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2 results on '"Traballi, G"'

1. Long-term methotrexate use in Rheumatoid Arthritis patients: real-world data from the MARTE study

Author

Serban, T., Allara, R., Azzolini, V., Bellintani, C., Belloli, L., Belai Beyene, N., Bucci, R., Caporali, R., Cappelli, A., Corbelli, V., de Gennaro, F., Fusaro, E., Giusti, A., Govoni, M., Magnani, L., Manzo, C., Romano, C., Rossini, M., Santilli, D., Savi Ola, G., Sinigaglia, L., Bianchi, G., Arnoldi, C., Arrigoni, E., Bajocchi, G., Beccaris, A., Brussino, L., Califano, E., Carlino, G., Castellana, P., Del Piano, M., Delvino, P. G., Denotti, A., Diana, P., Epis, O. M., Fava Lli, E., Foti, R., Ghiringhelli, P., Gilardi, A. G., Iagnocco, A., Idolazzi, L., Italiano, G., Lapadula, G., Lomater, C., Longhi, M., Lupo, A., Malav Olta, N., Manara, M., Marchetta, A., Marcialis, M. R., Mathieu, A., Mazzochi, D., Mosca, M., Muratore, M., Naclerio, C., Nallino, G., Nutile, G., Pendolino, M., Piccolo, S., Ricioppo, A., Romeo, N., Rossini, T., Salvatore, S., Sambataro, A., Sangari, D., Santo, L., Selmi, C. F., Semeraro, A., Serafino, L., Tartarelli, G., Tirri, E., Todoerti, M., Traballi, G., Tropea, S., Zizo, G., Zuccaro, C., Serban, Teodora, Allara, Roberto, Azzolini, Valeria, Bellintani, Claudio, Belloli, Laura, Belai Beyene, Nebiat, Bucci, Romano, Caporali, Roberto, Cappelli, Antonella, Corbelli, Vincenzo, DE Gennaro, Fabio, Fusaro, Enrico, Giusti, Andrea, Govoni, Marcello, Magnani, Luca, Manzo, Ciro, Romano, Ciro, Rossini, Maurizio, Santilli, Daniele, Saviola, Gianantonio, Sinigaglia, Luigi, and Bianchi, Gerolamo

Subjects
Male, rheumatoid arthritis, Time Factors, Cross-sectional study, Arthritis, Arthritis, Rheumatoid, 0302 clinical medicine, Methotrexate, Arthritis, rheumatoid, Long-term care, Citizen science, Intramuscular, Smokers, Subcutaneous, marte study, General Medicine, Postmenopause, Italy, 030220 oncology & carcinogenesis, Rheumatoid arthritis, Antirheumatic Agents, 030211 gastroenterology & hepatology, Female, medicine.drug, musculoskeletal diseases, medicine.medical_specialty, rheumatoid, Injections, Subcutaneous, Injections, Intramuscular, methotrexate, Injections, NO, 03 medical and health sciences, Route of administration, Sex Factors, Internal medicine, medicine, Humans, Dosing, Aged, Rheumatoid, Cross-Sectional Studies, Socioeconomic Factors, rheumatoid arthritis, marte study, methotrexate, business.industry, medicine.disease, Rheumatology, Discontinuation, business
Abstract

BACKGROUND The MARTE study investigated the demographic, clinical, and therapeutic characteristics of rheumatoid arthritis (RA) patients ongoing methotrexate (MTX) treatment for longer than 8 years. METHODS This cross-sectional, observational study considered 587 RA patients from 67 Rheumatology Units across Italy. Data collected included demographic, clinical, and therapeutic characteristics, focusing on MTX prescription patterns (route of administration, dosing regimens, treatment duration, and discontinuation). RESULTS As initial therapy, 90.6% of patients received one conventional synthetic Disease Modifying Anti Rheumatic Drug (csDMARD), with treatment started within the first 3 months from diagnosis in half of the patients. MTX was the first csDMARD in 46.2% of patients. The prevalent route of administration at diagnosis was the intramuscular (60.5%), while at study entry (baseline) 57.6% were receiving subcutaneous MTX. Patients who required a higher MTX dose at study entry were those who received a significantly lower starting MTX dose (P

Published
2021

2. High prevalence of fragility vertebral fractures in patients hospitalised in Internal Medicine Units. Results of the POINT (Prevalence of Osteoporosis in INTernal medicine) study

Author

Vitali, Claudio, Gussoni, Gualberto, Bianchi, Gerolamo, Albanese, Carlina V., Diacinti, Daniele, Sinigaglia, Luigi, Nuti, Ranuccio, Muzzulini, Carlo Lorenzo, Pintaudi, Carmelo, Scanelli, Giovanni, Magni, Giovanna, Valerio, Antonella, Iori, Ido, Mazzone, Antonino, Campanini, Mauro, Muzzulini, C. L., Pintaudi, C., Scanelli, G., Grandi, M., Sacchetti, C., Pieralli, F., D'Angelo, A., Fazio, M., Cagnoni, C., Occhipinti, L., Campanini, M., Bobbio, F., Mazzone, A., Rondena, M., Stefani, I., Sgnaolin, E., De Sandre, P., Mattiello, K., Vescovo, G., Parisi, D., Di Michele, D., Zullo, A., Stucchi, M., Franchi, T., Gasparini, M., Gerini, S., Landini, G., Fattorini, L., Roncucci, Luca, Mancini, Stefano, Paradiso, A., Leandri, P., Reta, M., Nardi, R., Vitali, C., Palombi, G., Frediani, R., Traballi, G., Andreoli, A., Errico, M., Molinaro, F., Fusconi, L., Tucci, V., Nocera, M., Zanardi, M., Maselli, A., Bulfoni, A., Vitale, C., Cipriani, M., Montagnani, A., Occhipinti, G., Costantino, S., Cortiggiani, M., Porciello, G., Anastasio, L., Manno, V., Massarelli, L., Sposito, P., Stobbione, P., Tancredi, M., Medico, P., Giorgi, R., Nuzzi, A. M., Mauro, G., Migliore, A., Vacca, F., Scarpato, S., Claudio Vitali, Cualberto Cussoni, Cerolamo Bianchi, Carlina Albanese, Daniele Diacinti, Luigi Sinigaglia, Ranuccio Nuti, Carlo Lorenzo Muzzulini, Carmelo Pintaudi, Giovanni Scanelli, Ciovanna Magni, Antonella Valerio, ldo lori, Antonino Mazzone, Mauro Campanini, and Giulia Letizia Mauro

Subjects
Male, medicine.medical_specialty, Histology, Physiology, Endocrinology, Diabetes and Metabolism, Osteoporosis, Prevalence, Very frequent, Endocrinology, Internal medicine, Internal Medicine, Medicine, Humans, In patient, vertebral fractures, Pathological, Aged, Demography, business.industry, Middle Aged, medicine.disease, Comorbidity, internal medicine, osteoporosis, Spine, Hospitalization, Diabetes and Metabolism, Logistic Models, Concomitant, Vertebral fractures, Cohort, Multivariate Analysis, Osteoporosis, vertebral fractures, Genant's semi-quantitative method, Spinal Fractures, Female, business
Abstract

Background Osteoporotic vertebral fractures (VFs) often go unrecognised in both healthy individuals and in pathological conditions. Few data exist on VFs in patients hospitalised in Internal Medicine Units (IMUs), who often suffer from multiple concomitant chronic disorders. Aim of the study This multicentre cross-sectional study was aimed at assessing the prevalence of VFs in an unselected population of patients referring to IMUs. Correlations between VFs and the main coexisting diseases were also investigated. Methods Information on demographic, clinical and laboratory findings, and on the presence of known risk factors for osteoporosis was recorded. The Genant's semi-quantitative method was used to evaluate, in a central reading centre, the presence and severity of VFs in the thoracic and lumbar spine. Results A cohort of 995 patients was evaluated. At least one VF of any grade was found in 47.5% of patients, with similar prevalence between females (48.1%) and males (46.7%). Older age, chronic obstructive pulmonary disease, and previous diagnosis of osteoporosis showed a significant association with VFs in multivariable analysis. However, 79.7% of the VFs were observed in patients without previous diagnosis of osteoporosis. Moreover, a VF of grade 2 or greater was found in 20.8% of patients. Conclusions Fragility VFs is a very frequent finding in patients hospitalised in IMUs. Consequently, more attention should be devoted in this clinical setting to this comorbidity, which is known to be an additional factor for mortality and, when localised in the thoracic part of the spine, may negatively influence a concomitant respiratory insufficiency.

Published
2015

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