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BackgroundImmune checkpoint inhibitors (ICI) can achieve durable responses in a subset of patients with locally advanced or metastatic urothelial carcinoma (aUC). The use of tumor genomic profiling in clinical practice may help suggest biomarkers to identify patients most likely to benefit from ICI.MethodsWe undertook a retrospective analysis of patients treated with an ICI for aUC at a large academic medical center. Patient clinical and histopathological variables were collected. Responses to treatment were assessed for all patients with at least one post-baseline scan or clear evidence of clinical progression following treatment start. Genomic profiling information was also collected for patients when available. Associations between patient clinical/genomic characteristics and objective response were assessed by logistic regression; associations between the characteristics and progression-free survival (PFS) and overall survival (OS) were examined by Cox regression. Multivariable analyses were performed to identify independent prognostic factors.ResultsWe identified 119 aUC patients treated with an ICI from December 2014 to January 2020. Genomic profiling was available for 78 patients. Overall response rate to ICI was 29%, and median OS (mOS) was 13.4 months. Favorable performance status at the start of therapy was associated with improved OS (HR 0.46, p=0.025) after accounting for other covariates. Similarly, the presence of a TERT promoter mutation was an independent predictor of improved PFS (HR 0.38, p=0.012) and OS (HR 0.32, p=0.037) among patients who had genomic profiling available. Patients with both a favorable performance status and a TERT promoter mutation had a particularly good prognosis with mOS of 21.1 months as compared with 7.5 months in all other patients (p=0.03).ConclusionsThe presence of a TERT promoter mutation was an independent predictor of improved OS in a cohort of aUC patients treated with an ICI who had genomic data available. Most of the clinical and laboratory variables previously shown to be prognostic in aUC patients treated with chemotherapy did not have prognostic value among patients treated with an ICI. Genomic profiling may provide important prognostic information and affect clinical decision making in this patient population. Validation of these findings in prospective patient cohorts is needed.

Typical fundus photography produces a two-dimensional image. This makes it difficult to observe the microvascular and neural abnormalities, because the depth of the image is missing. To provide depth appreciation, we develop a single-channel stereoscopic fundus video imaging system based on a rotating refractor. With respect to the pupil center, the rotating refractor laterally displaces the optical path and the illumination. This allows standard monocular fundus cameras to generate stereo-parallax and image disparity through sequential image acquisition. We optimize our imaging system, characterize the stereo-base, and image an eyeball model and a rabbit eye. When virtual realities are considered, our imaging system can be a simple yet efficient technique to provide depth perception in a virtual space that allows users to perceive abnormalities in the eye fundus.

This paper aims to explore potential issues in implementing peer-to-peer recognition to motivate employees. A qualitative inquiry is applied to enhance our understanding of peer-to-peer recognition schemes in practical situations. Sixteen participants, including HR researchers and managers from different organizations where this program has been implemented, attended semi-structured interviews. From which twelve cases are chosen for this study. Using thematic analysis on the collected responses, the researcher finds that challenges to peer-to-peer recognition are to be found in four categories: the impact of personal relationship, the unsuitability of working climate, the confusing nomination criteria, and the lack of an appropriate rewarding policy. Practical solutions to deal with those challenges are also proposed, which include building the culture and assigning monitor, to assist employers to effectively make use of a peer-to-peer program in motivating employees. This study therefore raises the awareness of optimizing motivation program for HR practitioners, as well as contributes a qualitative approach toward the non-cash recognition evaluation.

The humanized monoclonal antibody hR3, both alone and in combination with other chemotherapeutic agents and radiotherapy, can be used to treat head and neck cancers. Substantial progress has been made in the development of targeted radioimmunotherapy using iodine-131 (131I) and yttrium-90 (90Y) radioisotopes in recent years. In the present study, we examined the efficacy of hR3 conjugated with 131I or 90Y to inhibit tumor growth in a laryngeal carcinoma xenograft tumor model. hR3 was labeled with 131I or 90Y to generate the conjugates 131I-hR3 or 90Y-hR3. The conjugates were incubated with HEp-2 laryngeal carcinoma cells to evaluate binding capacity. The efficacy of the labeled hR3 conjugates to treat laryngeal cancer was also evaluated in nude mice inoculated with HEp-2 tumors. The purified radioimmunoconjugates with specific activities of 187–191 MBq/mg had radiochemical purity >98% and >80% immunoreactivity with HEp-2 cells. Mice with HEp-2 xenografts treated with 131I-hR3 or 90Y-hR3 showed reduced tumor volume and improved survival rates compared to the untreated control group and the group treated with unlabeled hR3. At equivalent doses, radioimmunotherapeutic hR3 labeled with 90Y had increased tumor inhibition activity compared to hR3 labeled with 131I. 131I-hR3 and 90Y-hR3 are promising targeted radiopharmaceuticals for treatment of head and neck cancers, especially laryngeal cancers.

This paper investigates a low-profile broadband circularly polarized (CP) antenna, which is composed of a single-dipole on a metasurface. Surface waves propagating on the metasurface are excited to...

In Vietnam, nasopharyngeal carcinoma (NPC) is the eighth most common cause of death from cancer. Cell-free Epstein Barr virus DNA (cf-EBV DNA) was reported to be present in almost all NPC patients. However, currently available assays in Vietnam can detect cf-EBV DNA in only 67.6% of NPC patients, thus leaving 32.4% of cancer cases undetected. Therefore, in this study, we aim to develop a highly sensitive quantitative PCR (qPCR) assay that measures the load of cf-EBV DNA for the purpose of early detection of NPC, and then evaluate the sensitivity and the specificity of the developed qPCR assay on the clinical samples. The major methods used in this study include primer/TaqMan probe design, cf-DNA extraction, optimization of qPCR assay and statistical analysis. Using an international standard panel from the Chinese University of HongKong, the linear range of developed qPCR assay is from 50-150,000 copies/ml (R2 = 0.99613) and the detection limit has been shown to be 25 copies/ml. The developed assay could detect cf-EBV DNA with a sensitivity of 96.9% (31/32 NPC patients) and cf-EBV DNA has not been detected in 103 out of 105 healthy controls, which corresponds to a specificity of 98%. Consequently, the performance of the optimal assay has achieved remarkably high sensitivity and specificity. Moreover, the detection limit of our optimal qPCR assay is 25 copies/ml of plasma, which is at least ten times better than other assays tested in recent studies in Vietnam. This developed qPCR assay will also form the basis for further studies in Vietnam and will open many new applications in management of NPC.

BackgroundOrbital exenteration is a disfiguring procedure reserved for life-threatening malignancies. This study examines the clinical course and outcomes of a large series of patients who underwent orbital exenteration for malignant periocular neoplasms.MethodsThis is a retrospective review of patients who underwent orbital exenteration from 1 July 2005 to 30 June 2015 at four tertiary referral centres in the USA, Australia and Canada. Demographics, indication for surgery, pathology, surgical technique, reconstruction type and outcomes were reviewed.ResultsOrbital exenteration was performed on 102 patients. The mean age at surgery was 67.5 years. The most common malignant tumours encountered were squamous cell carcinoma, melanoma and basal cell carcinoma. Seventy-six patients (75%) underwent reconstruction with a local myocutaneous flap, twelve with partial-thickness skin grafts (PTSG), or split skin graft, two had a free flap, and one had a dermis fat graft. Sixteen patients had combined procedures of two of the above. Complete removal of the tumour was achieved with clear margins in 81 cases. Of all patients, 72% were alive at 48 months or more.ConclusionThe majority of orbital exenterations performed in this series were secondary to periocular malignancies with unsuccessful/insufficient previous treatments. Regional myocutaneous flaps, PTSG, full-thickness skin grafts and dermis fat grafts were all highly effective and durable reconstructive options, and were able to withstand radiation therapy without complications.

Flood map nowadays is seen as an indispensable tool in urbanism, flood prevention and mitigation. For this reason, establishing flood map is mighty necessary for developing the socio economy of a river catchment. Ben Hai is the second largest river at Quang Tri province – Viet Nam central region. Besides the positive role towards the local socio economic development, the Ben Hai river in resent years has caused lots of disasters, specially on inundation. With the aim of providing an overview for mitigating the natural disaster consequences, the study is used the MIKE FLOOD-DHI to represent the Ben Hai river flooding. The model is set up for an area up to 100 km2. The flood maps are established with five historical flood events and several assumptions. The result is expected to provide the basic scientific evident for local authority to redude the impact of natural disaster, also for sustainable development.

476 Background: Reliable predictive markers are lacking in patients (pts) with locally advanced or metastatic urothelial carcinoma (aUC) treated with immune checkpoint inhibitors (ICI). We sought to determine whether specific genomic alterations could be used to predict overall survival (OS) in this patient population. Methods: We undertook a retrospective cohort study of pts with aUC who received ICI and underwent genomic profiling by next-generation sequencing (NGS). All patients underwent NGS using commercially available platforms (e.g. Foundation Medicine, Strata, Invitae), or testing on the CLIA-certified institutional panel UCSF500. Associations between the 20 most frequently altered genes and OS were first examined by Cox regression. Genes with a p

International audience; This article presents a systematic review on the past developments of Hydrate-Based Desalination process using Cyclopentane as hydrate guest. This is the first review that covers all required fundamental data, such as multiphase equilibria data, kinetics, morphology, or physical properties of cyclopentane hydrates, in order to develop an effective and sustainable desalination process. Furthermore, this state-of-the-art describes research and commercialization perspectives. When compared to traditional applications, cyclopentane hydrate-based desalination process could be a promising solution. Indeed, it operates under normal atmospheric pressure, lower operation energies are required, etc… However, there are some challenges yet to overcome. A decision aid in the form of a diagram is proposed for a new cyclopentane hydrates-based desalination process. Hopefully, concepts reviewed in this study will suggest new ideas to advance technical solutions in order to make commercial hydrate-based desalination processes a reality.

Software verification tools that build machine-checked proofs of functional correctness usually focus on the algorithmic content of the code. Their proofs are not grounded in a formal semantic model of the environment that the program runs in, or the program’s interaction with that environment. As a result, several layers of translation and wrapper code must be trusted. In contrast, the CakeML project focuses on end-to-end verification to replace this trusted code with verified code in a cost-effective manner.

This paper proposes a compact circularly-polarized (CP) Substrate Integrated Waveguide (SIW) cavity antenna for 5G application operating in 28 GHz band. The antenna consists of a patch with perpendicular-arrows-shaped on a SIW structure. Longitudinal slot etched on the SIW top metallic surface are also used to excite the radiator. The CP radiation is obtained by using a three-quarters-circle-shape loop structure, which make a 90° phase difference between two perpendicular arrows of the radiator. The low profile, light weight antenna offers both left and right hand circular polarization. The final design, with an overall size of 11 mm × 11 mm × 2.16 mm (λo × λo × 0.2λo at the 28 GHz frequency) yields a |S11| < −10 dB bandwidth of 25.200–28.375 GHz (3.175 GHz) and 3-dB axial ratio (AR) bandwidth of 27.466–29.200 GHz (1.734 GHz). At 28 GHz, the proposed antenna yielded a gain of 6.59 dBic.

502 Background: ICIs are effective agents in metastatic urothelial carcinoma in both platinum-refractory and frontline settings. Responses in patients (pts) with non-urothelial histological variants are not well defined. Methods: We undertook a retrospective analysis of pts with metastatic bladder cancer treated with ICI monotherapy. Pts were identified as having a variant histology if any non-urothelial component was present. Fisher’s exact test was used to assess differences in ORR by histology. Results: Between 12/2014 and 10/2019, 102 pts received ICI monotherapy, of whom 93 were evaluable for response and 33 had variant histology. Median age was 70 yrs, 66% were male, 50% received prior platinum-based chemotherapy. Most received pembrolizumab (66%) or atezolizumab (33%). ORR in the overall cohort was 26% (15% PR, 11% CR), with 12% having SD. Histology breakdown and responses are shown in Table. Although twice as many responses were seen in urothelial pts as in pts with variant histologies (ORR 31% vs 15%), this difference was non-significant (p = 0.14). Conclusions: In this large single-institution cohort, ORR in a heterogeneous population of bladder cancer pts was consistent with data previously reported in clinical trials. Pts with variant histologies had numerically lower responses relative to pure urothelial histology, but this difference was not statistically significant. Clinical benefit to ICIs was seen across multiple variant histologies suggesting potential efficacy in this patient population that should be confirmed prospectively.[Table: see text]

Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.

PURPOSE To perform a meta-analysis on postkeratoplasty glaucoma and directly compare the affect of trabeculectomy, cyclophotocoagulation (CPC), and glaucoma drainage device (GDD) on intraocular pressure (IOP) control and corneal graft survival. METHODS We searched Medline (Ovid, PubMed), EMBASE, and The Cochrane Library databases for clinical articles that maintained our inclusion criteria. The primary outcome measures were IOP control and overall corneal graft survival. The secondary outcomes were failure rate of the primary glaucoma procedure and change in visual acuity. We used 1-way analysis of variance weighed by the number of participants in each study to compare the outcomes. RESULTS Information from a total of 266 eyes was collected from 13 articles. Trabeculectomy reduced IOP by 13.6 mm Hg compared with 20.4 mm Hg with CPC and 20.2 mm Hg with GDD (P

Objectives: Cholera is an emergent infection due to Vibrio cholerae. Studying clinical and biochemical characteristics of cholera helps doctors in diagnosis, treatment, following up and prognosis. Aims: 1. To determine some clinical and biochemical characteristics of cholera patients in 2010 epidemics in Ben Tre province. 2. To evaluate the relation of leucocytosis to diarrheal duration. Materials and methods: Patients diagnosed as cholera treated in Nguyen Dinh Chieu Hospital and Cu Lao Minh Hospital, Ben Tre province, since May 2010 to September 2010. Results: 54 patients were enrolled in this study (males 16, females 38). All patients had Ogawa positive. More than 60% pts stayed in hospitals over 96 hours. Most of pts had diarrheal duration over 48 hours, 44.5% more than 72 hours. 20.3% pts had water loss in level 3. 50% pts had leucocytosis, in them 16.7% had over 15.109/L. 18,5% had acute renal failure. Group with leucocytosis had higher rate of diarrhoea over 72 hours than group without leucocytosis (77.7% vs. 36%). Conclusions: 1. Most of pts had long diarrheal duration. 20.3% pts had water loss in level 3. 50% pts had leucocytosis, in them 16.7% had over 15.109/L. 18,5% had acute renal failure. 2. Leucocytosis may be related to the diarrheal duration.

A 58-year-old Caucasian male presented with left periorbital oedema extending to the nasal area for 1 year along with nasal discharge for 1 month. Lab work was significant for positive cytoplasmic antineutrophil cytoplasmic antibodies. CT scan showed solid mass along the nasal soft tissue with bony nasal destruction. A CT scan of the thorax was performed to rule out granulomatosis with polyangiitis and showed multiple pulmonary nodules. Biopsies of the nasal mass and lung nodule were performed which showed fragments of fibrosis with spindle cell proliferation consistent with eosinophilic angiocentric fibrosis (EAF). EAF is a very rare disease, recently described as a subtype of immunoglobulin G4-related disease. A few rare cases of EAF involving the structures of the orbit have been reported in the literature.

UNLABELLED Polyspike ictal-onset absence seizures may predict an unfavorable response to treatment in patients with epilepsy. The authors assessed absences in adults with idiopathic generalized epilepsy (IGE) associated with polyspike onset before classic 3-Hz generalized spike-and-waves (GSW). Seven adults with absences undergoing video EEG were accompanied by 3-Hz GSW, preceded by polyspike-ictal onset by >1 second in two or more seizures. The clinical profile, interictal, and ictal EEG noted had at least 1-year follow-up. A total of 1,164 patients underwent video EEG, with 58 (5%) receiving a diagnosis of IGE or subsyndrome. All seven patients with absence seizures had an ictal EEG pattern of polyspike onset prior to 3-Hz GSW. Four female and three male adults (mean age, 28.9 years) had absence as their primary seizure type. All but one had seizure onset between 4 and 20 years and failed at least two broad-spectrum antiepileptic drug trials. Typical features of IGE were normal neurologic examination, brain MRI, and 3- to 3.5-Hz GSW and generalized polyspike-and-waves on interictal EEG. Atypical features included learning disability (2 of 7), absence status (1 of 7), and paroxysmal fast activity during nonrapid eye movement sleep (3 of 7). CONCLUSIONS Polyspikes are common during video EEG in adults with IGE. Absence seizures with polyspike onset 3-Hz GSW suggest an intermediary form of IGE that may be drug resistant.

We present a Ti-SALICIDE (self aligned silicide) process incorporating an argon or nitrogen-amorphization implantation prior to silicidation to enhance the C54-TiSi 2 formation for deep submicron CMOS devices. It was found that by incorporating a high-temperature titanium deposition at 400°C together with amorphization, excellent sheet p was obtained for poly widths down to 0.25 μm. The improvement seen using a lower temperature (100°C) deposition was relatively less. We postulate that the higher-temperature deposition ensures that the C54 phase is nucleated before the C49 phase forms large grains. We also study the impact placed on maintaining the integrity of the active junctions and minimizing gate-to-source drain leakage. It was found that both argon and nitrogen result in anomalous leakage behavior, whereas arsenic was found to give excellent performance in terms of these parameters.

In this paper, two printed monopole antennas are proposed which use a composite right/left-handed (CRLH) metamaterilal transmission line in oder to achieve WLAN band. The physical size and operation frequency of antenna are determined by the CRLH metamaterial's unit-cell. The both fabicated prototypes have compact radiation elements, and exhibits good agreement beetwen the measured and simulated parameters.

The modeling of a latent heat storage unit can be done analytically and numerically, with the two approaches intersecting to help to validate simpler models. In this paper, numerical simulation with a two dimensional FLUENT model is used to determine the accuracy of the fin resistance used in a heat exchanger. This resistance model can then be used to determine which changes within the unit can improve it with a relatively quick calculation. FLUENT tracks the melting and solidification of a material through the enthalpy-porosity method, which is utilized in this simulation. The one dimensional analytical model is based upon the resistance model approach from heat transfer, and can be used to quickly analyze what effect a change in the storage unit has on its operation. In the future, this model will be used to parametrically analyze the storage unit and optimize it in terms of the number of fins, the heat exchange material, and the heat transfer fluid. The analytical model developed shows the same trends as the FLUENT model within an acceptable amount of error on both the melting and solidification processes. The comparison of the analytical and FLUENT models to established analytical models and experimental data shows the fact that several factors need to be taken into consideration when modeling a phase change process, including the shape of the melt front, natural convection within the melted wax, and the fin dimensions of the heat exchanger.

Objectives. We examined how causes of and solutions to racial/ethnic health disparities are covered and framed in newspapers over time. Methods. We used LexisNexis to identify articles on racial/ethnic health disparities published from 1996 through 2005 in 40 US newspapers. We coded articles for diseases and racial/ethnic groups mentioned; whether causes and solutions were framed as genetic, behavioral, health care, or societal responsibility; and whether a social-justice rationale for eliminating racial/ethnic health disparities was invoked. Results. We identified 3823 racial/ethnic health disparity articles. Coverage peaked in 1998 and has declined since. Disparities in HIV/AIDS, cardiovascular disease, and cancer generated the most coverage. Articles focused primarily on African Americans. Only 30% of articles provided causal or solution explanations, with academic researchers providing the most causal explanations and advocacy groups providing the most solutions. For both causes and solutions, behavioral explanations dominated the discourse, followed by societal, health care, and genetic explanations. Only 4% of articles invoked a social-justice rationale. Conclusions. The dominance of behavioral explanations may limit public support for policy solutions to eliminate racial/ethnic health disparities. Future research should examine the design and dissemination of effective messages about the social determinants of health.

This is a preliminary numerical and experimental study on the film cooling effectiveness. Film cooling holes will be employed in the stagnation region (inner-diameter endwall or hub endwall) of GE-E3 first stage rotor blades of a high pressure turbine in a subsonic commercial aircraft. For deeper understanding of interaction behavior between film cooling jets and secondary flows inside the cascade passage, a realistic (0.8 Mach number) annular test rig has been built and completed in the CATER laboratory. Five (four and two halves) 3D profile airfoils are used to gain a periodic flow for the middle passage. The experimental test rig is a 3X scaled of the real engine geometry. It has an inner diameter surface of 970 mm and outer diameter surface of 1098 mm. It is the middle passage where all the measurement has been measured. A RANS numerical model has been simulated and is used to validate the experimental data and the existing open literature. The computational fluid dynamic simulation models a steady annular cascade with five realistic airfoils (4 and 2 halves). The computational fluid dynamic model is simulated using a commercial package. It is the computational fluid dynamic model will also be used to extract all the necessary data for the sensitivity analysis while certain cases will be parallel validated against with experimental data. Preliminary pressure and velocity data have been mapped and will be presented at this phase. The obtained data are useful and help the current investigation move forward. Detail study of interaction characteristic between trenched film cooling jets and the main stream will be reported in the next phase and parameter sensitivities analysis on the film cooling effectiveness and cooling uniformity coefficient using response surface methodology will also explicitly introduced.

Over the past few years, trench film cooling has ta ken a massive leap in the film cooling technology by helping the coolant flow spread out t o cover more down-stream area. This advancement improved the performance of film cooling in terms of effectiveness. However, there are instances in which a trench cannot be emp loyed due to the repairing and refurbishing process of the thermal barrier coating (TBC). In these cases, crater film cooling is used. The effectiveness of crater film cooling is not as adequate as the trench film cooling, but it is a far better method than basic f ilm cooling method as shown in previous study. Crater film cooling method (or so-called mas ked film cooling hole) is a noncontinuous type of traverse slot film cooling. Ther e are several geometrical masks that have been employed in gas turbines, which will be invest igated in a series of studies. However, for the current work, only rectangular masks will be co nsidered. Basic sensitivity analysis will be conducted to find out the optimum combination of geometrical parameters conjugated with the flow conditions that will provide the maxi mum spatially averaged film cooling effectiveness and to determine the uniformity of th e temperature distribution on downstream area of a flat plate. Since the above to pic is the primary purpose of this particular study, a cylindrical coolant pipe will b e employed in this work for simplicity purposes. A numerical model is used to analyze the geometric variation and the results are compared to data from literature.

Background: Venous thromboembolism (VTE) is an established complication of cancer, with a high incidence in patients with both lymphoma (5-15%) and gliomas (15-20%). There is minimal data describing the incidence of VTE in patients with CNS lymphoma. Known VTE risk factors including obesity, immobility, and hospitalization are present in those with central nervous system (CNS) lymphoma; however, concern for bleeding complications limits the use of pharmacologic prophylaxis. The aim of this study is to characterize the frequency of VTE in adult patients with CNS lymphoma treated at a large academic medical center. Methods: The University of California, San Francisco (UCSF) Cancer Registry was queried for all cases of adult CNS lymphoma diagnosed from 2008-2014. Chart review was performed and patients were excluded if the primary treatment occurred elsewhere. Demographics, histology, treatment and mortality data were examined. The presence of VTE was defined by radiographic evidence of a pulmonary embolism (PE) or deep vein thrombosis (DVT). Results: 134 cases of adult CNS lymphoma were reported at UCSF between 2008-2014; 18 patients were excluded. The average follow up time was 3.8 years from date of diagnosis. The mean age at diagnosis was 63. Of the 116 patient included in the study, 77 (66%) were identified as having Primary CNS Lymphoma and 39 (34%) had Secondary CNS Lymphoma including the following subtypes: Diffuse Large B-cell, Burkitt's, Mantle cell, Marginal zone, and NK cell lymphoma. There were 34 cases of VTE (29.3%): 12 were PE and 22 were DVT, 32 (94%) patients were hospitalized at the time of VTE diagnosis. Twenty eight (82%) were symptomatic. Ten (29%) were line-associated VTE. Fifty percent of VTE cases occurred during cycle 1 (18%) or cycle 2 (32%) of chemotherapy and 27 patients (79%) received systemic steroids within 30 days of VTE diagnosis. The median time from diagnosis of CNS lymphoma to VTE was 70 days. Confounding variables including age at diagnosis, race, sex, smoking history and histology were studied and no difference was found between the VTE and non-VTE groups. Notably, body mass index was significantly higher in the VTE group (29.85, 95% CI: 26.5-33.2) as compared to the non-VTE group (25.66, 95% CI: 24.76-26.55, p=0.019). There was a trend toward shorter time to death after the diagnosis of CNS lymphoma in the VTE group (382 days, 95% CI: 106-657) vs. the non-VTE group (699 days, 95% CI: 348-1049, p= 0.18). There was no difference in overall survival (log rank p=0.09). Conclusions: Here we report a remarkably high frequency of VTE (29%) in CNS Lymphoma patients treated at a large academic center. While there was no difference in age, sex, race, smoking history or histology, those who developed VTE did have a significantly greater BMI. Because many patients receive eight cycles of high dose methotrexate as treatment for CNS Lymphoma, our determination that half of the VTE episodes occurred during the first two cycles may be useful in defining the optimal timing of VTE prophylaxis in this high risk population. Most (82%) of the VTE reported in this study were symptomatic, which suggests VTE may have a significant impact on quality of life. There was a trend toward shorter time to death after diagnosis of CNS lymphoma in the VTE group, suggesting VTE may affect mortality. Larger, prospective studies are needed to characterize the timing and incidence of VTE in patients with CNS Lymphoma, but this study reports one of the largest single institution experiences in the literature. Disclosures Rubenstein: Genentech: Research Funding; Celgene: Research Funding.

An epidemiological study was undertaken to estimate the prevalence of Enterobius vermicularis infection among the primary (and infant) school children in Yongyang-gun, Kyongsangbuk-do. During the period from 2 to 14 December 1983, a total of 2,227 school children in 13 schools were examined one time by means of scotch-tape anal swab technique with a simple questionaire study on perianal itching, enuresis and school record. The results are as follows:The overall egg positive rate was 64.1 percent and the rate ranged from 46.6 to 86.7 percent by schools. The egg positive rates of boys and girls were 60.5 and 68.0 percent respectively and the difference was statistically significant (p0.005). There was noted a tendency of decrease in prevalence by increase of the age of children. It was revealed that perianal itching and school record were significantly correlated with E. vermicularis infection (p0.05) while not in case of enuresis (p0.l).