1. Markers of brain and endothelial Injury and inflammation are acutely and sex specifically regulated in SARS-CoV-2 infection
- Author
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Jude Savarraj, Eun S. Park, Gabriela Copo, Sarah Hinds, Diego Morales, Hilda Ahnstedt, Atzhiry Paz, Andres Assing, Shivanki Juneja, Eunhee Kim, Sung-min Cho, Aaron Gusdon, Pramod Dash, Louise McCullough, and H Alex Choi
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Inflammation ,Systemic inflammation ,Interleukin 10 ,Cytokine ,Interleukin 1 receptor antagonist ,Internal medicine ,Cohort ,medicine ,Tumor necrosis factor alpha ,Interleukin 8 ,medicine.symptom ,business - Abstract
ObjectiveTo investigate brain injury markers (BIM), endothelial injury markers (EIM) and cytokine/chemokine (CC) markers of systemic inflammation in coronavirus disease 2019 (COVID-19) and across sex.MethodsPlasma samples from 57 subjects at ResultsThree BIMs: MAP2, NSE and S100B, two EIMs: sICAM1 and sVCAM1 and seven CCs: GRO IL10, sCD40L, IP10, IL1Ra, MCP1 and TNFα were significantly (pConclusionThe acute elevation of BIMs, CCs, and EIMs and the robust associations among them at COVID-19 hospitalization suggest that brain injury is mediated by endotheliopathy and inflammation. Higher BIM and inflammatory markers in men additionally suggest that men are more susceptible to the risk compared to women.
- Published
- 2021
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