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Enteropathy-associated T-cell lymphoma (EATL) is a rare gastrointestinal non-Hodgkin's lymphoma, originating from intraepithelial T-lymphocyte, which is specifically associated with celiac disease. EATL most commonly presents in the sixth and seventh decades of life. We report a unique case of type I EATL in the colon with liver metastasis, which was presented with nonspecific radiological findings and at a very young age (29 years old) compared with previously published data. We suggest that EATL should be regarded as part of differential diagnosis in any patient presenting with abdominal pain, diarrhea, weight loss, and malabsorption because delay in treatment can result in an irreversible clinical outcome.

The new method of laser prestressed bending of Titanium alloy sheet is put forward in this paper. Titanium alloy sheet is produced pre-deformation by a clamp, the laser beam with some certain intensity scans its surface along the given path, and it is formed due to the thermal effect of the laser to reduce the yield strength of the scanning area and enhance its plastic deformation ability. A feasibility experiment for Ti-6Al-4V sheet is done and the bending effect is remarkable. Laser prestressed bending mechanism is described and the main influence factors are analyzed.

The sound transmission loss (STL) of the acoustic parts in the vehicle was proposed to be computed using the Sound Pressure Level measured at the several locations inside the vehicle and the transmitted Sound Intensity Level on the vehicles exterior panel, which the acoustic treated vehicle passenger compartment is assumed as a small reverberation room. The necessary parts retrofits and acoustic treatments for Sound transmission loss tests of the acoustic parts in the vehicle were listed. The values of the appropriate number and positions of the loud speakers, microphones and sound intensity probes for Sound transmission loss of the acoustic parts in the vehicle were recommended. The in vehicle sound transmission loss tests of the acoustic parts such as the doors, carpets, wheel house etc. were achieved in the semi-anechoic room. Based on the door system, the correlation work has been done among the methods of the proposed in vehicle STL test, the reverberation - semi-anechoic chamber buck STL test and SEA analysis.

In this paper, an experimental study on the powertrain in vehicle sound power test was presented. The necessary parts retrofits and acoustic treatments for the powertrain sound power test in the vehicle were listed. The criteria and correction method of the appropriate background noise level for the powertrain sound power level test in the vehicle were discussed. The powertrain sound power tests in the vehicle were achieved in the low noise chassis Dynamometer in the semi-anechoic chamber. Based on the test results, the acoustic component contributions for the powertrain sound power levels were given .

Harmonic components in holospectrum are mainly due to the lateral vibration, and they are important parameters in fault diagnosis of rotating machinery. However, defects on measuring shaft surface are also included in harmonic components in holospectrum and may lead to misdiagnosis. It’s necessary to study a method to identify the shaft surface defects. Based on the manufacturing process of outer round, this paper studies the forming mechanism of harmonic defects on outer round and their characteristics in holospectrum. An experimental example is also given to validate the theoretical analysis, and the results show that holospectrum can recognize the harmonic defects on outer round well.

Many automobile security systems are provided today, but their functions are not enough to satisfy the applications for Environmental Monitoring based on Service Oriented Architecture (SOA).In this paper, we proposed and introduced new device which is an automobile information Identification device with sensors network to strengthen automobile security system function for monitoring environment. This device aims at monitoring status of automobile as well as its environment by collecting data through sensors network. In order to increase the security, we used a new designed architecture of sensors network to gather data. GPS and GPRS were also added to locate the automobile and to transmit filtered data into the monitor. A New Design approach of system was discussed on both software and hardware. One math model for showing gas and voltage value relation was established. In order to improve system reliability, various testing methods were applied in this system. The results showed that the combination of average filtering algorithm and median filtering algorithm to inhibit interference signal at variety of frequency case can effectively filter different frequency interference signal in the software system. The advantage of this system was discussed. The system has low cost, high performance, real-time and reliability characteristics. It can not only strengthen current security system functions but also can satisfy requirements of future automobile. It also has large potential market.

Based on ARM,multifuncttion GPS/GPRS automobile security system was designed,which focused on security and detectiong.The system combines with detection technology, sensor technology, GPS technology, GPRS technology and digital filtering technology.This system was discussed from software and hardware. Related math model was established. Corresponding test was been brought forward to improve system reliability. Average filtering method and median filtering algorithm have been used to inhibiting interference signals with variety of frequency in software. In this paper,the advantages of this system have been discussed.The embeded system realizes the function with characteristics of low cost, high performance, real-time and reliability ,it has high practical value.

Mitomycin C (MMC) potently suppresses tumour growth. However, its use is limited by its severe toxicity to the kidney and bone marrow. The purpose of this study is to investigate whether the chemoprevention agent curcumin can reduce MMC-associated side-effects and improve MMC efficacy in a breast cancer xenograft model. We first determined the effectiveness of combined MMC and curcumin to inhibit in vitro cell growth and to regress in vivo tumour outgrowth. We then investigated the mechanisms associated with MMC/curcumin-induced cell death by examining the effect of MMC/curcumin treatment on apoptosis, the activation of caspase-3, 8 and 9 and the expression of bcl-2 and bax. We also evaluated the ability of curcumin to alleviate MMC-associated side-effects by comparing the levels of creatinine/blood urea nitrogen (Cr/BUN) and glutamic oxalacetic transaminase/glutamic pyruvic transaminase (GPT/GOT) in serum between animals receiving MMC alone and MMC/curcumin. Curcumin significantly sensitised MCF-7 and MDA-MB-231 cells to MMC-induced cell death and improved MMC's ability to regress MCF-7 xenograft. MMC and curcumin together synergistically enhanced apoptosis in MCF-7 cells and the apoptosis most likely resulted from both the activation of caspases and modulation of bcl-2/bax expression. Most importantly, the inclusion of curcumin in MMC treatment decreased MMC-caused severe side-effects evidenced by significant improvement in the kidney function. Enhancing the tumoricidal effect of MMC, curcumin greatly reduces MMC-associated severe side-effects. Therefore, the combination treatment of MMC and curcumin may be of significant therapeutic benefit in treating breast cancer.

Mitomycin C (MMC), a chemotherapeutic agent in breast cancer treatments, inhibits tumor growth through DNA cross-linking and breaking, but it has severe side effects. Here we examined whether and how curcumin reduced the side effects of MMC. We found that combination treatment with MMC and curcumin reduced tumor weight by 70% and 36% compared with saline and curcumin-treated groups, respectively. The combination treatment reduced weight loss and improved kidney function and bone marrow suppression compared with MMC treatment alone. Moreover, the combination treatment inhibited glucose regulatory protein (GRP58)-mediated DNA cross-linking. The combination treatment inhibited GRP58 through the ERK/p38 MAPK pathway. In conclusion, the current study provided evidence that MMC and curcumin combination treatment reduced MMC side effects by inhibiting GRP58-mediated DNA cross-linking through the ERK/p38 MAPK pathway.

Cardiomyocytes apoptosis can lead to heart failure. Conventional and alternative drugs, such as Chinese herbal remedies, have been developed to target cardiomyoblast cells apoptosis. In this study, we investigated the effects of ginsenoside Rb1 (Rb1), an active compound, which is isolated from Notoginseng and Ginseng on isoproterenol-(ISO-) induced apoptosis in rat cardiomyocytes and its mechanismin vivoandin vitro. Rb1 reduced the ISO-induced apoptosis in rat cardiomyocytes and H9c2 cells. The effect of Rb1 was significantly suppressed by H89 (inhibitor for PKA), but not by C-1 (inhibitor for PKC). Based on in-cell blot analysis, the ISO-induced PKA and PKC expressions were decreased by Rb1, which was inhibited by H89, but not by C-1. The expressions of caspase-3 and caspase-9 were decreased after treatment with both ISO and Rb1, but with no change for caspase-8. Our results indicated that Rb1 reducing ISO-induced rat cardiomyocytes apoptosis may be involved in PKA and caspase-9 pathways.

Cancer metastasis is refractory to most forms of chemotherapy. Conventional and alternative drugs, such as Chinese herbal remedies, have been developed to target metastatic cancer cells. In this study, we investigated the effects of PC-SPESII, an herbal formulation, on the migration, invasion, and metastasis of an experimental human breast cancer cell linein vivoandin vitro. PC-SPESII suppressed pulmonary metastasis and tumor growth of MDA-MB-231 human breast cancer xenografts without affecting body weight, liver function, and kidney function. PC-SPESII also inhibited MDA-MB-231 cell migration and invasionin vitroin a dose-dependent manner. Based on ELISA analysis, secretion of MMP-2 and MMP-9, proteins associated with extracellular matrix degradation, was reduced in response to PC-SPESII treatment. Western blot analysis of whole-cell extracts revealed that the levels of proteolytic proteins associated with matrix and base membrane degradation (MMP-2, MMP-9, and uPA) were decreased and the levels of their endogenous inhibitors (TIMP1 and TIMP2) were increased. Moreover, the p38MAPK and SAPK/JNK signaling pathway, which stimulates proteolytic enzymes and matrix degradation, was inhibited by PC-PSESII. Remarkably, cotreatment with PC-PSESII and p38MAPK or SAPK/JNK inhibitors magnified the antimetastatic phenotype. Our results indicate that PC-PSESII impairs human breast cancer metastasis by regulating proteolytic enzymes and matrix dynamics through the p38MAPK and SAPK/JNK pathway.

Aim: To investigate the efficacy of mitomycin C (MMC) in combination with curcumin in suppressing human breast cancer in vitro and in vivo . Methods: Human breast cancer MCF-7 cells were used. Cell viability was measured using MTT assay. The cell cycle phase was detected with flow cytometric analysis. Cell cycle-associated proteins were examined using Western blot analysis. MCF-7 breast cancer xenografts were established to monitor tumor growth and cell cycle-associated protein expression. Results: Curcumin inhibited MCF-7 breast cancer cell viability in a concentration-dependent manner (IC50 value=40 μmol/L). Similarly, MMC inhibited the cell viability with an IC50 value of 5 μmol/L. Combined treatment of MMC and curcumin showed a synergistic antiproliferative effect. In the presence of curcumin (40 μmol/L), the IC50 value of MMC was reduced to 5 μmol/L. In MCF-7 xenografts, combined administration of curcumin (100 mg/kg) and MMC (1-2 mg/kg) for 4 weeks produced significantly greater inhibition on tumor growth than either treatment alone. The combined treatment resulted in significantly greater G1 arrest than MMC or curcumin alone. Moreover, the cell cycle arrest was associated with inhibition of cyclin D1, cyclin E, cyclin A, cyclin-dependent kinase 2 (CDK2) and CDK4, along with the induction of the cell cycle inhibitor p21 and p27 both in MCF-7 cells and in MCF-7 xenografts. These proteins were regulated through p38 MAPK pathway. Conclusion: The results suggest that the combination of MMC and curcumin inhibits MCF-7 cell proliferation and cell cycle progression in vitro and in vivo via the p38 MAPK pathway.

To examine whether the cell growth inhibitory effect of the combination of baicalin and baicalein is related to apoptosis. Moreover, to determine whether the expression of some apoptosis-related proteins is regulated by the ERK/p38 MAPK pathway.Cell viability was measured using a 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected by acridine orange (AO) staining, DNA ladder assay and flow cytometric analysis. Apoptosis-related proteins were observed using Western blot analysis.Compared with baicalin or baicalein alone, the combination treatment of baicalin (50 micromol/L) and baicalein (25 micromol/L) had an anti-proliferative effect in a time-dependent manner. Isobologram analysis demonstrated that the combination treatment had a synergistic effect. Moreover, apoptosis in MCF-7 cells was increased by 12% and 20% with the combination treatment at 24 h and 48 h, respectively. With the combination treatment in MCF-7 cells, cleaved caspase-3 and caspase-9 were observed, and the level of bcl-2 expression was decreased approximately 20% and 40% at 24 h and 48 h, respectively. The expression of bax and p53 were increased about 25% and 15% at 48 h, respectively. Moreover, the activation of caspase-3, -9 and the regulation of bcl-2, bax and p53 were related to ERK /p38 MAPK activation.In this study, apoptosis was enhanced by the combination treatment of baicalin and baicalein, which activated caspases-3 and caspase-9, downregulated the level of bcl-2 and upregulated the level of bax or p53 via the ERK/p38 MAPK pathway.

WLAN location determination systems are gaining increasing attention due to the value they add to wireless networks. This paper focuses on how to determine the mobile devices’ location indoor by using signal strength (SS) in 802.11-based system. We propose an 802.11-based location determinat-ion technique Nearest Neighbor in Signal Space (NNSS) which locates mobile objects via collecting the sensed power strengths. Based on NNSS, we present a modification Modified Nearest Neighbor in Signal Space (MNNSS) to enhance the location determination accuracy by taking into account signal strength of more reference points in each estimating location of the mobile objects. In NNSS, we compare the measured SS (signal strength) with the SS of each reference point recorded in database to find the best match, but in MNNSS, we not only compare the measured SS with that of each reference point, but also the reference points around it, so it increases the location determination preciseness. The experimental results show that the location information provided by MNNSS assures higher correctness than NNSS. Implementation of this technique in the WLAN location determination system shows that the average system accuracy is increased by more than 0.5 meters. This significant enhancement in the accuracy of WLAN location determination systems helps increase the set of context-aware applications implemented on top of these systems.

Context-aware computing are gaining increasing attention due to the value they add to wireless networks. We described the innards of IGS (intelligent guide system), an 802.11 location-based tour guide system. Our objective is to empower mobile devices to recognize the context when the tourists visit some scenic spots and provide corresponding services. In our work, we proposed BAFO (be away from obstacles) algorithm to deploy access points (APs), and proposed a received signal strength (RSS) based algorithm MNNSS (modified nearest neighbor in signal space) to position mobile terminals. We divided the whole IGS system into four parts, and each part can do its job independently. We also used a friendly user interface so that the user can easily get the information they need. These proposed techniques can be further extended to the indoor guiding and tracing system.

Context-aware computing is emerging as a promising technology for mobile and pervasive environments. Unfortunately, complex context-aware applications are still hard to build. In this paper, we describe an 802.11 based indoor context-aware system used in hospital. Our objective is to empower mobile devices to recognize the context in which hospital workers perform their tasks. This system is an accessory of the management system in the hospital, and it can add Context-aware ability to the existing system by providing Context-aware communications. In our work, we use BAFO (Be Away From Obstacles) algorithm to deploy APs (Access Points), and use a Received Signal Strength (RSS) based Algorithm MNNSS (Modified Nearest Neighbor in Signal Space) to position mobile terminals, then describe the implementation of this multi-agent based system

In this paper, the properties of the gray level mixing function in two-dimensional chaotic map image encryption are analyzed. We also discuss the necessity of introducing parameters and the methods how to present diffusion mechanism and interfuse a pseudo-random number sequence in the gray level mixing function. We proposed a new kind of gray level mixing function which not only have diffusion mechanism but also have random variable . It is shown in experiment that this method has good performance.

Self-tuning regulators have been successfully applied to two installations in a chemical plant. A self-tuning regulator for liquid level in the acetic acid evaporator went into formal use in April 1979; a self-tuning regulator for temperature in the central part of a vinyl acetate synthesis reactor went into operation in July 1979. Both regulators show marked improvement over PI-regulators