1. The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage
- Author
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Wenlei Zhao, Aijie Wang, Xinru Ba, Hao Guo, Fang Wang, Mingzhuo Li, Heng Ma, and Qing Wang
- Subjects
Male ,obesity ,medicine.medical_specialty ,Histology ,Physiology ,Adipose tissue ,Computed tomography ,Intra-Abdominal Fat ,Logistic regression ,Gastroenterology ,Diseases of the endocrine glands. Clinical endocrinology ,Sex Factors ,Renal cell carcinoma ,Internal medicine ,medicine ,Humans ,QP1-981 ,Carcinoma, Renal Cell ,Visceral fat ,t stage ,QH573-671 ,medicine.diagnostic_test ,business.industry ,computed tomography ,Cell Biology ,Middle Aged ,RC648-665 ,medicine.disease ,Sex specific ,Obesity ,Kidney Neoplasms ,Subcutaneous Fat, Abdominal ,Adipose Tissue ,Multivariate Analysis ,abdominal ,T-stage ,Female ,clear renal cell carcinoma ,Tomography, X-Ray Computed ,Cytology ,business ,Research Article ,Research Paper - Abstract
Although much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CT-based sex-specific abdominal fat measurements in ccRCC patients to assess whether VFA distribution could predict the ccRCC T stage. In total, 253 patients (182 males and 71 females) from our hospital with pathologically confirmed ccRCC (178 low T-stage and 75 high T-stage) were retrospectively reviewed for the present study. Computed tomography (CT) scans were assessed using ImageJ to differentiate between the visceral and subcutaneous fat areas (VFA and SFA), after which the relative VFA (rVFA) and total fat area (TFA) were computed. The relationships between these fat area-related variables, patient age, sex, and BMI, and ccRCC T stage were then evaluated through univariate and multivariate logistic regression analysis to clarify the association between general or sex-specific abdominal visceral fat and T stage. Following adjustment for age, males with high T stage ccRCC exhibited an increased rVFA as compared to males with low T stage ccRCC, with the same relationship being observed among females. This association between rVFA and high T stage was confirmed through both univariate and multivariate models. As thus, sex-specific visceral fat composition is a reliable independent predictor that can identify both male and female patients with high T stage ccRCC.
- Published
- 2021
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