1. To explore the therapeutic effect of Kangfuxiaomi shuan II on cervicitis in rats
- Author
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Jian-Ting Zhao, Yu-Sheng Xu, Xiu-Qin Li, Gui-Ke Li, Heng Liu, Xiu-Ying Ma, and Xiao-Mei Duan
- Subjects
medicine.medical_specialty ,RD1-811 ,Cervicitis ,Nitric Oxide Synthase Type II ,Inflammation ,Suppository ,chemistry.chemical_compound ,Internal medicine ,Malondialdehyde ,Medicine ,Animals ,Periplaneta ,Interleukin 6 ,Cervix ,biology ,business.industry ,Superoxide Dismutase ,Therapeutic effect ,medicine.disease ,Uterine Cervicitis ,Rats ,Nitric oxide synthase ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Cyclooxygenase 2 ,biology.protein ,Cytokines ,Surgery ,Female ,Original Article ,medicine.symptom ,business - Abstract
Purpose: The rat cervicitis model was established with 20% phenol glue to explore the therapeutic effect of Kangfuxiaomi shuan II on rat cervicitis and its mechanism. Methods: After modeling, the rats were treated with Shuangzuotai suppository (37.84 mg/kg), Kangfuxiaoyan shuan (205.6 mg/kg) and Kangfuxiaomi shuan II (40, 80, 160 mg/kg). The histopathological changes and injury degree of cervix in rats were evaluated by vulvar inflammation score and organ index. The therapeutic effect of Kangfuxiaomi shuan II on cervicitis was evaluated by detecting the levels of copper-protein (CP), C-reactive protein (CRP), Rat interleukin 6 (IL-6), superoxide dismutase (SOD) and malondialdehyde (MDA) in serum and epidermal growth factor (EGF), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cervical tissue. Results: Compared with the model group, the vulvar inflammation score and cervical index of rats in other groups decreased significantly (P
- Published
- 2021