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Objective: Deregulation of long noncoding RNAs (lncRNAs) is involved in the initiation and progression of cancer. LncRNA DLX6-AS1 is regarded as an oncogene in many cancer types. However, the clinical role of serum exosomal lncRNA DLX6-AS1 in cervical cancer (CC) is poorly known. This study aimed to analyze the diagnostic and prognostic value of serum exosomal lncRNA DLX6-AS1 in CC. Methods: A total of 114 patients with CC, 60 patients with CIN (cervical intraepithelial neoplasia), and 110 healthy women were enrolled in this study. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to measure the serum exosomal lncRNA DLX6-AS1 levels in all participants. Results: Serum exosomal lncRNA DLX6-AS1 level was significantly elevated in CC patients compared with CIN patients and normal controls. In addition, high serum exosomal lncRNA DLX6-AS1 expression was positively associated with lymph node metastasis, differentiation, FIGO stage, and shortened survival. Patients with high serum exosomal lncRNA DLX6-AS1 expression were more prone to have a relapse. Furthermore, univariate and multivariate analyses suggested that serum exosomal lncRNA DLX6-AS1 was a potential prognostic indicator for overall survival of CC patients. Conclusions: These findings demonstrated that serum lncRNA DLX6-AS1 might serve as a promising marker for the diagnosis and prognosis prediction of CC. more...

The modern hospital is a knowledge intensity organization and the knowledge management has become inevitable development trend of the hospital management. The medical profession background is the data resources of the health profession, and the quality of data resources directly influences the effect of hospital knowledge management. How to fully use the data resources of hospital for enhancing the innovation strength and the core competitive power of the hospital have already become the main focus of the health and academic professionals. The current status of medical profession data resource has been reviewed, the related concepts about data, information and knowledge have been differentiated and analyzed, and the knowledge management system based on the data resources has been constructed, which mainly includes: the hospital background, the knowledge management technology, the knowledge management mechanism, the knowledge management system and the knowledge management process etc. The primary contents of these various parts have also been outlined. more...

Based on the target reflection section defined by The Bidirectional Reflectance Distribution Function, a method of approximate calculation and analysis of the cone and plate’s reflection section in laser-illuminated condition are derived in the paper. With the method, reflection section of cone is calculated and analyzed. Experimental platform was established with 1.319m Nd:YAG laser, measuring the reflection section of cone in diverse incident angle. Curve of the plate, cylinder and cone relative illumination changing in diverse incident angle were measured. The results of this study are helpful for many applications such as weapon designing, target invisible, and system modeling. more...

The residual stress of H-beam brought on roller straightening is very influential on carrying capacity of H-beam. It is not perfect to appraise the straightening effect only by residual curvature traditionally. In this paper, based on elastic-plastic theory, elastic core height of section and residual stress of H-beam on roller straightening are studied. Correlative formulae are deduced. Examples and simulation results show that the formulae are correct. The conclusions of this paper are important for the establishment of straightening technological parameters. more...

Aimming at the main failure modes such as the metal saw blade wearing and tearing too fast and short working life, this paper researched the influence of the vertex angle to the stress and it’s distribution using ANSYS. On the basis of static analysis, taking smaller stress and reasonable distribution as destination, the optimal vertex angle is obtained. more...

In order to acquire the best filling time, Mold trial is made by setting different injection time, or Moldflow software is used to analysis data recorded by computer. Whether doing successive trials or being simulated point by point, is very tedious. Put forward a method of using the Lagrange to simulate a curve based on the mold flow analysis, the minimum of the curve is the best filling time. This method can gain the best filling time as quickly as possible, and improve the efficiency of the mold flow analysis. more...

For plastic air intake manifold, the warpage is difficult to solve. By simulating injection process with Moldflow, researched warpage, air traps, weld lines of intake manifold. Analytic result showed four gates are better to Xiali 4GB plastic air intake manifold, and obtained the best gate’s location. Summarized some important experience on designing injection mould of plastic air intake manifold. Made out very instructive work to succeed to design injection mould of plastic air intake manifold. more...

A 1arge-scale tumble rather than swirl would exist in the cylinder in the case of two valves’ opening in a four-valve engine. A strong swirl was generated when one valve is closed, but the flow capacity was less than that of two valves opening. In order to change it, achieving different lifts of valves (DLV) was present. Both tumble and swirl would exist in the cylinder in the case of different lifts of two intake valves, and flow capacity will hardly change. more...

A series of failure phenomena of an in-service waste heat boiler is presented and the failure is analyzed. After the failed parts of the boiler were repaired, the boiler was tested by acoustic emission. The repaired and tested boiler had operated safely for three months by July 2004. more...

Patrinia heterophylla Bunge, a traditional Chinese herb, has long been used for therapy of many kinds of diseases, including cancer. Its extract or pure compound has displayed anti-proliferative effect on cancer cells as well. However, the underlying mechanism(s) by which P. heterophylla Bunge exhibited anti-tumor activity in vivo remains to be further elucidated. Herein, we investigated the effect of total flavonoid from P. heterophylla Bunge, named as PHBF, on mice bearing cervical cancer. As a result, the oral administration of PHBF (250 and 500 mg/kg BW) had significant inhibitory effect on tumor volume and weight. In addition, PHBF treatment increased thymus index of tumor-bearing mice in a dose-dependent manner ( P+ and CD8+ T lymphocytes in peripheral blood mononuclear cells (PBMC) of tumor-bearing mice. Furthermore, we observed that the serum level of interferon gamma (IFN-γ) and interleukin-2 (IL-2) was significant higher in mice treated with PHBF than those of control group, implicating that PHBF could function as an immunomodulatory agent. Taken together, these data suggested that PHBF harbored anti-tumor properties against cervical cancer and up-regulated immune response, therefore paving a path to develop as a potential therapeutic and preventive agent for cervical treatment. more...

Renal plasmacytoma is extremely rare, presenting diagnostic challenges due to its unusual location and non-specific or absent symptoms. To the best of our knowledge, only 24 cases of renal plasmacytoma have been reported in the literature. The present study reports a case of primary renal plasmacytoma in a 46-year-old female patient. Computed tomography (CT) revealed that the mass was located in the lower pole of the left kidney and metastasis was detected in an enlarged para-aortic lymph node. Following careful preparation, a partial nephrectomy was performed and the retroperitoneal lymph node was resected. A pathological examination revealed a renal parenchyma with lymph node involvement; this was confirmed by immunohistochemistry and nested polymerase chain reaction (PCR). Consequently, a diagnosis of a renal extramedullary plasmacytoma (EMP) was proposed. Following this unexpected diagnosis, various examinations were performed, but there was no evidence of systemic plasma cell disease. The patient refused further therapy, including external beam radiotherapy and chemotherapy. Abdominal CT was performed three months post-surgery and did not reveal any relapse. The patient remains disease-free at nine months post-surgery. The current study also presents a review of the literature. Although the general prognosis and outcome of EMP is good, a follow-up examination is recommended due to the possibility of relapse or progression to plasma cell neoplasm (PCN). more...

Based on the Defective Automobile Product Recall Management Regulations newly issued by the State, an information management system for defective automobile products recall is analyzed and designed in this paper. At first, according to the requirements of the Regulations, the recall flow chart is offered, and demands of industrial environment, consumers, governmental departments and manufacturing enterprises are explored. Then, overall structure of the information system is proposed, including technical structure and application structure. Finally, relevant functions of the information system are designed. more...

If a testicular cancer patient has a mass in the retroperitoneum, a metastasis is often the first suspicion, probably leading to improper diagnosis and overtreatment. Here we report a case of retroperitoneal schwannoma mimicking metastatic seminoma. A 29-year-old man, who had a history of seminoma, presented with a single retroperitoneal mass suspected to be a metastasis. Because the patient refused radiotherapy, 3 cycles of cisplatin, etoposide, and bleomycin were offered. Post-chemotherapy computed tomography scan revealed persistence of the retroperitoneal mass, with no change in tumor size or characteristics. Subsequently, retroperitoneal lymph node dissection was performed. The dissected tissue contained negative lymph nodes but a single mass in the attached fat. Pathology revealed retroperitoneal schwannoma, which was confirmed by immunohistochemistry. Thus, clinicians should be aware of retroperitoneal schwannoma and its distinction from metastatic seminoma to avoid misdiagnosis and ensure proper treatment. more...

An image compression method based on adaptive segment and adaptive quantified is presented in this paper. The image is divided into smooth and detail areas using the multi-threshold-segmentation method based on the potential function. The quantization table varied with the different image. The 2-D DCT is decomposed into 1-D fast DCT based on base-2 FFT. The Compression-to-PSNR Rate can evaluate the image compression result more effectively than that of the compression rate or PSNR respectively. The experiment shows that the algorithm gives the superior performance compared with traditional JPEG. more...

In this paper, a new version of wavelet digital watermark based on chaotic sequence is presented. In satisfying the constraint conditions of distortion, the intensity of watermark is self-adaptive, adjusted with the PSNR and the length of watermark. The existence of watermark can be detected by public key without the original image. The experiment shows that the proposed algorithm is robust for common signal processing and geometric distortion. more...