

20. Entecavir prophylaxis for hepatitis B virus reactivation in patients with CAR T-cell therapy

Author: Chaojiang Gu, Shangkun Zhang, Tongcun Zhang, Yang Cao, Na Wang, Lifang Huang, Wenyue Cao, Hao Xu, Yi Xiao, Liang Huang, Chunrui Li, Dengju Li, Jia Wei, Yicheng Zhang, Min Xiao, and Jianfeng Zhou
Subjects: Adult, Male, Hepatitis B virus, Guanine, Adolescent, medicine.medical_treatment, Immunology, medicine.disease_cause, Immunotherapy, Adoptive, Biochemistry, medicine, Humans, In patient, business.industry, Cell Biology, Hematology, Immunotherapy, Entecavir, Middle Aged, Hepatitis B, Virology, CAR T-cell therapy, Female, Virus Activation, business, medicine.drug
Published: 2020

21. Inhibition of Delta-like Ligand 4 enhances the radiosensitivity and inhibits migration in cervical cancer via the reversion of epithelial–mesenchymal transition

Author: Le Wang, Shanshan Yang, Yu-Ting Du, Yunyan Zhang, Lina Gu, De-Yang Yu, and Min Xiao
Subjects: Cancer Research, DLL4, lcsh:RC254-282, Flow cytometry, Metastasis, Radiosensitivity, 03 medical and health sciences, 0302 clinical medicine, Radioresistance, Genetics, medicine, Epithelial–mesenchymal transition, lcsh:QH573-671, education, 030304 developmental biology, Cervical cancer, 0303 health sciences, education.field_of_study, Delta-like ligand 4, medicine.diagnostic_test, Progression, Cell growth, business.industry, lcsh:Cytology, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncology, 030220 oncology & carcinogenesis, Cancer research, cardiovascular system, Primary Research, business
Abstract: BackgroundConcurrent chemoradiotherapy is the common first-line treatment for patients with advanced cervical cancer. However, radioresistance remains a major clinical challenge, which results in recurrence and poor survival. Many studies have shown the potential of Delta-like Ligand 4 (DLL4) as a novel prognostic biomarker and therapeutic target in many solid tumors. Previously, we have found that high DLL4 expression in tumor cells may predict the pelvic lymph node metastasis and poor prognosis in patients with cervical cancer. In our present study, we further studied the effects of DLL4 on the biological behavior and radiosensitivity of cervical cancer cells.MethodsThe expression of DLL4 and epithelial–mesenchymal transition (EMT) phenotype markers in cervical cancer cell lines or tissues were detected using Western blotting, and the expression of DLL4 mRNA in cervical cancer cell lines or tissues was detected using Quantitative real-time PCR. The effect of DLL4 on cell proliferation, migration, and radiosensitivity was evaluated using the CCK8 assay, flow cytometry, Transwell assays for cell invasion and migration, and Immunofluorescence staining in vitro.ResultsThe expression of DLL4 in radiotherapy-resistant SiHa cells was significantly higher than that in radiotherapy-sensitive Me-180 cells. Furthermore, downregulation of DLL4 enhanced the radiosensitivity of SiHa and Caski cells via the inhibition of cell proliferation, promotion of radiation-induced apoptosis, and inhibition of the DNA damage repair. Moreover, downregulation of DLL4 inhibited the EMT and reduced the proliferation, invasion, and migration ability in SiHa and Caski cells. Consistent with the DLL4 expression in the cell lines, the expression of DLL4 in the tissues of the radioresistant group was also higher than that of the radiosensitive group.ConclusionsDownregulation of DLL4 inhibited the progression and increased the radiosensitivity in cervical cancer cells by reversing EMT. These results indicated the promising prospect of DLL4 against the radioresistance and metastasis of cervical cancer and its potential as a predictive biomarker for radiosensitivity and prognosis in patients with cervical cancer patients receiving concurrent chemoradiotherapy (cCRT).
Published: 2020

22. Periodically poled LiNbO3 crystals from 1D and 2D to 3D

Author: Shining Zhu, Gang Zhao, Chuan Xu, Min Xiao, Yong Zhang, Dunzhao Wei, Xiaopeng Hu, Pengcheng Chen, and Tianxin Wang
Subjects: Quasi-phase-matching, Materials science, business.industry, Poling, General Engineering, Physics::Optics, Nonlinear optics, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Laser, 01 natural sciences, 0104 chemical sciences, law.invention, Crystal, Nonlinear system, law, Femtosecond, Optoelectronics, General Materials Science, 0210 nano-technology, business, Quantum
Abstract: A periodically-poled LiNbO3 (PPLN) crystal features space-dependent second-order nonlinear coefficients, which is one of the most important materials to effectively control nonlinear optical interactions through quasi-phase matching (QPM). By using electric-field poling method, 1D and 2D PPLN crystals have been successfully fabricated for laser frequency conversion, quantum light sources, nonlinear beam shaping and nonlinear optical imaging. Recently, femtosecond laser engineering technique is utilized to prepare 3D domain structures inside LiNbO3 crystal, which provides a promising platform to control nonlinear interacting waves in 3D configuration. After 40 years of developments, PPLN crystals still have exciting prospects in fundamental researches and practical applications for integrated photonic chip, quantum information processing, and so on.
Published: 2020

23. The incidence and survival outcomes of patients with primary cardiac lymphoma: A <scp>SEER</scp> ‐based analysis

Author: Yong Ye, Tingting Xiao, Min Xiao, Yan Lin, and Junpeng Lin
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Multivariate analysis, Adolescent, Cardiac Neoplasm, medicine.medical_treatment, Heart Neoplasms, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, Stage (cooking), Child, Aged, Retrospective Studies, Aged, 80 and over, Chemotherapy, business.industry, Incidence, Incidence (epidemiology), Hematology, General Medicine, Middle Aged, Prognosis, medicine.disease, Combined Modality Therapy, United States, Lymphoma, Survival Rate, 030220 oncology & carcinogenesis, Female, Lymphoma, Large B-Cell, Diffuse, Age of onset, business, Follow-Up Studies, SEER Program, 030215 immunology
Abstract: This study aimed to evaluate the incidence and prognosis of primary cardiac lymphoma (PCL) by using the Surveillance, Epidemiology, and End Results Program (SEER) database. Patients diagnosed with PCL and the disease incidence in the SEER database from 1975 to 2016 were included. Overall survival (OS) and cause-specific survival (CSS) curves were calculated using the Kaplan-Meier method and compared by the log-rank test. Univariate and multivariable Cox proportional hazard regression analyses were used to identify associations with outcome measures. The incidence of PCL was 0.011/100 000, and a predominance of elderly and male patients was observed. A total of 144 patients were enrolled. The median age of onset was 68 (9-96) years, including 80 (55.6%) males and 64 (44.4%) females. Multivariate analysis revealed that age and chemotherapy were independent prognostic factors for OS (both P < .05). Ann Arbor stage and chemotherapy were independent prognostic factors for CSS (both P < .05). In terms of treatment modality, chemotherapy combined with surgery was an independent protective factor for OS and CSS (both P < .05). For patients with primary cardiac diffuse large B-cell lymphoma (cardiac DLBCL), multivariate analysis also showed that age, Ann Arbor stage, and chemotherapy were all independent prognostic factors for OS and CSS (all P < .05). Chemotherapy combined with surgery was associated with a significant benefit in terms of OS and CSS (both P < .05). Our study confirmed that older age and advanced Ann Arbor stage were independent risk factors for PCL, and treatment with chemotherapy or cooperation with surgery resulted in better long-term survival.
Published: 2020

24. TEOS and Na2SiO3 as silica sources: study of synthesis and characterization of hollow silica nanospheres as nano thermal insulation materials

Author: Zhibo Zhang, Li Fangxian, Yang Yerong, Jie Hu, Qijun Yu, Jiangxiong Wei, and Min Xiao
Subjects: Yield (engineering), Materials science, Scanning electron microscope, business.industry, Materials Science (miscellaneous), Dispersity, Nanochemistry, 02 engineering and technology, Cell Biology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Thermal conductivity, Chemical engineering, Transmission electron microscopy, Thermal insulation, Nano, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, 0210 nano-technology, business, Biotechnology
Abstract: Hollow structured material (HSM) consisting of monodisperse hollow silica nanospheres (HSN) shows a promising potential for construction insulation due to its affordable cost and simple process. Yet the studies of high-yield and low-energy for the synthetic of HSN are still insufficient. This research reported the comparison of morphology and performance of synthesize HSN utilizing TEOS and Na2SiO3 as silica source. The average yield of Na2SiO3-based samples can reach 93.75%, which is about 10 times higher that of TEOS-based samples. Transmission electron microscopy (TEM) and Scanning electron microscopy (SEM) results revealed that the shell morphology of TEOS-based samples was raspberry-like or smooth structure, while the shell of the Na2SiO3-based samples was round honeycomb-like structure. Hot Disk thermal constant analyzer results demonstrated that the thermal conductivity of the Na2SiO3-based samples was lower than that of the TEOS-based samples with similar inner-diameter and shell thickness. Thereafter, the influence mechanism of the morphology on thermal insulation performance was also investigated. The prepared HSN as filler significantly enhanced the thermal insulation of acrylic coating. This research confirms that the synthesis route with Na2SiO3 was a greener method which can solve the low yield and high energy consumption caused using TEOS as a silica source. Excellent thermal insulation properties indicate HSN will have a broad application prospect in heat-insulating and energy-saving construction.
Published: 2020

25. Computer Network Security and Preventive Measures in the Age of Big Data

Author: Min Xiao and Mei Guo
Subjects: Network security, business.industry, Computer science, Scale (social sciences), Internet privacy, Big data, General Earth and Planetary Sciences, business, General Environmental Science
Abstract: Compared with the past, life is much more convenient now. Among them, computers have made great contributions to the convenience of people’s lives. As contemporary aspiring youth, while enjoying convenience, we should also see clearly the potential dangers behind the big data era. In our daily life, we may not know much about the potential dangers of computers. This is because we use computers in a relatively small area at this time, such as a family, company or campus, and so on. If we use computers on a large scale, there is a good chance that a series of problems will break out. Therefore, the author will sum up the forms and factors threatening computer security in this paper. After understanding the factors threatening computer security, the author puts forward his own suggestions on improving computer security precautions and makes his own contribution to the unlimited development of computer in the future.
Published: 2020

26. Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway

Author: Jing Chen, Min Xiao, Na Li, Haiyan Jiao, Jun Ling, Tao Li, Qin Shen, and Boxia Liu
Subjects: Cancer Research, biology, business.industry, Limonin, Angiogenesis, VEGF receptors, medicine.disease, Stat3 Signaling Pathway, Metastasis, STAT3, chemistry.chemical_compound, angiogenesis, breast cancer, Oncology, chemistry, Cancer cell, Cancer research, biology.protein, Medicine, metastasis, Radiology, Nuclear Medicine and imaging, Original Article, business, Human breast
Abstract: Background Limonin is one of the major active ingredients of citrus. In the present study, the anti-angiogenic and anti-metastatic effects of limonin were investigated. Methods The Molecular docking assay was carried out to assess the binding ability of limonin with VEGFR2 receptor. MTS assay was used to detect the effect of limonin on the proliferation of breast cancer cells (MDA-MB-231, MCF-7). The Wound-healing and Transwell chamber invasion assays were used to detect the inhibition effect of limonin on migration and invasion of HUVECs cells or breast cancer cells. The capillary-like tube formation assay and Matrixgel plug experiment were used to further measure the in vivo anti-angiogenic activity of limonin. Western blot, RNA isolation, microarray data analysis and RT-PCR were used to explore the molecular mechanism of limonin in suppressing breast cancer angiogenesis and metastasis. Left ventricular tumor metastasis model and caudal vein tumor metastasis model of breast cancer were both applied to verify in vivo anti-metastatic effects. Results Limonin dose-dependently inhibited the vascular endothelial growth factor (VEGF)-mediated tyrosine phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2) by blocking VEGF binding to VEGFR2 and suppressing constitutive STAT3 activation in human umbilical vein endothelial cells. Limonin effectively inhibited VEGF-induced endothelial cell proliferation, migration and tubular-structure formation in vitro and markedly reduced VEGF-triggered neovascularization in mouse matrigel plugs in vivo. Moreover, limonin treatment led to a remarkable suppression of tumor metastasis by decreasing the phosphorylation of insulin growth factor receptor 1-mediated STAT3 and the expression levels of its downstream members MMP-9 and VEGF in breast cancer cells. The data further showed that limonin increased the levels of the negative STAT3 regulator SHP-1 in breast cancer cells. Conclusions Limonin is a promising anti-angiogenic and anti-metastatic candidate compound that can be further optimized as a therapeutic agent for breast cancer.
Published: 2020

27. Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy

Author: Min’ Xiao Yi, Li Yang, Bo Liu, Yang Tang, Xianglin Yuan, and Wan Qin
Subjects: Male, Oncology, Lung Neoplasms, medicine.medical_treatment, 0302 clinical medicine, Prospective Studies, Prospective cohort study, 0303 health sciences, education.field_of_study, Hazard ratio, Radiotherapy Dosage, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cohort, Female, Radiation pneumonitis, Lung cancer, Adult, Risk, lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, lcsh:R895-920, Population, SNP, HIPK2, Protein Serine-Threonine Kinases, lcsh:RC254-282, 03 medical and health sciences, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Radiology, Nuclear Medicine and imaging, education, Aged, Proportional Hazards Models, 030304 developmental biology, Lung, business.industry, Research, Genetic Variation, medicine.disease, Confidence interval, Radiation therapy, Carrier Proteins, business
Abstract: Background Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, proliferation and DNA damage repair. Most importantly, HIPK2 was shown to play regulatory role in inflammation and influence the phenotype and activity of fibroblasts. In this study, we aimed to evaluate the impact of HIPK2 gene variant on risk of radiation pneumonitis for patients with pulmonary malignancies. Methods 169 lung cancer patients with radiotherapy were included in our prospective study and genotyped by Sanger Sequence method. Multivariable Cox hazard analysis and multiple testing were applied to estimate the hazard ratio (HR) and 95% confidence intervals (CIs) of all factors possibly related to the risk of radiation pneumonitis (RP). Results Patients with Mean Lung Dose (MLD) ≥ 15Gy, Lung V20 ≥ 24% had higher risk of RP ≥ grade 2 compared with those counterparts (HR = 1.888, 95% CI: 1.186–3.004, P = 0.007; HR = 2.126, 95% CI: 1.338–3.378, P = 0.001, respectively). Importantly, CC genotype of HIPK2: rs2030712 were strongly related to an increased occurrence of RP ≥ grade 2 (HR = 2.146, 95% CI: 1.215–3.791, P = 0.009). Conclusion HIPK2: rs2030712 was found to be significantly related to RP of grade ≥ 2 in our cohort, and may thus be one of the important predictors of severe RP before radiotherapy, if further validated in larger population. Trial registration Our study was prospective and observational. The research was registered in ClinicalTrials.gov database as NCT02490319.
Published: 2020

28. Few-Layer PbI2 Nanoparticle: A 2D Semiconductor with Lateral Quantum Confinement

Author: Yong Zhou, Chunfeng Zhang, Yan Sun, Xiaoyong Wang, Lin Wang, Jinqiu Liu, and Min Xiao
Subjects: Photoluminescence, Photon, Materials science, business.industry, Band gap, Exciton, Nanoparticle, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Semiconductor, Quantum dot, Optoelectronics, General Materials Science, Direct and indirect band gaps, Physical and Theoretical Chemistry, 0210 nano-technology, business
Abstract: Inspired by the superior optoelectronic performances of various 2D semiconductors, their new compositions and structures are being actively pursued in order to foster novel fundamental physics and device applications. As a layered semiconductor with a direct bandgap, few-layer PbI2 should have drawn much research attention due to their capability of emitting photons at short wavelengths of the visible spectrum. Here we chemically synthesize few-layer PbI2 flakes and nanoparticles, which demonstrate unique exciton properties that have rare counterparts in other 2D semiconductors. For three layers and more, the single PbI2 flakes can be utilized to show how the bandgap energy of a 2D semiconductor evolves with the changing layer thickness. The single PbI2 nanoparticles are associated with an ultranarrow photoluminescence line width of ∼1 meV, thus reflecting the influence of lateral quantum confinement on the energy-level structures of a 2D semiconductor. The above findings mark the emergence of a potent 2D platform that is more than complementary to well-studied transition-metal dichalcogenide monolayers.
Published: 2019

29. Serum exosomal long noncoding RNA CRNDE level for hepatocellular carcinoma diagnosis

Author: Min Xiao, Shao Zhou, Ting Wang, and Hengkai Zhu
Subjects: Oncology, Male, Microbiology (medical), medicine.medical_specialty, Cirrhosis, Carcinoma, Hepatocellular, diagnosis, Clinical Biochemistry, Biology, Exosomes, CRNDE, Internal medicine, Biomarkers, Tumor, medicine, exosome, Humans, Immunology and Allergy, Stage (cooking), Letter to the Editor, Research Articles, Cell Proliferation, Oncogene, Receiver operating characteristic, business.industry, Liver Neoplasms, Biochemistry (medical), Public Health, Environmental and Occupational Health, Cancer, hepatocellular carcinoma, Hematology, Middle Aged, Prognosis, medicine.disease, Long non-coding RNA, MicroRNAs, Medical Laboratory Technology, Hepatocellular carcinoma, Cancer research, biomarker, Biomarker (medicine), Female, RNA, Long Noncoding, business, Research Article
Abstract: Background Accumulating evidence has shown that long noncoding RNA (lncRNA) CRNDE functions as an oncogene in many cancer types. However, its clinical value has not yet been explored in hepatocellular carcinoma (HCC). Methods A total of 166 patients with HCC and 100 healthy volunteers were enrolled in this study. The expression levels of serum exosomal lncRNA CRNDE were detected in patients with HCC and controls by quantitative real‐time PCR (qRT‐PCR). Results The serum exosomal lncRNA CRNDE expression levels were significantly increased in patients with HCC compared with normal controls. High serum exosomal lncRNA CRNDE expression was significantly associated with tumor size, tumor differentiation, and TNM stage. Receiver operating characteristic (ROC) analysis revealed that an area under the ROC curve (AUC) of 0.839, with a sensitivity and specificity of 69.3% and 85.0%. In addition, the overall survival (OS) and disease‐free survival (DFS) were significantly longer in patients with lower serum exosomal lncRNA CRNDE expression compared to those with higher CRNDE expression. Moreover, HCC patients with cirrhosis had worse OS and DFS than those without cirrhosis. Univariate and multivariate analyses indicated that high serum exosomal lncRNA CRNDE expression was an independent indicator of poor prognosis. Conclusion Taken together, serum exosomal lncRNA CRNDE might serve as a potential biomarker for HCC diagnosis and prognosis., A, OS curve of HCC patients stratified by serum exosomal lncRNA CRNDE expression. B, DFS curve of HCC patients stratified by serum exosomal lncRNA CRNDE expression. C, OS curve of HCC patients stratified by cirrhosis. D, DFS curve of HCC patients stratified by cirrhosis.
Published: 2021

30. Chronic Hematuria Increases Chronic Kidney Injury and Epithelial–Mesenchymal Transition in 5/6 Nephrectomy Rats

Author: Min Xiao, Ajay K. Medipally, Laura Biederman, Anjali A. Satoskar, Iouri Ivanov, Brad H. Rovin, and Sergey V. Brodsky
Subjects: Medicine (General), medicine.medical_specialty, Tubular atrophy, medicine.medical_treatment, Urology, Vimentin, urologic and male genital diseases, chemistry.chemical_compound, R5-920, iron, epithelial mesenchymal transition (EMT), Medicine, Epithelial–mesenchymal transition, anticoagulation, Original Research, Prothrombin time, Creatinine, Kidney, biology, medicine.diagnostic_test, business.industry, urogenital system, General Medicine, medicine.disease, Nephrectomy, female genital diseases and pregnancy complications, hematuria, medicine.anatomical_structure, chemistry, biology.protein, business, chronic kidney disease, Kidney disease
Abstract: Chronic kidney disease (CKD) is a common outcome of many kidney diseases. Interstitial fibrosis and tubular atrophy (IFTA) is a histologic hallmark of CKD. Hematuria is a common symptom in many human kidney diseases. Free hemoglobin may affect tubular epithelial cells by generating reactive oxygen species (ROS). Epithelial–mesenchymal transition (EMT) of the tubular epithelial cells has been shown to play an important role in the IFTA development. The aim of this study was to determine the effects of chronic hematuria on the CKD progression in 5/6 nephrectomy (5/6NE) rat model of CKD. 5/6 NE rats were treated with oral warfarin (0.5 mg/kg/day) or vehicle (control). The animals were monitored for 26 weeks, while prothrombin time (PT), serum creatinine (SCr), and hematuria were measured weekly. Staining for iron, trichrome, and EMT (vimentin, E-cadherin, smooth muscle actin) markers was performed on the remnant kidneys. ROS were detected in the kidneys by protein carbonyl assay and immunohistochemistry for heme oxygenase 1 (HMOX1), at the end of the study. Apoptosis was detected by TUNEL assay. Warfarin treatment resulted in a PT increase 1.5–2.5 times from control and an increase in hematuria and SCr. Histologically, warfarin-treated animals had more iron-positive tubular epithelial cells and increased IFTA as compared to control (42.9 ± 17% vs. 18.3 ± 2.6%). ROS were increased in the kidney in warfarin-treated rats. The number of tubules that show evidence of EMT was significantly higher in warfarin-treated 5/6NE as compared to control 5/6NE rats. The number of apoptotic tubular epithelial cells was higher in warfarin-treated 5/6 NE rats. Chronic hematuria results in increased iron-positive tubular epithelial cells, EMT, apoptosis, and more prominent IFTA in CKD rats. Our data suggest an important role of chronic hematuria in the progression of CKD.
Published: 2021
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31. Optimizing single-photon generation and storage with machine learning

Author: Min Xiao, Miao Cai, Keyu Xia (夏可宇), and Yanqing Lu (陆延青)
Subjects: Physics, Quantum network, Photon, business.industry, Interface (computing), media_common.quotation_subject, Process (computing), Fidelity, Quantum information processing, Machine learning, computer.software_genre, Quantum system, Artificial intelligence, business, Wave function, computer, media_common
Abstract: Single photons are at the heart of quantum information processing. The tasks of generating and storing single photons with arbitrary wave-packet shapes are crucial for building quantum networks, but they remain challenging. Here, we present a general machine learning (ML) algorithm with a self-adaptive process to optimize the control of a cavity-atom system for these tasks. This ML algorithm shows high efficiency and fidelity for both generation and storage of single photons. This ML-enhanced single-photon interface may pave the way for building flexible and reliable quantum networks because this ML algorithm can automatically adjust the quantum system according to single-photon wave functions in an ``intelligent'' way.
Published: 2021

32. CDKN2B-AS1 participates in high glucose-induced apoptosis and fibrosis via NOTCH2 through functioning as a miR-98-5p decoy in human podocytes and renal tubular cells

Author: Min Xiao, Zhao Hu, Yaxi Li, Shu Zhang, Shoujun Bai, and Jing Chen
Subjects: Gene knockdown, RC620-627, medicine.diagnostic_test, business.industry, Kinase, Research, Endocrinology, Diabetes and Metabolism, CDKN2B-AS1, medicine.disease, Flow cytometry, Blot, miR-98-5p, NOTCH2, Downregulation and upregulation, Apoptosis, Fibrosis, embryonic structures, DN, Internal Medicine, medicine, Cancer research, Viability assay, Nutritional diseases. Deficiency diseases, business
Abstract: Background Diabetic nephropathy (DN) is the most common causes of end-stage renal disease. Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) is connected with the development of DN, but the role of CDKN2B-AS1 in DN has not been entirely elucidated. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to measure CDKN2B-AS1 and miR-98-5p levels. Cell viability, proliferation, and apoptosis were analyzed with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) or flow cytometry assays. Protein levels were measured by western blotting. The relationship between CDKN2B-AS1 or notch homolog 2 (NOTCH2) and miR-98-5p was verified via dual-luciferase reporter assay. Results CDKN2B-AS1 and NOTCH2 were upregulated in the serum of DN patients and high glucose-disposed human podocytes (HPCs) and human renal tubular cells (HK-2), whereas miR-98-5p was downregulated. High glucose repressed viability and accelerated apoptosis of HPCs and HK-2 cells. CDKN2B-AS1 knockdown impaired high glucose-induced apoptosis and fibrosis of HPCs and HK-2 cells. Mechanistically, CDKN2B-AS1 sponged miR-98-5p to regulate NOTCH2 expression. Also, CDKN2B-AS1 inhibition-mediated effects on apoptosis and fibrosis of high glucose-disposed HPCs and HK-2 cells were weakened by miR-98-5p inhibitor. Also, NOTCH2 knockdown partly reversed miR-98-5p inhibitor-mediated impacts on apoptosis and fibrosis of high glucose-disposed HPCs and HK-2 cells. Conclusion High glucose-induced CDKN2B-AS1 promoted apoptosis and fibrosis via the TGF-β1 signaling mediated by the miR-98-5p/NOTCH2 axis in HPCs and HK-2 cells. Supplementary Information The online version contains supplementary material available at 10.1186/s13098-021-00725-5., Highlights CDKN2B-AS1 was upregulated in DN and high glucose-induced HPCs and HK-2 cells.Inhibition of CDKN2B-AS1 alleviated high glucose-induced apoptosis and fibrosis of HPCs and HK-2 cells.CDKN2B-AS1 regulated NOTCH2 expression via acting as a miR-98-5p sponge. Supplementary Information The online version contains supplementary material available at 10.1186/s13098-021-00725-5.
Published: 2021

33. Risk Factors for the Development of Hemophagocytic Lymphohistiocytosis in Children With Severe Adenovirus Pneumonia: A Single-Center Retrospective Study

Author: Hua-yong Zhang, Min Xiao, Mao-rong Zhang, Yong Zhang, and Fan Yan
Subjects: Hemophagocytic lymphohistiocytosis, Pediatrics, medicine.medical_specialty, Univariate analysis, endocrine system, Receiver operating characteristic, business.industry, retrospective study, Retrospective cohort study, medicine.disease, Single Center, severe adenovirus pneumonia, RJ1-570, Pneumonia, hemophagocytic lymphohistiocytosis, risk factor, children, Pediatrics, Perinatology and Child Health, Medicine, Binary logistic regression analysis, Risk factor, business, Original Research
Abstract: Objective: To investigate and analyze the relevant risk factors for hemophagocytic lymphohistiocytosis (HLH) in children with severe adenovirus pneumonia (SAP).Methods: A retrospective study of children with SAP was performed in 30 cases developing HLH and 94 cases not developing HLH from December 2018 to August 2019. The binary logistic regression analysis was used to identify risk factors that were significantly associated with the development of HLH after the univariate analysis, and the receiver operating characteristic (ROC) curve was performed to find out the cut-off value for the significant relevant factors.Results: Two factors were associated with the development of HLH, which were the length of fever (OR = 1.331, 95%CI: 1.002–1.769) and triglycerides (TG) (OR = 17.345, 95%CI: 1.358–221.538). The cut-off value of the length of fever was 12.5 days, and the cut-off value of TG was 3.02 mmol/L.Conclusion: Children with SAP who had a duration of fever over 12.5 days and the TG level over 3.02 mmol/L are more likely to develop HLH.
Published: 2021

34. Angle-Multiplexing Nonlinear Holography for Controllable Generations of Second-Harmonic Structured Light Beams

Author: Wenzhe Yao, Chao Zhou, Tianxin Wang, Pengcheng Chen, Min Xiao, and Yong Zhang
Subjects: Materials Science (miscellaneous), QC1-999, Airy beam, Biophysics, Holography, General Physics and Astronomy, Physics::Optics, Multiplexing, law.invention, Optics, law, Physical and Theoretical Chemistry, Mathematical Physics, Physics, multiplexing, business.industry, second harmonic generation, noncritical phase matching (NCPM), Second-harmonic generation, beam shaping, Nonlinear system, Wavelength, nonlinear holography, Harmonic, business, Structured light
Abstract: Nonlinear multiplexing holography emerges as a powerful tool to produce structured lights at new wavelengths. In this work, we propose and experimentally demonstrate an angle-multiplexing nonlinear holography in an angular noncritical phase-matching configuration. In experiment, various types of structured light beams, such as vortex beam, Airy beam and Airy vortex beam, are simultaneously output at second-harmonic waves along different paths. Because of the large angular acceptance bandwidth of noncritical phase-matching, one can achieve high conversion efficiency of angle-multiplexing nonlinear holography. Our method has potentially applications in high-capacity holographic storage and security encryption.
Published: 2021

35. Early intervention (≤6h) reduces the degree of multiple organ dysfunction with wasps sting patients

Author: Dongle Chen, Ping Chen, Yuwen Sun, Rui Gong, Min Xiao, Yuhui Sun, Cuiping Guo, Wei Yao, and Ruijie Ling
Subjects: medicine.medical_specialty, Sting, business.industry, Internal medicine, Intervention (counseling), Organ dysfunction, medicine, MEDLINE, General Medicine, medicine.symptom, business, Degree (temperature)
Published: 2021

36. Generation of Optical Frequency Comb via Giant Optomechanical Oscillation

Author: Shulin Ding, Yong Hu, Yingchun Qin, Min Xiao, Xiaoshun Jiang, Wenjie Wan, and Jiaxin Gu
Subjects: Physics, Oscillation, business.industry, Optical communication, Physics::Optics, General Physics and Astronomy, Resonator, Nonlinear system, Optics, Optical frequency comb, Spectroscopy, business, Oscillation amplitude, Phase modulation
Abstract: Optical frequency combs (OFCs) are essential in precision metrology, spectroscopy, distance measurement, and optical communications. Significant advances have been made recently in achieving micro-OFC devices based on parametric frequency conversion or electro-optic phase modulation. Here, we demonstrate a new kind of microcomb using a cavity optomechanical system with giant oscillation amplitude. We observe both optical and microwave frequency combs in a microtoroid resonator, which feature a flat OFC with 938 comb lines and a repetition rate as low as 50.22 MHz, as well as a flat microwave frequency comb with 867 comb lines. To generate such giant oscillation amplitude, we excite an overcoupled optical mode with a large blue detuning that is assisted with the thermo-optic nonlinearity. A new type of nonlinear oscillation, induced by competition between the optomechanical oscillation and thermo-optic nonlinearity, is also observed.
Published: 2021

37. Epidemiology and Mortality of Sepsis in Intensive Care Units in Prefecture-Level Cities in Sichuan, China: A Prospective Multicenter Study

Author: Chaogui Zhang, Lianghai Cao, Xiangde Zheng, Xiaofeng Gao, Xianhua Xiao, Yong Wan, Yuanhua Zhang, Xuemei Chen, Min Xiao, and Mingquan Yang
Subjects: Male, medicine.medical_specialty, China, Epidemiology, Sepsis, Tertiary Care Centers, Risk Factors, Clinical Research, Intensive care, Internal medicine, medicine, Humans, Prospective Studies, Cities, Mortality, Aged, business.industry, Septic shock, Mortality rate, General Medicine, Odds ratio, Middle Aged, medicine.disease, Shock, Septic, Confidence interval, Intensive Care Units, Observational study, Female, business
Abstract: BACKGROUND Studies on the epidemiology of sepsis in intensive care units (ICUs) of prefecture-level hospitals in China are rare. This study aimed to investigate the epidemiological characteristics and mortality risk factors of sepsis in ICUs of tertiary hospitals in Sichuan, China. MATERIAL AND METHODS In this prospective, multicenter, observational study, patients admitted to the ICU of 7 tertiary hospitals in Sichuan (China) between October 10, 2017 and January 9, 2018 were screened for sepsis using the Sepsis-3 criteria. Patients with sepsis were included. RESULTS Of the 1604 patients screened for sepsis, 294 (18.3%) had sepsis, and 140 (47.6%) had septic shock. Of these, 169 (57.5%) died. Multivariable analysis showed that central nervous system dysfunction (odds ratio [OR]=2.59, 95% confidence interval [CI]: 1.15-5.84, P=0.022), lowest blood phosphorus level (OR=2.56, 95% CI: 1.21-5.44, P=0.014), highest lactate level (OR=1.20, 95% CI: 1.10-1.32, P
Published: 2021

38. Ultralow-power all-optical switching via a chiral Mach-Zehnder interferometer

Author: Keyu Xia, Lei Tang, Wei Hu, Han Zhang, Shi-Jun Ge, Haodong Wu, Min Xiao, Fei Xu, Ya-Ping Ruan, Yan-qing Lu, and Zhi-Xiang Li
Subjects: Physics, Extinction ratio, business.industry, FOS: Physical sciences, Mach–Zehnder interferometer, Atomic and Molecular Physics, and Optics, law.invention, Power (physics), Interferometry, law, Optical cavity, Bandwidth (computing), Optoelectronics, business, Realization (systems), Ultrashort pulse, Optics (physics.optics), Physics - Optics
Abstract: All-optical switching increasingly plays an important role in optical information processing. However, simultaneous achievement of ultralow power consumption, broad bandwidth and high extinction ratio remains challenging. We experimentally demonstrate an ultralow-power all-optical switching by exploiting chiral interaction between light and optically active material in a Mach-Zehnder interferometer (MZI). We achieve switching extinction ratio of 20.0(3.8) and 14.7(2.8) dB with power cost of 66.1(0.7) and 1.3(0.1) fJ/bit, respectively. The bandwidth of our all-optical switching is about 4.2 GHz. Our theoretical analysis shows that the switching bandwidth can, in principle, exceed 110 GHz. Moreover, the switching has the potential to be operated at few-photon level. Our all-optical switching exploits a chiral MZI made of linear optical components. It excludes the requisite of high-quality optical cavity or large optical nonlinearity, thus greatly simplifying realization. Our scheme paves the way towards ultralow-power and ultrafast all-optical information processing., 6 figures
Published: 2021

39. Hemoporfin photodynamic therapy for a case of unilateral nevoid telangiectasia

Author: Jie Kang, Han-Jin Xie, Yan-Yan Lin, Li-Hang Lin, Xue-Min Xiao, and Jing Ni
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Correspondence, medicine, Hemoporfin, Medicine, Photodynamic therapy, General Medicine, business, Dermatology, Unilateral nevoid telangiectasia
Published: 2020

40. Neural crest-like stem cell transcriptome analysis identifies LPAR1 in melanoma progression and therapy resistance

Author: Gao Zhang, Anastasia Samarkina, David W. Speicher, Vito W. Rebecca, Yiling Lu, Delaine Zayasbazan, Katrin Sproesser, Chih-Cheng Yang, Gordon B. Mills, Andrew V. Kossenkov, Mizuho Fukunaga-Kalabis, Pedro Aza-Blanc, Clemens Krepler, Qin Liu, Ravi K. Amaravadi, Dennie T. Frederick, Genevieve M. Boland, Denitsa Hristova, Jianglan Liu, Bela Delvadia, Jie Zhang, Patricia Brafford, Min Xiao, Keith T. Flaherty, Giorgos C. Karakousis, Ling Li, Lawrence N. Kwong, Marilda Beqiri, Gretchen M. Alicea, Tara C. Mitchell, Alice S. Morias, Alexis Gutierrez, Rajasekharan Somasundaram, Joseph M. Salvino, Thomas Connelly, Xiaowei Xu, Ye Huang, Ze'ev Ronai, Meenhard Herlyn, Cynthia Tong, Wei Xu, Chaoran Cheng, Zhi Wei, Joshua X. Wang, Lawrence W. Wu, Adina Vultur, Lynn M. Schuchter, and Maya Delvadia
Subjects: Cancer Research, medicine.medical_treatment, Antineoplastic Agents, Apoptosis, Mice, SCID, Article, Targeted therapy, Transcriptome, Mice, Neural Stem Cells, Mice, Inbred NOD, medicine, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, Humans, Treatment resistance, Receptors, Lysophosphatidic Acid, Melanoma, Cell Proliferation, LPAR1, business.industry, Neural crest, medicine.disease, Prognosis, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Oncology, Drug Resistance, Neoplasm, Neural Crest, Cancer cell, Cancer research, Stem cell, business
Abstract: Metastatic melanoma is challenging to clinically address. Although standard-of-care targeted therapy has high response rates in patients with BRAF-mutant melanoma, therapy relapse occurs in most cases. Intrinsically resistant melanoma cells drive therapy resistance and display molecular and biologic properties akin to neural crest-like stem cells (NCLSC) including high invasiveness, plasticity, and self-renewal capacity. The shared transcriptional programs and vulnerabilities between NCLSCs and cancer cells remains poorly understood. Here, we identify a developmental LPAR1-axis critical for NCLSC viability and melanoma cell survival. LPAR1 activity increased during progression and following acquisition of therapeutic resistance. Notably, genetic inhibition of LPAR1 potentiated BRAFi ± MEKi efficacy and ablated melanoma migration and invasion. Our data define LPAR1 as a new therapeutic target in melanoma and highlights the promise of dissecting stem cell–like pathways hijacked by tumor cells. Significance: This study identifies an LPAR1-axis critical for melanoma invasion and intrinsic/acquired therapy resistance.
Published: 2021

41. Tennis Ball Picking Robot Based on Bluetooth Control

Author: Wei Wang, Min Xiao, Li Ji, and Qingfeng Wen
Subjects: Computer science, business.industry, law.invention, Bluetooth, Microcontroller, Software, law, Mobile phone, Ball (bearing), Systems architecture, Robot, Tennis ball, business, Simulation
Abstract: With the development of tennis, tennis ball picking robots have received more and more attention. Aiming at the characteristics that the existing tennis ball picking robot is expensive, complicated in design, and relies heavily on various sensors for control, a tennis ball picking robot with simple structure and Bluetooth control is designed. It is mainly composed of STC89C51 microcontroller, L298N drive motor, Bluetooth chip and mobile phone software. Focusing on Bluetooth control, the application of the robot's system architecture and hardware model under Bluetooth control is described. Finally, the tennis ball picking robot was tested on the ground by Bluetooth control and ball picking. The experimental results show that the tennis ball picking robot can perform corresponding operations according to the information sent by the mobile phone software, and can complete the task of picking the ball.
Published: 2021

42. Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Author: Labeau, Sonia O, Afonso, Elsa, Benbenishty, Julie, Blackwood, Bronagh, Boulanger, Carole, Brett, Stephen J, Calvino-Gunther, Silvia, Chaboyer, Wendy, Coyer, Fiona, Deschepper, Mieke, François, Guy, Honore, Patrick M, Jankovic, Radmilo, Khanna, Ashish K, Llaurado-Serra, Mireia, Lin, Frances, Rose, Louise, Rubulotta, Francesca, Saager, Leif, Williams, Ged, Blot, Stijn I, Dritan, Muzha, Antoni Margarit Ribas, Fernando, Lipovesty, Cecilia, Loudet, Fiona, Coyer, Philipp, Eller, Nafseen, Mostafa, Patrick, M Honoré, Vanesa Mercado Telleria, Jasmina, Smajic, Paula Cristina Nogueira, Khalid Mahmood Khan Nafees, Romuald, Hentchoya, Louise, Rose, Javiera, Soledad, Frances, Lin, Yenny, Cardenas, Amylkar Garay Reyes, Alan, Sustic, Meropi, Mpouzika, Tamas, Vymazal, Hanne Irene Jensen, Hernan, Aguirre-Bermeo, Liivi, Maddison, Maija, Valta, Silvia, Calvino-Gunther, Frank, Bloos, Faustina Excel Adipa, Vasilios, Koulouras, Judy, Enamorado, Zsuzsann, Ágoston, Hrönn, Birgisdóttir, Amit, Gupta, Mohan, Gurjar, Bram, Kilapong, Seyed Mohammadreza Hashemian, Ignacio, Martin-Loeches, Julie, Benbenishty, Andrea, Cortegiani, Kelly, Fletcher, Yoshiro, Hayashi, Wangari, Waweru-Siika, Khalid, Abidi, Sang-Min, Lee, Burhan, Hadri, Mihails, Dolgusevs, Fayez François Abillama, Tomas, Jovaisa, Cyril, Thix, Muhammed, Elhadi, Basri Mat Nor, Shanti, Ratnam, Mohd Zulfakar Mazlan, Sundaresan, Maiyalagan, Luis, Sánchez-Hurtado, Adrian, Belii, Mendsaikhan, Naranpurev, Prabha, Gautam, Dylan De Lange, Rachael, Parke, Rose Ekama Ilesanmi, Mirjana, Shosholcheva, Antonija, Petosic, Ranveig, Lind, Madiha Hashmi Ffarcsi, Javier, Bogarin, Aaron Mark Hernandez, Malgorzata, Mikaszewska-Sokolewicz, Bruno, Sousa, Dana, Tomescu, Dorel, Sandesc, Theogene, Twagirumugabe, Vitaly, Gusarov, Maie, Ebaid, Radmilo, Jankovic, Gari, Slobodianiuk, Andrea, Martonova, Rihard, Knafelj, Mervyn, Mer, Emilio, Maseda, Bernardo, Panka, Joerg, C Schefold, Eva, Joelsson-Alm, Konlawij, Trongtrakul, Lorna, Merritt-Charles, Lamia Ouanes Besbes, Yalım, Dikmen, Lesia, Zgrzheblovska, Mark, Fielding, Francesca, Rubulotta, Ashish, K Khanna, Leif, Saager, Ingrid von der Osten, Alban, Greca, Alma, Cani, Nordian, Xhindi, Genci, Hyska, Antonio Margarit Ribas, Susana, Pinto, Paulo, Alves, Romina, Esposito, Emanuel, Valgolio, John Thomas Sanchez Minope, Antonio, Abdala, Maria, Ayala, Silvina, Bravo, Ana, Bantar, Patricia, Delgado, Gustavo, Badariotti, Fernando, Lipovestky, Ana, Diaz, Pablo, Saul, Mariano, Setten, Alejandra, Aucapina, Ysica, Acosta, Victor, Gonzalez, Luis, Camputaro, Fernando, Baccaro, Robert, Villa, Marcela, Mastantuono, Emiliano, Dean, Oscar Fernández Rostello, Patricia, Brizuela, Julio Ricardo Bartoli, Matias, Guereschi, Cristian, Quiroga, Sofia, Putruele, Paula, Villegas, Veronica, Curilen, Ruben, Fernandez, Mariangeles Gabriela Nocheretti, Rosana Gabriela Escalante, Cecilia Inés Loudet, Silvia, Fernandez, Ana Laura Gonzalez, Gustavo Andres Alvarez, Federico, Iglesias, Silvia, Chaparro, Graciela, Zakalik, Gonzalo, Pagella, Matías, Baini, Pierina Arias Campos, Ignacio, Sabbag, Armando, Schmukler, Imelda Perdomo Fonseca, Gonzalo Martín Alvarez, Mario, Ramirez, Fernando, Tapia, Carlos Alejandro Bascary, Graciela Del Valle Gimenez, Fernando Pablo Bertoletti, Esteban, Milioto, Pablo Julio Maldonaldo Bonsignore, Maria Alejandra Fernandez, Julie, Smith, Tim, Chimunda, Lorraine, Thompson, Teena, Maguire, Wendy, Chaboyer, Stacey, Watts, Marion, Mitchell, Madeleine, Powell, India, Lye, Leanne, Parsons, Nerilee, Baker, Claire, Reynolds, Amy, Thompson, Kristy, Masters, Kellie, Sosnowski, Lynette, Morrison, Gavin, D Leslie, Ramanathan, Lakshmanan, Alexis, Tabah, Wendy, Brown, Sharon, McDowell-Skaines, Andrea, Mclucas, Chris, Smith, Mandy, Tallot, Sarah, Jones, Michelle, Barakat-Johnson, Thomas, Leong, Rand, Butcher, Kerrie, Martin, Philipp, Douschan, Dirk von Lewinski, René, Schmutz, Uta, Kolussi, Fatema, Salman, Zainab, Ateya, Koen De Decker, Niels Van Regenmortel, Anita, Jans, Patricia, Wijnands, Stefano, Coremans, Patrick, M Honore, David De Bels, Tanja, Depuydt, Caroline, Paillet, Luc-Marie, Jacquet, Walter, Swinnen, Francis, Hannes, Matthia, Mergeay, Stijn Van de Velde, Silvie, Allaert, Pieter, Hoste, Christophe, Borin, Sandrine, Balon, Vincent, Fraipont, Patrick, Biston, Nicolas De Schryver, Thierry, Dugernier, Ilse Van Cotthem, Angelica Olivetto de Almeida, Silvia Angelica Jorge, Delmiro, Becker, Raysa Cristina Schmidt, Evellyn, Oliveira, Aline, Ramalho, Eliane, Mazocoli, Audrey, Fioretti, Elaine, Barros, Leticia, Serpa, Suzana, Bianchini, Ticiane, Campanili, Taís, Pantaleao, Paulo Carlos Garcia, Ana Lucia Vitti Ronchini, Rayanne, Santos, Nurulhuda Binti, A Manap, Sean, Bagshaw, Dominic, Carney, Jon, Davidow, Ella, Rokosh, Andréa Maria Laizner, Samantha, Smith, Megan, Mcquirter, Betty Star Kampayana, René, Favre, Martin, Sills, Julie, Dallaire, Cathy, Becker, Sherissa, Microys, Bonnie, Bowes, Jennifer, Lajeunesse, Rishi, Ghosh, Jacqueline, Baptiste-Savoie, Rose, Raizman, Gabriel, Suen, Noushin, Taghavi, Orla, Smith, Clare, Fielding, Julieta, Canales, Pia, Molina, Javiera, Chaparro, Maria Idalia Sepulveda, Matias Jesús Flamm Zamorano, Pamela, Rocha, Ximena, Villanueva, Paola, Araya, Meneses, Dayan, Fernando, Avalos, Xiaohan, Li, Liu, Yu, Xinxia, Li, Xiaoyan, Chen, Zhixia, Jiang, Jing, Yang, Jingfang, Chen, Lei, Yang, Kefang, Wang, Jie, Gao, Xiuhua, Fang, Ronghua, Zhao, Xinhua, Xia, Hongmei, Liu, Jing, Li, Haiyan, Wang, Gen, Meng, Yanhong, Di, Damei, Wang, Rong Hua Zhao, Li Ping Hu, Peipei, Xu, Qing Feng Jiao, Hai Yun Wang, Chun Jie Xia, Yan, Liu, Mei, Ye, Yan, Wan, Wenmei, Wang, Yajun, Ding, Aiua, Ren, Yan, Gao, Qi, Li, Guifang, Du, Yanling, Shen, Yanming, Ding, Ning, Li, Cui, Yuan, Lei, Tan, Qiang, Lin, Hailing, Guo, Howe, Yan, Xiao, Xu, Wei, Zhang, Jinxian, Liang, Libing, Zhang, Eryun, Tian, Qian, Zhao, Lin, Insu, Jingwen, Dong, Yanmei, Gu, Ying, Liu, Lina, Zhao, Wei, Wang, Hongmei, Qiao, Lili, Tuo, Mengmeng, Lv, Jin Yu Zhu, Jifen, Zhu, Ying, Wei, Man, Liu, Yin, He, Jiyin, Cheng, Jin, Liu, Jia, Na, Dongfang, Wei, Qing, Li, Xiaoying, Wu, Huan, Duan, Dongliang, Lin, Qiong, Liang, Xiaofang, Luo, Yunfeng, Xiong, Rong Fen Huang, Jing, Fu, Tao, Zan, Man, Ye, Zeya, Shi, Yanfei, Long, Yang, Lei, Xiaodi, Liu, Chen, Yumei, Lingling, Wang, Yali, Zhang, Yan, Xu, Cheng, Wang, Zhijuan, Chengxia, Sun, Jinhui, Song, Yingli, Wang, Xiumei, Liu, Yupeng, Liu, Yuxia, Yuan, Qingping, Huang, Fengling, Yang, Yun, Wu, Xianping, Luo, Xiaowu, Bai, Hong, Zheng, Min, Song, Yue, Sun, Zhangshuangzi, Li, Feifei, Luo, Miao, Liu, Li Chuntang Li, Xinjian, Li, Guiping, Zhang, Lina, Xiao, Tingting, Yu, Guangyuan, Gao, Wei, Wei, Fanglan, Wang, Ting, Han, Tingting, Li, Zeng, Qi, Jing Mei Zeng, Yan, Long, Fuqun, Pan, Jing, Wang, Guoxue, He, Haiyan, Chen, Feifei, Zhang, Chao, Yu, Gao, Chunhua, Xiuying, Yao, Dongmei, Bai, Liu, Lu, Xuelian, Xu, Yan, Wang, Xuejuan, Liang, Zhang, Na, Aizhi, Zhang, Xiaochun, Hu, Hui, Zhang, Ruixia, Wang, Poon Shing Tak, Sung Wai Ho, Qun Xia Jiang, Xinran, Ding, Liu, Hong, Limei, Miao, Zhaoxia, Feng, Liping, Huang, Juan, Wu, Yuping, Wang, Jiye, Guo, Baoke, Zhang, Chaoqun, Ma, Han, Yu, Congcong, Liu, Min, Ding, Linlin, Luan, Jing, Zheng, Shanshan, Lv, Shumin, Jiang, Wenzhen, Cao, Xiujuan, Xue, Guangyan, Liu, Xiyan, Wei, Youru, Jiang, Zhiru, Yao, Gao, Li, Jinhua, Li, Wenwen, Zhao, Mei, Jiang, Junping, Hao, Jing, Zhang, Caiju, Song, Feifei, Chen, Shuhui, Wang, Lili, Hu, Deyan, Cao, Jianhong, Wan, Xiaomin, Wang, Hongyan, Shao, Zhenxia, Zhang, Xia, Cui, Jingyu, Liu, Lijuan, Zhao, Xingguo, Li, Limei, Fan, Ling, Zhang, Min, Yu, Biyan, Li, Chunxia, Li, Ling, Liu, Xuelian, Liu, Wenmin, Chen, Yan, Li, Zhang, Zhigang, Yuchen, Wu, Chenghau, Mu, Guoyan, Zhu, Fan, Yang, Qi, Bo, Ling, Li, Meili, Chen, Jing Hua Jiang, Hai, Yin, Xuelian, Pang, Yue Ying Gong, Shunzhu, Yang, Xiaoli, Yan, Xianhong, Zheng, Dehong, Lei, Lei, Lei, Yinhua, Guo, Lihong, Liu, Jing, Yu, Wei, Sun, Aiping, Bi, Weiwei, Li, Yang, Wu, Ji, Li, Dongshu, Ni, Zijing, Wu, Bing, Song, Qin, Fei, Yang, Xiaoyan, Qiong, Ran, Xixi, Li, Xueping, Jiao, Hua, Ji, Sun, Zhiping, Hong, Ma, Jianhong, Mu, Yanhua, Hao, Yin, Li, Ying, Wang, Caihong, Hui, Wenjie, Ju, Yuxia, Huo, Yuxia, Wang, Lei, Chen, Yan, Yan, Qingli, Zhao, Hongjuan, Chen, Guijun, Bao, Ying, Cao, Hong, Li, Hong, Zhang, Ying, Zhang, Lina, Xu, Jia, Guixiang, Ying, Li, Hui Min Zhao, Xia, Huang, Zhaoxing, Dai, Yanman, Jian, Hongsu, Zhang, Zhixia, Tian, Zu Qing Cao, Miao, Li, Yang, Liu, Fei, Ouyang, Fuying, Ma, Wangyan, Jin, Liuyan, Ge, Shifen, Wu, Weilian, Yuan, Tianfei, Chen, Guanxiu, Shi, Zhihong, Chen, Kewei, Liu, Xue, Lin, Yuemen, Ly, Sun, Lijuan, Xiao Fang Tian, Shuo, Wang, Zhangxia, Feng, Xiaozhe, Liu, Yunchun, Dong, Jundi, Zhang, Nie, Bocui, Guoxian, Wang, Yingjuan, Zhao, Xiaojun, Wu, Qiao, Yang, Rongjun Ling Hu, Xue Qin Li, Zhu Jun Yu, Yanlan, Yao, Xiaoqiong, Deng, Yan, Xiao, Yan, Xie, Yanping, Yang, Huai, Yang, Yuming, Zhou, Zhuqing, Li, Min, Xiao, Yongxia, Yang, Yani, Tian, Luz Marina Silva Gama, Juan Sebastian Hernandez, Nestor, Caicedo, Jorge, Marin, Maria-Elena, Ochoa, Monica, Gomez, José, Rojas-Suarez, Jeniffer, Gonzalez, Amylkar José Garay Reyes, Edwin, Chapeta, Estefania, Orozco, Ina, Filipović-Grčić, Anita, Vuković, Suzana, Pečenković, Aleksandar, Šuput, Gordana, Zivanovic-Posilovic, Armanda, Bozena, Nikolina, Udiljak, Morena, Milic, Renata Curic Radivojevic, Slobodan, Mihaljevic, Marijana, Matas, Dinko, Tonkovic, Hemena, Čuljak, Ivana, Herceg, Gordana, Pavlisa, Milena, Dobric, Tatjana, Beker, Višnja Nesek Adam, Tanja, Goranovic, Chrysanthos, Markoulias, Mina, Mathaios, Maria, Mylordou, Eleni, Achilleos, Pavlina, Kleanthous, Veronika, Kotanidi, Maria, Foka, Iwy, Charalabous, Anna, Alexandrou, Marios, Georgiou, Artemis, Patsalos, Sofia, Zepoy, Constantina, Constantinou, Petr, Piza, Tomas, Vymazal, Elisabeth, Wiborg, Louise, Bruhn, Karin, Kaasby, Karin Rehnholt Pedersen, Sanne, Mikkelsen, Marie, Collet, Anne, Langvad, Hanne, Andresen, Susanne, Fischer, Inger Ebbesen Kjærgård, Britta, Jepsen, Birthe, Husted, Morten, Bestle, Anne Marie Kodal, Tina Charlotte Bitsch Hansen, Anne Sofie Bomholt Pedersen, Tina Damgaar Thomsen, Anisette, Hoegenhaven, Mette, From, Tine Melgaard Frandsen, Grit, Henning, Anja, Hansen, Inger Abildgaard Bliksted, Luis Mario Tamayo, Pedro, Mogrovejo, Carolina, Palaez, Diego Rolando Morocho Tutillo, Cintia Valencia Hurtado, Maria Fernanda García, Diana, Alvarez, Fausto, Guerrero, Alexandra, Vasquez, Martin, Kütimets, Kadri, Tamme, Eneli, Anvelt, Lomangisi, Dlamini-Sserumaga, Carita, Löfqvist, Virpi, Lusenius, Outi, Kauppi, Jenni-Katarina, Sakki, Tarja, Tervo-Heikkinen, Ulla, Kesti, Merja, Merilainen, Elina, Karjula, Minna, Peltomaa, Auli, Palmu, Maarit, Ahtiala, Maija Anniina Valta, Hervé, Mentec, Gaëtan, Plantefève, Guillaume, Besch, Sébastien, Pili-Floury, Stanislas, Ledochowski, Marc Danguy des Déserts, Christophe, Giacardi, Cédric, Daubin, Audrey, Massard, Yann Le Guen, Agnès, Blanc, Simon, Mandaroux, Silvia Calvino Günther, Prune, Avogadro, Anthony, Radavidson, Jean, Turc, Sébastien, Jochmans, Hervé, Quintard, Laetitia, Boyer, Cédric, Bruel, François, Philippart, Philippe, Montravers, Enora, Atchade, Nadine, Flessel, Benoît, Chinardet, Léa, Soulisse, Cindy, Pillard, Delphine, Ngo, Benjamin, Bongiorno, Nathalie, Heitzler, Virginie, Souppart, Nathalie, Gautheret, Jean-Francois, Timsit, Fatiha, Essardy, Muriel, Fartoukh, Daisy, Mehay, Fabienne, Etourneau, Jean-Christophe, Farkas, Pascal, Beuret, Gabriel, Preda, Etienne De Montmollin, Vincent, Castelain, Ulrich, Jaschinski, Monika, Rothenfusser, Detlef, Kindgen-Milles, Thomas, Dimski, Christine, Fiedler, Tobias, Heinicke, Patrick, Meybohm, Tobias, Schulze, Marc, Bota, Sabrina, Pelz, Tobias, Odenthal, Martin, Christ, Kathrin, Bösl, Achilleas, Chovas, Sebastian, Stehr, Philipp, Simon, Sarah, Grotheer, Sebastian, Schüppel, Stefan, Schaller, Lea, Albrecht, Andeas, Stübner, Stephan, Graeser, Nina, Kolbe, Martina, Lausch, Anja, Diers, Ulf, Guenther, Reimer, Riessen, Martin, Roller, Irene Pearl Osei, Anita-Chrysolyte, Kusi-Appiah, Yakubu, H Yakubu, Belinda, Guadi-Gosh, Christos, Dragoumanis, Christos, Christofis, Nikolaos, Kazakos, Styliani, Bastani, Charalampos, Martinos, Vasileios, Bekos, Metaxia, Papanikolaou, Theonymfi, Papavasilopoulou, Anna, Efthymiou, Vasiliki, Chantziara, Anna, Kyriakoudi, Nikolaos, Kakaras, Chrisi, Diakaki, Aikaterini, Flevari, Charikleia, Nikolaou, Kounougeri, Katerina, Lamprini, Avramopoulou, Kyriaki, Tsikritsaki, Georgios, Gkiokas, Eirini, Pantiora, Chrysostomos, Katsenos, Eirini-Chysovalanto, Patsiou, Paraskevi, Alexandropoulou, Ioannis, Koutsodimitropoulos, Epaminontas, Farmakis, Konstantina, Nestora, Marinos, Chatzis, Eumorfia, Kondili, Stella, Soundoulounaki, Ourania, Mousafiri, Dimitra, Lepida, Antonia, Liarmakopoulou, Georgios, Papathanakos, Mrina, Oikonomou, Panagiotis, Ioannides, Dimitrios, Papadopoulos, Ioannis, Staikos, Maria, Stafylaraki, Bogdan, Raitsiou, Konstantinos, Mandis, Ifigenia, Ravani, Styliani, Kourelea, Aikaterini, Efthimiou, Giannoula, Thoma, Apostolos, Bakas, Konstantinos, Psarulis, Souzana, Anisoglou, Eirini, Papageorgiou, Evangelia, Michailidou, Thomai, Tholioti, Athena, Lavrentieva, Evdokia, Sourla, Anastasia, Spyropoulou, Nikolaos, Pantelas, Kristina Mariana Matei Stalika, Ioannis, Georgakas, Antigoni, Karathanou, Syragoula, Tsikriki, Aikaterini, Dimoula, Sofia, Kanakaki, Aristeidis, Vakalos, Konstantinos, Pagioulas, Judy Enamorado Enamorado, Gabor, Nardai, Fatime, Hawchar, Asbjorn, Blondal, Brynja, Rygvadottir, Rannveig, J Jonasdottir, Hrönn, Birgisdottir, Bhagyesh, Shah, Shuchi, Kaushik, Swagata, Tripathy, Mukta, Singh, Sonika, Agarwal, Manish, Gupta, Meraj, Ahmad, Kishore, Mangal, Vaibhav, Bhargava, Vilas, Kushare, Simant, Jha, Lakshay, Bhakhtiani, Manoj, Kamal, Arvind, Baronia, Ade, Susanti, Mayang Indah Lestari, Zulkifli, Zulkifli, Windu, Baskoro, Farid, Zand, Fatemeh, Zarei, Ata, Mahmoodpoor, Farshad, Heidari, Fateme, Jafaraghaee, Aidan, O'Shea, Fiona, O'Shea, Caroline, O'Donnell, Geraldine, Craig, Gerry, Fitzpatrick, Lisa, Dunne, Jennifer, Hastings, Brian, Marsh, Caitriona, Cody, Elizabeth, Campbell, Deirdre, Doyle, Michelle, Pacturanan, Christine, Sheehan, Annette, Carey, Charlotte, Carter, Regina, Mulvey, Damien O'Connell Rosemary Finn, Catherine, Motherway, Amy, Walsh, Jennifer, Kehoe, Shella, Delossantos, Jennifer, Lalor, Siobhan, O'Nuallain, Helena, Behan, Sandra, Mcpherson, Ailesh, Corcoran, Patricia, Gordon, Glenda, Rooney, Dassy, Levy, Mazal, Azencot, Vladimir, Gurevich, Alinoy, Lavy, Valentina, Bendelari, Romina, Marconi, Antonio, Barone, Chiara, Gatti, Andrea, Giampaoletti, Cinzia, Borgognoni, Davide Massimo Ghioldi, Arena, Raimondo, Giacomo, Castiglione, Anna Vita Bruno, Giorgia, Rubulotta, Antonella, Mo, Amalia, Corso, Salvatore, Girianni, Andrea, Bruni, Eugenio, Garofalo, Salvatore Maurizio Maggiore, Alessandro Di Risio, Italo, Calamai, Rosario, Spina, Savino, Spadaro, Carlo Alberto Volta, Antonella, Cotoia, Lucia, 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Harding-Goldson, Shunsuke, Taito, Nobuaki, Shime, Ryohey, Yamamoto, Fumiya, Kanda, Akemi, Hirao, Moritoki, Egi, Ayako, Noguchi, Satoru, Hashimoto, Umeda, Aya, Hideaki, Sakuramoto, Akira, Ohuchi, Jun, Kataoka, Kumi, Maruyama, Izumi, Nakayama, Yoshimasa, Nishime, Koji, Fujimoto, Kenji, Takahashi, Mayumi, Tsujimoto, Masako, Shimizu, Eunice, Tole, Malcolm, C Correia, Je Hyeong Kim, Sunghoon, Park, Kyung Chan Kim, Jonghyun, Baek, Jung-Min, Bae, So Young Park, Tai Sun Park, Heung Bum Lee, Seung Yong Park, Jisoo, Park, Lee, Yeon-Joo, Cho, Young-Jae, Sang-Miin, Lee, Kyeongman, Jeon, Seok Chan Kim, Jongmin, Lee, Hyun Keun Chee, Jin Won Huh, Yun Su Sim, Junghyun, Kim, Youjin, Chang, Jong-Joon, Ahn, Byung Ju Kang, Won-Yeon, Lee, Seok Jeong Lee, Nehat, Baftiu, Ivasr, Krastins, Sonia, Stiban, Michel El Feghaly, Elie, Gharios, Marie, Merheb, Mohamed, Benlamin, Ala, Khaled, Wesal Ali Belkhair, Majd, Tabib, Firas, Ashour, Ahmed, Elhadi, Osama Wanees Emhemid Tababa, Taha, Khaled, Soad Imhmed, R Alkhumsi, Abdualhamid, I Alshrif, Ahmed Ali Aboufray, Aya, Alabuzidi, Ahmed Ramadan Triki, Mala, Elgammudi, Hajer Ben Zahra, Enas, Soula, Maram Milud Said Al-Alawi, Hazem, Ahmed, Mohamed Abdurazzag Ali Ghula, Saulius, Vosylius, Lucie, Mouton, Touraj, Rastegar, Claude, Sertznig, Gilles, Martin, Christian, Theisen, Christian, Ferretti, Fränk, Gils, Marc, Gallion, Asmah, Zainudin, Laila Kamaliah Kamalul Bahrin, Shanti Rudra Deva, Azmin Huda Abdul Rahim, Sherliza, Wahab, W Nazaruddin, W Hassan, Wan Nasrudin Wan Ismail, Mohd Nazri Ali, Tien Meng Khoo, Noryani Mohd Samat, Jenny May Geok Tong, Nik Azman Nik Adib, Mohd Basri Mat Nor, Shanthi, Ratnam, Nahla, Ismail, Siti Rohayah Sulaiman, Kit Weng Foong, Anita, Alias, Ngu Pei Hua, Jorge Macias Zermeno, Daniel, Blanco, Karely, Duran, Claudia Lizbeth Lopez Nava, San Juan Roman Nandyelly, Luis Alejandro Sanchez-Hurtado, Brigitte, Tejeda-Huezo, Mario Del Moral Armengol, Luis Pedro Ambriz Nava, Jorge Guerra Herrera, Gilberto Felipe Vazquez de Anda, Humberto, Gallegos-Perez, Nancy, Hernandez-Sanchez, Lucia, Hernandez-Ponce, Luis, Gorordo-Delsol, Marcos, Hernandez-Romero, Saira, Gomez, Fernando, Molinar, Silvio, A Ñamendys-Silva, Juan, P Romero-Gonzalez, Daira, Gonzalez, Antonio, Landaverde, Miguel Ángel Sosa, Berenice, Navarro, José Ivan Rodriguez de Molina Serrano, Sergio Reyes Iburrigarro, Alejandro, Ibarra, Joaquin, Aguirre, Mayra, Martinez-Gonzalez, Nayeli Rocio Cañas Padilla, Ana Alícia Velarde Pineda, Missael Vladimir Espinoza Villafuerte, María Ocotlan Gonzalez Herrera, Battsetseg, Baasanjav, Abdelhamid, Hachimi, Mina, Elkhayari, Tarek, Dendane, Nisha Bhandari Subedi, Sabina Dhakal Pathak, Meena, Manandhar, Laura Van Gulik, Mark Van Den Brink, Peter Van Vliet, Benjamin, Gerretsen, Lettie Van Den Berg, Marina De Haan, Binny, Tuinstra, Paul, Kuijpers, Jennifer, Reijntjens, Jan Wytze Vermeijden, Martin, Rinket, Margijske, Vanroest, Auke, Reidinga, Bert, Loef, Willem, Dieperink, Marisa, Onrust, Tom, Dormans, Laura, Bormans, Matty, Koopmans, Rik, T Gerritsen, Arlette Van Den Elst, Mirjam, Evers, Oscar, Oiting, Rob, Wilting, Bart, Ramaker, Mark van der Kuil, Jan-Willem, Fijen, Lenneke, Haas, Jasper, Haringman, Lynette, Newby, Eileen, Gilder, Danielle, Hacking, Rica, Dagooc, Rima, Song, Hansjoerg, Waibel, Frances, Dawn, Jackie, Rapley, Llesley, Chadwick, Carmel, Chapman, Petra, Crone, Jonathan, Albrett, Peter, Marko, Jennifer, Goodson, Troy, Browne, Richard, Whitticase, Cheryl, Davidson, Harriet, Judd, Daniel, Owens, Tonia, Onyeka, Innocent, Ugwu, Rose, Ilesanmi, Prisca Olabisi Adejumo, Afolabi, Owojuyigbe, Anthony, Adenekan, Stella, Uba, Christiana, Chime, Deborah, Jibrin, Babangida John Sankey, Oyebola, Adekola, Simeon, Olanipekun, Mirjana, Shosolcheva, Vanja, Gievski, Andrijan, Kartalov, Filip, Naumovski, Biljana, Kuzmanovska, Angela, Trposak, Zaneta, Bogoevska-Miteva, Rodney, Rosalia, Brita Fosser Olsen, Britt, Sjobo, Karianne Dale Jensen, Drammen, Sykehus, Birgitte Fosser Johansen, Esben, Straede, Edda, Johansen, Inger Johanne Finnstrom, Annette, Toellefsen, Hege, Ostenjo, Hege, Bjorgen, Bjorn, Bratsberg, Elin, Kristoffersen, Elin Mari Skorstad, Siri, Hansen, Sylvi, Vullum, Gro Anne Lunde, Wenche, Arntsen, Mette, Lund, Gro Ringstad Akselsen, Kristina Reinertsen Monstad, Ane, Stenset, Hanne, Haugom, Bjoern, Monsen, Lisa, Høgvall, Siw, Trudvang, Britt, Galaaen, Siv Karin Malmin, Marit Hildegunn Andersen, Rita Foss Hargott, Yvonne, Andersen, Elin, Steffenak, Marit, Nyhus, Barbro, Meland, Madiha, Hashmi, Noelia, Rivas, Elizabeth, Maidana, Alberto de Jesús Ortiz, Dolly Mabel Bordon Cabral, Marcelo, Simi, Cesar, Aponte, Juan Carlos Rivas, Sirley, Gill, Amilcar, Garcia, Gloria, Alvarenga, Laura, Cespedes, Hugo, Perez, Maria Liz Moreira, Fidelina, Canete, Roberto, Gonzalez, Natalia, Monges, Mary, Coman, Marcelo, Pederzani, Natalia, Franco, Ferdinand, Aganon, Regina, Martinez, Debbie, Noblezada-Uy, Chris Gerome Ellazar, Franklin Dean Cerezo, Jose Emmanuel Palo, Cristal April Jane Aperocho, Michael, Isanan, Marta, Tubacka, Przemyslaw, Jasiewicz, Miroslaw, Czuczwar, Michal, Borys, Aleksandra, Gutysz-Wojnicka, Lidia, Glinka, Ryszard, Gawda, Jan, Bilawicz, Paula, Cabrita, João, Vieira, Margarida Ferreira Figueiredo, Cristiana Mota Pinheiro, Nelson, Antunes, Laura, Pedro, Fatima, Ferreira, Isabel, Parente, Maria, Varela, Fatima, Fernandes, Claudia, Martins, Abel, Viveiros, Raquel, Cavaco, Clara Santa Rita, Sofia, Dias, Ana Margarida Feranandes, Pedro, Silva, Catarina, Nunes, João, Cabral, Filpe, Pires, Hilaryano, Ferreira, Jacinta, Santos, Vitor Manuel Vaz Pinto, Bruno Miguel Bispo, Amelia, Ferreira, Elena, Molinos, Estevão, Lafuente, Ricardo, Gregorio, Humberto, Costa, Ângela, Lima, Susana, Ferreira, Vanda, Seromenho, Eulália, Luis, Idália, Valerio, Helena, Cesar, Ana, Tavares, Ahmed Subhy Alsheikhly, Saeed, Mahmood, Catalin Traian Guran, Alida, Moise, Daniela Carmen Filipescu, Mihail, Luchian, Mihai, Popescu, Monica Adriana Scutariu, Cristina, Petrisor, Natalia, Hagau, Ioana, Grigoras, Tatiana, Patrichi, Vitaly, Gusarev, Alexandra, Pivkina, Vladimir, Kulakov, Olga, Ignatenko, Julia, Kovaleva, Trina, Zhivotneva, Marina, Zhedaeva, Nikita, Matiushkov, Olga, Ershova, Natalya, Egorova, Victoria, Khoronenko, Danil, Baskakov, Dmitry, Sergeev, Michael, Piradov, Liudmila, Grishina, Marat, Magomedov, Evgeniy, Zuev, Uri, Gorokhovatsky, Anna, Leonova, Liudmila, Fadeeva, Vladislav, Belskiy, Dmitriy, Galishevskiy, Nadezhda, Zubareva, Maksim, Tribulev, Oksana, Zueva, Alexander, Kiselev, Nikolaj, Kamenshchikov, Ekaterina, Tokareva, Maxim, Petrushin, Irina, Starchenko, Isaac, Nshimyumuremyi, Jerome, Muhizi, Egide, Buregeya, Josue, Nzarora, Amer, Assiri, Maie Salem Ebaid, Ghaleb, Almekhlafi, Yasser, Mandourah, Jelena, Velickovic, Dejan, Veličković, Bojan, Jovanovic, Adi, Hadzibegovic, Branislava, Stefanovic, Vanja, Misic, Vesna, Bumbasirevic, Marija, Rajković, Milena, Stojanovic, Srđan, Gavrilovic, Maja, Stanojević, Aktham, Yaghi, Anton, Turčan, Peter, Firment, Garri, Slobodianiuk, Daria, Rabarova, Danca, Lančaričová, Janko, Vlaovic, Matjaž, Groznik, Milica, Lukic, Janja, Perme, Maja, Sostaric, Nejc, Umek, Tomislav, Mirkovic, Simon, Dolenc, Misa, Fister, Nika, Zorko, Andrej, Markota, Nomhle Princess Yeni, Phumele, Jali, Shelley, Schmollgruber, Muhommed Ridwaan Syed, Nivisha, Parag, Robert, Wise, Maria, Galiana, José Alejandro Navarro, Ana María De Pablo, Patricia, Albert, Pilar, Martinez, Yolanda, Mendiara, Barbara, Garcia, Ana Alabart Llinas, Marilyn, Riveiro, Elisabet, Gallart, Alba, Riera, Miquel, Sanz, Swagotika, Salo, Miguel Angel Gimenez Lajara, Montserrat Venturas Nieto, Rosa, Garcia, José Manuel Garcia Pena, Maria Carmen Gorgolas, Maria Aranzazu Isasi, Rafael, Sierra, Federico, Gordo, Isabel, Conejo, Vicent, Salvà-Costa, Carolina, Garzón-Tovar, Sara, Lospitao, Rafael, Gonzalez, Pedro, Gutierrez, Mercè, Girona, Jordi, Adamuz, Pablo Garcia Olivares, José Peral Gutierrez de Ceballos, Celia, Tirado, Irene De Wit, Ana Belén Curto Polo, Maria Del Mar Diaz Salcedo, Javier, Ripolles-Melchor, Eugenio, Martinez-Hurtado, Jorge Duerto Alvarez, María Luisa Bravo Arcas, Juan Ignacio Torres Gonzalez, Ana Belén Sánchez de la Ventana, Pablo Lopez-Arcas Calleja, Raquel Garcia Alvarez, Purificacion Sanchez Zamora, Alvaro Ortega Guerrero, Rosario, Cosano, Jonathan, Perez-Vacas, Margarita, Campos-Perez, Emma Moreno Barreiro, Losune Cano Sanchez, Monica Garcia Diaz, Raquel, Jimenez, Lorena Del Rio Cabajo, Daniel Sancho Muriel, Helena Fernandez Alonso, Ana Wensell Fernández, Isabel Santín Piñan, Guillermo Muñiz Albaiceta, Maria Cristina Iglesias Fernandez, Francisco Javier Saenz Abos, Pablo, Monedero, Ramon Molina Chueca, Lydia Gallego Aguirre, Silvia Call Manosa, Carmen Partera Luque, Neus, Calpe, Monica Recio Losilla, Meritxell Tapia Fores, Olga, Farre, Oscar, Fernandez, M Del Rosario Villar Redondo, Donaldo, S Arteta Arteta, Maria Angeles Hurtado Sanchez, Cristina Paños Espinosa, Laura Martinez Reyes, Laura Claramunt Domenech, Carmen Velasco Guillén, Josep Trenado Alvarez, Mercedes Del Cotillo, Jesus Emilio Barrueco-Francioni, Belen Burgos Conde, Maria Pilar Sogues Blanco, Maria Luisa Blasco, Ana Isabel Clement, Clara, Hurtado, Luz Coronado Sanz, David, Perez-Torres, Estefanía, Prol-Silva, Jorge, Pereira, Iván Areán González, Anastasio Espejo Cano, Cesar Rodriguez Nuñez, Inmaculada Lorenzo Fernadez, Alejandra Azahara Marguello Fernandez, Rosa Del Bosque Diez, Badiola, Hilario, Begoña, Zalba-Etayo, Ana, Pascual-Bielsa, Preveen, Banwarie, Dick, Nahar, Alisha van Axel, Naraindath, N Boedjawan, Erika Backlund Jansson, Ann-Sofie, Malvemyr, Lotta, Johansson, Ulla, Sandberg, Catarina, Tingsvik, Gunilla, Mattsson, Gun, Löf, Martin, Spångfors, Mona, Ringdal, Sebastian, Geijer, Lotti, Orvelius, Mia, Hylen, Caroline, Lagerhäll, Eva, Åkerman, Viveca Hamback Hellkvist, Ulrica, Mickelsson, Ewa, Wahlbom, Ing-Marie, Larsson, Ewa, Wallin, Filippo, Boroli, Solenne, Ory, Margaret Lynn Jong, Alexander, Dullenkopf, Martin, Lang, Yvan, Fleury, Marianne, Maus, Nawfel, Ben-Hamouda, Anne, Fishman, Mei Yu Hsu, Shu Chuan Chang, Konlawij, Trongtratul, Chaiwut, Sawawiboon, Sunthiti, Morakul, Bodin, Khwannimit, Keevan, Singh, Dale, Ventour, Dianne, Figaro-Barclay, Sasha, Sankar-Maharaj, Mhamed Sami Mebazaa, Salma, Kamoun, Souheil, Elatrous, Lamia, Besbes, Fekri, Abroug, Walid, Naija, Youssef Zied Elhechmi, Walid, Sellami, Zied, Hajjej, Takoua, Merhabene, Imen, Talik, Ozlem Ozkan Kuscu, Ozcengiz, Dilek, Avşar, Zerman, Hayriye Cankar Dal, Sema, Turan, Semih, Aydemir, Hakan, Yilmaz, Duygu Kayar Calili, Seval, İzdes, Melike, Cengiz, Ayça, Gümüş, Banu, Taşdemir, Ali, Kağnıcı, Mustafa, Ay, Serap Avcı Ay, Gulbahar, Caliskan, Turkay, Akbas, Abidin Oner Balbay, Serdar, Efe, Volkan, Inal, Gülseren, Elay, Pınar, Karabacak, Boğaç, Özserezli, Evren, Şentürk, Oktay, Demirkiran, Suha, Bozbay, Elif, Erdogan, Mustafa, Akker, Nebia, Peker, Asu, Ozgultekin, Sibel Ocak Serin, Can, Turan, Gulsah, Karaoren, Senay, Goksu, Sait, Karakurt, Huseyin, Arikan, Fethi, Gül, İsmail, Cinel, Iskender, Kara, Hasan Nabi Undar, Yesim Serife Bayraktar, Jale Bengi Çelik, Murat Emre Tokur, Demet Tok Aydin, İsmail, Yildiz, Beysim, Özcan, Başar, Erdivanli, Ahmet, Eroglu, Devrim, Akdağ, Nurdan, Ünlü, Adonis, Dungca, Ashwaq, Ali, Bindu, Thankamma, Paul Eric Reyes, Sini, John, Ajitha, Rajendran, Fatima Kasem El Ahmad, Kathleen Ann Smiley, Susanna, Hojden, Mia Thorning Miller, Vishnu Das Sasidharan Nair, Maria Gracia San Antonio, Khaled Al Qawasmeh, Sabah Abu Shawish, Hilary, Twiggs, Ines, Rosado, Volodymyr, Babych, Faye, Morren, Charlotte, Young, Nicola, Vaughan-Jones, Stephanie, Harris, Karen, Burns, Carmel, Georgiev, Rosina, Shayamano, Ian, Kerslake, Peter, Creber, Ana, Vochin, Catherine, O'Brien, Paul, Caddell, Samantha, Hagan, Mandy, Hughes, Tomasz, Torlinski, James, Sherwin, Santhana, Kannan, Amber, Markham, Richard, Lebon, Jason, Cupitt, Julius, Cranshaw, Nigel, White, Victoria, Marriott, Wendy, Milner, Casiano Barrera Groba, Joao, Azoia, Petra, Polgarova, Shaly, George, Ritoo, Kapoor, Ceri, Lynch, Nathalie, Fox, Karen, Cranmer, Natalie, Fox, Thomas, Llewellym, Kelly, Matthews, Louise, Maltby, Jowena, Ibao, Karen, Boulton, Rachel, Jarman, Karen, Baxter, Ashok Sundai Raj, Arif, Moghal, Joanne, White, Suzanne, Barrowcliffe, Mark, Pulletz, Vaarisan, Ganeshalingam, Rosaleen, Baruah, Carole, Boulanger, Helen, Baker, Justin, Woods, Poe Poe Ei, Vongayi, Ogbeide, Paul, Hayden, Jennifer, Hughes, Madhu, Balasubramanian, Armorel, Salberg, Rajnish, Saha, Dagmar, Holmquist, Claire, Derbyshire, Neil, Smith, Elizabeth, Stones, Jane, Ademokun, Monica, Popescu, Maria Schofield Legorburo, Samantha, North, Carole, Brett, Helen, Jaundoo, Jayne, Craig, Simon, Whiteley, Clare, Howcroft, Liz, Wilby, Peter, Delve, David, Shaw, Karen, Williams, Ingeborg, D Welters, Jane, Mcmullen, Stephen, Brett, Leah, Flores, Treiza, Trueman-Dawkins, Mae, Templeton, John, Adams, Catherine, Smith, John, Prowle, Heather, Byers, Andrea, Mcdonnell, Bernd Oliver Rose, Rosie, Reece-Anthony, Luis, Mendes, Marcela, Vizcaychipi, Rhian, Bull, Grace, Lacaden, Eleanor, Santiago, Carlos Castro Delgado, Sarah, Farnell-Ward, Elaine, Thorpe, Justine, Somerville, Anne, Williams, Donna, Cummings, Helen, Derrick, Sarah, Brumwell, Claire, Randell, Nicola, Mccann, Emma, Aves, Gillian, Berry, Tamas, Szakmany, Una, Gunter, Paul, Pulak, Nikki, Sarkar, Kerry, Wright, Vitor, Gomes, Jones, Jo, Ruth, Palfrey, Julie, Camsooksai, Abby, Lewis, Antony, Eneas, Ascanio, Tridente, Louise, Barr, Beverley, Thomas, Emma, Parkin, Daniel, Horner, Christian, Frey, Suzanne, Bench, Rachel, Baumber, Phil, Broadhurst, Matthew, Jackson, Lynne, Williams, Michele, Clark, Jonathan, Paddle, Sarah, Bean, Sarah, Buckley, Christopher, Palfreeman, Sophie, Liu, Nicola, Allison, Ben, Attwood, Penny, Parsons, Victoria, Houghton, Sarah Jane Turner, David, Higgins, Egidija, Bielskute, Nicola, Horrigan, Reni, Jacob, Karen, Habgood, Ahmed, Zaki, Amy, Collins, Jenny, Lord, Charalice, Ramiro, Agnieszka, 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European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators, Muzha, D., Ribas, A.M., Lipovesty, F., Loudet, C., Coyer, F., Eller, P., Mostafa, N., Honoré, P.M., Telleria, V.M., Smajic, J., Nogueira, P.C., Nafees, KMK, Hentchoya, R., Rose, L., Soledad, J., Lin, F., Cardenas, Y., Reyes, A.G., Sustic, A., Mpouzika, M., Vymazal, T., Jensen, H.I., Aguirre-Bermeo, H., Maddison, L., Valta, M., Calvino-Gunther, S., Bloos, F., Adipa, F.E., Koulouras, V., Enamorado, J., Ágoston, Z., Birgisdóttir, H., Gupta, A., Gurjar, M., Kilapong, B., Hashemian, S.M., Martin-Loeches, I., Benbenishty, J., Cortegiani, A., Fletcher, K., Hayashi, Y., Waweru-Siika, W., Abidi, K., Lee, S.M., Hadri, B., Dolgusevs, M., Abillama, F.F., Jovaisa, T., Thix, C., Elhadi, M., Nor, B.M., Ratnam, S., Mazlan, M.Z., Maiyalagan, S., Sánchez-Hurtado, L., Belii, A., Naranpurev, M., Gautam, P., De Lange, D., Parke, R., Ilesanmi, R.E., Shosholcheva, M., Petosic, A., Lind, R., Ffarcsi, M.H., Bogarin, J., Hernandez, A.M., Mikaszewska-Sokolewicz, M., Sousa, B., Tomescu, D., Sandesc, D., Twagirumugabe, T., Gusarov, V., Ebaid, M., Jankovic, R., Slobodianiuk, G., Martonova, A., Knafelj, R., Mer, M., Maseda, E., Panka, B., Schefold, J.C., Joelsson-Alm, E., Trongtrakul, K., Merritt-Charles, L., Besbes, L.O., Dikmen, Y., Zgrzheblovska, L., Fielding, M., Rubulotta, F., Khanna, A.K., Saager, L., von der Osten, I., Greca, A., Cani, A., Xhindi, N., Hyska, G., Pinto, S., Alves, P., Esposito, R., Valgolio, E., Minope, JTS, Abdala, A., Ayala, M., Bravo, S., Bantar, A., Delgado, P., Badariotti, G., Lipovestky, F., Diaz, A., Saul, P., Setten, M., Aucapina, A., Acosta, Y., Gonzalez, V., Camputaro, L., Baccaro, F., Villa, R., Mastantuono, M., Dean, E., Rostello, O.F., Brizuela, P., Bartoli, J.R., Guereschi, M., Quiroga, C., Putruele, S., Villegas, P., Curilen, V., Fernandez, R., Nocheretti, M.G., Escalante, R.G., Loudet, C.I., Fernandez, S., Gonzalez, A.L., Alvarez, G.A., Iglesias, F., Chaparro, S., Zakalik, G., Pagella, G., Baini, M., Campos, P.A., Sabbag, I., Schmukler, A., Fonseca, I.P., Alvarez, G.M., Ramirez, M., Tapia, F., Bascary, C.A., Del Valle Gimenez, G., Bertoletti, F.P., Milioto, E., Bonsignore, PJM, Fernandez, M.A., Smith, J., Chimunda, T., Thompson, L., Maguire, T., Chaboyer, W., Watts, S., Mitchell, M., Powell, M., Lye, I., Parsons, L., Baker, N., Reynolds, C., Thompson, A., Masters, K., Sosnowski, K., Morrison, L., Leslie, G.D., Lakshmanan, R., Tabah, A., Brown, W., McDowell-Skaines, S., McLucas, A., Smith, C., Tallot, M., Jones, S., Barakat-Johnson, M., Leong, T., Butcher, R., Martin, K., Douschan, P., von Lewinski, D., Schmutz, R., Kolussi, U., Salman, F., Ateya, Z., De Decker, K., Van Regenmortel, N., Jans, A., Wijnands, P., Coremans, S., Honore, P.M., De Bels, D., Depuydt, T., Paillet, C., Jacquet, L.M., Swinnen, W., Hannes, F., Mergeay, M., Van de Velde, S., Allaert, S., Hoste, P., Borin, C., Balon, S., Fraipont, V., Biston, P., De Schryver, N., Dugernier, T., Van 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Yuan, C., Tan, L., Lin, Q., Guo, H., Yan, H., Xu, X., Zhang, W., Liang, J., Zhang, L., Tian, E., Zhao, Q., InSu, L., Dong, J., Gu, Y., Zhao, L., Qiao, H., Tuo, L., Lv, M., Zhu, J.Y., Zhu, J., Wei, Y., Liu, M., He, Y., Cheng, J., Liu, J., Jia, N., Wei, D., Wu, X., Duan, H., Lin, D., Liang, Q., Luo, X., Xiong, Y., Huang, R.F., Fu, J., Zan, T., Shi, Z., Long, Y., Lei, Y., Liu, X., Yumei, C., Wang, L., Zhang, Y., Xu, Y., Cheng, X., Zhijuan, W., Sun, C., Song, J., Wang, Y., Yuan, Y., Huang, Q., Yang, F., Wu, Y., Bai, X., Zheng, H., Song, M., Sun, Y., Li, Z., Luo, F., Li, L.C., Zhang, G., Xiao, L., Yu, T., Gao, G., Wei, W., Wang, F., Han, T., Li, T., Zeng, Q., Zeng, J.M., Pan, F., Wang, J., He, G., Chen, H., Zhang, F., Chao, Y., Chunhua, G., Yao, X., Bai, D., Liu, L., Liang, X., Zhang, N., Zhang, A., Hu, X., Zhang, H., Wang, R., Tak, P.S., Ho, S.W., Jiang, Q.X., Ding, X., Hong, L., Miao, L., Feng, Z., Huang, L., Wu, J., Guo, J., Zhang, B., Ma, C., Han, Y., Liu, C., Ding, M., Luan, L., Zheng, 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McPherson, S., Corcoran, A., Gordon, P., Rooney, G., Levy, D., Azencot, M., Gurevich, V., Lavy, A., Bendelari, V., Marconi, R., Barone, A., Gatti, C., Giampaoletti, A., Borgognoni, C., Ghioldi, D.M., Raimondo, A., Castiglione, G., Bruno, A.V., Rubulotta, G., Mo, A., Corso, A., Girianni, S., Bruni, A., Garofalo, E., Maggiore, S.M., Di Risio, A., Calamai, I., Spina, R., Spadaro, S., Volta, C.A., Cotoia, A., Mirabella, L., Maulicino, L., Abregal, G., Donvito, M., D'Ambrosio, P., Binda, F., Adamina, I., Galazzi, A., Negro, A., Vaschetto, R., Capuzzi, F., Boschetto, M., Stivanello, L., Bonaccorso, L., Megna, C., Iozzo, P., Rizzo, A., Scire, G., Taibi, M.R., Tranello, F.P., Manzo, A., Traina, L., Pastore, B., Quaini, A., Giusti, G.D., Montaldi, G., Piergentili, F., Mancini, F., Casaioli, S., Uccelli, F., Guarracino, F., Onelli, A., Di Gravio, V., Cossu, M., Matrona, O., Rocco, M., Alampi, D., Dellafiore, F., Ranalli, F., Bossolasco, M., Brizio, E., Migliorino, P., Cortellazi, P., Rosati, M., D'Ambrosio, F., Quagliotto, C., Roman-Pognuz, E., Peratoner, A., De Rosa, S., Martin, M.A., De Sanctis, F., Ciorba, P., Toppin, P., Harding-Goldson, H., Taito, S., Shime, N., Yamamoto, R., Kanda, F., Hirao, A., Egi, M., Noguchi, A., Hashimoto, S., Aya, U., Sakuramoto, H., Ohuchi, A., Kataoka, J., Maruyama, K., Nakayama, I., Nishime, Y., Fujimoto, K., Takahashi, K., Tsujimoto, M., Shimizu, M., Tole, E., Correia, M.C., Kim, J.H., Park, S., Kim, K.C., Baek, J., Bae, J.M., Park, S.Y., Park, T.S., Lee, H.B., Park, J., Yeon-Joo, L., Young-Jae, C., Jeon, K., Kim, S.C., Lee, J., Chee, H.K., Huh, J.W., Sim, Y.S., Kim, J., Chang, Y., Ahn, J.J., Kang, B.J., Lee, W.Y., Lee, S.J., Baftiu, N., Krastins, I., Stiban, S., Feghaly, M.E., Gharios, E., Merheb, M., Benlamin, M., Khaled, A., Belkhair, W.A., Tabib, M., Ashour, F., Elhadi, A., Tababa, OWE, Khaled, T., Alkhumsi, SIR, Alshrif, A.I., Aboufray, A.A., Alabuzidi, A., Triki, A.R., Elgammudi, M., Zahra, H.B., Soula, E., Al-Alawi, MMS, Ahmed, H., Ghula, MAA, Vosylius, S., Mouton, L., Rastegar, T., Sertznig, C., Martin, G., Theisen, C., Ferretti, C., Gils, F., Gallion, M., Zainudin, A., Bahrin, LKK, Deva, S.R., Rahim, AHA, Wahab, S., Hassan, WNW, Ismail, WNW, Ali, M.N., Khoo, T.M., Samat, N.M., Tong, JMG, Adib, NAN, Nor, MBM, Ismail, N., Sulaiman, S.R., Foong, K.W., Alias, A., Hua, N.P., Zermeno, J.M., Blanco, D., Duran, K., Nava, CLL, Nandyelly, SJR, Sanchez-Hurtado, L.A., Tejeda-Huezo, B., Del Moral Armengol, M., Nava, LPA, Herrera, J.G., de Anda, GFV, Gallegos-Perez, H., Hernandez-Sanchez, N., Hernandez-Ponce, L., Gorordo-Delsol, L., Hernandez-Romero, M., Gomez, S., Molinar, F., Ñamendys-Silva, S.A., Romero-Gonzalez, J.P., Gonzalez, D., Landaverde, A., Sosa, M.Á., Navarro, B., de Molina Serrano, JIR, Iburrigarro, S.R., Ibarra, A., Aguirre, J., Martinez-Gonzalez, M., Padilla, NRC, Pineda, AAV, Villafuerte, MVE, Herrera, MOG, Baasanjav, B., Hachimi, A., Elkhayari, M., Dendane, T., Subedi, N.B., Pathak, S.D., Manandhar, M., Van 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A.S., Goller, S., Afonso, E., Larina, E., Labeau, Sonia O. 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[0000-0003-2145-0345], Apollo - University of Cambridge Repository, Critical Care, Labeau S.O., Afonso E., Benbenishty J., Blackwood B., Boulanger C., Brett S.J., Calvino-Gunther S., Chaboyer W., Coyer F., Deschepper M., Francois G., Honore P.M., Jankovic R., Khanna A.K., Llaurado-Serra M., Lin F., Rose L., Rubulotta F., Saager L., Williams G., Blot S.I., Muzha D., Ribas A.M., Lipovesty F., Loudet C., Eller P., Mostafa N., Telleria V.M., Smajic J., Nogueira P.C., Nafees K.M.K., Hentchoya R., Soledad J., Cardenas Y., Reyes A.G., Sustic A., Mpouzika M., Vymazal T., Jensen H.I., Aguirre-Bermeo H., Maddison L., Valta M., Bloos F., Adipa F.E., Koulouras V., Enamorado J., Agoston Z., Birgisdottir H., Gupta A., Gurjar M., Kilapong B., Hashemian S.M., Martin-Loeches I., Cortegiani A., Fletcher K., Hayashi Y., Waweru-Siika W., Abidi K., Lee S.-M., Hadri B., Dolgusevs M., Abillama F.F., Jovaisa T., Thix C., Elhadi M., Nor B.M., Ratnam S., Mazlan M.Z., Maiyalagan S., Sanchez-Hurtado L., Belii A., 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Subjects: Male, Original, medicine.medical_treatment, artificial, Critical Care and Intensive Care Medicine, Medical and Health Sciences, Pressure ulcer, law.invention, Decubitus epidemiology, ICU, Morbidity, Mortality, Outcome, Pressure injury, Risk factors, Adult, Aged, Hospital Mortality, Humans, Patient Discharge, Prevalence, Risk Factors, Intensive Care Units, Respiration, Artificial, 0302 clinical medicine, decubitus epidemiology, pressure injury, pressure ulcer, outcome, risk factors, morbidity, mortality, law, Medicine and Health Sciences, adults, Medicine, Simplified Acute Physiology Score, icu, ziekenhuissterfte, Immunodeficiency, intensive care, European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators, mannen, volwassenen, COST, Intensive care unit, STATE, ULCERS, Underweight, medicine.symptom, Life Sciences & Biomedicine, Human, medicine.medical_specialty, risicofactoren, Decubitus epidemiology, ICU, Pressure injury, Pressure ulcer, Outcome, Risk factors, Morbidity, Mortality, pressure injuries, Intensive Care Unit, prevalentie, NO, 1117 Public Health and Health Services, DecubICUs Study Team, 03 medical and health sciences, Critical Care Medicine, Anesthesiology, General & Internal Medicine, Health Sciences, ouderen, Mechanical ventilation, Science & Technology, business.industry, decubitus, Risk Factor, 030208 emergency & critical care medicine, 1103 Clinical Sciences, Odds ratio, medicine.disease, Emergency & Critical Care Medicine, Confidence interval, 030228 respiratory system, Emergency medicine, kunstmatige ademhaling, RISK-FACTORS, business, respiration
Abstract: Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347, Funder: Flemish Society for Critical Care Nurses, Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score < 19, ICU stay > 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat.
Published: 2021
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43. Cortical Venous Changes on Susceptibility-Weighted Imaging Predict the Cerebral Collateral Circulation as Confirmed by Digital Subtraction Angiography

Author: Wei-Min Xiao, Cai-Qin Xie, Yong-Lin Liu, Wei-Dong Hu, Zhi-Qiang Wu, Yun-Hao Zhan, Gen-Pei Luo, Run-Xiong Li, and Yang-Kun Chen
Subjects: susceptibility weighted imaging, acute ischemic stroke, viruses, digital subtraction angiography, Occlusion, medicine, collateral circulation, RC346-429, skin and connective tissue diseases, Stroke, Original Research, medicine.diagnostic_test, business.industry, virus diseases, Magnetic resonance imaging, Digital subtraction angiography, asymmetrical cortical vessel sign, Cortical Vein, medicine.disease, Collateral circulation, Neurology, Susceptibility weighted imaging, Neurology (clinical), Neurology. Diseases of the nervous system, business, Nuclear medicine, Perfusion
Abstract: Objective: Asymmetrical cortical vein sign (ACVS) shown on susceptibility-weighted imaging (SWI) can reflect regional hypoperfusion. We investigated if ACVS could predict the cerebral collateral circulation (CC) as assessed by digital subtraction angiography (DSA) in acute ischemic stroke patients with ipsilateral severe stenosis/occlusion of the anterior circulation.Methods: Clinical data and imaging data of 62 acute ischemic stroke patients with ipsilateral severe stenosis or occlusion of the anterior circulation confirmed by DSA were collected retrospectively. Participants underwent magnetic resonance imaging, including an SWI sequence. ACVS was defined as more and/or larger venous signals in the cerebral cortex of one side of SWI than that in the contralateral side. ACVS was measured using the Alberta Stroke Program Early Computed Tomography score based on SWI. The grading of the cerebral CC was judged using DSA.Results: Of the 62 patients, 30 patients (48.4%) had moderate-to-severe ACVS. According to DSA assessment, 19 patients (30.6%) had a good CC (grade 3–4), and 43 (69.4%) patients had a poor-to-moderate CC (grade 0–2). Among the 30 patients with moderate-to-severe ACVS, only three (10%) patients had a good CC, and 27 (90%) patients had a poor-to-moderate CC; among the 32 patients with none or mild ACVS, 16 (50%) of them had a good CC, and the other 50% had a moderate-to-severe CC. We constructed two logistic regression models with ACVS grading and none or mild ACVS entered into the models, respectively, together with age and large-artery occlusion. In model 1, no ACVS (compared with severe ACVS; OR = 40.329, 95%CI = 2.817–577.422, P = 0.006), mild ACVS (compared with severe ACVS; OR = 17.186, 1.735–170.224, 0.015) and large-artery occlusion (OR = 45.645, 4.603–452.592, 0.001) correlated with a good CC. In model 2, none or mild ACVS (OR = 36.848, 95%CI = 5.516–246.171, P < 0.001) was significantly associated with a good CC as judged by DSA, adjusted by age and large-artery occlusion.Conclusions: Cortical venous changes in SWI may be a useful indicator for the cerebral CC as confirmed by DSA.
Published: 2021

44. Benefits and Safety of Chinese Herbal Medicine in Treating Psoriasis: An Overview of Systematic Reviews

Author: Jie Zhang, Qianying Yu, Li Peng, Yuesi Qin, Mingyi Jing, Dan Huang, Jing Guo, Min Xiao, and Mingling Chen
Subjects: medicine.medical_specialty, media_common.quotation_subject, PRISMA, RM1-950, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, AMSTAR-2, 0302 clinical medicine, systematic review, Randomized controlled trial, law, Psoriasis, medicine, Pharmacology (medical), Quality (business), 030212 general & internal medicine, Intensive care medicine, Adverse effect, media_common, grade, Pharmacology, Protocol (science), business.industry, psoriasis, medicine.disease, Checklist, ROBIS, Systematic review, Chinese herbal medicine, Therapeutics. Pharmacology, business, Western medicine
Abstract: Background: In recent years, systematic reviews/meta-analyses (SRs/MAs) of Chinese herbal medicine (CHM) for psoriasis have continuously emerged. Their methods and evidence quality, however, are yet to be evaluated, and whether their conclusions can provide clinicians with reliable evidence is still debatable.Objectives: This overview aims to evaluate the methodological quality, risk of bias, and reporting quality of relevant SRs/MAs, as well as the current evidence of CHM for treating psoriasis.Methods: We searched nine electronic databases from their respective time of establishment to January 20, 2021, as well as the reference lists of the included SRs/MAs, protocol registries, and gray literature. Two reviewers independently used the following: A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2, Risk of Bias in Systematic Reviews (ROBIS), the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and Grades of Recommendations, Assessment, Development and Evaluation (GRADE) to evaluate the methodological quality, risk of bias, reporting quality, and evidence quality of the included SRs/MAs.Results: This review included 14 SRs/MAs involving 45 outcomes, of which 12 (85.71%) SRs/MAs had a very low quality evaluated by AMSTAR 2 and 7 (50.00%) SRs/MAs had a high risk of bias assessed by ROBIS. The protocol and registration and funding statements were the major reporting flaws according to the PRISMA checklist. The evaluation with the GRADE system demonstrated no outcome of high-quality evidence, and inconsistent efficacy evaluations were found in this overview. Only 15 (33.33%) outcomes were moderate-quality evidence, supporting the claim that CHM plus Western medicine (WM) was superior to WM. Generally low quality of evidence showed no difference in the incidence of adverse events between the combined therapy and WM. However, the conclusion that CHM was superior to WM cannot be drawn due to the inconsistent results.Conclusion: Despite that CHM has the potential benefit and safety in the adjuvant treatment of psoriasis, the conclusion should be treated with caution because of the generally low quality of methodology and evidence. In the future, high-quality randomized controlled trials (RCTs) should be carried out, and the quality of relevant SRs should also be improved to promote their clinical application.
Published: 2021

45. Towards On-Demand Heralded Single-Photon Sources via Photon Blockade

Author: Haodong Wu, Tao Li, Jiangshan Tang, Min Xiao, Hui Sun, Keyu Xia (夏可宇), Han Zhang, Yang Wu, Lei Tang, and Yanqing Lu (陆延青)
Subjects: Physics, Quantum Physics, Photon, business.industry, FOS: Physical sciences, Physics::Optics, General Physics and Astronomy, 02 engineering and technology, 021001 nanoscience & nanotechnology, Laser, 01 natural sciences, law.invention, law, Nonlinear medium, On demand, Yield (chemistry), 0103 physical sciences, Optoelectronics, Quantum Physics (quant-ph), 010306 general physics, 0210 nano-technology, business, Excitation
Abstract: Spontaneous parametric down-conversion (SPDC) in a laser pumped optical nonlinear medium can produce heralded single photons with a high purity but a very low yield. Improving the yield by increasing the pump power in SPDC inevitably reduces the purity due to excitation of multi-photon events. We propose a scheme to overcome this purity-yield trade-off by suppressing multi-photon events in a cavity-enhanced SPDC via the photon blockade effect. By introducing a strong photon-photon interaction into the intracavity medium and increasing the pump power, we can improve the available single-photon yield to larger than $90\%$, while maintaining a high purity of $99\%$, towards on-demand generation of single photons through the SPDC process. Our quasi-on-demand SPDC sources may boost single-photon-based quantum information technology.
Published: 2021

46. Severity of Lesions Involving the Cortical Cholinergic Pathways May Be Associated With Cognitive Impairment in Subacute Ischemic Stroke

Author: Yang-Kun Chen, Zhi-Qiang Wu, Jian-Feng Qu, Dong-Hai Qiu, Wei-Min Xiao, Huo-Hua Zhong, Yong-Lin Liu, and Wen-Cong Liang
Subjects: 0301 basic medicine, medicine.medical_specialty, brain MRI, cortical cholinergic pathways, 03 medical and health sciences, 0302 clinical medicine, Informant Questionnaire on Cognitive Decline in the Elderly, Internal medicine, Medicine, Dementia, Vascular dementia, RC346-429, Stroke, Depression (differential diagnoses), Original Research, cognitive impairment, business.industry, white matter lesions, Neuropsychology, medicine.disease, stroke, Hyperintensity, 030104 developmental biology, Neurology, Neurology. Diseases of the nervous system, Neurology (clinical), Verbal memory, business, 030217 neurology & neurosurgery
Abstract: Purpose: Impairment of cortical cholinergic pathways (CCP) is an important risk factor for chronic vascular cognitive impairment. However, this phenomenon has rarely been studied in post-stroke cognitive impairment (PSCI). We investigated the relationship between PSCI and CCP lesions assessed by structural magnetic resonance imaging (MRI).Patients and methods: We prospectively enrolled 103 patients within 7 days of ischemic stroke onset. CCP was measured by the cholinergic pathways hyperintensities scale (CHIPS), which semiquantitatively grades MR lesions strategically located on the CCP identified in human brains. We also measured other MRI parameters, including the location and volumes of acute infarcts, cerebral microbleeds, medial temporal lobe atrophy, and white matter lesions. Neuropsychological assessments were performed using the 60-min modified vascular dementia battery (VDB) at 3 months after the index stroke, and PSCI was defined according to VDB as well as ADL.Results: Of all 103 patients, 69 men (67.0%) and 34 women (33.0%) with a mean age of 57.22 ± 12.95 years, 55 patients (53.4%) were judged to have PSCI at 3 months, including 43 (41.7%) patients with PSCI-no dementia and 12 (11.7%) patients with poststroke dementia. According to the VBD assessment, the most commonly impaired cognitive domain was visuomotor speed (27.2%) followed by verbal memory (25.2%). Univariate analysis showed that patients with PSCI were older; had higher informant questionnaire on cognitive decline in the elderly (IQCODE) scores; had more frequent previous stroke history and atrial fibrillation; and had higher CHIPS scores, more severe white matter lesions, and medial temporal lobe atrophy. PSCI patients also had higher depression scores at 3 months. In the multivariate regression analysis, age, IQCODE score, CHIPS score, and Hamilton depression rating scale score were independent predictors of PSCI. Ordinal regression analysis for risk factors of poor functional outcomes revealed that IQCODE scores and cognitive function status were related to mRS score at 3 months after stroke.Conclusion: In patients with early subacute ischemic stroke, the severity of lesions involving the CCP may be associated with cognitive impairment at 3 months.Clinical Trial Registration: Chinese Clinical Trial Registry, identifier: ChiCTR1800014982.
Published: 2021
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47. The acute effects of particulate matter air pollution on ambulatory blood pressure: A multicenter analysis at the hourly level

Author: Ya Gao, Weidong Wang, Min Xiao, Haidong Kan, Renjie Chen, Jialu Hu, Junbo Ge, Xiaowei Xue, and Zhaoqiang Cui
Subjects: Fine particulate matter, Distributed lag, medicine.medical_specialty, Mean arterial pressure, Ambulatory blood pressure, Air pollution, Blood Pressure, medicine.disease_cause, complex mixtures, Coarse particulate matter, Interquartile range, Internal medicine, Air Pollution, medicine, Humans, GE1-350, General Environmental Science, Air Pollutants, business.industry, Environmental Exposure, Particulates, Blood Pressure Monitoring, Ambulatory, Multicenter study, Pulse pressure, Environmental sciences, Blood pressure, Cardiology, Particulate Matter, business
Abstract: Epidemiological evidence from ambulatory blood pressure monitoring is needed to clarify the associations of particulate air pollution with blood pressure and potential lag patterns. We examined the associations of fine and coarse particulate matter (PM2.5, PM2.5–10) with ambulatory blood pressure among 7108 non-hypertensive participants from 7 Chinese cities between April 2016 and November 2020. Hourly concentrations of PM2.5 and PM2.5–10 were obtained from the nearest monitoring stations. We measured four blood pressure indicators, including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure (PP). Linear mixed-effect models combined with distributed lag models were applied to analyze the data. Generally, very short-term exposure to PM2.5 was significantly associated with elevated blood pressure. These effects occurred on the same hour of blood pressure measurement, attenuated gradually, and became insignificant approximately at lag 12 h. An interquartile range (IQR, 33 μg/m3) increase of PM2.5 was significantly associated with cumulative increments of 0.58 mmHg for SBP, 0.31 mmHg for DBP, 0.38 mmHg for MAP, and 0.33 mmHg for PP over lag 0 to 12 h. The exposure–response relationship curves were almost linear without thresholds, but tended to be flat at very high concentrations. No significant associations were observed for PM2.5–10. Our study provides independent and robust associations between transient PM2.5 exposure and elevated blood pressure within the first 12 h, and reinforces the evidence for a linear and non-threshold exposure–response relationship, which may have implications for blood pressure management and hypertension prevention in susceptible population.
Published: 2021

48. Coexistence of acne inversa with psoriasis and Dowling-Degos disease harboring impaired PSENEN-Notch signaling

Author: Xue-Min Xiao, Peng-Jun Zhou, Chang-Hua Zhu, Li-Hang Lin, Jing-Jing Liu, Yue Han, and Li-Shao Guo
Subjects: medicine.medical_specialty, Dowling-Degos Disease, business.industry, Skin Diseases, Papulosquamous, lcsh:R, Notch signaling pathway, Membrane Proteins, Skin Diseases, Genetic, lcsh:Medicine, General Medicine, medicine.disease, Dermatology, Hidradenitis Suppurativa, Hyperpigmentation, Psoriasis, Correspondence, medicine, Humans, Amyloid Precursor Protein Secretases, business, Acne
Published: 2020

49. Beyond cheap talk: management's informative tone in corporate disclosures

Author: Jiaxing You, Min Xiao, Huiying Wu, and Maoliang Li
Subjects: 050208 finance, Earnings, business.industry, 05 social sciences, Economics, Econometrics and Finance (miscellaneous), Institutional investor, Accounting, 050201 accounting, Tone (literature), Cheap talk, 0502 economics and business, Accounting information system, Cash flow, Business, China, Emerging markets, Finance
Abstract: This study investigates the information content of Management Discussion and Analysis (MD&A) reports of listed Chinese companies. We develop a Chinese word dictionary and measure the tones of MD&As. Our results indicate that tone is positively associated with future earnings and is particularly useful when a firm's future prospect is uncertain, accounting information is difficult to understand, or board monitoring is strong. Further analyses show that tone also predicts future cash flow, future sales growth, market reactions, analysts’ revisions, and institutional investors’ shareholdings. Together, we provide robust evidence that in emerging markets such as China, management tone conveys valuable information beyond cheap talk.
Published: 2019

50. Monolithic all-perovskite tandem solar cells with 24.8% efficiency exploiting comproportionation to suppress Sn(ii) oxidation in precursor ink

Author: Yuan Gao, Chunfeng Zhang, Renxing Lin, Makhsud I. Saidaminov, Qiaolei Han, Min Xiao, Jun Xu, Ke Xiao, Zhengyuan Qin, Jia Zhu, Edward H. Sargent, Mingyang Wei, Hairen Tan, and Aidong Li
Subjects: Materials science, Maximum power principle, Energy Engineering and Power Technology, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Metal, Photovoltaics, Perovskite (structure), Tandem, Renewable Energy, Sustainability and the Environment, business.industry, Photovoltaic system, Comproportionation, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Fuel Technology, chemistry, visual_art, visual_art.visual_art_medium, Optoelectronics, 0210 nano-technology, business, Tin
Abstract: Combining wide-bandgap and narrow-bandgap perovskites to construct monolithic all-perovskite tandem solar cells offers avenues for continued increases in photovoltaic (PV) power conversion efficiencies (PCEs). However, actual efficiencies today are diminished by the subpar performance of narrow-bandgap subcells. Here we report a strategy to reduce Sn vacancies in mixed Pb–Sn narrow-bandgap perovskites that use metallic tin to reduce the Sn4+ (an oxidation product of Sn2+) to Sn2+ via a comproportionation reaction. We increase, thereby, the charge-carrier diffusion length in narrow-bandgap perovskites to 3 μm for the best materials. We obtain a PCE of 21.1% for 1.22-eV narrow-bandgap solar cells. We fabricate monolithic all-perovskite tandem cells with certified PCEs of 24.8% for small-area devices (0.049 cm2) and of 22.1% for large-area devices (1.05 cm2). The tandem cells retain 90% of their performance following 463 h of operation at the maximum power point under full 1-sun illumination. Improvements in the efficiency and stability of low-bandgap perovskite solar cells are key to enabling all-perovskite solar cells. Here, Lin et al. use metallic tin to prevent oxidation in such low-gap perovskite and demonstrate 24.8%-efficient tandems that are stable for over 400 h under operating conditions.
Published: 2019

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