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Background: Patellar tendinopathy is a common cause of limitations in daily life activities in young and/or active people. The patellar tendon consists of a complex of collagen fibers; therefore, collagen could be used as a scaffold in the treatment of patellar tendinopathy. Purpose: To evaluate the healing capacity of injected atelocollagen as a treatment scaffold for patellar tendon defect and, hence, its potential for the treatment of patellar tendinopathy. Study Design: Controlled laboratory study. Methods: After receiving a full-thickness patellar tendon defect, 24 New Zealand White rabbits were divided into a control group (without treatment) and an experimental group that received an atelocollagen injection into the defect. Six rabbits from each group were subsequently used for either histologic scoring or biomechanical testing. The Mann-Whitney U test was used to compare histologic evaluation scores and load to failure between the 2 groups. Statistical significance was set at P < .05. Results: The experimental group showed excellent repair of the damaged patellar tendon and good remodeling of the defective area. In contrast, the control group showed defective healing with loose, irregular matrix fibers and adipose tissue formation. A statistically significant difference was found between the 2 groups in both histologic scores and biomechanical tests at postoperative week 12. Conclusion: Injection of atelocollagen significantly improved the regeneration of damaged patellar tendons. Clinical Relevance: Atelocollagen gel injections could be used to treat patellar tendinopathy in outpatient clinic settings.

Envelope tracking (ET) is a key technology improving efficiency of RF power amplifiers (PAs) and battery lifetime in mobile handsets. It has been commercialized since 4G LTE era, and is also being employed in 5G NR handsets. A supply modulator (SM) is a circuit generating power supplies of RF PAs for ET and average power tracking (APT) operations. Currently, the maximum channel BW and supported ET BW of 5G NR handset is 100MHz [1]–[4]. In a short time, over 100MHz BW will be necessary to support intra-band contiguous carrier aggregation cases of n77C/n78C/n79C in 3GPP standard [5]. The required instantaneous maximum output power of SM is about 10W which is calculated by the following parameters: 26dBm output power by power class 2 (PC2), 2dB loss of RF front-end module (FEM) due to complex operating band combinations (EN-DC for non-standalone mode, NE-DC, 2CA/3CA), 6dB higher instantaneous power due to peak-to-average power ratio (PAPR) at 1 resource block (RB), 1dB margin, and poor PA efficiency of around 33% (worst example) due to high carrier frequency of 5GHz at n79 band. The poor PA efficiency can be relaxed by high voltage PA design beyond 5V. In [1], a supply modulator with boosted output larger than battery voltage $(V_{BAT})$ is proposed, and the designed PA with 30% higher voltage shows 10% higher efficiency and broader BW owing to low impedance transformation ratio from $50 \Omega$ and small parasitic output capacitance of power cell. The challenge is how to design a supply modulator for 5G NR that can achieve both wide ET BW and high output voltage/power capability, while satisfying high efficiency, low receiver-band noise, short transition time, and multi-mode/standard operation.

Background This study aimed at determining the effect of the herbal mixture estrogen inhibition formula (EIF) and its possible mechanisms by precocious puberty animal models and network pharmacology-based analysis. Methods Precocious puberty animal models were established by a single injection of 300 μg danazol, then female rats were administered EIF, vaginal openings were monitored, uterus and pituitary indices were determined. The levels of ALP, E2, LH, and FSH were measured using ELISA kits. Real-time PCR was performed to evaluate the mRNA expression of GnRH, UNC5C, and netrin-1 in hypothalamic tissues. We applied network pharmacological analysis to predict potential targets and pathways of EIF. Results EIF delayed danazol-induced early vaginal opening. In the onset model, EIF reduced the increased levels of serum ALP, E2, LH, and FSH; as well as mRNA expressions of GnRH, Netrin-1, and UNC5C. Moreover, long-term administration of EIF not only diminished all impaired factors but also had no effect on the normal development of the animals. The gene set enrichment analysis showed that the targets of EIF are mainly associated with the GnRH signaling and ovarian steroidogenesis pathways. Conclusion EIF could be used in preclinical research for the treatment of precocious puberty by the inhibition of HPGA pre-maturation.

Patients who commit self-wrist cutting injuries (SWCIs) are a heterogeneous group composed of patients with non-suicidal self-injury (NSSI) and suicide attempt (SA). The purpose of this study was to compare the demographic features and wound characteristics of patients with NSSI and SA. A retrospective review of 300 patients who visited the emergency department (ED) for treatment of SWCIs between January 2011 and December 2015 was performed. Data collected from the electronic medical records included age, sex, the reason for SWCIs, presence of suicidal ideation, concomitant intoxication with alcohol or drugs, past psychiatric history, whether or not the patient received psychiatric counseling at the ED, the principal psychiatric diagnosis, the number and severity of external wounds, and subsequent follow-up at the psychiatric or hand surgery outpatient department (OPD). The patients were divided into the NSSI and SA groups according to the presence of suicidal ideation and other variables were compared between the two groups. There were 138 NSSI patients and 162 SA patients. The NSSI group was younger (33.9 years vs 40.9 years, P

In recent years, buck-boost converters have been widely utilized for battery-powered mobile systems such as RF power amplifiers, battery chargers, and LED drivers. However, in a wide battery voltage range, they face challenges including dynamic voltage scaling (DVS), wide load current range, and dynamic line/load transients while ensuring reliability for an industrial usage. To resolve these issues, the conventional buck-boost (CBB) converter should overcome the characteristic of discontinuity in the output transfer current (OTC) which causes degradation of loop dynamics and transient response. Several past works with continuous OTC have been proposed to resolve these problems, but their voltage conversion ratios are limited [1], [2]. Moreover, in [3], [4], a high-voltage (HV) process, which necessitates large active area and incurs high fabrication cost, is required to withstand voltage stresses over 10V (2×V IN ) applied across power switches. To overcome the above challenges, this paper proposes a voltage-tolerant three-level buck-boost (TLBB) converter. The TLBB has continuous OTC and uses only normal 5V CMOS devices for its switches. In addition, a voltage-tolerant dual channel-interleaved three-level buck-boost (DTLBB) converter is suggested for applications [5] requiring a wide range of load current and high conversion ratio while supporting fast DVS transition.

Background/aims This study analyzed the risk factors for technique survival in dialysis patients and compared technique survival rates between hemodialysis (HD) and peritoneal dialysis (PD) in a prospective cohort of Korean patients. Methods A total of 1,042 patients undergoing dialysis from September 2008 to June 2011 were analyzed. The dialysis modality was defined as that used 90 days after commencing dialysis. Technique survival was compared between the two dialysis modalities, and the predictive risk factors were evaluated. Results The dialysis modality was an independent risk factor predictive of technique survival. PD had a higher risk for technique failure than HD (hazard ratio [HR], 10.8; 95% confidence interval [CI], 1.9 to 62.0; p = 0.008) during a median follow-up of 11.0 months. In the PD group, a high body mass index (BMI) was an independent risk factor for technique failure (HR, 1.3; 95% CI, 1.0 to 1.8; p = 0.036). Peritonitis was the most common cause of PD technique failure. The difference in technique survival between PD and HD was more prominent in diabetic patients with a good nutritional status and in non-diabetic patients with a poor nutritional status. Conclusions In a prospective cohort of Korean patients with end-stage renal disease, PD was associated with a higher risk of technique failure than HD. Diabetic patients with a good nutritional status and non-diabetic patients with a poor nutritional status, as well as patients with a higher BMI, had an inferior technique survival rate with PD compared to HD.

Unilateral sagittal split fracture (USSF) of the C1 lateral mass (LM) has been recently recognized as a rare variant of C1 atlas fracture. To date, there has been no study to investigate whether radiologic criteria can be applied to determine the presence or absence of transverse atlantal ligament (TAL) injury in USSF of the C1 LM. Twenty six consecutive cases of USSF of the C1 LM were included in this study. According to Dickman classification, 16 cases were TAL injury, and 10 cases were TAL intact. Radiologic parameters were measured and compared between the 2 groups. Total LM displacement (LMD) of the 2 sides (5.9 ± 2.0 mm vs 1.2 ± 2.0 mm), unilateral LMD of the fracture side (4.3 ± 1.2 mm vs 1.0 ± 1.1 mm), atlanto-dental interval (ADI) (2.0 ± 0.9 mm vs 1.5 ± 0.4 mm), and fracture gap (6.9 ± 2.7 mm vs 2.1 ± 1.1 mm) were statistically higher in the TAL injury group than the TAL intact group. However, basion-dental interval, clivus canal angle, and atlanto-occipital joint axis angle were not different between the 2 groups. Total LMD and unilateral LMD positively correlated with ADI and fracture gap. The incidence of fracture gap larger than 7 mm was statistically higher in the TAL injury group than the TAL intact group (81% vs 30%). In conclusion, total LMD > 5.9 mm or unilateral LMD > 4.3 mm suggests the presence of TAL injury in USSF of the C1 LM. The possibility of diagnostic error for TAL injury can be further reduced in USSF of the C1 LM by considering the fracture gap larger than 7 mm.

The doctor blade is equipped in a toner cartridge and is a device to maintain the uniform thickness of a toner by controlling the pressure on the developing roller. The contact pressure between the developing roller and the doctor blade is one of the significant factors for image quality and durability of toner cartridge. The purpose of this study is to develop approximation model in order to minimize the time and cost which are needed much required in making optimal design of the doctor blade. Central composite design was used for the design of experiment and response surface design was used for approximation. The data for contact pressure were acquired through finite element analysis and data of image density and toner weight were acquired through experiment. The approximation model developed in this study has presented very high fitness.

This paper proposes an oppositely coupled varactor pair and reports the measured results for applying to a test digitally controlled oscillator (DCO). The pair exploits the differences between the accumulation region capacitance and inversion region capacitance of pMOS varactors. The novel varactor pairs provide much smaller switchable capacitances than those of other approaches, and hence, the test DCO for verifying the property of the pair achieves the high-frequency resolution. The pairs and test DCO are implemented in a 0.18-μm CMOS process. The switchable discrete capacitance of 32 aF is obtained by using the novel varactor pairs, and the test DCO has a frequency resolution of about 110 kHz at 5.8 GHz. Furthermore, ΔC of 4-aF and 14-kHz frequency resolution can be obtained through the dithering processes. The test DCO achieves a low phase noise of -117.6 dBc/Hz at 1-MHz offset from 5.8 GHz.

This paper presents the finite element analysis for the dynamic characteristics of an inverter-fed permanent magnet linear synchronous motor (PMLSM) having the conductive sheet secondary. The time-stepping finite element method and the moving mesh technique are used for the simulation. The eddy currents in the secondary aluminum sheet and solid back-iron are taken into account in the electromagnetic field analysis.

Attracting ferromagnetic forces between magnet and reaction rail provide the supporting force in Electromagnetic Suspension. Miniature maglev using permanent magnets and electromagnets is based on the idea to generate the nominal magnetic force by permanent magnets and superimpose the variable magnetic field required for stabilization by currents flowing through control windings in electromagnets. Permanent magnets with a high energy density have lower power losses with regard to supporting force and magnet weight. So the advantage of the maglev using electromagnets and permanent magnets is partially reduced by the power required to feed the remaining onboard supply system so that the overall onboard power is diminished as compared to that of the electromagnet. In this paper we proposed the how to design and control the miniature maglev and confirmed the feasibility of the levitation system using electromagnets and permanent magnets through the manufacturing the miniature maglev.

A fully integrated HF multi-standard RFID transceiver for compact mobile terminals is proposed. Considerations for multi-standard are concerned in each part of the proposed transceiver and all of them are implemented as digitally-controlled components. A transmitter controls its modulation index with a mode selector and its emitting power to tags with a power controller, thus covering various standards and recognition ranges. A receiver has a compact size as it excludes capacitors. In a receiver, an ASK demodulator controls its reference level of modulation by switching a resistor, and an adaptable Schmitt trigger alters its hysteresis range by switching additional transistors. The proposed transceiver is implemented in a TSMC 0.18 um CMOS technology. Measurement results of the transceiver and communication test between a reader with the transceiver and tags verify abilities of the proposed transceiver for multi-standard.

An ultra compact CMOS transceiver for HF multi-standard RFID application is proposed. For supporting multi-standard, two structures are adopted in a transmitter: ASK modulator with various modulation indexes and power control circuit which can control the recognition range between the reader and the tag. A receiver consists of a half-wave rectifier, an ASK demodulator using a supply-independent biasing circuit, and an adjustable Schmitt trigger. The designed transceiver is fabricated using TSMC 0.18 µm CMOS process. Through the simulation, the designed transceiver system can be operated in multiple standard conditions.

In this paper, single-sided linear induction motors (LIM) for magnetically levitated vehicle (MAGLEV) are analyzed according to the secondary structure. The secondary structure is redesigned to improve the performance of the MAGLEV. Finite element method is used in order to calculate thrust, normal force and electrical performance of the LIMs.

The objective of this paper is to propose a two phase reverse neural network (NN) model to predict sequential human bio signal data for decreasing the risk of acute and likely fatal diseases and syndromes in patients (e.g., COPD and hypertension) based on a simulated learning algorithm. Our approach uses a two phase sequential neural network with back-propagation learning. The modeling is done using time-varying inputs such as heart rate, SpO_2, and blood pressure as measured and communicated by wireless devices. The output of the prediction system results into distinct classification levels for patient?s condition through sequential points. Such a prediction facilitates an early detection of exacerbating risk factors thereby saving a sudden death and other high risk diseases. The system is plausible to be used for the prevention and management of high risk diseases.

This paper analyzes static characteristics of permanent magnet type stepping motors with claw poles using three-dimensional finite element method. The outer diameter of the stepping motor to be analyzed is approximately 6 mm. In this paper we analyze only 2 poles of the stepping motor which has 10 magnetic poles made up of Nd-Fe-B material, using periodic boundary condition. The shape of the claw-pole makes a severe influence on the performance of the motor, so that we examine the characteristics according to the shape change of the claw-poles. Therefore we clarify static torque characteristics by changing the shape of claw-poles. As a result, we present an optimal shape of the claw-pole which allows the holding torque to be maximized.

In the vector control of a linear induction motor (LIM), it is difficult to calculate air gap field vector exactly because of end effects of LIM. So, this paper shows the longitudinal end effect and the transverse edge effect of LIM by experiment and determines the position of the sensor for detecting the air gap field vector. The direct vector control scheme is utilized to control the speed of LIM. As a result, simulation values by finite element analysis and experimental values of direct vector control using DSP are compared, and investigated.

A new optimization technique using neural network is presented in the design of single–sided linear induction motor (SLIM) for subway trains. In this method a classical optimization technique such as sequential unconstrained minimization technique (SUMT) combined with a trained neural network which predicts the various characteristics of SLIM in the solution procedure of SUMT, is used.

In the moving secondary type linear induction motor(LIM), because the secondary don't get continual thrust, it is difficult to analyze the dynamic characteristics. So we have resolved this problem by using the neural network.

Exogenous lipoid pneumonia (ELP) is a chronic inflammatory reaction of the lungs resulting from the aspiration of vegetable, animal or mineral oils. Squalene, is a derivative of shark liver oil that is taken as a traditional remedy in some Asian countries, and is used widely also in cosmetics. Similar to the symptoms in most cases of oil aspiration, the symptoms of squalene-induced lipoid pneumonia are either absent or nonspecific. Hence, the disease is generally detected incidentally. Although many cases with predisposing factors have been reported, ELP with achalasia is quite rare. We report a 47-year old woman with achalasia who developed ELP after ingesting squalene. The patient was treated successfully by supportive care and surgical treatment of the achalasia.

Acinar cell carcinoma is a rare tumor that represents 1~2% of all pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease. Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-old man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased -fluorodeoxyglucose (FDG) uptake. Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the pancreas. The patient underwent a total gastrectomy three months later because of gastric recurrence. Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy. During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabine.

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its pathogenesis, optimal treatment, and prognosis. A 29-year-old pregnant woman (21 weeks) presented with abdominal discomfort. CA 19-9, CA 125, and CEA were normal. Abdominal CT scanning revealed a retroperitoneal tumor. Exploratory laparotomy and tumor excision were performed. Mucinous retroperitoneal implants were removed as completely as possible. Histologically, the tumor showed focal areas of capsular invasion, but free resection margins. The uterus and both ovaries were normal in appearance. No adjuvant therapy was pursued. Six months later, peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous cystadenocarcinoma and present a review of the literature.