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Resume Introduction. – La thrombose intracardiaque est une complication rare de la maladie de Behcet (MB), qui peut se presenter comme une tumeur intracardiaque. Sa decouverte precede, dans la moitie des cas, le diagnostic de MB. La mortalite elevee peut etre en rapport avec des complications postchirurgicales et/ou une atteinte associee des arteres pulmonaires. Exegese. – Nous rapportons l'observation d'une femme francaise caucasienne de 31 ans, aux antecedents de maladie thromboembolique veineuse (MTEV), qui a subi une chirurgie apres la decouverte d'une tumeur du ventricule droit. Il s'agissait d'un thrombus organise avec fibrose endomyocardique et dans les suites operatoires nous avons diagnostique une MB. L'evolution a ete favorable sous traitement medical associant une corticotherapie, de la colchicine et des antivitamines K (AVK), sans recidive quatre ans apres. Conclusion. – La decouverte d'une masse intracardiaque chez un sujet jeune doit faire evoquer le diagnostic de thrombus cardiaque et de maladie de Behcet, meme en l'absence de facteur ethnique ou geographique predisposant.

Resume Les auteurs rapportent deux cas de syndrome de Lambert-Eaton associes a un cancer bronchique a petites cellules. Les donnees concernant le diagnostic clinique sont rappelees. Les acquisitions recentes sur le caractere auto-immun de cette affection, les relations entre le syndrome paraneoplasique et le cancer a petites cellules sont discutees. Ce syndrome est lie a la presence d'anticorps qui bloquent les canaux calciques voltage-dependants des terminaisons nerveuses. Les cellules du cancer a petites cellules expriment des canaux calciques, ces determinants antigeniques induisent probablement la production des anticorps. L'hypothese de l'origine auto-immune de ce syndrome paraneoplasique repose sur la notion d'antigenicite croisee.

Resume Deux cas de femmes jeunes, avec occlusion arterielle aigue du membre superieur droit et diagnostic concomitant de maladie de Basedow sont rapportes. Il s'agit vraisemblablement d'embolies arterielles sur trouble du rythme paroxystique, sans notion de cardiopathie. Le bilan thyroidien doit etre rajoute a la liste des examens complementaires a pratiquer au cours de la demarche etiologique d'une occlusion arterielle chez un sujet jeune sans facteur de risque cardio vasculaire.

OBJECTIVE To assess the potential role of allo-immunization, either by former pregnancies, or by a history of blood transfusion, in the pathogenesis of giant cell arteritis and polymyalgia rheumatica. METHODS Two hundred and eighty-five incident female cases and 186 age-matched, population-based female controls were prospectively included in a multicentre case-control study. RESULTS The number of pregnancies was significantly lower in cases than in controls (nulliparous: 21.55% vs 12.90%; > or =4 pregnancies: 16.25% vs 27.42%; Wilcoxon rank sum test: P = 0.0019) in biopsy-proven or negative temporal arteritis and, to a lesser extent, in polymyalgia rheumatica. No difference was found for history of blood transfusion. Pregnancies remained negatively associated with the disease in a multivariate analysis including cardiovascular risk factors such as smoking or a pre-existing peripheral vascular disease. CONCLUSION Former pregnancies are not a risk factor for giant cell arteritis. Pregnancies may be protective thanks to an effect of the associated hyperoestrogenic state against alterations of the artery wall, as suggested in animal models.

We report two cases of fatal necrotizing vasculitis in patients under 50, with intestinal gangrena resistant to immunosuppressive treatment, plasmapheresis and hyperbar oxygen. Although showing signs of necrotizing arteritis, biopy failed to recognize any specific feature of known vasculitis.

Jaw claudication and clinically abnormal temporal artery are shown to be highly specific of giant cell arteritis with positive biopsy, whereas headache and fever, more commonly seen in negative biopsy arteritis, may reflect the inclusion of non-related pathologies in this group.

We report a set of clinical criteria easily collected at the time of patient's examination, which allow the diagnostic of Giant Cell Arteritis with a sensitivity of 85 % and a positive predictive value of 72,5 % when the biopsy is negative.

We report one case of biopsy-proved large cell arteritis with polyneuropathy and intestinal involvement leading in 15 days to mesenteric ischemia, small bowel perforation, multivisceral failure and death in spite of the administration of high-dose steroids, symptomatic treatment and abdominal surgery.

We report a series of 40 cases of infectious endocarditis, diagnosed on a 10-year period in a department of Internal Medicine. Initial clinical features were not suggestive of endocarditis and led to delayed hospitalization and diagnosis.

33 % of patients giant cell arteritis (Ta and PMR) versus 9 % of controls have been tested positive for anticardiolipine antibodies at the time of diagnosis. Positive patients presented severe vascular complications.

We report a case of a 60-year old woman, with a tracheal stenosis as the first sign of Wegener's granulomatosis. This is the twelfth observation described in the literature.

We report a case of digital necrosis after treatment with diclofenac, regressive after cessation of the drug and steroid therapy. Biological findings were those of a chemically induced lupus.

We report 2 complications of celiac disease, which were the first sign of the disease previously unknown : a B lymphoma and an adenocarcinoma of the small intestine.

We report a case of painless giant cell thyroiditis with inflammatory syndrome, hypothyroidism, and multinodular goiter regressive after steroid treatment. The association with headache rises the question of its relation with giant cell arteritis.