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The aim of this study was to investigate the correlation between v-set and transmembrane domain-containing 1 (VSTM1) expression and incidence of major adverse cardiac events (MACE) in patients with coronary heart disease (CHD). A total of 310 patients were divided into a non-acute coronary syndrome (non-ACS) group (containing the stable angina group, and the asymptomatic coronary artery diseaseand other patients group) and an ACS group (containing unstable angina and acute myocardial infarction patients). Monocytic VSTM1 expression levels (assessed via average fluorescence intensity derived from antibody binding to VSTM1) in each group were detected and analyzed. The cut-off value of monocytic VSTM1 expression to predict the onset of ACS and MACE was confirmed. VSTM1 expression in monocytes from the ACS group was lower than that of the non-ACS group. The incidence of MACEs in the high VSTM1-expression group was much less than that of those in the low VSTM1 expression group at the 1 year follow-up stage. VSTM1 expression had an independent-inversed association with increased incidence of MACE and ACS. VSTM1 expression in monocytes may help to predict the occurrence of ACS in patients with CHD, and moreover it may provide the means to evaluate MACE prognosis during CHD patient follow-up.

Background Colorectal cancer (CRC) is the second most common cause of cancer-related deaths and has the third highest incidence in the world. Almost half of the patients with CRC have metastases at the time of diagnosis. However, the treatment for patients with metastatic CRC that progresses after approved conventional chemotherapy is still controversial. Chinese medicine (CM) has unique characteristics and advantages in treating metastatic CRC. Objective To assess the effectiveness and safety of CM in patients with metastatic CRC after failure of conventional chemotherapy. Methods The study is a multicenter prospective cohort study. A total of 384 patients with documented metastatic CRC after failure of conventional chemotherapy will be included from 9 hospitals among Beijing, Shanghai, Nanjing, and Guizhou, and assigned to three groups according to paitents' wishes: (1) integrated Chinese and Western medicine (ICM) group receiving CM herbal treatment combined with Western medicine (WM) anti-tumor therapy, (2) Chinese medicine (CM) group receiving only CM herbal treatment, and (3) WM group receiving only WM anti-tumor therapy. The primary endpoint is the overall survival (OS). Secondary endpoints include the progression free survival (PFS), quality of life (QOL) assessed by the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) questionnaire, tumor control, and CM symptom score. Discussion This prospective study will assess the effectiveness and safety of CM in treating metastatic CRC after conventional chemotherapy failure. Patients in the ICM group will be compared with those in the WM group and CM group. If certified to be effective, national provision of CM treatment in metastatic CRC will probably be advised. (Registration No. NCT02923622 on ClinicalTrials.gov).

As a written language used for thousands of years, Ancient Chinese has some special characteristics like complex semantics as polysemy and the one-to-many alignment with Modern Chinese. Thus it may be translated in a large number of fully different but equally correct ways. In the absence of multiple references, reference-dependent evaluations like Bilingual Evaluation Understudy (BLEU) cannot identify potentially correct translation results. The explore on automatic evaluation of Ancient-Modern Chinese Translation is completely lacking. In this paper, we proposed an automatic evaluation metric for Ancient-Modern Chinese Translation called DTE (Dual-based Translation Evaluation), which can be used to evaluate one-to-many alignment in the absence of multiple references. When using DTE to evaluate, we found that the proper nouns often could not be correctly translated. Hence, we designed a new word segmentation method to improve the translation of proper nouns without increasing the size of the model vocabulary. Experiments show that DTE outperforms several general evaluations in terms of similarity to the evaluation of human experts. Meanwhile, the new word segmentation method promotes the Ancient-Modern Chinese translation models perform better on proper nouns’ translation, and get higher scores on both BLEU and DTE.

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by abnormal DNA replication of bone marrow stem cells and chemotherapy resistance is a major obstacle to the effective treatment of patients with CML. Imatinib (IM), a tyrosine kinase inhibitor (TKI), is a first-line drug clinically used for CML. Mounting evidence has indicated that the dysregulation of microRNAs (miRNAs) is associated with the chemoresistance of CML. In this study, miR-153-3p, which had been implicated with numerous types of tumors, was identified to be downregulated in IM-resistant CML cells. Upregulation of miR-153-3p significantly increased IM sensitivity and decreased the survival rate of IM-resistant CML cells, whereas downregulation of miR-153-3p attenuated these effects in IM-resistant CML cells. Upregulated miR-153-3p could decrease the autophagy caused by IM in IM-resistant CML cells. Dual-luciferase reporter assays confirmed that Bcl-2 is a direct target of miR-153-3p. Bcl-2 restoration reversed the increased sensitivity to IM induced by miR-153-3p-mimic transfection in IM-resistant CML cells. The results of the present study showed that dysregulated miR-153-3p may target Bcl-2 to promote the development of IM resistance and attenuate IM-induced apoptosis in CML. Therefore, miR-153-3p upregulation combined with IM treatment may serve as a promising therapeutic strategy for patients with low sensitivity.

Incorporating prior knowledge like lexical constraints into the model’s output to generate meaningful and coherent sentences has many applications in dialogue system, machine translation, image captioning, etc. However, existing auto-regressive models incrementally generate sentences from left to right via beam search, which makes it difficult to directly introduce lexical constraints into the generated sentences. In this paper, we propose a new algorithmic framework, dubbed BFGAN, to address this challenge. Specifically, we employ a backward generator and a forward generator to generate lexically constrained sentences together, and use a discriminator to guide the joint training of two generators by assigning them reward signals. Due to the difficulty of BFGAN training, we propose several training techniques to make the training process more stable and efficient. Our extensive experiments on three large-scale datasets with human evaluation demonstrate that BFGAN has significant improvements over previous methods.

with the diversification of power services and the access of mass terminals, different services have different QoS requirements, large bandwidth, low delay and low cost. In this regard, the power heterogeneous network parallel transmission technology is used to improve the power business transmission capacity, and data diversion is an important problem of parallel transmission. The minimum transmission delay model and cost model of wireless heterogeneous network are established. Combined with the improved nsga-2 algorithm, the multi-objective function model is solved. The results show that the improved nsga-2 algorithm can quickly solve the Pareto optimal solution and the optimal data transmission parameters of each link.

In the power communication network, a network selection algorithm based on QoS guarantee of power service is proposed for the heterogeneous multi network mixed coexistence scenarios composed of 230MHz wireless private network, 1800MHz wireless private network, WLAN, WiMAX and 5G public network. Firstly, QoS parameters are selected and classified according to the network performance and power service demand index; Secondly, the subjective weight and objective weight are obtained respectively based on the analytic hierarchy process and the improved entropy weight method, and the subjective and objective weights are balanced by game theory; Finally, the multi-attribute decision theory is used to select wireless network access which can meet the QoS requirements of power service and the best performance. The simulation results show that the algorithm can effectively guarantee the QoS of power service, and realize the reasonable allocation of access network resources, balance the load and improve the utilization of resources.

Introduction Beard hair serves as an important additional donor supply to support hair transplantation in hirsute patients with extensive alopecia and lacking sufficient occipital hair. However, the efficacy and safety of large-scale beard hair extraction have not been studied extensively in the East Asian population. Methods Data obtained from hirsute patients with extensive alopecia who underwent hair transplantation between March 2017 and December 2018 at Nanfang Hospital were analyzed. Occipital and beard hair were evaluated separately during the pre-, intra-, and post-operative periods. Individual beard hair follicular units (FUs) were harvested under tumescence using a hollow punch with an outer diameter of 0.8–0.9 mm. Follow-up examinations were scheduled at 3–5 days, 1 month, and 9 months postoperatively to check for complications, determine the survival rate of mixed, transplanted FU grafts, and assess patient satisfaction. Data were collected and analyzed statistically. Results A total of 36 hirsute, male patients with advanced androgenetic alopecia (AGA) (Norwood-Hamilton V–VI) were included in this study. The density of the occipital and beard areas was 78.6 ± 4.6 and 48.4 ± 9.3 FU, respectively. It took 3.1 ± 0.9 h to harvest 3135 ± 863 FUs from the occipital area and 2.1 ± 0.6 h to harvest 2352 ± 599 FUs from the beard area. The transection rate for occipital FUs and beard FUs was 3.7 ± 0.4 and 3.9 ± 0.2%, respectively. Completion of the operation took approximately 10.0 ± 0.9 h, and no serious complications were reported 5 days after the procedure. An FU survival rate of 95.7 ± 1.6% was observed at 9 months after transplantation, with no visible hypopigmented scars observed in the bare areas. All patients were satisfied with the resulting cosmetic appearance. Conclusion Large-scale beard extraction, when combined with occipital hair extraction, is a safe and effective treatment to enhance the cosmetic appearance of East Asian men with advanced AGA.

Background Cranial hair loss is one of the characteristics of age. Hairline recession has been confirmed adversely to affect the perceptions of age in Western males. However, comparatively little is known about the effect of frontal recession on the perceived facial age (PFA) of East Asian males. Moreover, specific roles of different types of hairline recession in PFA of different age groups still remain a mystery. Objective To investigate and quantify the effect of different types of hairline recession on PFA in East Asian young males of different age groups. Methods Thirty non-bald males were selected and divided equally into three groups (20s, 30s, and 40s). With the aid of modern software, the frontoparietal area of facial images from 30 experimenters was modified into three basic types of hair loss (M2 , C2 , and U2 ) according to the basic and specific classification of androgenic alopecia. In a web-based survey, approximately 900 naive participants were asked to estimate the PFA of males from their original and modified facial images. Results Perceived facial age increased to 1.58 ± 0.79, 4.19 ± 1.27, and 5.90 ± 1.00 years when the original facial images were modified to have hair loss types M2 , C2 , or U2 , respectively. In addition, the PFA of males with hair loss type C2 or U2 appeared significantly older than the original facial images in the 30s group. Conclusion Different types of hairline recession can increase the PFA to different degrees in East Asian males of different age groups.

BACKGROUND Frustrated with the embarrassing appearance, patients with androgenetic alopecia (AGA) suffer from poor quality of life and low self-esteem. Moreover, several researches indicate that self-esteem is an important factor affecting outcomes of cosmetic surgery. OBJECTIVE This retrospective study aims to investigate the impact of hair transplantation on patients' self-esteem and satisfaction with appearance, as well as relationship between self-esteem and patient satisfaction which includes preoperative and postoperative satisfaction. METHODS The preoperative and 9-month postoperative self-esteem were evaluated by Rosenberg Self-Esteem Scale (RSES), and preoperative satisfaction indicators (satisfaction with appearance, visual age and expected visual age) were assessed by Face-Q scale. At the same time, postoperative satisfaction indicators (satisfaction with appearance, visual age, satisfaction with decision, psychological well-being, and social function) were reevaluated as well. RESULTS Of the 1106 male AGA patients, 875 completed a 9-month postoperative questionnaire. Compared with preoperative scores, postoperative scores of self-esteem and satisfaction with appearance showed an increase of 1.56 and 30.25 respectively (P

In a reduced dimensional space, linear discriminant analysis looks for a projective transformation that can maximizes separability among classes. Since linear discriminant analysis demands the within-class scatter matrix appear to non-singular, which cannot directly used in condition of small sample size (SSS) issues in which the dimension of image is much higher, while the number of samples isn’t unlimited. Both the between-class and within-class scatter matrices are always exceedingly ill-posed in SSS problems. And many algorithms are suffered from small sample size issues still. To solve SSS problems, many methods including regularized linear discriminant analysis were proposed. In this article, a way was presented by optimized regularized linear discriminant analysis for feature extraction in FR which can not only fix the singularity problem existing in scatter matrix but also the problem of parameter estimation. The experiment is conducted on several databases and promising results are obtained compared to some state-of-the-art methods to demonstrate the effectiveness of the proposed approach.

Androgenic alopecia (AGA), also known as male pattern baldness, is one of the most common hair loss diseases worldwide. The main treatments of AGA include hair transplant surgery, oral medicines, and LDL laser irradiation, although no treatment to date can fully cure this disease. Animal models play important roles in the exploration of potential mechanisms of disease development and in assessing novel treatments. The present study describes androgen receptor (AR) in C57BL/6 mouse hair follicles that can be activated by dihydrotestosterone (DHT) and translocate to the nucleus. This led to the design of a mouse model of androgen-induced AGA in vivo and in vitro. DHT was found to induce early hair regression, hair miniaturization, hair density loss, and changes in hair morphology in male C57BL/6 mice. These effects of DHT could be partly reversed by the AR antagonist bicalutamide. DHT had similar effects in an ex vivo model of hair loss. Evaluation of histology, organ culture, and protein expression could explain the mechanism by which DHT delayed hair regrowth.

Androgenetic alopecia (AGA) is a global challenge, affecting a large number of people worldwide. Efficacy of the existed treatments can barely meet the demands of patients. Patients who are poorly responding to those treatments are seeking for a more effective and suitable technique to treat their disease. Low-level light therapy (LLLT) is a newly developed technique, which has been proved to stimulate hair growth. Based on the function principle of LLLT in other domains and refer to the published literatures, we write this review to neaten and elucidate the possible mechanism of LLLT in the treatment of AGA. A review of published literature which is associated with keywords LLLT, photobiomodulation, AGA, treatment, hair growth, and mechanism was performed to elucidate the proposed mechanism of LLLT in the treatment of AGA. The present study shows that LLLT can accelerate hair growth in AGA patients. The proposed mechanism of LLLT in treating AGA may vary among different specialists. But we can summarize the consensual mechanisms as follows; low-level light absorbed by chromophores can lead to the production of nitric oxide (NO) and the modulation of reactive oxygen species (ROS). These mobilized molecules subsequently activate redox-related signaling pathways in hair follicle cells and perifollicular cells. Finally, these activated cells participate in the regrowth of hair follicle. Even though the efficacy of LLLT in the treatment of AGA in both men and women has already been confirmed, the present studies focusing on discovering LLLT are still inadequate and unsystematic. More studies are needed to standardize the optimum treatment parameters applied in promoting hair growth and determine the long-term safety and efficacy of LLLT. Current recognitions about the mechanisms of LLLT, mainly focused on the molecules that may take effect, neglected different cellular components that are functional in the hair follicle macro-environment.

Objective To assess the performance of pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) radiomics features for predicting EGFR mutation status in patients with non-small cell lung cancer (NSCLC). Patients and methods We enrolled total 173 patients with histologically proven NSCLC who underwent preoperative 18F-FDG PET/CT. Tumor tissues of all patients were tested for EGFR mutation status. A PET/CT radiomics prediction model was established through multi-step feature selection. The predictive performances of radiomics model, clinical features and conventional PET-derived semi-quantitative parameters were compared using receiver operating curves (ROCs) analysis. Results Four CT and two PET radiomics features were finally selected to build the PET/CT radiomics model. Compared with area under the ROC curve (AUC) equal to 0.664, 0.683 and 0.662 for clinical features, maximum standardized uptake values (SUVmax) and total lesion glycolysis (TLG), the PET/CT radiomics model showed better performance to discriminate between EGFR positive and negative mutations with the AUC of 0.769 and the accuracy of 67.06% after 10-fold cross-validation. The combined model, based on the PET/CT radiomics and clinical feature (gender) further improved the AUC to 0.827 and the accuracy to 75.29%. Only one PET radiomics feature demonstrated significant but low predictive ability (AUC = 0.661) for differentiating 19 Del from 21 L858R mutation subtypes. Conclusions EGFR mutations status in patients with NSCLC could be well predicted by the combined model based on 18F-FDG PET/CT radiomics and clinical feature, providing an alternative useful method for the selection of targeted therapy.

In this paper, the uplink resource scheduling process of wireless network is introduced in detail, and then through the comprehensive analysis of uplink resource scheduling under carrier aggregation, we can know that after adding carrier aggregation technology, LTE-A uplink system scheduling not only has the resource block level scheduling, but also adds a layer of component carrier level scheduling, that is, the scheduling structure adds multiple carrier scheduling management Management module. Finally, combined with carrier aggregation technology, the uplink resource scheduling strategies of wireless networks are summarized, and their scheduling categories, advantages and disadvantages are summarized.

This study was conducted in order to compare the safety and efficacy of LLLT, 5% minoxidil, and combination therapy in the treatment of FPHL. A randomized controlled trial was developed to study the effect of LLLT on FPHL using a device called iHelmet®, which is equipped with 200 5mW laser diode source (650 nm) arrays. Ninety Ludwig’s types II–III FPHL patients were randomly divided into 3 groups: LLLT group (A), 5% minoxidil group (B), and combination group(C). Hair density, hair diameter, and scalp oil-secretion were detected to evaluate the treatment effect. Significant improvement of hair density and hair diameter was observed in all stages of FPHL after treatment. Oil-secretion of the three groups was decreased after treatment. The effectiveness of reducing oil-secretion in LLLT group and combination group was higher than minoxidil group (P

Androgenetic alopecia (AGA) is the most common type of baldness affecting both men and women. Studies investigating combination therapies for AGA reported greater efficacy than monotherapy but without rigorous examination. The authors performed a meta-analysis and systemic review to further verify the evidence. To evaluate the effectiveness of three common combination therapies of minoxidil with finasteride, low-level laser light therapy (LLLT) or microneedling versus minoxidil monotherapy. We conducted a systematic review of randomized controlled trials (RCTs) of combination therapies consisting of topical minoxidil for AGA through April 2020. Quality assessment and data analysis were performed by Review Manager 5.3. Fifteen studies met the inclusion criteria involving a total of 1172 AGA patients. We conducted meta-analysis for three groups of combined treatment separately, and all were superior to monotherapy in terms of global photographic assessment (P < .05). Combination of LLLT or microneedling with minoxidil also showed significant increase in hair count (P < .05) compared to monotherapy. The present study suggests that combination therapy could be an effective, safe and promising option for the treatment of AGA. However, more RCTs are needed to further investigate and confirm the efficacy of combined treatment.

In June 2019, Ministry of Industry and Information Technology awarded 5G licenses to three operators and National Radio and Television Administration. This marks that China has officially entered the 5G era. 5G is not only a technological upgrading of the communication industry, but also can speed up the upgrading of other vertical industries. In this paper, we introduce three key technologies of 5G: network slicing, network function virtualization (NFV) and software defined network (SDN), we also elaborate the application status of 5G network slicing technology in power communication network. Finally, we prospect the development of network slicing technology in power communication network.

This paper summarizes the research progress of TD-LTE interference coordination at home and abroad, summarizes the relevant interference suppression technologies used in TD-LTE system, discusses them in order of interference principle, system capacity and key technologies, and summarizes their application in power wireless special network.

Background Transplanted hair follicles suffer from various injuries, which are difficult to prevent. Hyperbaric oxygen therapy (HBOT) was reported to be an excellent procedure to promote capillary regeneration and reduce ischemia-reperfusion injury. Aim To evaluate the clinical efficacy of HBOT as an adjuvant therapy for hair transplantation surgery. Methods Thirty-four patients with II-IV alopecia were divided into the control group and HBOT group randomly. The control group was treated with routine FUE procedure, while HBOT group combined with HBOT. Patients were treated with 100% oxygen under 2.0 atmospheres absolute pressure for 60 minutes through a facemask during HBOT and take the therapy daily for 7 days continuously after operation. Satisfaction and clinical improvement were evaluated at the fourth week and the sixth month postoperatively. Results Itching and folliculitis were significantly decreased in HBOT group (11.8% vs 35.3%). In addition, HBOT resulted in a lower postoperative shedding rate (27.6 ± 2.6% vs 69.1 ± 2.4%); nevertheless, the survival rate at 9 months showed no significant difference between HBOT (96.9 ± 0.5%) and control (93.8 ± 0.6%). The early postoperative satisfaction in control group was much lower than HBOT group (52.9% vs 88.2%), whereas all patients showed satisfaction with the final result. Conclusion Hyperbaric oxygen therapy is able to minimize the postsurgical follicle shedding and lead to less folliculitis and itching, which provides evidence for HBOT to act as an adjuvant therapy for hair transplantation surgery.

The aim of this study was to evaluate the knowledge of and attitudes toward coronavirus disease 2019 (COVID-19) among the parents of child dental patients in Shenzhen during the outbreak. A structured questionnaire containing 10 questions was used, and each question had 2 or 3 possible answers. The parents of children (aged 0-14 years) who visited the dental department of our hospital last year were eligible to participate in this study. A total of 148 parents were interviewed by telephone in February 2020 by research staff. A total of 94.59% of the parents said they paid high attention to COVID-19 and explained it to their children; 66.22% thought the dental department environment was more dangerous than other public places; 91.89% believed the dental department had a higher risk of virus infection; and 83.78% said they would take their children to a dental department if the children had a severe toothache. Approximately 81.08% of the parents expressed confidence after we informed them about the preventive measures taken in the dental department to ensure safe treatment for their children. In conclusion, all parents were concerned about COVID-19, and most of them had talked about it with their children often. In addition, a considerable percentage of them would not take their children to the dental department even if they had severe dental pain and thought that the dental environment could be more dangerous than other environments. More information about this topic should be delivered to this population.

The rapid technological advances in the Internet of Things (IoT) allows the blueprint of Smart Cities to become feasible by integrating heterogeneous cloud/fog/edge computing paradigms to collaboratively provide variant smart services in our cities and communities. Thanks to attractive features like fine granularity and loose coupling, the microservices architecture has been proposed to provide scalable and extensible services in large scale distributed IoT systems. Recent studies have evaluated and analyzed the performance interference between microservices based on scenarios on the cloud computing environment. However, they are not holistic for IoT applications given the restriction of the edge device like computation consumption and network capacity. This paper investigates multiple microservice deployment policies on the edge computing platform. The microservices are developed as docker containers, and comprehensive experimental results demonstrate the performance and interference of microservices running on benchmark scenarios., Comment: Accepted by the 2020 IEEE INFOCOM WKSHPS: CNERT: Computer and Networking Experimental Research using Testbeds

There is a bidirectional relationship between inflammatory bowel disease (IBD) and depression/anxiety. Emerging evidences indicate that the liver may be involved in microbiota-gut-brain axis. This experiment focused on the role of melatonin in regulating the gut microbiota and explores its mechanism on dextran sulphate sodium- (DSS-) induced neuroinflammation and liver injury. Long-term DSS-treatment increased lipopolysaccharide (LPS), proinflammation cytokines IL-1β and TNF-α, and gut leak in rats, breaking blood-brain barrier and overactivated astrocytes and microglia. Ultimately, the rats showed depression-like behavior, including reduction of sucrose preference and central time in open field test and elevation of immobility time in a forced swimming test. Oral administration with melatonin alleviated neuroinflammation and depression-like behaviors. However, melatonin supplementation did not decrease the level of LPS but increase short-chain fatty acid (SCFA) production to protect DSS-induced neuroinflammation. Additionally, western blotting analysis suggested that signaling pathways farnesoid X receptor-fibroblast growth factor 15 (FXR-FGF 15) in gut and apoptosis signal-regulating kinase 1 (ASK1) in the liver overactivated in DSS-treated rats, indicating liver metabolic disorder. Supplementation with melatonin markedly inhibited the activation of these two signaling pathways and its downstream p38. As for the gut microbiota, we found that immune response- and SCFA production-related microbiota, like Lactobacillus and Clostridium significantly increased, while bile salt hydrolase activity-related microbiota, like Streptococcus and Enterococcus, significantly decreased after melatonin supplementation. These altered microbiota were consistent with the alleviation of neuroinflammation and metabolic disorder. Taken together, our findings suggest melatonin contributes to reshape gut microbiota and improves inflammatory processes in the hippocampus (HPC) and metabolic disorders in the liver of DSS rats.

Carpal tunnel syndrome is the most common compressive neuropathy, presenting with sensorimotor dysfunction. In carpal tunnel syndrome patients, irregular afferent signals on functional magnetic resonance imaging are associated with changes in neural plasticity during peripheral nerve injury. However, it is difficult to obtain multi-point neuroimaging data of the brain in the clinic. In the present study, a rat model of median nerve compression was established by median nerve ligation, i.e., carpal tunnel syndrome model. Sensory cortex remodeling was determined by functional magnetic resonance imaging between normal rats and carpal tunnel syndrome models at 2 weeks and 2 months after operation. Stimulation of bilateral paws by electricity for 30 seconds, alternating with 30 seconds of rest period (repeatedly 3 times), resulted in activation of the contralateral sensorimotor cortex in normal rats. When carpal tunnel syndrome rats received this stimulation, the contralateral cerebral hemisphere was markedly activated at 2 weeks after operation, including the primary motor cortex, cerebellum, and thalamus. Moreover, this activation was not visible at 2 months after operation. These findings suggest that significant remodeling of the cerebral cortex appears at 2 weeks and 2 months after median nerve compression.

Increasing number of offshore wind farm projects with wind turbines supported by suction bucket foundation in mildly sloping sandy seabed have being planned in earthquake-prone areas. Hence, it is crucial to evaluate the seismic performance of suction bucket foundations for offshore wind turbines in such liquefiable ground, especially considering the interaction between the bucket and both outside and inside bucket soil. Based on a pair of centrifuge shaking table tests, the seismic response of the bucket foundations and turbines in liquefiable ground is evaluated in this study. The dynamic response of soil, foundation, and turbine are presented. The test results indicate that the horizontal displacement of mildly sloping liquefiable seabed during earthquakes can results in excessive displacement and rotation of the bucket foundation. The influence of inside-bucket soil on foundation and turbine response, and especially on the kinematic and inertial interactions of the system are analyzed in detail. The analysis results indicate that inside-bucket soil plays an important role in stabilizing the foundation-turbine system during earthquakes, restricting the displacement and rotation of the foundation and the acceleration of the turbine.

The novel two-dimensional semiconductors with high carrier mobility and excellent stability are essential to the next-generation high-speed and low-power nanoelectronic devices. Because of the natural abundance, intrinsic gap, and chemical stability, metal oxides were also recently suggested as potential candidates for electronic materials. However, their carrier mobilities are typically on the order of tens of square centimeters per volt per second, much lower than that for commonly used silicon. By using first-principles calculations and deformation potential theory, we have predicted few-layer MoO3 as chemically stable wide-band-gap semiconductors with a considerably high acoustic-phonon-limited carrier mobility above 3000 cm2 V–1 s–1, which makes them promising candidates for both electron- and hole-transport applications. Moreover, we also find a large in-plane anisotropy of the carrier mobility with a ratio of about 20–30 in this unusual system. Further analysis indicates that, because of the unique...

Androgenetic alopecia is the most common form of hair loss disorder. The features of this process are shortening of the anagen phase in hair cycling and progressive miniaturization of the hair follicle. However, the mechanisms in androgenetic alopecia are still unclear, and the treatment methods are also limited. Therefore, further study on the pathogenesis and new therapies for androgenetic alopecia are urgently needed. In this study, we found that endogenous autophagy was severely impaired, accompanied by increased apoptosis in early catagen-like miniaturized hair follicles from the balding scalps of androgenetic alopecia patients. Moreover, inhibition of autophagy using 3-methyladenine could induce apoptosis, premature hair follicle regression and slow down the hair growth in organ-cultured hair follicles. Taken together, these results suggest that impairment of autophagy could be a potential mechanism in androgenetic alopecia.

Background Hair transplantation is the gold standard method for the treatment of alopecia. Recently, demand for the surgery has increased rapidly. However, high demands also require more professional training for the surgeons. With the maturing of hairline design skills, parietal whorl design has become the next challenge and no appropriate training models have yet been reported. Aims To present an innovative, simple, and appropriate training model for designing the scalp parietal whorl. Methods Outward divergent arc curves were drawn from the navel of an orange. Recipient sites were created with 23G needles or 1.0-mm knives or 1.0-mm blades according to the outward divergent arc curves, then hair shafts were transplanted using forceps. Results Different densities of hair shafts were transplanted. Transplantation of 10-20 follicular units (FU)/cm2 was too sparse, 30 FU/cm2 achieved a good appearance, but 40-50 FU/cm2 was better. Through practicing on the model, excellent results of parietal whorl transplantation on patients can be achieved. Conclusions This new model can perfectly suit the lines and direction of the parietal whorl and also present different density transplantation practicing. We provide a training method for new surgeons as well as a rehearsal opportunity for previously trained doctors.

Platelet-rich plasma (PRP) has received growing attention as a valuable therapeutic tool in androgenetic alopecia (AGA). However, knowledge regarding specific effectiveness and satisfaction of PRP for different grades of AGA in male pattern hair loss (MPHL) and female pattern hair loss (FPHL) is missing. This study aims to ascertain and compare the efficacy and safety of PRP treatment for different grades of AGA in males and females over 6 months. In this study, 51 MPHL patients with Norwood-Hamilton stage II-V and 42 FPHL patients with Ludwig stage I to III were enrolled for 6 monthly sessions of PRP injections. A longitudinal analysis was used to compare the hair density, thickness, and hair pull test over 6 months for MPHL and FPHL through generalized estimating equation (GEE) models. Phototrichograms of scalp inflammation and oil secretion, global photographs and overall patient satisfaction were also assessed. Consequently, improvement of hair density, hair thickness, hair pull test, the level of scalp inflammation and oil secretion were observed with statistical significance in all stages for both MPHL and FPHL at 6 months. Noteworthy, lower level of alopecia (Grade II, III in MPHL and Grade I in FPHL) had better response to PRP, and also had a better tendency of increment of hair growth than that of high-grade patients with prolonged treatment. PRP injections, as an efficacious and reliable therapy, can be recommended for Grade II and Grade III in MPHL and Grade I in FPHL.

Background Severe androgenetic alopecia has significant impact on patients' self-image and emotional health. As the most advanced way to achieve the growth of a full head of hair in shortest period of time, the megasession hair transplant procedure is a promising treatment for severe androgenetic alopecia. Aims To introduce the procedure and technical details of follicular unit extraction megasession and to evaluate the surgery outcome. Method A total of 273 male patients undergoing follicular unit extraction (FUE) megasession between 2016 and 2018 were included in our study. The extraction was performed using 1.0 mm punch. The BASP classification degree of patient hair loss, the number of extracted hair, surgery consuming time, and graft survival rate were recorded. We finally evaluated patients' satisfaction with surgery outcomes. Results Ages of patients ranged from 28 to 53 years, with a mean of 42 years (SD, 8.42). All of them were at C3 and U1 degree of BA type hair loss according to the BASP classification. The number of follicular units transplanted was between 3000 and 6000, with surgery duration range from 6 hours to 12 hours and graft survival rate varies from 93.5% to 96.6%. A total of 81% of them were satisfied with the outcomes, 19% of them had a second procedure performed to provide further hair density. None of them had infection after the surgery. Conclusion Compared with multi-stage hair transplantation, FUE megasession has the advantages of reducing operation frequency and overall surgery duration. Thus, FUE megasession is an appealing treatment option for severe AGA patients, who expect to a more desirable natural and esthetically pleasing result in a one-stage operation.

With the increasing complexity of access and network structure of smart devices, there are many security threats in smart distribution networks. How to ensure the security of smart distribution network communication has become an important challenge for the safe and stable operation of smart distribution networks in the future. In response to this, this paper proposes an encryption algorithm based on electric emergency communication system. The algorithm uses the random number sequence generated by the two-dimensional mapping to XOR with the plaintext to obtain two ciphertexts. Then, the two ciphertexts are subjected to different scrambling operations, and the two ciphertexts are combined into a matrix according to the parity of the number of loops of the encryption algorithm. The first round of encryption is then completed through column confusion, diagonal interchange, and generation of the next round of keys. Loop through the above steps to get the final encrypted ciphertext. The algorithm is innovative in preventing the attacker from exhausting the key, and the algorithm is simple, the running speed is fast, the encryption is efficient, and the reliability of the data transmission is improved. The algorithm is suitable for application in the electric power emergency communication system to ensure the safe operation of the power communication network, and can effectively improve the security of information transmission and the real-time performance of data transmission in the emergency communication system.

A novel data streaming scheme, simply named RS-BSS, is proposed based on Bundle Streaming Service (BSS) framework to perform high quality data streaming service in deep space. By integrating the Reed–Solomon (RS) codes into the BSS, the RS-BSS scheme can get more in-order data streaming within the initial transmission, which improves the performance of the “best-effort” service in BSS. Meanwhile, the “reliable” service in BSS can also be improved since the recovery capabilities provided by RS codes would reduce the retransmission times. By implementing the RS codes into the transport layer of BSS, the proposed scheme has the advantages of strong error recovery capabilities and better real-time performance. An emulated data streaming communication experiment between two nodes is conducted to evaluate the performance of the proposed scheme in deep space environment. The evaluation results show that the proposed scheme has less stream delivery time (SDT) and more stable end user’s display efficiency (EDE) against the severe transmission conditions. This means the RS-BSS scheme improves the performance of both “best-effort” and “reliable” services in BSS.

Ancient Chinese brings the wisdom and spirit culture of the Chinese nation. Automatic translation from ancient Chinese to modern Chinese helps to inherit and carry forward the quintessence of the ancients. However, the lack of large-scale parallel corpus limits the study of machine translation in Ancient-Modern Chinese. In this paper, we propose an Ancient-Modern Chinese clause alignment approach based on the characteristics of these two languages. This method combines both lexical-based information and statistical-based information, which achieves 94.2 F1-score on our manual annotation Test set. We use this method to create a new large-scale Ancient-Modern Chinese parallel corpus which contains 1.24M bilingual pairs. To our best knowledge, this is the first large high-quality Ancient-Modern Chinese dataset. Furthermore, we analyzed and compared the performance of the SMT and various NMT models on this dataset and provided a strong baseline for this task., To appear in the ACM Transactions on Asian and Low-Resource Language Information Processing (TALLIP)

It is necessary to evaluate a successful cosmetic procedure from the patients’ perspective. FACE-Q is a patient-reported outcome scale for patients undergoing cosmetic procedures. However, currently there are no FACE-Q scales used in the field of hair transplant surgery. This article aims to apply FACE-Q scales to evaluate the satisfaction of patients undergoing hair transplantation surgery. FACE-Q scales were modified to contain both preoperative and 6-month postoperative self-assessment, including baseline preoperative information of patients (such as age, family history of alopecia, Hamilton’ alopecia grade),preoperative self-assessment (satisfaction with appearance, the preoperative visual age, expected visual age) and postoperative self-assessment (satisfaction with appearance, postoperative visual age, satisfaction with decision, psychological well-being and social function). Besides, early life impact and recovery early symptoms were also re-evaluated. The mean difference between the 6-month satisfaction with appearance and baseline scores showed a significant increase of 29.62 (baseline, 46.97; 6-month, 76.59; P

China is the largest global producer of antibiotics. With the demand for antibiotics increasing every year, it is necessary to assess potential environmental risks and the spread of antibiotic resistance genes (ARGs) associated with antibiotic production. Here, we investigated the occurrence and distribution of ARGs in soil in the vicinity of a pharmaceutical factory. The results showed that antibiotic concentrations were under the detection limit; however, ARGs were present in soil and tended to be enriched near the factory. A significant correlation between the relative abundance of intI-1 and tetracycline ARGs implied that horizontal gene transfer might play an important role in the spread of ARGs. The occurrence of these ARGs could be the results of previous antibiotic contamination. However, the soil bacterial community structure seemed to be more affected by nutrients or other factors than by antibiotics. Overall, this study supports the viewpoint that long-term pharmaceutical activity might have a negative effect on environmental health, thus, underscoring the need to regulate antibiotic production and management.

Aims Scientific evidence on the effects of chronic periodontitis on end-stage renal disease (ESRD) remains inadequate and inconclusive. This intervention study was designed to evaluate the effects of non-surgical periodontal therapy on the clinical response and systemic status of ESRD patients. Materials and Methods Patients in the intervention group (n = 48) received non-surgical periodontal therapy and then a supragingival prophylaxis at the 3-month follow up, and those in the control group (n = 49) received no intervention throughout the study. At 6 weeks, 3 months, and 6 months after therapy, clinical periodontal examinations were conducted and blood samples were taken to evaluate inflammatory, nutritional and lipid profiles. Results The results showed a significant improvement in clinical periodontal parameters (p

Objective This study aimed to analyze the focal uptake of iodine-131 (131I) in the upper pelvis superior to the urinary bladder on whole-body images of patients who underwent this treatment after thyroidectomy for differentiated thyroid cancer. Methods Between June 2012 and March 2013, 205 patients (72 men and 133 women, with an average age of 47.9 ± 11.7 years) who underwent 131I radioactive treatment after thyroid cancer surgery were analyzed retrospectively. Pathological findings confirmed papillary thyroid carcinoma. A whole-body scan was acquired 5 days after 100-120 mCi sodium iodide was administered orally to the patients. Single-photon emission computed tomography/computed tomography (SPECT/CT) scanning was carried out to locate the lesion; this showed abnormal intense activity in the upper pelvis superior to the urinary bladder, which was further evaluated by ultrasonography. Results Using 131I-SPECT scanning, five (3.76%) female patients were shown to have abnormal focal radioactivity in the lower abdomen. Subsequent SPECT/CT examination showed that the radioactivity was located in the cervix in four of the five patients and in the sigmoid colon in one patient. Transvaginal ultrasonography was performed in the former four patients, which revealed several echo-free regions in the cervix. These findings are consistent with the diagnosis of a nabothian cyst. Three of these patients were administered a second course of radioiodine therapy. Radioactive uptake was still visible at the same sites on whole-body imaging. Conclusion Nabothian cyst should be considered in cases in which abnormal uptake in the upper pelvis superior to the urinary bladder is detected on 131I whole-body scans after differentiated thyroid cancer resection.

Due to the node failures incurred by intrusion threat, a wireless sensor networks will initiate topology re-generation, which is based on correct availability evaluation of current intrusion-tolerant topology. The paper proposes an availability evaluation model based on semi-Markov process (SMP) to estimate topology availability of the intrusion-tolerant topology concerning the effects from intrusion behaviors. In view of some limitations of node computation ability and storage ability, this model reduces the complexities resulting from modeling the different intrusion threats and is set up on the uniform intruding results to simplify the model design. Using the DTMC model embedded in SMP topology availability is computed and finally we analyze the sensitivity to parameters in the model.

OBJECTIVE To analyze the prognostic factors in patients with non-Hodgkin’s lymphoma (NHL) and to investigate the prognostic value of the absolute lymphocyte count (ALC) in peripheral blood in NHL patients at admission. METHODS The clinical features and follow-up data from 108 NHL patients whose diagnosis was confi rmed through pathologic examination during a period from January 2000 to January 2008 were reviewed. SPSS 14.0 package was used for statistical analysis, and the Kaplan-Meier curve method for assessment of survival probability. Furthermore, the Cox regression model was utilized for multivariate analysis for all parameters which were statistically significant and confi rmed by univariate analysis. RESULTS In the 108 NHL patients, the male-female ratio was approximately 1.5 : 1 and the median age was 48 years. Before treatment, 61.1% of the patients had stage I and II disease, based on the Ann Arbor Clinical Classifi cation. The ECOG performance status (PS) score reached a range from 0 to 1 in about 93% of total patients, and an elevated serum lactate dehydrogenase (LDH) was seen in 19.2%. Based on the international prognostic index (IPI) score, 80.6% of patients were in the low risk group. On admission, 35.2% of patients had an ALC ≤ 1 × 109 /L. Anemia, i.e. hemoglobin (Hb) ≤ 110 g/L was seen in 29.6% and B-symptoms in 26.9% of patients. The mean value of Hb was 129.2 ± 17.5 g/L in patients with ALC > 1 × 109 /L (n = 70) and 98.1 ± 20.6 g/L in those with ALC ≤ 1 × 109 /L (n = 38), and the difference between the 2 groups was statistically significant (P < 0.05). With a median follow-up period of 2 years, the median survival time was 2.3 years among all patients. The 2-year and 5-year overall survival (OS) rates were 73.2% and 39.6%, respectively. It was shown by univariate analysis that ALC ≤ 1 × 109 /L, Hb ≤ 110 g/L, B-symptoms, and the IPI ≥ 2 were statistically signifi cant unfavorable prognostic factors in NHL patients. Multivariate analysis revealed that ALC ≤ 1 × 109 /L, B-symptoms, and the IPI ≥ 2 were independent unfavorable prognostic factors in NHL patients. CONCLUSION The numerical value of ALC and the presence of B-symptoms are prognostic factors independent of IPI in NHL patients. Clinically, determining prognosis based on the IPI combined with simple clinical parameters, such as the numerical value of ALC and B-symptom status, might be of more practical value in determining individualized treatment regimens for NHL patients.

Men with congestive heart failure (CHF) have relatively low testosterone levels. Several studies demonstrated that testosterone treatment increases cardiac output and reduces peripheral vascular resistance. However, the effects of testosterone on heart function, cardiomyocyte apoptosis and ventricular remodeling have not been fully elucidated. This study was conducted to investigate the effects of testosterone on heart function, cardiomyocyte apoptosis and ventricular remodeling in male rats post-myocardial infarction. A total of 86 male rats were randomly assigned to undergo ligation of the coronary artery (n=70) or pseudosurgery (n=16). After 6 weeks, a left ventricular ejection fraction (LVEF) of ≤45% was defined as a successful model of CHF. The model rats were randomly assigned to 3 groups, namely low-dose testosterone (TU), high-dose TU and placebo (PL) groups. After treatment for 12 weeks, the expression of several mRNA transcripts in myocardial tissue was measured by quantitative polymerase chain reaction. Immunofluorescence was used to measure myocardial caspase-3 expression. Compared to the PL group, LVEF was significantly improved in the TU treatment groups. Moreover, the mRNA expression of atrial natriuretic peptide, brain natriuretic peptide, matrix metalloproteinase-2 and sarcoendoplasmic reticulum Ca2+-ATPase 2a was significantly reduced, while the mRNA expression of glycogen synthase kinase 3β and tissue inhibitor of metalloproteinase-2 was markedly increased in the TU groups. TU treatment also significantly reduced caspase-3 expression. Therefore, different doses of TU suppressed ventricular remodeling and improved left ventricular function, reduced apoptosis and prevented mortality in a CHF rat model.

This paper evaluated the effect of capitation payment reform in New Rural Cooperative Medical Scheme designating primary facilities in Qianjiang 2007-2009. Retrospective administrative claims were analyzed. Intercepts changes of cost per visit in facilities started the reform in different stages and of overall Qianjiang were compared. Referral rate, prescribing indicators, hospitalization rate, income of facility and individuals were compared pre- and post- the reform. Growth rate of cost per visit in health centers was contained in 2008, kept unchanged in 2009. Cost containment effect on village clinics was observed in each starting stage of reforms, but vanished later on. Except for the fact the proportion of essential medicines used in health centers significantly increased (X2 test, P

Objective: This study was designed to investigate the relation between plasma von Willebrand factor (VWF) or endothelin-1 (ET-1) and post-carotid artery stenting (CAS) restenosis. Materials andMethods: Plasma levels of VWF and ET-1 were measured in 61 patients (36 males, mean age 64.4 ± 6.8 years) before and after CAS. The mean follow-up time was 13.8 ± 1.7 months (range, 6–63). In-stent restenosis was defined as a >10% narrowing of the vascular lumen with or without ischemic symptoms following CAS. Results: In-stent restenosis was identified in 14 (23%) patients, including 3 with >50% restenosis. In the restenosis group, mean VWF and ET-1 levels at 2 weeks, 1 and 6 months after CAS were higher than the baseline levels (p < 0.05 or p < 0.01). Mean levels of VWF and ET-1 in the restenosis group were higher than in the non-restenosis group within 6 months after CAS (p < 0.05 or p < 0.01). Conclusion: Persistent elevation in plasma VWF and ET-1 within the first 6 months of CAS was found in patients with in-stent restenosis.

According to the exist problems of traditional electromechanical theory, this paper make new analysis and industrial test on ac motor speed control principle, propose a new power control theory on ac motor speed control, that is ‘P’ theory. This theory is: motor speed control principle comes from mechanical. Speed regulation is the control of mechanical power in nature. Therefore, electric control speed has two principles that are electromagnetic power and loss power control, the former change ideal running-in speed n0. It is high efficiency, the latter increasing the speed drop Δn belonging to low efficiency speed control. The main performance of speed control lies in speed control principle, not specific adjustment speed method. Meanwhile, propose the speed control formula of induction motor.

In order to accurately get extent of the water deficit and therefore realize effective and water-saving irrigation, the application of wireless sensor networks (WSN) to precision irrigation system is explored based on the acoustic emission principle for crop water stress. Cluster based multi-hop routing algorithm is proposed to reduce energy consumption of node transmitting data. By the newest gateway in WSN, the system realizes bridging between wireless networks and wired networks. It runs distributed and possesses many advantages, such as good robustness, extensibility, scalability, and so forth. Simulation results show that the application is correct and reasonable and enables user to precisely acquire the crop water requirement information. The system can be effectively applied to some water-saving agriculture areas, for example, the cropland, the nursery garden, the greenhouse, etc.

In this paper, we describe an approach to OOV translation mining based on web search. Without comparable corpus or parallel corpus, we first expand the Chinese OOV phrase with English segments by a C-E dictionary. Then the OOV and the expansion will be submitted to the web search engine. From the snippets we can mine the translation of the OOV. Experiment shows that the algorithm is simple and the approach is feasible.