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Most commercially available optical see-through head-mounted displays (OST-HMDs) utilize optical combiners to simultaneously visualize the physical background and virtual objects. The displayed images perceived by users are a blend of rendered pixels and background colors. Enabling high fidelity color perception in mixed reality (MR) scenarios using OST-HMDs is an important but challenging task. We propose a real-time rendering scheme to enhance the color contrast between virtual objects and the surrounding background for OST-HMDs. Inspired by the discovery of color perception in psychophysics, we first formulate the color contrast enhancement as a constrained optimization problem. We then design an end-to-end algorithm to search the optimal complementary shift in both chromaticity and luminance of the displayed color. This aims at enhancing the contrast between virtual objects and the real background as well as keeping the consistency with the original displayed color. We assess the performance of our approach using a simulated OST-HMD environment and an off-the-shelf OST-HMD. Experimental results from objective evaluations and subjective user studies demonstrate that the proposed approach makes rendered virtual objects more distinguishable from the surrounding background, thereby bringing a better visual experience.

Objective Advanced age is associated with a higher risk of both pain and dementia, with many studies finding that dementia often heightens sensitivity to pain. Vascular dementia (VaD) is the second most common type of dementia. Only a few observational or retrospective studies have examined pain responsiveness in VaD, suggesting that it could increase pain unpleasantness (i.e., pain affect). This study compared thermal pain psychophysics between a cohort of patients with VaD and healthy control (HC) subjects. Design Single-center, cross-sectional, between-subjects design. Subjects Verbally communicative patients with probable VaD (n = 23) and age- and sex-matched HCs (n = 23). Methods A thermal psychophysics protocol assessed “mild pain” and “moderate pain” thresholds (temperature in degrees Celsius) and associated unpleasantness ratings (0–20 scale) in both the VaD and HC groups. Psychophysics were compared between groups by way of a mixed-effects analysis, controlling for depressive symptoms. Results There were no significant differences between groups for pain thresholds (main effect P = 0.086, Cohen’s d: mild = 0.55, moderate = 0.27). However, unpleasantness ratings were higher in the VaD group than in the HC group (main effect P = 0.003; mild pain P = 0.022, Cohen’s d = 0.79; moderate pain P = 0.057, Cohen’s d = 0.6). Conclusions These results are consistent with prior observational findings suggesting that VaD could make patients more susceptible to pain, particularly its affective component.

Heinrich Muller was a nineteenth-century German retinal anatomist who, during his short career, was one of the discoverers of the rod photopigment rhodopsin and neuroglia in the retina, now known as Muller cells. He also described the ocular muscles and double foveae of some birds. An important, but largely neglected, insight by Muller was to combine careful psychophysical measurements and geometrical optics to find the location of the photosensitive layer of the retina in the living eye. Here, we provide translated passages from Muller's (1855) publication and compare his entoptic observations with retinal imaging using optical coherence tomography. Muller correctly deduced from his careful experiments that vision is initiated in the photoreceptors located in the back of the retina.

Visual perception of surfaces is of utmost importance in everyday life. Therefore, it comes naturally, that different surface structures evoke different visual impressions in the viewer even if the material underlying these surface structures is the same. This topic is especially virulent for manufacturing processes in which more than one stakeholder is involved, but where the final product needs to meet certain criteria. A common practice to address such slight but perceivable differences in the visual appearance of structured surfaces is that trained evaluators assess the samples and assign a pass or fail. However, this process is both time consuming and cost intensive. Thus, we conducted two studies to analyze the relationship between physical surface structure parameters and participants visual assessment of the samples. With the first experiment, we aimed at uncovering a relationship between physical roughness parameters and visual lightness perception while the second experiment was designed to test participants' discrimination sensitivity across the range of stimuli. Perceived lightness and the measured surface roughness were nonlinearly related to the surface structure. Additionally, we found a linear relationship between the engraving parameter and physical brightness. Surface structure was an ideal predictor for perceived lightness and participants discriminated equally well across the entire range of surface structures.

Anomalous trichromacy is a form of color vision deficiency characterized by the presence of three cone types, but with shifted spectral sensitivities for L or M cones, causing a red-green color deficiency. However, long-term adaptation to this impoverished opponent input may allow for a more normal color experience at the suprathreshold level (“compensation”). Recent experimental evidence points to the presence of compensation in some tasks. The current study used threshold detection, suprathreshold contrast matching, and a reaction-time task to compare contrast coding in normal and anomalous observers along the cardinal cone-opponent axes. Compared to color normals, anomals required more L-M contrast, but not S contrast, to detect stimuli and to match an achromatic reference stimulus. Reaction times were measured for several contrast levels along the two cone-opponent axes. Anomals had higher overall reaction times, but their reaction-time versus contrast functions could be matched to those of controls simply by scaling contrast by the detection thresholds. Anomalous participants were impaired relative to controls for L-M stimuli in all three tasks. However, the contrast losses were three times greater for thresholds and reaction times than for suprathreshold matches. These data provide evidence for compensation in anomalous trichromats, but highlight the role that the experimental task plays in revealing it.

Sensory processing necessitates discarding some information in service of preserving and reformatting more behaviorally relevant information. Sensory neurons seem to achieve this by responding selectively to particular combinations of features in their inputs, while averaging over or ignoring irrelevant combinations. Here, we expose the perceptual implications of this tradeoff between selectivity and invariance, using stimuli and tasks that explicitly reveal their opposing effects on discrimination performance. We generate texture stimuli with statistics derived from natural photographs, and ask observers to perform two different tasks: Discrimination between images drawn from families with different statistics, and discrimination between image samples with identical statistics. For both tasks, the performance of an ideal observer improves with stimulus size. In contrast, humans become better at family discrimination but worse at sample discrimination. We demonstrate through simulations that these behaviors arise naturally in an observer model that relies on a common set of physiologically plausible local statistical measurements for both tasks., Visual processing necessitates both extracting and discarding information. Here, the authors use a specialized set of stimuli and two complementary discrimination tasks to demonstrate the opposing perceptual implications of these two aspects of information processing.

The present work analyses the effect of three spatial filters, modelling the psychophysics data on brightness perception, when applied to a difficult computer vision problem. This pertains to the automatic grain-matrix segmentation of cross-polar images of sedimentary rock thin sections, gathered through petrographic microscopy. These three filters are assumed to be modelling three modes of vision, viz. vision-at-a-glance (VG, through Magnocellular or M channel in primate visual pathway), vision-in-strong-contrast mode (VSC, through Parvocellular or P channel of visual pathway), and vision-with-scrutiny (VS, through Magno-Parvochannels combined referred as the PM filter). The aforementioned biologically inspired filters related to brightness–contrast modelling are applied on the cross-polar microscopic images. Then binary segmentation is performed on the original, as well as the filtered, images using a k-means clustering algorithm which effectively segment the input images according to the homogeneity present. The binary segmented output when compared with our manually built grain-matrix segmented ground truth using suitable indices, forecasts noticeable difference in terms of the applied filter on them and the grain size distribution in that image, manifested sometimes by the resolution scale of capturing the image. Mostly for images with higher resolution of microscope lens while capturing, or for images displaying larger grain size, the PM filtered image has shown better grain-matrix segmentation, though the effect of filtering is not very pronounced for such images. On the other hand, for lower resolution of microscope lens for capturing the image or for smaller grain size featured images, the P filtered image has consistently shown more accurate grain-matrix aggregation result as also distinct improvement over those not filtered. The novelty of the approach lies in the application of a psychophysics model that attempts to mimic the manual segmentation performed by the trained eye of the expert in various visual modes. The proposed method achieves a reasonably higher accuracy in grain segmentation when compared with relevant existing methods especially while dealing with more difficult images containing many small-sized grains.

Humans and animals rely on accurate object size perception to guide behavior. Object size is judged from visual input, but the relationship between an object's retinal size and its real-world size varies with distance. Humans perceive object sizes to be relatively constant when retinal size changes. Such size constancy compensates for the variable relationship between retinal size and real-world size, using the context of recent retinal sizes of the same object to bias perception towards its likely real-world size. We therefore hypothesized that object size perception may be affected by the range of recently viewed object sizes, attracting perceived object sizes towards recently viewed sizes. We demonstrate two systematic biases: a central tendency attracting perceived size towards the average size across all trials, and a serial dependence attracting perceived size towards the size presented on the previous trial. We recently described topographic object size maps in the human parietal cortex. We therefore hypothesized that neural representations of object size here would be attracted towards recently viewed sizes. We used ultra-high-field (7T) functional MRI and population receptive field modeling to compare object size representations measured with small (0.05–1.4°diameter) and large objects sizes (0.1–2.8°). We found that parietal object size preferences and tuning widths follow this presented range, but change less than presented object sizes. Therefore, perception and neural representation of object size are attracted towards recently viewed sizes. This context-dependent object size representation reveals effects on neural response preferences that may underlie context dependence of object size perception.

To provide immersive haptic experiences, proxy-based haptic feedback systems for virtual reality (VR) face two central challenges: (1) similarity, and (2) colocation. While to solve challenge (1), physical proxy objects need to be sufficiently similar to their virtual counterparts in terms of haptic properties, for challenge (2), proxies and virtual counterparts need to be sufficiently colocated to allow for seamless interactions. To solve these challenges, past research introduced, among others, two successful techniques: (a) Dynamic Passive Haptic Feedback (DPHF), a hardware-based technique that leverages actuated props adapting their physical state during the VR experience, and (b) Haptic Retargeting, a software-based technique leveraging hand redirection to bridge spatial offsets between real and virtual objects. Both concepts have, up to now, not ever been studied in combination. This paper proposes to combine both techniques and reports on the results of a perceptual and a psychophysical experiment situated in a proof-of-concept scenario focused on the perception of virtual weight distribution. We show that users in VR overestimate weight shifts and that, when DPHF and HR are combined, significantly greater shifts can be rendered, compared to using only a weight-shifting prop or unnoticeable hand redirection. Moreover, we find the combination of DPHF and HR to let significantly larger spatial dislocations of proxy and virtual counterpart go unnoticed by users. Our investigation is the first to show the value of combining DPHF and HR in practice, validating that their combination can better solve the challenges of similarity and colocation than the individual techniques can do alone.

Reflectance, lighting and geometry combine in complex ways to create images. How do we disentangle these to perceive individual properties, such as surface glossiness? We suggest that brains disentangle properties by learning to model statistical structure in proximal images. To test this hypothesis, we trained unsupervised generative neural networks on renderings of glossy surfaces and compared their representations with human gloss judgements. The networks spontaneously cluster images according to distal properties such as reflectance and illumination, despite receiving no explicit information about these properties. Intriguingly, the resulting representations also predict the specific patterns of ‘successes’ and ‘errors’ in human perception. Linearly decoding specular reflectance from the model’s internal code predicts human gloss perception better than ground truth, supervised networks or control models, and it predicts, on an image-by-image basis, illusions of gloss perception caused by interactions between material, shape and lighting. Unsupervised learning may underlie many perceptual dimensions in vision and beyond., Storrs et al. train unsupervised generative neural networks on glossy surfaces and show how gloss perception in humans may emerge in an unsupervised fashion from learning to model statistical structure.

BackgroundThe long-term recovery rate for coronavirus disease 2019 related chemosensory disturbances has not yet been clarified.MethodsOlfactory and gustatory functions were assessed with psychophysical tests in patients in the first seven days from coronavirus disease 2019 onset and one, two, three and six months after the first evaluation.ResultsA total of 300 patients completed the study. The improvement in olfactory function was significant at the two-month follow up. At the end of the observation period, 27 per cent of the patients still experienced a persistent olfactory disturbance, including anosmia in 5 per cent of cases. As for taste, the improvement in the psychophysical scores was significant only between the baseline and the 30-day control. At the 6-month evaluation, 10 per cent of the patients presented with a persistent gustatory disturbance with an incidence of complete ageusia of 1 per cent.ConclusionSix months after the onset of coronavirus disease 2019, about 6 per cent of patients still had a severe persistent olfactory or gustatory disturbance.

Introduction: Positive dysphotopsia (PD) is a topic of great interest in intraocular lens (IOL) field. Several approaches have been developed from the physics, psychophysics and psychometry fields to measure PD. However, the complexity of characterizing this phenomenon and the lack of standardization have resulted in a considerable bias between studies that avoid its inclusion in systematic reviews and meta-analysis. Areas Covered: The purposes of this review were first to suggest a definition and classification of PD that minimize the bias between studies that use different questions to rate PD prevalence. Second, to describe the limitations found in psychophysical studies. Finally, to identify the associations between photic phenomena (PP) and the design of monofocal and multifocal IOLs. A non-systematic literature review was conducted from the last 30 years. Expert Opinion: PD can be defined as any bothering bright artifact perceived by patients along or around direct bright lights or reflected over objects located in the visual field. If the patient is not bothered by the artifact, the term PP should be used instead. Psychophysical approaches measure PP and not PD. Whereas LED approaches are preferable, these really measure Light Disturbance because the classification of PP cannot be differentiated.

This paper describes the creation and testing of a prototype device for rendering texture, using a touch-sensitive surface consisting of a linear soft potentiometer (LSP) attached to a 3D-printed p...

Perceiving the temporal regularity in a sequence of repetitive sensory events facilitates the preparation and execution of relevant behaviors with tight temporal constraints. How we estimate temporal regularity from repeating patterns of sensory stimuli is not completely understood. We developed a decision-making task in which participants had to decide whether a train of visual, auditory, or tactile pulses, had a regular or an irregular temporal pattern. We tested the hypothesis that subjects categorize stimuli as irregular by accumulating the time differences between the predicted and observed times of sensory pulses defining a temporal rhythm. Results suggest that instead of waiting for a single large temporal deviation, participants accumulate timing-error signals and judge a pattern as irregular when the amount of evidence reaches a decision threshold. Model fits of bounded integration showed that this accumulation occurs with negligible leak of evidence. Consistent with previous findings, we show that participants perform better when evaluating the regularity of auditory pulses, as compared with visual or tactile stimuli. Our results suggest that temporal regularity is estimated by comparing expected and measured pulse onset times, and that each prediction error is accumulated towards a threshold to generate a behavioral choice.

Background: The optimisation of learning has long been a focus of scientific research, particularly in relation to improving psychological treatment and recovery of brain function. Previously, partial N-methyl-D-aspartate agonists have been shown to augment reward learning, procedural learning and psychological therapy, but many studies also report no impact of these compounds on the same processes. Aims: Here we investigate whether administration of an N-methyl-D-aspartate partial agonist (D-cycloserine) modulates a previously unexplored process – tactile perceptual learning. Further, we use a longitudinal design to investigate whether N-methyl-D-aspartate-related learning effects vary with time, thereby providing a potentially simple explanation for apparent mixed effects in previous research. Methods: Thirty-four volunteers were randomised to receive one dose of 250 mg D-cycloserine or placebo 2 h before tactile sensitivity training. Tactile perception was measured using psychophysical methods before and after training, and 24/48 h later. Results: The placebo group showed immediate within-day tactile perception gains, but no further improvements between-days. In contrast, tactile perception remained at baseline on day one in the D-cycloserine group (no within-day learning), but showed significant overnight gains on day two. Both groups were equivalent in tactile perception by the final testing – indicating N-methyl-D-aspartate effects changed the timing, but not the overall amount of tactile learning. Conclusions: In sum, we provide first evidence for modulation of perceptual learning by administration of a partial N-methyl-D-aspartate agonist. Resolving how the effects of such compounds become apparent over time will assist the optimisation of testing schedules, and may help resolve discrepancies across the learning and cognition domains.

Psychophysical methods in haptic technology help in comparative study and eventually be a data set to achieve realism over skin sensation. Textural based haptic applications are widely developed using tactile displays over human fingertips. The tactile displays work on open-loop admittance feedback system and are controlled with flexible parameters by ignoring the impact of noise or disturbance variables. Human skin undergoes various noise factors like temperature, humidity, sweat, and influence of alternative senses. This paper presents the newly adopted method of psychophysics to study the influence of environmental conditions over perceiving textural surfaces. The paper adopts the detection mode of psychophysics which uses perception time as an output parameter for understanding perception memory of the human skin. We have recorded the period of the perception in three environmental conditions over human subjects under a single blindfold method to study the behaviour of human skin at fingertips. The perception time of stimulus is analysed with arithmetic average roughness value (Ra) to understand the tolerance factor required during tactile based textural applications. The proposed method is simple to structure and improves in creating the dataset required to consider the noise factor for an open-loop admission feedback system.

Because of the COVID-19 pandemic, researchers are facing unprecedented challenges that affect our ability to run in-person experiments. With mandated social distancing in a controlled laboratory environment, many researchers are searching for alternative options to conduct research, such as online experimentation. However, online experimentation comes at a cost; learning online tools for building and publishing psychophysics experiments can be complicated and time-consuming. This learning cost is unfortunate because researchers typically only need to use a small percentage of these tools' capabilities, but they still have to deal with these systems' complexities (e.g., complex graphical user interfaces or difficult programming languages). Furthermore, after the experiment is built, researchers often have to find an online platform compatible with the tool they used to program the experiment. To simplify and streamline the online process of programming and hosting an experiment, I have created SimplePhy. SimplePhy can save researchers' time and energy by allowing them to create a study in just a few clicks. All researchers have to do is select among a few experiment settings and upload the stimuli. SimplePhy is able to run most psychophysical perception experiments that require mouse clicks and button presses. In addition to collecting online behavioral data, SimplePhy can also collect information regarding the estimated viewing distance between the participant and the monitor, the screen size, and the experimental trial's timing-features not always offered in other online platforms. Overall, SimplePhy is a simple, free, open-source tool (code can be found here: https://gitlab.com/malago/simplephy ) aimed to help labs conduct their experiments online.

Objectives: To evaluate different intervals of exposure to staining solutions and artificial aging on translucency parameter (TP 00) of CAD-CAM materials. Material and Methods: One millimeter thick square-shaped specimens (N = 288) were cut from Cerasmart (CS), IPS e.max (IE), Lava Ultimate (LU), Shofu HC (SH), Vita Enamic (VE), and Vita Suprinity (VS) and were divided into laboratory and chairside polishing. Reflection wavelength spectra, CIE D65 standard illuminant, 2 ° standard observer, SCI, UV included, SAV aperture, 6 mm diameter, were recorded at 10 nm sensitivity against white and black calibration tiles using a benchtop spectrophotometer. Subsequently, they were converted into CIEDE 2000 TP 00. After baseline measurements (T0), the specimens were divided as follows (n = 8): staining in coffee (C) and wine (W), for 60 (T1) and 120 hours (T2), and accelerated artificial aging (A). Artificial aging (ISO 4892-2 standard) was performed in two cycles of 150 KJ/m 2, for T1 and T2, respectively. TP measurements were repeated at T1 and T2. Data of TP 00 retention were submitted to analysis of variance and Fisher’s PLSD multiple comparison test (α=0.05). Results: Fisher’s PLSD critical differences among materials, time intervals and staining/aging were 0.16, 0.11 and 0.11, respectively. SH showed the highest TP 00 followed by LU > CS > IE = VS > VE. For all time intervals, the lowest TP 00 retention was observed with C. W, and A presented similar values. Conclusions: Translucency Parameter was material, time and staining/aging-dependent material. In majority of cases, it decreased upon staining/aging., Svrha rada: Procijeniti utjecaj različitih intervala izloženosti otopinama za bojenje i umjetnom starenju na parameter translucencije (TP 00) CAD/CAM materijala.Materijal i metode: Uzorci kvadratnog oblika debljine 1 mm (N = 288) izrezani su iz blokova Cerasmart (CS), IPS e.max (IE), Lava Ultimate (LU), Shofu HC (SH), Vita Enamic (VE) i Vita Suprinity ( VS) te su razvrstani u skupine u kojima je provedeno poliranje ili u laboratoriju ili u ordinaciji. Mjereni su referentnim spektrofotometrom spektri valne duljine refleksije (standardno osvjetljenje CIE D65, standardni promatrač od 2°, SCI, uključen UV, otvor SAV, promjer 6 mm) pri osjetljivosti od 10 nm na bijelim i crnim kalibracijskim pločicama i pretvoreni u CIEDE 2000 TP 00 . Nakon početnih mjerenja (T0) uzorci su podijeljeni na sljedeći način (n = 8): bojenje u kavi (C) i vinu (W) 60 (T1) i 120 sati (T2) te ubrzano umjetno starenje (A) . Umjetno starenje (ISO 4892-2 standard) obavljeno je u dvama ciklusima od 150 KJ/m2, za T1, odnosno T2. Mjerenja TP-a ponovljena su nakon T1 i T2. Podatci o TP 00 podvrgnuti su analizi varijance Fisherovim PLSD- testom višestruke usporedbe (α = 0,05).Rezultati: Kritične razlike Fisherova PLSD-testa između materijala, vremenskih intervala i bojenja/starenja bile su 0,16, 0,11, odnosno 0,11. SH je imao najviši TP 00 , a zatim slijede LU > CS > IE = VS > VE. Za sve intervale zabilježeno je najmanje zadržavanje TP 00 kod C-a. Slične vrijednosti imali su W i A. Zaključci: Parametar translucencije ovisio je o materijalu, vremenu i bojenju/starenju. U većini slučajeva smanjio se nakon bojenja/starenja.

Patient preference of lower limb prosthesis behavior informally guides clinical decision making, and may become increasingly important for tuning new robotic prostheses. However, the processes for quantifying preference are still being developed, and the strengths and weaknesses of preference are not adequately understood. The present study sought to characterize the reliability (consistency) of patient preference of alignment during level-ground walking, and determine the patient-preferred ankle angle for ascent and descent of a 10° ramp, with implications for the design and control of robotic prostheses. Seven subjects with transtibial amputation walked over level ground, and ascended and descended a 10° ramp on a semi-active prosthetic ankle capable of unweighted repositioning in dorsiflexion and plantarflexion. Preferred ankle angle was measured with an adaptive forced-choice psychophysics paradigm, in which subjects walked on a randomized static ankle angle and reported whether they would prefer the ankle to be dorsiflexed or plantarflexed. Subjects had reliable preferences for alignment during level-ground walking, with deviations of 1.5° from preference resulting in an 84% response rate preferring changes toward the preference. Relative to level walking, subjects preferred 7.8° (SD: 4.8°) of dorsiflexion during ramp ascent, and 5.3° (SD: 3.8°) plantarflexion during ramp descent. As the ankle angle better matched the ramp angle, socket pressures and tibial progression (shank pitch) both more closely mirrored those during level walking. These findings provide baseline behaviors for prosthetic ankles capable of adapting to slopes based on patient preference, and provide strong evidence that people with transtibial amputation can finely perceive ankle alignment.

Highlights • Obesity has been associated to altered sensitivity to food reward. • Sugar triggers brain reward circuitries, encouraging its consumption. • There is methodological heterogeneity in studies of taste perception in obesity. • Research on the association between obesity and sweet taste perception is inconclusive. • Following bariatric surgery there is limited evidence of changes in sweet taste perception., For more than 50 years, there has been evidence for greater consumption of sweet- foods in overweight humans and animals, relative to those that have a normal weight. Furthermore, it has long been suggested that energy deficit resulting from dieting, while moving the individual from a higher weight set point, would result in heightened susceptibility to palatable tastants, namely to sweet tastants. This was the motivation behind the first studies comparing sweet taste perception between individuals with obesity and those of a normal weight. These studies, using direct measures of taste, have been characterized by significant methodological heterogeneity, contributing towards variability in results and conclusions. Nevertheless, some of these findings have been used to support the theory that patients with obesity have decreased taste perception, particularly for sweet tastants. A similar hypothesis has been proposed regarding evidence for reduced brain dopamine receptors in obesity and, in both cases, it is proposed that increased food consumption, and associated weight gain, result from the need to increase sensory and brain stimulation. However, the available literature is not conclusive on the association between obesity and reduced sweet taste perception, with both negative and contradictory findings in comparisons between individuals with obesity and normal weight control subjects, as well as within-subject comparisons before and after bariatric surgery. Nevertheless, following either Roux-en-Y gastric bypass or sleeve gastrectomy, there is evidence of changes in taste perception, particularly for reward-related measures of sweet tastants, that should be further tested and confirmed in large samples, using consensual methodology.

Determine sex- and age-associated psychophysical and neurophysiological differences in the processing of pain across the adult lifespan.Preliminary, exploratory, cross-sectional study.Using psychophysics (to measure intensity and unpleasantness) and functional magnetic resonance imaging blood oxygenation level dependent methods (to measure stimulus-evoked brain activation), we will examine sex- and age-associated differences in thermal pain processing and their underlying neurophysiology in a broad range of healthy adults (ages 30-89). We will acquire resting state functional connectivity data for secondary analyses exploring whether resting state connectivity predicts psychophysical and neurophysiological responses to thermal pain. To examine the effects of altered blood flow, we will acquire resting-state arterial spin labeling magnetic resonance imaging data to quantify resting cerebral blood flow. We will interpret findings in the context of a proposed neural model of pain, ageing, and sex. Study funding was received in June of 2014. Ethical approval was obtained from the Vanderbilt University IRB prior to study initiation.Exploring the biological reasons for age- and sex-associated differences in pain processing will increase our understanding of pain in older adults. The paucity of neurobiological evidence to support best practice pain management in older adults places these individuals at risk for poor pain management.Poorly treated pain in older adults is a critical public health problem associated with a poor quality of life and increased healthcare costs. Understanding how age and sex have an impact on central processing of pain across the lifespan is a critical step toward improving personalized pain medicine.目的: 确定成年期疼痛处理中与性别和年龄相关的心理、生理和神经生理学差异。 设计: 初步、探索性、分类排列研究。 方法: 利用心理物理学 (测量强度和不愉快程度) 和功能磁共振成像血氧水平依赖法 (测量刺激诱发的脑激活) , 我们将在广泛的健康成年人 (30-89岁) 中研究与性别和年龄相关的热痛处理差异及其潜在的神经生理学。我们将获得静息状态功能连接数据, 用于二次分析, 以便探索静息状态连接是否能预测热痛的心理、生理和神经生理学反应。为检测血液流动改变的影响, 我们将获取静息状态动脉自旋标记磁共振成像数据, 以量化静息脑血流。我们将按照提出的疼痛、衰老和性别的神经模型解释这些发现。我们已于2014年6月收到研究资金。研究开始前, 我们已获得范德堡大学IRB的伦理批准。 结论: 探索与年龄和性别相关的疼痛处理差异的生物学原因将增加我们对老年人疼痛的了解。缺乏神经生物学证据来支持老年人疼痛管理的最佳实践, 将这些个体置于疼痛管理不善的风险之中。 影响: 老年人疼痛治疗不当是严重的公共卫生问题, 其与生活质量差和保健费用增加有关。了解年龄和性别对整个生命周期内疼痛中枢处理的影响是改善个体化疼痛医学的关键一步。.

Rewarding choice options typically contain multiple components, but neural signals in single brain voxels are scalar and primarily vary up or down. In a previous study, we had designed reward bundles that contained the same two milkshakes with independently set amounts; we had used psychophysics and rigorous economic concepts to estimate two-dimensional choice indifference curves (IC) that represented revealed stochastic preferences for these bundles in a systematic, integrated manner. All bundles on the same ICs were equally revealed preferred (and thus had same utility, as inferred from choice indifference); bundles on higher ICs (higher utility) were preferred to bundles on lower ICs (lower utility). In the current study, we used the established behavior for testing with functional magnetic resonance imaging (fMRI). We now demonstrate neural responses in reward-related brain structures of human female and male participants, including striatum, midbrain and medial orbitofrontal cortex that followed the characteristic pattern of ICs: similar responses along ICs (same utility despite different bundle composition), but monotonic change across ICs (different utility). Thus, these brain structures integrated multiple reward components into a scalar signal, well beyond the known subjective value coding of single-component rewards.Significance StatementRewards have several components, like the taste and size of an apple, but it is unclear how each component contributes to the overall value of the reward. While choice indifference curves of economic theory provide behavioural approaches to this question, it is unclear whether brain responses capture the preference and utility integrated from multiple components. We report activations in striatum, midbrain and orbitofrontal cortex that follow choice indifference curves representing behavioral preferences over and above variations of individual reward components. In addition, the concept-driven approach encourages future studies on natural, multi-component rewards that are prone to irrational choice of normal and brain-damaged individuals.

Localized muscle fatigue (LMF) manifests as a reduction in muscle force generating capacity, an increase in electromyography signal amplitude and a decrease in mean power frequency (MnPF). Estimate...

Funder: University of Cambridge, Due to increasing ease of use and ability to quickly collect large samples, online behavioural research is currently booming. With this popularity, it is important that researchers are aware of who online participants are, and what devices and software they use to access experiments. While it is somewhat obvious that these factors can impact data quality, the magnitude of the problem remains unclear. To understand how these characteristics impact experiment presentation and data quality, we performed a battery of automated tests on a number of realistic set-ups. We investigated how different web-building platforms (Gorilla v.20190828, jsPsych v6.0.5, Lab.js v19.1.0, and psychoJS/PsychoPy3 v3.1.5), browsers (Chrome, Edge, Firefox, and Safari), and operating systems (macOS and Windows 10) impact display time across 30 different frame durations for each software combination. We then employed a robot actuator in realistic set-ups to measure response recording across the aforementioned platforms, and between different keyboard types (desktop and integrated laptop). Finally, we analysed data from over 200,000 participants on their demographics, technology, and software to provide context to our findings. We found that modern web platforms provide reasonable accuracy and precision for display duration and manual response time, and that no single platform stands out as the best in all features and conditions. In addition, our online participant analysis shows what equipment they are likely to use.

Boundaries in the visual world can be defined by changes in luminance and texture in the input image. A “contour integration” process joins together local changes into percepts of lines or edges. A previous study tested the integration of contours defined by second-order contrast-modulation. Their contours were placed in a background of random wavelets. Subjects performed near chance. We re-visited second-order contour integration with a different task. Subjects distinguished contours with “good continuation” from distractors. We measured thresholds in different amounts of external orientation or position noise. This gave two noise-masking functions. We also measured thresholds for contours with a baseline curvature to assess performance with more curvy targets. Our subjects were able to discriminate the good continuation of second-order contours. Thresholds were higher than for first-order contours. In our modelling, we found this was due to multiple factors. There was a doubling of equivalent internal noise between first- and second-order contour integration. There was also a reduction in efficiency. The efficiency difference was only significant in our orientation noise condition. For both first- and second-order stimuli, subjects were also able to perform our task with more curved contours. We conclude that humans can integrate second-order contours, even when they are curved. There is however reduced performance compared to first-order contours. We find both an impaired input to the integrating mechanism, and reduced efficiency seem responsible. Second-order contour integration may be more affected by the noise background used in the previous study. Difficulty segregating that background may explain their result.

Traditional color vision tests depend on subjective judgments and are not suitable for infant children and subjects with cognitive dysfunction. We aimed to explore an objective and quantitative color vision testing method based on sweep steady-state visual evoked potentials (sweep SSVEPs) and compare the results with subjective Farnsworth–Munsell (FM) 100-hue test results. A red-green SSVEP pattern reversal checkboard paradigm at different luminance ratios was used to induce visual evoked potentials (VEPs) from 15 color vision deficiencies (CVDs) and 11 normal color vision subjects. After electroencephalography signals were processed by canonical correlation analysis, an equiluminance turning curve corresponding to the activation of the L-cones and M-cones at different levels of color vision was established. Then, we obtained different equiluminance T and proposed the SSVEP color vision severity index (ICVD) to quantify color vision function and the severity of CVDs. In addition, the FM 100-hue test was used to obtain subjective data for the diagnosis of color vision. The value of ICVD can be an indicator of the level of color vision. Both the total error scores (TES) and confusion index (C-index) of the FM 100-hue test were significantly correlated with ICVD values (P

Objective This study used high-speed cooling of the skin and exact control of stimulus duration to measure the cold detection threshold in healthy participants. The objective was to compare the method of limits, in which the temperature is slowly and gradually increased/decreased until the subject perceives the stimulation, and the method of levels, in which the subject must detect brief thermal stimulations close to the threshold of perception. Methods Twenty healthy volunteers (nine women, 11 men) aged 20–30 years participated in the study. The method of limits and method of levels were performed in all subjects in a counterbalanced order. Four cold detection thresholds were measured with the method of levels, with a temperature ramp of 300°C/sec and stimulus durations of 50 ms, 100 ms, 300 ms, and 500 ms. Three thresholds were measured with the method of limits, with temperature ramps of 1°C/sec, 2°C/sec, and 4°C/sec. Results On average, the cold detection thresholds were −0.47°C below skin temperature with the method of levels and −1.67°C the method of limits. Interindividual variability was significantly lower with the method of levels than with the method of limits. Conclusions These results suggest that the method of levels is more accurate than the method of limits for measuring cold detection threshold. The improvement of cold detection threshold measurement may provide new perspectives to more precisely assess the function of A-delta fibers and the spino-thalamic pathway.

Introduction The Rutgers Acquired Equivalence Test is a visually guided equivalence learning paradigm that involves rule acquisition and generalization. Earlier we found impaired performance in this paradigm among adult migraine patients without aura. The aim of the study was to investigate if similar impairments can be found already in the pediatric form of the disease and to compare the performance of the pediatric study population with that of an adult study population. We hypothesized that the deficits observed in adults would be observable already in the pediatric population. Methods Twenty-seven children and adolescents newly diagnosed with migraine without aura and 27 age- and sex-matched healthy controls were tested with the Rutgers Acquired Equivalence Test. Their performance data were compared to each other and those of an earlier adult study population involving 22 patients and 22 age- and sex-matched healthy controls. Four parameters characterizing performance in the two main phases of the paradigm were calculated for each of the four groups. Performance parameters were compared with Mann-Whitney U test. Results In contrast to the decreased performance of the adult patients in the Rutgers Acquired Equivalence Test, no significant difference was found between pediatric patients and controls in any phase of the paradigm. Conclusion Children living with migraine without aura do not exhibit the same cognitive deficits in the Rutgers Acquired Equivalence Test as their adult counterparts. It can be hypothesized that the deficit of equivalence learning is not an inherent feature of the migrainous cognitive profile, rather the result of the interference of the disease with normal development.

In this review, I develop an empirically based model of optical image formation by the human eye, followed by neural sampling by retinal ganglion cells, to demonstrate the perceptual effects of blur, aliasing, and distortion of visual space in the brain. The optical model takes account of ocular aberrations and their variation across the visual field, in addition to variations of defocus due to variation of target vergence in three-dimensional scenes. Neural sampling by retinal ganglion cells with receptive field size and spacing that increases with eccentricity is used to visualize the neural image carried by the optic nerve to the brain. Anatomical parameters are derived from psychophysical studies of sampling-limited visual resolution of sinusoidal interference fringes. Retinotopic projection of the neural image onto brainstem nuclei reveals features of the neural image in a perceptually uniform brain space where location and size of visual objects may be measured by counting neurons.

An ideal observer is a theoretical model observer that performs a specific sensory-perceptual task optimally, making the best possible use of the available information given physical and biological constraints. An image-computable ideal observer (pixels in, estimates out) is a particularly powerful type of ideal observer that explicitly models the flow of visual information from the stimulus-encoding process to the eventual decoding of a sensory-perceptual estimate. Image-computable ideal observer analyses underlie some of the most important results in vision science. However, most of what we know from ideal observers about visual processing and performance derives from relatively simple tasks and relatively simple stimuli. This review describes recent efforts to develop image-computable ideal observers for a range of tasks with natural stimuli and shows how these observers can be used to predict and understand perceptual and neurophysiological performance. The reviewed results establish principled links among models of neural coding, computational methods for dimensionality reduction, and sensory-perceptual performance in tasks with natural stimuli.

Made available in DSpace on 2020-12-10T20:07:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-06 This multicenter study evaluated the effect of harmonizing spectrophotometric (d/8 degrees) color measurements by using actual dental materials of clinically relevant thickness and translucency as calibration tiles. Ten tooth-colored, 1-mm thick, resin- and ceramic-based materials were tested at the coordinating center (CC) and six research sites (RS). Correction factors were calculated for each material and each site to obtain the corrected reflection spectra from the non-corrected data set. Non-corrected ((NC)) and corrected ((C)) reflection values were converted into CIEDE2000 and CIELAB color parameters for the following comparisons: CC vs RSNC and CC vs RSC, between RSNC vs RSNC and RSC vs RSC pairs, and among RS separately (alpha = 0.05). Mean color differences for CC vs RSNC and corresponding CC vs RSC values were Delta E-00 = 4.2 (2.6) and Delta E-00 = 0.7 (0.6), respectively. Corresponding values for RSNC vs RSNC and RSC vs RSC specimen pairs were Delta E-00 = 5.9 (2.9) and Delta E-00 = 1.0 (0.5), respectively. The CIEDE2000 NC vs C comparison for each research site separately ranged from 0.5 to 8.5. Color differences of CC vs RSC and RSC vs RSC pairs decreased 83% to 84.5% as compared with respective color differences for non-corrected research site measurements and was RS dependent (P

Animal models have significantly contributed to understanding the pathophysiology of chronic subjective tinnitus. They are useful because they control etiology, which in humans is heterogeneous; employ random group assignment; and often use methods not permissible in human studies. Animal models can be broadly categorized as either operant or reflexive, based on methodology. Operant methods use variants of established psychophysical procedures to reveal what an animal hears. Reflexive methods do the same using elicited behavior, for example, the acoustic startle reflex. All methods contrast the absence of sound and presence of sound, because tinnitus cannot by definition be perceived as silence.

Background Quantitative sensory testing of thermal detection abilities is used as a clinical tool to assess the function of pain pathways. The most common procedure to assess thermal sensitivity, the 'method of limits', provides a quick but rough estimate of detection thresholds. Here, we investigate the potential of evaluating not only the threshold but also the slope of the psychometric functions for cold and warm detection. Method A convenience sample of 15 patients with diabetes mellitus (DM) and 15 age-matched healthy controls (HC) was tested. Thirty brief (100 ms) stimuli of each modality were applied to the volar wrist and foot dorsum. Cold and warm stimuli were delivered with a Peltier thermode and a temperature-controlled CO2 laser, respectively. Stimulus intensities were dynamically selected using an adaptive Bayesian algorithm (psi method) maximizing information gain for threshold and slope estimation. ROC analyses were used to assess the ability of slopes, thresholds and the combination of both to discriminate between groups. Results Assessment of the slope and threshold of the psychometric function for thermal detection took about 10 min. The ability to detect warmth was not reduced in DM patients as compared to HC. Cold detection performance assessed using slope or threshold parameters separated DM from HC with good discriminative power. Discrimination was further increased when both parameters were used together (93% sensitivity and 87% specificity), indicating that they provide complementary information on patient status. Conclusion The psi method may be an interesting alternative to the classical method of limits for thermal QST. Significance Current QST protocols provide an incomplete and potentially biased estimate of sensory detection performance. We propose a method that estimates the slope and the threshold of the psychometric function, defining heat and cold sensory detection performance, in only a few minutes. Furthermore, we provide preliminary evidence that combining slope and threshold parameters of cold detection performance leads to a better discriminative ability than relying solely on the threshold.

We have developed a novel button click rendering mechanism based on active lateral force feedback. The effect can be localized because electroadhesion between a finger and a surface can be localized. Psychophysical experiments were conducted to evaluate the quality of a rendered button click, which subjects judged to be acceptable. Both the experiment results and the subjects' comments confirm that this button click rendering mechanism has the ability to generate a range of realistic button click sensations that could match subjects' different preferences. We can thus generate a button click on a flat surface without macroscopic motion of the surface in the lateral or normal direction, and we can localize this haptic effect to an individual finger., Comment: Accepted, IEEE Transactions on Haptics

Recognition of simple shapes and numerosity estimation for small quantities are often studied independently of each other, but we know that these processes are both rapid and accurate, suggesting that they may be mediated by common neural mechanisms. Here we address this issue by examining how spatial configuration, shape complexity, and luminance polarity of elements affect numerosity estimation. We directly compared the Event Related Potential (ERP) time-course for numerosity estimation under shape and random configurations and found a larger N2 component for shape over lateral-occipital electrodes (250–400 ms), which also increased with higher numbers. We identified a Left Mid Frontal (LMF; 400–650 ms) component over left-lateralised medial frontal sites that specifically separated low and high numbers of elements, irrespective of their spatial configuration. Different luminance-polarities increased N2 amplitude only, suggesting that shape but not numerosity is selective to polarity. Functional microstates confined numerosity to a strict topographic distribution occurring within the LMF time-window, while a microstate responding only to shape-configuration was evidenced earlier, in the N2 time-window. We conclude that shape-coding precedes numerosity estimation, which can be improved when the number of elements and shape vertices are matched. Thus, numerosity estimation around the subitizing range is facilitated by a shape-template matching process.

Gustatory dysfunctions are more frequent than other chemosensory dysfunctions in aging people. Gustatory event-related potentials (ERPs) has been suggested as a reliable and effective approach for assessing gustatory functions in young and middle subjects, but has rarely been investigated in aging people, leaving influencing factors of ERPs in that population not completely understood. In this study, we analyzed gustatory ERPs results of aging participants and characterized potential impacting factors, including age, sex, BMI, drinking, smoking, hypertension, diabetes, cognition and psychophysical test scores of gustation and olfaction. Our results revealed three components (P1, N1 and P2) in gustatory ERPs upon salty stimulation. Significant differences between responses collected from different recording electrodes were observed: minimum latencies and maximum amplitudes of P1 were detected at frontal electrode, and maximum amplitudes of N1 and P2 were detected at central and centro-parietal electrodes, respectively. Major cortical sources of components P1, N1 and P2 were located at bilateral insula, frontal operculum, and orbitofrontal cortex. Diabetes was positively associated with latencies of P1. Sex was positively associated with amplitudes of P1, N1 and P2. Hypertension was negatively associated with amplitudes of P1 and P2. In conclusion, gustatory ERPs in aging people exhibited a specific topographical distribution, represented by sex-related differences and negative impacts of diabetes and hypertension.

For gray or achromatic objects, brightness is a relatively simple transformation where very low luminance levels are perceived as black and higher levels are perceived as white. For chromatic objects, the transformation is more complex, depending on color purity as well. This influence of color purity on a color’s perceived brightness is a well-established phenomenon known as the Helmholtz–Kohlrausch (H-K) effect. We investigated gender differences in the H-K effect by measuring brightness (via direct brightness matching [DBM]) and luminance (via heterochromatic flicker photometry [HFP]) at five wavelengths (450, 520, 560, 580, and 650 nm) perceived as blue, green, green-yellow, yellow, and red hues. We compared DBM/HFP ratios between 13 males and 18 females. Based on previous evidence of a female advantage in chromatic processes, we hypothesized that DBM/HFP ratios would be higher in female subjects. While HFP measures were essentially the same between male and female subjects, DBM measures and DBM/HFP ratios were significantly higher for female subjects than males. There were no significant effects of contraceptive use based on a post hoc comparison. We also derived simple models of brightness as a function of luminance and saturation, which further suggest gender dimorphism in the H-K effect.

Available tools for recording neuronal activity are limited and reductive due to massive data arising from high-frequency measurements. We have developed a method that utilizes variance within the physiological activity and includes all data points per measurement. Data is expressed geometrically in a physiologically meaningful manner, to represent a precise and detailed view of the recorded neural activity. The recorded raw data from any pair of electrodes was plotted and following a covariance calculation, an eigenvalues and chi-square distribution were used to define the ellipse which bounds 95% of the raw data. We validated our method by correlating specific behavioral observation and physiological activity with behavioral tasks that require similar body movement but potentially involve significantly different neuronal activity. Graphical representation of telemetrically recorded data generates a scatter plot with distinct elliptic geometrical properties that clearly and significantly correlated with behavior. Our reproducible approach improves on existing methods by allowing a dynamic, accurate and comprehensive correlate using an intuitive output. Long-term, it may serve as the basis for advanced machine learning applications and animal-based artificial intelligence models aimed at predicting or characterizing behavior.

At an early stage, 3 different systems independently extract visual motion information from visual inputs. At later stages, these systems combine their outputs. Here, we consider a much studied (>650 publications) class of visual stimuli, plaids, which are combinations of 2 sine waves. Currently, there is no quantitative theory that can account for the perceived motion of plaids. We consider only perceived plaid direction, not speed, and obtain a large set of data exploring the various dimensions in which same-spatial-frequency plaids differ. We find that only 2 of the 3 motion systems are active in plaid processing, and that plaids with temporal frequencies 10 Hz or greater typically stimulate only the first-order motion system, which combines the plaid components by vector summation: Each plaid component is represented by a contrast-strength vector whose length is contrast-squared times a factor representing the relative effectiveness of that component's temporal frequency. The third-order system, which becomes primary at low temporal frequencies, also represents a plaid as 2 vectors that sum according to their contrast strength: a pure plaid in which both components have equal contrast and a residual sine wave. Second-order motion is irrelevant for these plaids. These principles enable a contrast-strength-vector summation theory for the responses of the first-order and third-order motion systems. With zero parameters estimated from the data, the theory captures the essence of the full range of the plaid data and supports the counterintuitive hypothesis that motion direction is processed independently of speed at early stages of visual processing. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Background. Cervical dystonia (CD) is a neurological movement disorder characterized by involuntary contractions of the cervical musculature and is known to be associated with proprioceptive dysfunction in dystonic/nondystonic limbs. Objectives. We examined how neck botulinum neurotoxin (BoNT) injection affects wrist proprioception and the corresponding sensorimotor cortical activity in CD. Method. Wrist position sense acuity of the dominant (right) hand was evaluated in 15 CD and 15 control participants. Acuity measures were a psychophysical position sense discrimination threshold (DT; based on passive joint displacement) and joint position matching error (based on active movement). Cortical activity during the motor preparation period of the active joint position matching was examined using electroencephalography. Results. In their symptomatic state, patients demonstrated a significantly higher wrist proprioceptive DT, indicating an abnormal passive wrist position sense. Yet BoNT injections had no significant effect on this threshold. During active joint position matching, errors were significantly larger in patients, but this difference vanished after the administration of BoNT. Motor preparation of active wrist position matching was associated with a significantly higher rise of β-band (13-30 Hz) power over contralateral somatosensory-motor cortical areas in patients. This excessive cortical activity significantly declined post-BoNT. Conclusion. Wrist proprioceptive perception during passive/active movements is abnormal in CD. An excessive rise of premotor/motor cortical β-oscillations during motor planning is associated with this proprioceptive dysfunction. Neck BoNT injections normalized the cortical processing of proprioceptive information from nonsymptomatic limbs, indicating that local injections may affect the central mechanisms of proprioceptive function in CD.

The appearance of fabric motion is suggested to affect the human perception of bending stiffness. This study presents a novel spatial augmented reality, or projection mapping, approach that can visually manipulate the perceived bending stiffness of a fabric. Particularly, we proposed a flow enhancement method that can change the apparent fabric motion by using a simple optical flow analysis technique rather than complex physical simulations for interactive applications. Through a psychophysical experiment, we investigated the relationship between the magnification factor of our flow enhancement and the perceived bending stiffness of a fabric. Furthermore, we constructed a prototype application system that allows users to control the stiffness of a fabric without changing the actual physical fabric. By evaluating the prototype, we confirmed that the proposed technique can manipulate the perceived stiffness of various materials (i.e., cotton, polyester, and mixed cotton and linen) at an average accuracy of 90.3 percent.

Many augmented reality (AR) applications operate within near-field reaching distances, and require matching the depth of a virtual object with a real object. The accuracy of this matching was measured in three experiments, which examined the effect of focal distance, age, and brightness, within distances of 33.3 to 50 cm, using a custom-built AR haploscope. Experiment I examined the effect of focal demand, at the levels of collimated (infinite focal distance), consistent with other depth cues, and at the midpoint of reaching distance. Observers were too young to exhibit age-related reductions in accommodative ability. The depth matches of collimated targets were increasingly overestimated with increasing distance, consistent targets were slightly underestimated, and midpoint targets were accurately estimated. Experiment II replicated Experiment I, with older observers. Results were similar to Experiment I. Experiment III replicated Experiment I with dimmer targets, using young observers. Results were again consistent with Experiment I, except that both consistent and midpoint targets were accurately estimated. In all cases, collimated results were explained by a model, where the collimation biases the eyes' vergence angle outwards by a constant amount. Focal demand and brightness affect near-field AR depth matching, while age-related reductions in accommodative ability have no effect., Comment: 14 pages, 18 figures

Numerous studies have shown that more visual features can be stored in visual short-term memory (VSTM) when they are encoded from fewer objects (Luck & Vogel, 1997, Nature, 390, 279-281; Olson & Jiang, 2002, Perception & Psychophysics, 64[7], 1055-1067). This finding has been consistent for simple objects with one surface and one boundary contour, but very few experiments have shown a clear performance benefit when features are organized as multipart objects versus spatially dispersed single-feature objects. Some researchers have suggested multipart object integration is not mandatory because of the potential ambiguity of the display (Balaban & Luria, 2015, Cortex, 26(5), 2093-2104; Luria & Vogel, 2014, Journal of Cognitive Neuroscience, 26[8], 1819-1828). For example, a white bar across the middle of a red circle could be interpreted as two objects, a white bar occluding a red circle, or as a single two-colored object. We explore whether an object benefit can be found by disambiguating the figure-ground organization of multipart objects using a luminance gradient and linear perspective to create the appearance of a unified surface. Also, we investigated memory for objects with a visual feature indicated by a hole, rather than an additional surface on the object. Results indicate the organization of multipart objects can influence VSTM performance, but the effect is driven by how the specific organization allows for use of global ensemble statistics of the memory array rather than a memory benefit for local object representations.

The human hand detects high-frequency vibrations in all directions but cannot distinguish the direction, which suggests a multi-dimensional vibrotactile stimulus is haptically equivalent to some one-dimensional (1D) stimulus. In this article, we explore how a 6D vibrotactile stimulus rendered at the haptic interaction point (HIP) of a kinesthetic haptic interface, with the stylus held in a precision pen-hold grasp, is mapped to an equivalent 1D stimulus normalized by the detection threshold. We gather a large human-subjects data set in which we determine detection thresholds for 45 distinct combinations of three orthogonal forces and three orthogonal torques rendered at the HIP, at a single frequency of 108 Hz corresponding to the peak sensitivity in our prior study. Using this data set, we find a general quadratic weighting function to predict the 1D normalized stimulus for a given 6D vibrotactile stimulus. We find that including just seven (out of a possible 21) independent parameters in the symmetric weighting matrix is sufficient to capture the non-obvious coupling between forces and torques rendered at the HIP for dimensional reduction from 6D to 1D.

While online experiments have shown tremendous potential to study larger and more diverse participant samples than is possible in the lab, the uncontrolled online environment has prohibited many types of psychophysical studies due to difficulties controlling the viewing distance and stimulus size. We introduce the Virtual Chinrest, a method that measures a participant’s viewing distance in the web browser by detecting a participant’s blind spot location. This makes it possible to automatically adjust stimulus configurations based on an individual’s viewing distance. We validated the Virtual Chinrest in two laboratory studies in which we varied the viewing distance and display size, showing that our method estimates participants’ viewing distance with an average error of 3.25 cm. We additionally show that by using the Virtual Chinrest we can reliably replicate measures of visual crowding, which depends on a precise calculation of visual angle, in an uncontrolled online environment. An online experiment with 1153 participants further replicated the findings of prior laboratory work, demonstrating how visual crowding increases with eccentricity and extending this finding by showing that young children, older adults and people with dyslexia all exhibit increased visual crowding, compared to adults without dyslexia. Our method provides a promising pathway to web-based psychophysical research requiring controlled stimulus geometry.

There are at least two distinct ways in which the brain encodes spatial information: in egocentric representations locations are encoded relative to the observer, whereas in allocentric representations locations are encoded relative to the environment. Both inform spatial memory, but the extent to which they influence behaviour varies depending on the task. In the present study, two preregistered experiments used a psychophysical approach to measure the precision of spatial memory while varying ego- and allocentric task demands. Participants were asked to detect the changed location of one of four objects when seen from a new viewpoint (rotated by 0°, 5°, 15°, 45° or 135°). Experiment 1 used a Same/Different task and Experiment 2 used a 2AFC task. Psychophysical thresholds were calculated, showing that in both experiments, spatial change detection thresholds showed a monotonic but non-linear increase as viewpoint change increased. This was consistent with a preregistered model including distinct parameters corresponding to egocentric and allocentric contributions that change lawfully as a function of viewpoint shift. Our results provide a clearer understanding of how underlying memory representations interact to inform our spatial knowledge of the environment.

Clinical observations showed that schizophrenia (SCZ) patients reported little or no pain under various conditions that are commonly associated with intense painful sensations, leading to a higher risk of morbidity and mortality. However, this phenomenon has received little attention and its underlying neural mechanisms remain unclear. Here, we conducted two experiments combining psychophysics, electroencephalography (EEG), and functional magnetic resonance imaging (fMRI) techniques to investigate neural mechanisms of pain insensitivity in SCZ patients. Specifically, we adopted a stimulus–response paradigm with brief stimuli of different sensory modalities (i.e., nociceptive, non‐nociceptive somatosensory, and auditory) to test whether pain insensitivity in SCZ patients is supra‐modal or modality‐specific, and used EEG and fMRI techniques to clarify its neural mechanisms. We observed that perceived intensities to nociceptive stimuli were significantly smaller in SCZ patients than healthy controls, whereas perceived intensities to non‐nociceptive somatosensory and auditory stimuli were not significantly different. The behavioral results were confirmed by stimulus‐evoked brain responses sampled by EEG and fMRI techniques, thus verifying the modality‐specific nature of the modulation of nociceptive information processing in SCZ patients. Additionally, significant group differences were observed in the spectral power of alpha oscillations in prestimulus EEG and the seed‐based functional connectivity in resting‐state fMRI (seeds: the thalamus and periaqueductal gray that are key nodes in ascending and descending pain pathways respectively), suggesting a possible contribution of cortical–subcortical dysfunction to the phenomenon. Overall, our study provides insight into the neural mechanisms of pain insensitivity in SCZ and highlights a need for systematic assessments of their pain‐related diseases.

Indoor visible light communications (VLCs) have a major disadvantage that communications are not sustentative when and where artificial lightings are unavailable (e.g., bedroom with dim lighting, cinema). Thus, different from WiFi, its counterpart in RF, VLC is not “always on”. We promote the concept of “always on” VLC system and devote to realizing imperceptible VLC (iVLC). Considering flicker is relative easy to overcome, the essential restriction of this question is glaring sensation of people. In this letter, just imperceptible difference (JID) is proposed as a basic metric in iVLC system design, which is the maximum imperceptible difference in intensity between two physical stimuli and derived from psychophysics laws. Relying on JID, we obtain the upper bound of LED power below which a communication link does not annoy people in room under weak even dark lighting. Numerical results show that iVLC system is available through power control, modulation, and components design.