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At the clinical department of Dermatology at the Medical University Hospital in Graz, approximately 30 outpatients consult the pigmented lesion clinic each day. During the visit, the patients are asked to complete a questionnaire, which is necessary, both for the clinical information system and for a scientific database for research in skin cancer. However, motorically and visually handicapped people usually have problems in completing paper based questionnaires. Consequently, a system was built, using a mobile touch computer with a specially designed interface, in order to assist these people and to allow full mobility within the clinical department, as well as the possibility of completing questionnaires, for example: during a cancer survey even in the open-air swimming resort. The system was developed by applying a User Centered Design including four levels: paper mock-up studies, low-fi prototypes, hi-fi prototypes and the system in real life. Scientifically this work provided insights into the technical possibilities, Human-Computer Interaction and Usability Engineering, user acceptance in the clinical field and the possible optimization potential of clinical workflows