1. The Role of Tumor Necrosis Factor-α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis
- Author
-
Azadeh Hajipour, Azam Pourtaheri, Saied Doaei, Afshin Shafaghi, Naser Kalantari, Mohammad Esmail Akbari, Hadi Sedigh Ebrahim-Saraie, Samaneh Mirzaei Dahka, Samira Rastgoo, and Maryam Gholamalizadeh
- Subjects
medicine.medical_specialty ,Tumor Necrosis Factor-alpha ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Cancer ,Odds ratio ,medicine.disease ,Polymorphism, Single Nucleotide ,Confidence interval ,Cytokine ,Asian People ,Oncology ,Stomach Neoplasms ,Polymorphism (computer science) ,Case-Control Studies ,Internal medicine ,Meta-analysis ,medicine ,Humans ,Genetic Predisposition to Disease ,Tumor necrosis factor alpha ,business ,Tumor necrosis factor α - Abstract
Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine which may play a role in the development of gastric cancer (GC). This study aimed to investigate the association of five TNF-α polymorphisms including TNF-α-857, TNF-α-1031, TNF-α-863, TNF-α-308, and TNF-α-238 polymorphisms with GC risk. All eligible case–control studies were collected by searching PubMed, Scopus, and Web of Science. The association of the risk of GC with TNF-α polymorphisms was estimated using odds ratio (OR) and 95% confidence interval (CI). Heterogeneity was assessed via Cochrane’s Q and I2 analyses. A total of 46 publications involving 16, 715 cases with GC and 27, 998 controls were recruited. The study revealed a significant association for TNF-α 308 (recessive model: OR = 0.646, P = 0.035), TNF-α-1031 (homozygote model: OR = 1.584, P = 0.027), and TNF-α-857 (homozygote model: OR = 1.760, P = 0.001) polymorphisms with the GC risk. The results of subgroup analysis based ethnicity found a significant association between GC risk and TNF-α-857 polymorphism in Caucasian subgroup (P = 0.005) and TNF-α-1031 polymorphism and GC risk in Asians (P = 0.018). This study suggested that TNF-α-857 and TNF-α-1031 polymorphisms may be associated with the increased gastric cancer risk. more...
- Published
- 2021
- Full Text
- View/download PDF