1. Impact of ABO and Rhesus blood groups on COVID-19 susceptibility and severity: A case-control study
- Author
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Albert Riachy, Fadi Nasr, Elio Mekhael, Anthony Kerbage, Sara F. Haddad, Moussa Riachy, Karim Hoyek, Ghassan Sleilaty, Lewis Nasr, and Nabil Nassim
- Subjects
medicine.medical_specialty ,ABO ,Coronavirus disease 2019 (COVID-19) ,Population ,Rhesus ,Positive control ,severity ,Gastroenterology ,Group A ,blood groups ,susceptibility ,ABO Blood-Group System ,Disease severity ,COVID‐19 ,Virology ,Internal medicine ,ABO blood group system ,Statistical significance ,medicine ,Humans ,education ,Research Articles ,Retrospective Studies ,education.field_of_study ,business.industry ,SARS-CoV-2 ,pandemic ,Case-control study ,COVID-19 ,Infectious Diseases ,Case-Control Studies ,business ,Research Article - Abstract
Early evidence from China suggested that blood groups may be involved in susceptibility to COVID‐19. Several subsequent studies reported controversial results. We conducted a retrospective matched case‐control study that aims to investigate the association between blood groups and the risk and/or severity of COVID‐19. We compared the blood groups distribution of 474 patients admitted to the hospital for COVID‐19 between March 2020 and March 2021, to that of a positive control group of outpatients infected with COVID‐19 and matched them for sex and age, as well as to the distribution in the general population. Three hundred and eighteen HC+ pairs with available blood group information were matched. The proportion of group A Rh+ in hospitalized patients (HC+) was 39.9% (CI 35.2%–44.7%), compared to 44.8% (CI 39.8%–49.9%) and 32.3% in the positive outpatient controls (C+) and the general population (C−), respectively. Both COVID‐19‐positive groups (HC+ and C+) had significantly higher proportions of group A Rh+ compared to the general population (p = 0.0019 and p
- Published
- 2021