504 results on '"YONG Tao"'
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2. Focal intramural hematoma as a potential pitfall for iatrogenic aortic dissection during subclavian artery stenting: A case report
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Ge Jin, Jun-Wei Wang, Bo Liang, Yu Zhang, Yong-Tao Yang, Xin Li, and Qun-Ling Zhan
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Aortic dissection ,medicine.medical_specialty ,business.industry ,General Medicine ,Iatrogenic aortic dissection ,equipment and supplies ,medicine.disease ,Subclavian artery stenting ,Surgery ,body regions ,Intramural hematoma ,surgical procedures, operative ,medicine.artery ,Case report ,medicine ,cardiovascular system ,cardiovascular diseases ,business ,Subclavian artery - Abstract
BACKGROUND Iatrogenic aortic dissection (IAD) is a rare but fatal complication of interventional treatment for the proximal supra-aortic large vessels. Several cases of IAD after endovascular treatment of subclavian artery have been reported. Nevertheless, the pathogenesis of IAD is still unclear. Here we report a patient with IAD following a balloon expandable stent implanted into the left subclavian artery (LSA). CASE SUMMARY An 84-year-old man with a history of hypertension was admitted to the Neurology Department of our hospital complaining of dizziness and gait disturbance for more than 1 mo. Computed tomography angiography of the head and neck showed severe stenosis at the proximal LSA and the origin of the left vertebral artery. Magnetic resonance diffusion-weighted imaging of the brain revealed subacute infarctions in cerebellum, occipital lobe and medulla oblongata. He suffered a Stanford type B aortic dissection after the proximal LSA angioplasty with a balloon expandable stent. Thoracic endovascular aortic repair was performed immediately with the chimney technique and he was discharged 20 d later. After exploring the pathogenesis with multimodal imaging analysis, an easily neglected focal intramural hematoma (IMH) in the aorta near the junction of the LSA was found to be the main cause of the IAD. The risk of IAD should be sufficiently evaluated according to the characteristics of aortic arch lesions before the proximal LSA angioplasty. CONCLUSION Focal aortic IMH is a potential risk factor for IAD during a seemingly simple stenting of the proximal LSA. more...
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- 2021
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3. Repigmentation of nipple‐areola complex after ReCell® treatment on breast vitiligo
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Panxi Yu, Runzhu Liu, Nanze Yu, Xia Zenan, Zhifei Liu, Yong Tao, Fei Long, Ang Zeng, Ruijia Dong, Ping Ma, and Cheng Chen
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medicine.medical_specialty ,business.industry ,Nipple areola complex ,Medical record ,Vitiligo ,Dermatology ,Breast treatment ,Treatment results ,Hyperpigmented skin ,medicine.disease ,body regions ,Treatment Outcome ,Satisfaction rate ,Patient Satisfaction ,Nipples ,Humans ,Medicine ,Treatment strategy ,skin and connective tissue diseases ,business ,Retrospective Studies - Abstract
BACKGROUND Nipple-areola complex is a naturally hyperpigmented skin area which can be involved in vitiligo. But limited study focused on the treatment of nipple-areola complex vitiligo, and few methods were proven to be effective. In this study, we aimed to explore the feasibility and efficacy of ReCell® on vitiligo in the nipple-areola complex area. METHODS Medical records of patients with vitiligo involving nipple-areola complex and underwent ReCell® treatment from October 2016 to April 2020 were retrospectively reviewed. The repigmentation rate of the nipple-areola complex and other breast area were calculated under the Wood's light at each follow-up. The grade of repigmentation and patient-reported satisfaction rate were also evaluated to prove the effect of ReCell® on vitiligo of breast and especially in the nipple-areola complex area. RESULTS A total of 18 patients were included in this study. No surgical complications were reported. The mean postoperative repigmentation rate in the nipple-areola complex area (3rd-month, 78.7 ± 5.8%; 6th-month, 87.6 ± 5.1%; and 12th-month, 96.1 ± 3.5%) was significantly higher than that in the other breast treatment area (3rd-month, 70.4 ± 6.9%; 6th-month, 84.2 ± 5.7%, and 12th-month, 93.2 ± 3.6%). All patients showed good or excellent grades at the last follow-up, and 94.4% of them considered the overall treatment results satisfactory. CONCLUSIONS ReCell® is a feasible and efficient treatment strategy in the nipple-areola complex vitiligo. more...
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- 2021
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4. Study on the Shear Capacity of the Wet Joint of the Prefabricated Bridge Panel with a Special-Shaped Shear Key
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Weibin Wen, Fan Feng, Yong Tao, De Zhou, and Fanglin Huang
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Article Subject ,business.industry ,Shear force ,Structural engineering ,Engineering (General). Civil engineering (General) ,Finite element method ,Composite beams ,Shear (sheet metal) ,TA1-2040 ,business ,Joint (geology) ,Geology ,Civil and Structural Engineering ,Shear capacity - Abstract
Steel-concrete composite beam has been widely applied in civil engineering, and the concrete during operation may crack due to the large shear force at the wet joint. A new concrete panel shear key with the boss is designed to strengthen the shear capacity of the wet joint part. Three different configurations of specimens are tested to study the shear capacity of the wet joint. These specimens include plain concrete specimens with shear keys, specimens with reinforcement and no shear key, and specimens with both shear keys and reinforcements. An experimental study is designed and conducted to verify the shear capacity of each specimen. The experimental results show that the ultimate shear capacity of the new wet joint structure is 73% higher than the conventional one. Meanwhile, the shear capacity of the new wet joint structure is theoretically predicted, and the finite element models are established to demonstrate the effectiveness of the experiment and the good performance of the new wet joint design. more...
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- 2021
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5. Imaging Dual-Moiré Lattices in Twisted Bilayer Graphene Aligned on Hexagonal Boron Nitride Using Microwave Impedance Microscopy
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Haomin Wang, Chengxin Jiang, Shujie Tang, Xiong Huang, Zhi-Xun Shen, Chen Chen, Wang Huishan, Lingxiu Chen, and Yong-Tao Cui
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Materials science ,business.industry ,Mechanical Engineering ,Superlattice ,Bioengineering ,02 engineering and technology ,General Chemistry ,Conductive atomic force microscopy ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Reciprocal lattice ,symbols.namesake ,Microscopy ,Monolayer ,symbols ,Optoelectronics ,General Materials Science ,van der Waals force ,0210 nano-technology ,business ,Bilayer graphene ,Microwave - Abstract
Moire superlattices (MSLs) formed in van der Waals materials have become a promising platform to realize novel two-dimensional electronic states. Angle-aligned trilayer structures can form two sets of MSLs which could potentially interfere. In this work, we directly image the moire patterns in both monolayer and twisted bilayer graphene aligned on hexagonal boron nitride (hBN), using combined scanning microwave impedance microscopy and conductive atomic force microscopy. Correlation of the two techniques reveals the contrast mechanism for the achieved ultrahigh spatial resolution ( more...
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- 2021
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6. Research for an Adaptive Classifier Based on Dynamic Graph Learning
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Li Li, Ruizhi Sun, Saihua Cai, Yong-tao Liu, and Kaiyi Zhao
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0209 industrial biotechnology ,Computer Networks and Communications ,Computer science ,business.industry ,General Neuroscience ,Data classification ,Computational intelligence ,02 engineering and technology ,Machine learning ,computer.software_genre ,Matrix (mathematics) ,020901 industrial engineering & automation ,Data point ,Binary classification ,Artificial Intelligence ,Classifier (linguistics) ,0202 electrical engineering, electronic engineering, information engineering ,Graph (abstract data type) ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,computer ,Software ,Extreme learning machine - Abstract
Extreme Learning Machine (ELM) is a representative learning algorithm commonly used in data classification and prediction. In the previous literature on ELM, there are few works that pay attention to the relationship and geometric information of data, it may bring about the relatively low accuracy and poorer performance. Combining the classic ELM algorithm and the basic knowledge of dynamic graph learning, considering the geometric information between two data points to construct the graph matrix, an adaptive graph classifier on the basis of extreme learning machine is presented in our work. Besides, a matrix preserving the geometric information of the data is constructed from the original data and adaptively update during each training iteration. To do this, we use an alternative optimization strategy to update the graph matrix, so that the new classifier can adapt to the graph matrix and the graph matrix can update the classifier. The results on fifteen real data sets demonstrate that the proposed method outperforms in binary classification and multi-classification tasks. more...
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- 2021
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7. Cannabinoid Receptor-2 Activation in Keratinocytes Contributes to Elevated Peripheral β-Endorphin Levels in Patients With Obstructive Jaundice
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Yong Tao, Mei Zhu, Kun-Ming Tao, Xiao-Yan Meng, Weifeng Yu, Jiao Zhu, Zhi-Jie Lu, and Kai Wei
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Keratinocytes ,Male ,Agonist ,medicine.medical_specialty ,Indoles ,Polyunsaturated Alkamides ,medicine.drug_class ,medicine.medical_treatment ,Arachidonic Acids ,Rats, Sprague-Dawley ,Receptor, Cannabinoid, CB2 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,030202 anesthesiology ,Internal medicine ,Threshold of pain ,medicine ,Cannabinoid receptor type 2 ,Animals ,Humans ,Opioid peptide ,Cells, Cultured ,Cell Line, Transformed ,Pain Measurement ,Cannabinoid Receptor Agonists ,Morphine ,business.industry ,beta-Endorphin ,Anandamide ,Middle Aged ,Endocannabinoid system ,Rats ,Jaundice, Obstructive ,Anesthesiology and Pain Medicine ,Endocrinology ,chemistry ,Cannabinoid ,business ,030217 neurology & neurosurgery ,Endocannabinoids ,medicine.drug - Abstract
Background Cholestatic diseases are often accompanied by elevated plasma levels of endogenous opioid peptides, but it is still unclear whether central or peripheral mechanisms are involved in this process, and little is known about the change of pain threshold in these patients. The purpose of this study was to determine the preoperative pain threshold, postoperative morphine consumption, and central and peripheral β-endorphin levels in patients with obstructive jaundice. This study also tests the hypothesis that activation of the cannabinoid receptor-2 (CB2R) in skin keratinocytes by endocannabinoids is the mechanism underlying circulating β-endorphin elevation in patients with obstructive jaundice. Methods The electrical pain thresholds, 48-hour postoperative morphine consumption, concentrations of β-endorphin in plasma and cerebrospinal fluid, skin and liver β-endorphin expression, and plasma levels of endocannabinoids were measured in jaundiced (n = 32) and control (n = 32) patients. Male Sprague-Dawley rats and human keratinocytes (human immortalized keratinocyte cell line [HaCaT]) were used for the in vivo and in vitro experiments, respectively. Mechanical and thermal withdrawal latency, plasma level, and skin expression of β-endorphin were measured in CB2R-antagonist-treated and control bile duct-ligated (BDL) rats. In cultured keratinocytes, the effect of CB2R agonist AM1241-induced β-endorphin expression was observed and the phosphorylation of extracellular-regulated protein kinases 1/2, p38, and signal transducer and activator of transcription (STAT) pathways were investigated. Results This study found (1) the plasma level of β-endorphin (mean ± standard error of the mean [SEM]) was 193.9 ± 9.6 pg/mL in control patients, while it was significantly increased in jaundiced patients (286.6 ± 14.5 pg/mL); (2) the electrical pain perception threshold and the electrical pain tolerance threshold were higher in patients with obstructive jaundice compared with controls, while the 48-hour postoperative morphine consumption was lower in the jaundiced patients; (3) there was no correlation between plasma β-endorphin levels, electrical pain thresholds, and 48-hour postoperative morphine consumption in patients with obstructive jaundice; (4) the plasma level of the endogenous cannabinoid anandamide was increased in the jaundiced patients; (5) CB2R antagonist treatment of the BDL rats reduced β-endorphin levels in plasma and skin keratinocytes, while it did not alter the nociceptive thresholds in BDL and control rats; (6) the endocannabinoid anandamide-induced β-endorphin synthesis and release via CB2R in cultured keratinocytes; and (7) phosphorylation of extracellular-regulated protein kinases 1/2 is involved in the CB2R-agonist-induced β-endorphin expression in keratinocytes. Conclusions CB2R activation in keratinocytes by the endocannabinoid anandamide may play an important role in the peripheral elevation of β-endorphin during obstructive jaundice. more...
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- 2021
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8. Utilizing dexamethasone intravitreal implant to control postoperative inflammation in refractory uveitis undergoing cataract surgery
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Xiao-Tong Yang, Xiaorong Li, Xue-Xue Cui, Xiaomin Zhang, Xinjun Ren, Bing Li, and Yong-Tao Li
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medicine.medical_specialty ,Intraocular pressure ,dexamethasone intravitreal implant (ozurdex) ,Visual acuity ,genetic structures ,medicine.medical_treatment ,Intraocular lens ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,intraocular lens implantation ,Ophthalmology ,medicine ,Dexamethasone Intravitreal Implant ,business.industry ,Brief Report ,Phacoemulsification ,refractory uveitis ,Cataract surgery ,medicine.disease ,eye diseases ,lcsh:RE1-994 ,phacoemulsification ,030221 ophthalmology & optometry ,Capsulotomy ,sense organs ,medicine.symptom ,business ,Uveitis - Abstract
AIM: To report the effectiveness of intravitreal implantation of dexamethasone implant (Ozurdex) after phacoemulsification and intraocular lens implantation in refractory uveitis patients. METHODS: This single-center retrospective study conducted for refractory pan-uveitis patients who underwent cataract surgery combined with intravitreal Ozurdex implantation. The main outcome measurements were best-corrected visual acuity (BCVA), central retinal thickness (CRT), grade of anterior chamber cell (AAC), intraocular pressure (IOP), and systemic/ocular adverse events. RESULTS: Ten eyes of 7 patients were included. BCVA showed significant improvement at 1mo (P=0.004), 3mo (P=0.0004), and 6mo (P=0.001) post operation. There were no statistically significant differences in the postoperative CRT among follow-up groups (P>0.05). No significant differences were observed in the baseline IOP when compared to 1, 3, and 6mo (all P>0.05) post operation. One patient developed a transient elevated IOP post injection. Two eyes (20%) developed posterior capsular opacifications and underwent neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy. In six patients (8 eyes, 71.4%), the systemic steroid usage was reduced to below 10 mg/d. The patients experienced a mean of 1.4±0.52 recurrences of inflammation in the 6mo before operation and 0.7±0.48 in the 6mon post operation. The mean recurrence time was 13±0.58wk (range 12-14wk) post operation. In five of seven patients (7 out of 10 eyes), inflammation relapse was developed postoperatively. Only one patient (2 eyes) needed increased amounts of oral corticosteroids. Intraocular inflammation recurrence in the remaining patients was controlled by topical steroids. CONCLUSION: Ozurdex is considered a safe and effective approach to control postoperative inflammation in cataract surgery for patients with refractory uveitis in our study. After the disappearance of Ozurdex’s anti-inflammatory effects over time, in most cases the recurrent inflammation can be controlled by topical steroids. more...
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- 2021
9. Relationship between the higher inflammatory cytokines level in the aqueous humor of Fuchs uveitis syndrome and the presence of cataract
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Hui Wang and Yong Tao
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0301 basic medicine ,medicine.medical_specialty ,genetic structures ,Senile cataract ,VEGF receptors ,medicine.medical_treatment ,Inflammation ,Aqueous humor ,Fuchs uveitis syndrome ,Cataract ,Proinflammatory cytokine ,Uveitis ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Ophthalmology ,medicine ,Humans ,Retrospective Studies ,biology ,business.industry ,General Medicine ,eye diseases ,Posterior subcapsular cataract ,030104 developmental biology ,Cytokine ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,biology.protein ,Cytokines ,sense organs ,medicine.symptom ,business ,Research Article - Abstract
Background This study aims to compare the levels of intraocular cytokines between Fuchs uveitis syndrome (FUS) eyes and the senile cataract eyes. The association between inflammatory cytokine levels and cataract severity in FUS is evaluated to find the possible mechanism of cataract in FUS eyes. Methods A retrospective study of 28 eyes with FUS was performed. Auxiliary examinations were performed, including ophthalmic examinations, laser flare-cell photometry, and levels of inflammatory cytokines in the aqueous humor were measured. The control group included 25 eyes with senile cataract. Data on the aqueous humor inflammatory cytokines were compared between the two groups. The association between the aqueous humor cytokine levels and severity of posterior subcapsular cataract was assessed. Results There were 28 eyes with FUS in 27 patients. Unilateral involvement was noted in 26 patients (96.30%). Stellate keratic precipitates (KPs) were noted in 16 eyes (57.14%). Heterochromia was observed in 21.43% of affected eyes. Posterior subcapsular cataract (PSC) was observed in 16 of the 28 eyes. Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P P = 0.001, P = 0.002, respectively). Conclusions Expression of VEGF, bFGF, IL-6, IL-8 and IL-10 in the AH of FUS patients was significantly higher than in senile cataract eyes, and the aqueous humor levels of IL-6 and IL-8 were significantly positively associated with the severity of posterior subcapsular cataract. Our results imply that an inflammation mechanism may be involved in the early development of cataract in FUS. more...
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- 2021
10. Self-catalyst β-Ga2O3 semiconductor lateral nanowire networks synthesis on the insulating substrate for deep ultraviolet photodetectors
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Zhang Kun, Wenqiang Lu, Zhi-Yong Tao, Yutong Wu, Shuanglong Feng, Miaomiao Zhang, Shuai Kang, and Ya-Xian Fan
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Materials science ,business.industry ,General Chemical Engineering ,Nanowire ,Oxide ,Photodetector ,General Chemistry ,Chemical vapor deposition ,Substrate (electronics) ,chemistry.chemical_compound ,Semiconductor ,Nanoelectronics ,chemistry ,Optoelectronics ,Thin film ,business - Abstract
Monoclinic gallium oxide (β-Ga2O3) is a super-wide bandgap semiconductor with excellent chemical and thermal stability, which is an ideal candidate for detecting deep ultraviolet (DUV) radiation (100–280 nm). The growth of β-Ga2O3 is challenging and most methods require Au as the catalyst and a long reacting time (more than 1 hour). In this work, the self-catalyst β-Ga2O3 lateral nanowire networks were synthesized on an insulating substrate rapidly by a simple low-cost Chemical Vapor Deposition (CVD) method. A thin film of β-Ga2O3 nanowire networks was synthesized within a reacting time of 15 minutes, which possesses a huge possibility for the rapid growth of β-Ga2O3 metal oxide nanowires networks and application in the future solar-blind photodetector. MSM (metal–semiconductor–metal) photodetectors based on the β-Ga2O3 nanowire networks revealed fast response (on–off ratios is about 103), which is attributed to the unique cross-junction barrier-dominated conductance of the nanowire networks. In addition, the self-catalyst β-Ga2O3 nanowires grown on insulating SiO2 are achieved and could be expected to find important applications in a bottom-up way of fabricating the next generation semiconductor nanoelectronics. more...
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- 2021
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11. Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1: interim analysis of the randomized, controlled, phase 3, non-inferiority TALENT study
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Bin Su, Cheng Yao, Qing-Xia Zhao, Wei-Ping Cai, Min Wang, Hong-Zhou Lu, Yuan-Yuan Chen, Li Liu, Hui Wang, Yun He, Yu-Huang Zheng, Ling-Hua Li, Jin-Feng Chen, Jian-Hua Yu, Biao Zhu, Min Zhao, Yong-Tao Sun, Wen-Hui Lun, Wei Xia, Li-Jun Sun, Li-Li Dai, Tai-Yi Jiang, Mei-Xia Wang, Qing-Shan Zheng, Hai-Yan Peng, Yao Wang, Rong-Jian Lu, Jian-Hua Hu, Hui Xing, Yi-Ming Shao, Dong Xie, Tong Zhang, Fu-Jie Zhang, Hao Wu, Xin Chen, Peng Lyu, and for the TALENT Study Team more...
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Adult ,medicine.medical_specialty ,China ,Anti-HIV Agents ,Population ,lcsh:Medicine ,HIV Infections ,LPV/r ,Maleimides ,03 medical and health sciences ,0302 clinical medicine ,Phase 3 clinical trial ,Internal medicine ,Antiretroviral Therapy, Highly Active ,Clinical endpoint ,Medicine ,Humans ,education ,Adverse effect ,Fusion inhibitor ,education.field_of_study ,Ritonavir ,Respiratory tract infections ,business.industry ,Albuvirtide ,lcsh:R ,HIV ,virus diseases ,Lopinavir ,General Medicine ,Original Articles ,Viral Load ,Interim analysis ,Clinical trial ,Regimen ,Treatment Outcome ,030220 oncology & carcinogenesis ,HIV-1 ,Drug Therapy, Combination ,business ,Peptides ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background. Albuvirtide is a once-weekly injectable human immunodeficiency virus (HIV)-1 fusion inhibitor. We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs. Methods. We carried out a 48-week, randomized, controlled, open-label non-inferiority trial at 12 sites in China. Adults on the World Health Organization (WHO)-recommended first-line treatment for >6 months with a plasma viral load >1000 copies/mL were enrolled and randomly assigned (1:1) to receive albuvirtide (once weekly) plus ritonavir-boosted lopinavir (ABT group) or the WHO-recommended second-line treatment (NRTI group). The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks. Non-inferiority was prespecified with a margin of 12%. Results. At the time of analysis, week 24 data were available for 83 and 92 patients, and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups, respectively. At 48 weeks, 80.4% of patients in the ABT group and 66.0% of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL, meeting the criteria for non-inferiority. For the per-protocol population, the superiority of albuvirtide over NRTI was demonstrated. The frequency of grade 3 to 4 adverse events was similar in the two groups; the most common adverse events were diarrhea, upper respiratory tract infections, and grade 3 to 4 increases in triglyceride concentration. Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group. Conclusions. The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug. This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure. Trial registration. ClinicalTrials.gov Identifier: NCT02369965; https://www.clinicaltrials.gov. Chinese Clinical Trial Registry No. ChiCTR-TRC-14004276; http://www.chictr.org.cn/enindex.aspx more...
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- 2020
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12. White matter hyperintensities and the progression from mild parkinsonian signs to parkinsonism and Parkinson’s disease
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Yingchao Huo, Shu-Yang Dong, Ling Li, Wenjuan Hong, Le Chen, Huadong Zhou, Lei Liu, Hai Yang, Jingjing Ma, Zeyan Peng, Yong Tao, Dong Liu, Jie Huang, and Congguo Wang
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Male ,Risk ,0301 basic medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,Aging ,medicine.medical_specialty ,Time Factors ,Parkinson's disease ,Hypokinesia ,Disease ,Lower risk ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,skin and connective tissue diseases ,Gait ,Postural Balance ,Aged ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Parkinsonism ,nutritional and metabolic diseases ,Parkinson Disease ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,White Matter ,Hyperintensity ,Muscle Rigidity ,nervous system diseases ,030104 developmental biology ,Disease Progression ,Cardiology ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Follow-Up Studies ,Developmental Biology - Abstract
This study investigated the impact of white matter hyperintensities (WMHs) on the progression from mild parkinsonian signs (MPS) to parkinsonism and Parkinson's disease (PD). Participants with MPS completed 5 years of follow-up. WMHs were divided into periventricular WMHs and deep WMHs according to magnetic resonance imaging scans. The diagnosis of MPS, parkinsonism, and PD was based on the motor portion of the Unified Parkinson's Disease Rating Scale. Cox proportional hazard models were used to identify the association between WMHs and MPS progression. Of the 636 participants, 166 (26.1%) with MPS developed parkinsonism and PD after follow-up. After adjusting for potential factors, severe WMHs were associated with an increased risk of MPS progression, moderate and severe periventricular WMHs and severe deep WMHs were associated with the risk of MPS progression, and severe WMHs were associated with the progression of gait/balance impairment, bradykinesia, and rigidity. Additionally, participants treated for vascular risk factors such as hypertension, diabetes mellitus, and hypercholesterolemia had a lower risk of MPS progression. more...
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- 2020
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13. Clinical Features and Prognostic Factors in Northern Chinese Patients with Peripheral Granuloma Type of Ocular Toxocariasis: A Retrospective Cohort Study
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Yong Tao and Hui Wang
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030203 arthritis & rheumatology ,Ocular toxocariasis ,medicine.medical_specialty ,genetic structures ,business.industry ,Retrospective cohort study ,medicine.disease ,Dermatology ,humanities ,eye diseases ,Peripheral ,03 medical and health sciences ,Ophthalmology ,0302 clinical medicine ,Corticosteroid therapy ,Granuloma ,030221 ophthalmology & optometry ,medicine ,Immunology and Allergy ,sense organs ,business - Abstract
To summarize the clinical features and probable factors associated with recurrence within 6 months in northern Chinese ocular toxocariasis (OT) patients. A retrospective cohort study (38 OT eyes) w... more...
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- 2020
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14. A Flexible Low-Pass Filter Based on Laser-Induced Graphene
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Jiang Zhao, Hengxin Yang, Yong Tao, Xiangfu Wang, and Yixuan Cui
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010302 applied physics ,Materials science ,business.industry ,Graphene ,Low-pass filter ,Phase (waves) ,02 engineering and technology ,Filter (signal processing) ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Laser ,01 natural sciences ,Flexible electronics ,Electronic, Optical and Magnetic Materials ,law.invention ,law ,0103 physical sciences ,Materials Chemistry ,Optoelectronics ,Waveform ,Transient response ,Electrical and Electronic Engineering ,0210 nano-technology ,business - Abstract
A graphene-based flexible filter was obtained via one-step laser heating of a polyimide film. The key parameters of a laser have been confirmed by comparing simulated results and experimental data. High-frequency components of input signals were filtered out effectively for different waveforms, such as sine, rectangular, triangle and pulse waveforms. In order to study filtering performance, this paper focused on amplitude frequency curve, phase frequency curve, transient response and mechanical stability. The phase frequency curve is linear distribution, indicating that it is convenient to control phase shift. The mechanical stability of the device remains good even after 5000 bends, which is unreported in previous work. This paper demonstrated that a graphene-based flexible filter prepared by one-step laser heating has excellent performance and opens new way of thinking about flexible electronics in the future. more...
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- 2020
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15. Levels of cytokines in the aqueous humor guided treatment of refractory macular edema in adult-onset coats’ disease
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Ke Gao, Hua Fan, Wei He, Yewei Wang, and Yong Tao
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Adult ,Adult-onset coats’ disease ,medicine.medical_specialty ,Visual acuity ,medicine.medical_treatment ,Angiogenesis Inhibitors ,Proinflammatory cytokine ,Aqueous Humor ,Refractory ,lcsh:Ophthalmology ,Ophthalmology ,Case report ,Humans ,Medicine ,Coats' disease ,Macular edema ,Dexamethasone ,business.industry ,General Medicine ,medicine.disease ,eye diseases ,Cytokine ,lcsh:RE1-994 ,Beijing ,Intravitreal Injections ,Cytokines ,Retinal Telangiectasis ,sense organs ,Implant ,medicine.symptom ,business ,medicine.drug - Abstract
Background Two cases with refractory macular edema secondary to adult-onset Coats’ disease underwent unsatisfactory treatment by intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs and retinal photocoagulation. Case presentation The authors highlight the guiding effect of the measurement of cytokines in the aqueous humor for the treatment of adult-onset Coats’ disease with refractory macular edema. In the two cases, typical Coats’ disease changes, including telangiectasis, subretinal exudation and macular edema were observed. Initial treatment consisted of intravitreal anti-VEGF drugs and retinal laser photocoagulation; however, the response was poor. Then, the aqueous humor was acquired and the cytokine concentrations were measured (Flow Cytometry Analysis, Beijing Giantmed Medical Diagnostics Lab). When the cytokine levels were tested every time there would be quality control, with a fixed concentration of cytokines samples to detect before the results reported. A low level of VEGF and a high level of inflammatory cytokines were found. Then, treatment was switched to intravitreal injection of dexamethasone implant (Ozurdex®) (Allergan, Inc., Irvine, Calif., USA), which resulted in resolution of the refractory macular edema and improvement of visual acuity in both cases. Conclusions For refractory macular edema secondary to adult-onset Coats’ disease, measurement of the levels of VEGF and inflammatory cytokines can help clinic doctors precisely investigate the molecular mechanism of macular edema and thereby find a suitable treatment. more...
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- 2020
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16. The prevalence of stroke and related risk factors among residents aged ≥ 40 years in Chongqing, Southwest China
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Yin Yang, Zhongbi Jiang, Zhao-hui Zhong, Yalan Yang, Ge Jin, Yong-Tao Yang, Liang Chen, Li Xie, Li Liu, Dewei Zeng, and Qunling Zhan
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Prevalence ,Physical examination ,Odds ratio ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,Medicine ,Family history ,Risk factor ,business ,Stroke ,030217 neurology & neurosurgery ,Demography - Abstract
Background China bears the largest global stroke burden, yet little is known about its rates in Chongqing, southwest China. We aimed to investigate the prevalence and related risk factors for stroke in Chongqing, and to provide evidence for improved formulation of targeted primary preventive measures for stroke. Methods In 2015, a cross-sectional study was conducted in Nan’an district, Chongqing. Participants responded to a questionnaire surveying general information and common risk factors for stroke, and related physical examinations were conducted. Results Of 25,000 people aged ≥ 40 years who were investigated, 24,859 participants completed the questionnaire and underwent the physical examination. The crude prevalence rate for stroke was 1.71%, and was higher in men than in women (1.9% versus 1.6%). Prevalence rates increased with age (p p-values p Conclusions These findings suggest that controlling stroke risk factors for stroke prevention is still crucial. Moreover, this study provides comprehensive resource data for further stroke research in southwest China. more...
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- 2020
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17. Out-of-plane dynamic crushing behavior of joint-based hierarchical honeycombs
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Liming Chen, Yongmao Pei, Yong Tao, Daining Fang, Tianbao Cheng, Zhonggang Wang, and Weiguo Li
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Condensed Matter::Quantum Gases ,Materials science ,business.industry ,020502 materials ,Mechanical Engineering ,02 engineering and technology ,Structural engineering ,Out of plane ,0205 materials engineering ,Mechanics of Materials ,Energy absorption ,Ceramics and Composites ,business ,Joint (geology) - Abstract
Hierarchical structures have been viewed as promising candidates to offer superior performance compared to regular structures. In this study, six hierarchical honeycombs are constructed by replacing each joint of regular hexagonal and square honeycombs in three different ways. Numerical simulations are performed to study the out-of-plane dynamic crushing behavior and energy absorption performance of these hierarchical honeycombs. The results show that the three ways of introducing structural hierarchy can enhance the plateau stress, crash load efficiency, and specific energy absorption of regular honeycombs. Moreover, hierarchical honeycomb constructed by replacing each joint of regular hexagonal honeycomb with a smaller circle has the highest energy absorption capacity. In addition, the optimal configurations for different hierarchical honeycombs are presented, and the region of optimal structural parameter for these hierarchical honeycombs is determined, which are useful for the selection and design of hierarchical honeycomb configuration with desirable energy absorption performance. more...
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- 2020
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18. Genetic analysis of DNA methylation in dyslipidemia: a case-control study
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Shuai Liu, Min Han, Fen Liu, Dilare Adi, Yi-Ning Yang, Zhen-Yan Fu, Xian Wei, Yang Li, Yi-Tong Ma, Yong-Tao Wang, Bang-Dang Chen, and Xiao-Mei Li
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business.industry ,General Neuroscience ,Case-control study ,General Medicine ,Computational biology ,Biology ,medicine.disease ,Genetic analysis ,General Biochemistry, Genetics and Molecular Biology ,Text mining ,DNA methylation ,medicine ,General Agricultural and Biological Sciences ,business ,Dyslipidemia - Abstract
Background Coronary heart disease has become the leading cause of death in developed countries, and dyslipidemia is closely associated with the risk of cardiovascular disease. Dyslipidemia is caused by the abnormal regulation of several genes and signaling pathways, and dyslipidemia is influenced mainly by genetic variation. AMFR, FBXW7, INSIG1, INSIG2, and MBTPS1 genes are associated with lipid metabolism. In a recent GWAS study, the GRINA gene has been reported to be associated with dyslipidemia, but its molecular mechanism has not been thoroughly investigated. The correlation between the DNA methylation of these genes and lipid metabolism has not been studied. This study aimed to examine the relationship between the DNA methylation of these genes and the risk of dyslipidemia by comparing the methylation levels of dyslipidemia and control samples. Methods A case-control research method was used in this study. The patient’s blood samples were collected at the Heart Center of the First Affiliated Hospital of Xinjiang Medical University. In the Xinjiang Han population, 100 cases of hyperlipidemia and 80 cases of the control group were selected. The two groups were age and gender-matched. Quantitative methylation analysis of CpG sites in the gene promoter regions of six genes was performed by Solexa high-throughput sequencing. Results The DNA methylation levels of 23 CpG sites in six genes were shown to be associated with hyperlipidemia, and a total of 20 DNA methylation haplotypes showed statistically significant differences between the two groups. When compared with the control group, the dyslipidemia group had significantly higher levels of methylation in the GRINA gene (2.68 vs 2.36, P = 0.04). Additionally, we also discovered a significant methylation haplotype of GRINA (P = 0.017). Conclusion The findings of this study reveal that the DNA methylation of GRINA increases the risk for dyslipidemia in humans. more...
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- 2022
19. Global modes and coupled modes for integrated twin circular-side octagon microlasers
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Jin-Long Xiao, Ke Yang, Jia-Chen Liu, Yue-De Yang, You-Zeng Hao, Yong-Zhen Huang, Ji-Liang Wu, and Yong-Tao Huang
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Physics ,Coupling ,General Computer Science ,business.industry ,Photonic integrated circuit ,Mode (statistics) ,Physics::Optics ,Optical microcavity ,Semiconductor laser theory ,law.invention ,law ,Optoelectronics ,Photonics ,business ,Lasing threshold ,Refractive index - Abstract
Whispering-gallery mode (WGM) microlasers are potential light sources for photonic integrated circuits and optical information processing. In this paper, an integrated twin circular-side octagon microlaser (TCOM) composed of two identical circular-side octagon microcavities (COMs) is proposed and demonstrated for realizing lasing mode control. In a TCOM, we found a global mode with the mode field of an “8” pattern (labeled “8” mode) in addition to weak coupling modes of traditional four-bounce modes. The “8” mode belongs to the whole coupled cavity and is insensitive to the refractive index offset of coupled COMs, but the weak coupling modes are strongly sensitive to the refractive index offset. Lasing mode transformation from multiple coupled modes to a single “8” mode is demonstrated by adjusting the refractive index offset through injection currents. Weak coupling modes for directly connected TCOMs and lasing mode control make the COM a potential unit for large-scale photonic integration and optical information processing. more...
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- 2021
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20. A Robot Dynamic Target Grasping Method Based on Affine Group Improved Gaussian Resampling Particle Filter
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Tianmiao Wang, Jiangbo Lan, He Gao, Fan Ren, Shan Jiang, Yufang Wen, and Yong Tao
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visual servo control ,Technology ,Computer science ,QH301-705.5 ,Gaussian ,QC1-999 ,Servo control ,Tracking (particle physics) ,symbols.namesake ,Robustness (computer science) ,Resampling ,General Materials Science ,Computer vision ,Biology (General) ,robot position servo grasping ,Instrumentation ,QD1-999 ,Fluid Flow and Transfer Processes ,robotics ,affine groups ,business.industry ,Process Chemistry and Technology ,Physics ,General Engineering ,Engineering (General). Civil engineering (General) ,dynamic target grasping ,Computer Science Applications ,Chemistry ,improved geometric particle filtering ,symbols ,Robot ,Affine transformation ,Artificial intelligence ,TA1-2040 ,business ,Particle filter - Abstract
Tracking and grasping a moving target is currently a challenging topic in the field of robotics. The current visual servo grasping method is still inadequate, as the real-time performance and robustness of target tracking both need to be improved. A target tracking method is proposed based on improved geometric particle filtering (IGPF). Following the geometric particle filtering (GPF) tracking framework, affine groups are proposed as state particles. Resampling is improved by incorporating an improved conventional Gaussian resampling algorithm. It addresses the problem of particle diversity loss and improves tracking performance. Additionally, the OTB2015 dataset and typical evaluation indicators in target tracking are adopted. Comparative experiments are performed using PF, GPF and the proposed IGPF algorithm. A dynamic target tracking and grasping method for the robot is proposed. It combines an improved Gaussian resampling particle filter algorithm based on affine groups and the positional visual servo control of the robot. Finally, the robot conducts simulation and experiments on capturing dynamic targets in the simulation environment and actual environment. It verifies the effectiveness of the method proposed in this paper. more...
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- 2021
21. Diagnostic Value of Genetic Mutation Analysis and Mutation Profiling of cfDNA in Intraocular Fluid for Vitreoretinal Lymphoma
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Xiaoqing Chen, Yunwei Hu, Wenru Su, Shizhao Yang, Xiaoxiao Wang, Ping Zhang, Xiaoyu Hong, Chuqiao Liang, Zhuyun Qian, Ziqiang Li, Yong Tao, Huiqiang Huang, and Dan Liang
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Oncology ,Mutation profiling ,medicine.medical_specialty ,Mutation ,business.industry ,Gold standard (test) ,CD79B ,medicine.disease ,medicine.disease_cause ,ETV6 ,Internal medicine ,Intraocular fluid ,medicine ,Mutation testing ,business ,Uveitis - Abstract
ObjectiveVitreoretinal lymphoma (VRL) is a rare but aggressive masquerade syndrome, with challenging diagnosis. Since the tumor-related genetic mutation analysis based on cell-free DNA (cfDNA) are underutilized in ocular oncology, we aimed to test the VRL diagnostic value of cfDNA genetic mutation analysis using intraocular fluid (IOF) samples and to identify its mutation profile.SubjectsSeventeen VRL and 6 uveitis patients from Zhongshan Ophthalmic Centre were selected as training group, and 5 VRL and 5 uveitis patients from Beijing Chaoyang Hospital were selected as validation group.MethodsThe medical records and genetic mutation analysis using a panel containing 446 tumor-related genes of included patients were retrospectively reviewed. We analyzed the mutation profile, and identified the molecular subtypes and subdivisions of B-cell differentiation pathways of our VRL patients.Main outcomesThe cfDNA genetic mutations detected in IOF.ResultsThe VRL patients from the training group exhibited abundant cfDNA mutations in IOF (sensitivity 100%), while only 2 out of 6 uveitis patients were positive (specificity 67%). However, the number of cfDNA mutations observed in VRL patients was higher than that of uveitis patients. The mutation-positive patients from the validation group were diagnosed with VRL while the mutation-negative patients were diagnosed with uveitis (sensitivity and specificity 100%). VRL patients were characterized by the high mutation frequencies of PIM1, MYD88, CD79B, ETV6, and IRF4.ConclusionsThe genetic mutation analysis of IOF samples represents a feasible diagnosis method for VRL with 100% sensitivity; it could track genetic profiles; thus, revealing genetic heterogeneity of VRL.Statement of translational relevanceThe anterior chamber paracentesis and diagnostic vitrectomy have been widely used in ophthalmic clinics, as they are less invasive sampling techniques for liquid biopsies. Genetic mutation analysis of cell-free DNA (cfDNA) of intraocular fluid using a panel containing 446 targeted genes represents a feasible method with 100% sensitivity for vitreoretinal lymphoma (VRL) diagnosis. Furthermore, it can address cytological diagnostic issues including limited cellular yield, cell lysis associated with the fragile nature of lymphoma cells, and high risks associated with retinal tissue biopsies. Furthermore, it allows for genetic profile tracking, having the potential to reveal genetic heterogeneity and molecular characteristics of VRL in the future more...
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- 2021
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22. Optical digital-to-analog conversion based on weighted fiber coupler
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Zhi-Yong Tao, Huan Liu, Yu-Kun Zhang, Zhao-Yun Li, Hai-Yue Pang, and Ya-Xian Fan
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Physics ,Wavelength ,Optics ,Matching (graph theory) ,Interference (communication) ,business.industry ,Quantization (signal processing) ,Bandwidth (signal processing) ,Filter (signal processing) ,Function (mathematics) ,business ,Signal - Abstract
The scheme of optical digital-to-analog conversion based on weighted fiber coupler is proposed. The simulation results show that when the output signal without filter, the time domain waveform is interfered by beat noise, and the function of optical digital-to-analog conversion cannot be realized. Fortunately, the beat noise is concentrated in the high frequency region which is more than 100GHz by setting the wavelength interval of the directly modulated laser array, and it can be removed effectively by the low-pass filter. However, some peak interference will appear at the time of signal alternation. When the filtering processing matching with the bandwidth of the transform signal, the peak interference can be suppressed. Finally, the optical digital-to-analog conversion with signal rate of 10Gbps and quantization accuracy of 5 bits can be realized. more...
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- 2021
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23. Modeling of errors resulting from vehicle motions for CHZII mobile gravimeter and its performance verification during marine surveys
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Zhang Hui, Tu hai-bo, Hu Ming, Lang jun-jian, Liu Lintao, Sun Heng, He jian-gang, Liu sun-jun, Fu yong-tao, Liu Lei-jun, Dong qin-qin, and Liang Xinghui
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Accuracy and precision ,Gravity (chemistry) ,Geophysics ,Observational error ,Gravimeter ,business.industry ,Computer science ,Mechanical design ,Aerospace engineering ,business ,Residual - Abstract
Mobile gravity survey plays a paramount role in many research fields, particularly geophysics and geodesy. Mobile gravimeters with delicate mechanisms and gyroscope-stabilized platforms are robust to motion-induced errors. In the past few years, a novel spring-based mobile gravimeter, CHZII, constructed with a sensitive probe based on an axisystematic mechanism and supported by a two-axis gyro platform, has been developed for mobile gravity surveys. This study mainly analyzes the system and models measurement errors derived from carrier motions. The system’s performance was varied in a laboratory and on the sea. The constructed system experimentally shows that the residual error introduced by carrier motions is less than 1 mGal (∼1 × 10−5 m/s2) in general working conditions due to the delicate mechanical design and precise assembly. A repeatability test for the CHZII engineering prototype and a comparison test with a KSS32 gravimeter have been conducted in 2016–2017, demonstrating that the measurement accuracy approaches 1.1 mGal, which is con-sistent with the expectation. more...
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- 2021
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24. Reduced Expression of Erythropoietin After Intravitreal Ranibizumab in Proliferative Diabetic Retinopathy Patients—Retrospective Interventional Study
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Fang Ma, Yanhong Shi, Weiqiang Yang, Fuxiao Luan, Li Chen, Jing Feng, Yong Tao, and Yingjie Wang
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medicine.medical_specialty ,Medicine (General) ,medicine.medical_treatment ,Urology ,Vitrectomy ,proliferative diabetic retinopathy (PDR) ,vascular endothelial growth factor (VEGF) ,chemistry.chemical_compound ,R5-920 ,medicine ,Original Research ,intravitreal ranibizumab ,business.industry ,General Medicine ,Diabetic retinopathy ,Endoglin ,medicine.disease ,eye diseases ,Vascular endothelial growth factor ,intraocular fluid ,chemistry ,Erythropoietin ,Intraocular fluid ,Medicine ,sense organs ,erythropoietin ,Ranibizumab ,business ,Immunostaining ,medicine.drug - Abstract
Purpose: To evaluate the expressions of erythropoietin (EPO) and vascular endothelial growth factor (VEGF) in the vitreous and fibrovascular membranes (FVMs) of proliferative diabetic retinopathy (PDR) after the intravitreal injection of ranibizumab (IVR) and further explore the relationship between EPO and VEGF.Method: The concentrations of EPO and VEGF levels in the vitreous fluid were measured in 35 patients (24 PDR and 11 non-diabetic patients) using enzyme-linked immunosorbent assay. The patients were divided into three groups: PDR with IVR (IVR group) before par plana vitrectomy (n = 10), PDR without IVR (Non-IVR group) (n = 14) and a control group [macular holes (MHs) or epiretinal membranes (ERM), n = 11]. Fluorescence immunostaining was performed to examine the expressions of VEGF, EPO and CD 105 in the excised epiretinal membranes.Result: The PDR eyes of Non-IVR group had the highest vitreous VEGF and EPO levels (836.30 ± 899.50 pg/ml, 99.29 ± 27.77 mIU/ml, respectively) compared to the control group (10.98 ± 0.98 pg/ml and 18.96 ± 13.30 mIU/ml/ml). Both the VEGF and EPO levels in the IVR group (13.22 ± 2.72 pg/ml and 68.57 ± 41.47 mIU/ml) were significantly lower than the Non-IVR group (P = 0.004 and P = 0.04, respectively). Furthermore, no significant difference was observed for VEGF levels between the control and IVR groups (10.9 ± 0.98 pg/ml and 13.22 ± 2.72 pg/ml, respectively, P = 0.9). Yet the EPO level in the IVR group was significantly higher than that in the Non-diabetic group (68.57 ± 41.47 pg/ml and 18.96 ± 13.30 pg/ml, respectively, P = 0.001). The expressions of EPO, VEGF, and CD105 were significantly reduced in fluorescence immunostaining of FVMs in the IVR group compared with the Non-IVR group. The receiver operating characteristic (ROC) curve of the EPO and VEGF levels were 0.951 and 0.938 in the PDR group.Conclusion: Both of the VEGF and EPO level were significantly increased in PDR patients, which have equal diagnostic value in the prediction of PDR. IVR could reduce the EPO level, but not enough to the normal level. more...
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- 2021
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25. Sigmoid colon perforation caused by migrated plastic biliary stents: a case report
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Yong Tao and Jiegen Long
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Male ,medicine.medical_specialty ,Abdominal pain ,medicine.medical_treatment ,Perforation (oil well) ,digestive system ,03 medical and health sciences ,0302 clinical medicine ,Colon, Sigmoid ,Internal medicine ,medicine ,Humans ,Cholangiopancreatography, Endoscopic Retrograde ,Endoscopic retrograde cholangiopancreatography ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Sigmoid colon ,Stent ,Emergency department ,Hepatology ,equipment and supplies ,medicine.disease ,digestive system diseases ,Surgery ,surgical procedures, operative ,medicine.anatomical_structure ,Intestinal Perforation ,030220 oncology & carcinogenesis ,Stents ,030211 gastroenterology & hepatology ,Foreign body ,medicine.symptom ,business ,Plastics - Abstract
Endoscopic migration of plastic biliary stents is performed by endoscopic retrograde cholangiopancreatography (ERCP) for biliary and pancreatic diseases. This plays an increasingly important role. Intestinal perforation caused by stent migration is one of the complications. Although sigmoid colon perforation caused by stent migration is rare, it can be life-threatening. This case shows us that we should increase awareness of sudden abdominal pain after ERCP. We provide a review of the clinical manifestations, imaging data of this case, and the literature related to the perforation caused by stent migration. A male patient had a history of choledocholithiasis, cholecystolithiasis, and biliary pancreatitis treated with ERCP and a pancreatic stent. After the operation, the patient developed cholangitis and was treated with ERCP and a plastic biliary stent. This patient was admitted to the emergency department with sudden lower abdominal pain. A CT scan showed sigmoid colon perforation by a foreign body and infra-diaphragmatic free air. An emergency surgery confirmed that the stent had caused the perforation. The patient was then treated with sigmoid colectomy and sigmoidostomy. Biliary stent migration after ERCP is rare, but intestinal perforation caused by migration should be considered in cases of abdominal pain of unknown cause. more...
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- 2020
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26. The use of facemasks may not lead to an increase in hand–face contact
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Juan Dong, Richard Culleton, and Zhi-Yong Tao
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China ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,040301 veterinary sciences ,Short Communication ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Internet privacy ,Face (sociological concept) ,0403 veterinary science ,03 medical and health sciences ,COVID‐19 ,Humans ,face touching ,030304 developmental biology ,0303 health sciences ,General Veterinary ,General Immunology and Microbiology ,Health professionals ,business.industry ,Social distance ,Masks ,COVID-19 ,04 agricultural and veterinary sciences ,General Medicine ,facemasks ,Psychology ,business - Abstract
Advocacy of the use of facemasks by the public as a measure against the spread of COVID‐19 is controversial, with some healthcare professionals arguing that the use of a face mask may increase the rate at which people touch their faces, due to readjusting the mask. We assessed the facial touching behaviour of bus passengers in China before and after the outbreak of COVID‐19 and found that wearing a face mask does not increase the number of hand‐face contacts and is likely, therefore, to have a positive beneficial effect on suppressing the spread of COVID‐19 within populations when used in conjunction with social distancing measures. more...
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- 2020
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27. Analysis of risk factors for depression in Alzheimer’s disease patients
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Wenjuan Hong, Le Chen, Yong Tao, Hua-Dong Zhou, Zeyan Peng, and Hai Yang
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Male ,0301 basic medicine ,China ,medicine.medical_specialty ,Comorbidity ,Disease ,Suicide rates ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Risk Factors ,Humans ,Hypoglycemic Agents ,Medicine ,Psychiatry ,Cognitive impairment ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Glycated Hemoglobin ,Depressive Disorder ,business.industry ,General Neuroscience ,food and beverages ,General Medicine ,Middle Aged ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Clinical evidence ,Female ,business ,030217 neurology & neurosurgery - Abstract
Purpose: Depression, which affects about 52% of Alzheimer's disease (AD) patients, can worsen cognitive impairment and increase mortality and suicide rates. We hope to provide clinical evidence for... more...
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- 2020
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28. Epigenetic therapy inhibits metastases by disrupting premetastatic niches
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Ken Kang Hsin Wang, Zhihao Lu, John Wrangle, Charles M. Rudin, Michelle Vaz, Michael J. Topper, Yuping Mei, Stephen R. Broderick, Drew M. Pardoll, Ray Whay Chiu Yen, Hariharan Easwaran, Rosalyn A. Juergens, Stephen M. Cattaneo, Cynthia A. Zahnow, Joseph B. Margolick, Beverly Lee, Hao Zhang, Yi Cai, Richard J. Battafarano, Yujiao Wang, Kristen Rodgers, Barry D. Nelkin, Patrick M. Forde, Wenbing Xie, Ki Bem Kim, Malcolm V. Brock, Xi Jiao, Jianling Zou, Shuang Li, Yong Tao, Stephen B. Baylin, Stephen C. Yang, Chi-Ping Day, Joanne Riemer, Lin Shen, Errol L. Bush, Yanni Wang, Ying Cui, Huili Li, Young J. Kim, Alicia Hulbert, Peng Huang, Franck Housseau, Weiqiang Zhang, Limin Xia, Bin Zhang, Julie R. Brahmer, and Xiangqian Kong more...
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0301 basic medicine ,Multidisciplinary ,Entinostat ,business.industry ,Cellular differentiation ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Downregulation and upregulation ,chemistry ,030220 oncology & carcinogenesis ,Cancer research ,medicine ,CXC chemokine receptors ,Histone deacetylase ,Epigenetics ,Bone marrow ,business ,Epigenetic therapy - Abstract
Cancer recurrence after surgery remains an unresolved clinical problem1–3. Myeloid cells derived from bone marrow contribute to the formation of the premetastatic microenvironment, which is required for disseminating tumour cells to engraft distant sites4–6. There are currently no effective interventions that prevent the formation of the premetastatic microenvironment6,7. Here we show that, after surgical removal of primary lung, breast and oesophageal cancers, low-dose adjuvant epigenetic therapy disrupts the premetastatic microenvironment and inhibits both the formation and growth of lung metastases through its selective effect on myeloid-derived suppressor cells (MDSCs). In mouse models of pulmonary metastases, MDSCs are key factors in the formation of the premetastatic microenvironment after resection of primary tumours. Adjuvant epigenetic therapy that uses low-dose DNA methyltransferase and histone deacetylase inhibitors, 5-azacytidine and entinostat, disrupts the premetastatic niche by inhibiting the trafficking of MDSCs through the downregulation of CCR2 and CXCR2, and by promoting MDSC differentiation into a more-interstitial macrophage-like phenotype. A decreased accumulation of MDSCs in the premetastatic lung produces longer periods of disease-free survival and increased overall survival, compared with chemotherapy. Our data demonstrate that, even after removal of the primary tumour, MDSCs contribute to the development of premetastatic niches and settlement of residual tumour cells. A combination of low-dose adjuvant epigenetic modifiers that disrupts this premetastatic microenvironment and inhibits metastases may permit an adjuvant approach to cancer therapy. In mouse models of pulmonary metastasis, adjuvant epigenetic therapy targeting myeloid-derived suppressor cells disrupts the premetastatic microenvironment after resection of primary tumours and inhibits the dissemination of residual tumour cells. more...
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- 2020
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29. An Optimization Method of Ghost Imaging Based on Multiple Speckle Patterns Combination-modulation
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王肖霞 Xiao-xia Wang, 杨风暴 Feng-bao Yang, 陶勇 Yong Tao, and 习江涛 Jiang-tao Xi
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Physics ,Speckle pattern ,Optics ,Modulation ,business.industry ,Ghost imaging ,business ,Atomic and Molecular Physics, and Optics - Published
- 2020
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30. SOAT1 methylation is associated with coronary heart disease
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Yong-Tao Wang, Zhen-Yan Fu, Yi-Ning Yang, Yi-Tong Ma, Fen Liu, Xiang Ma, Xiao-Mei Li, Bang-Dang Chen, and Jialin Abuzhalihan
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Male ,0301 basic medicine ,Oncology ,Candidate gene ,medicine.medical_specialty ,Genotype ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Coronary Disease ,Clinical nutrition ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,Leukocytes ,Humans ,Medicine ,Cholesterol absorption ,cardiovascular diseases ,Promoter Regions, Genetic ,lcsh:RC620-627 ,Aged ,DNA methylation ,business.industry ,Research ,Biochemistry (medical) ,Confounding ,Methylation ,Middle Aged ,Coronary heart disease ,lcsh:Nutritional diseases. Deficiency diseases ,030104 developmental biology ,CpG site ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,CpG Islands ,Female ,business ,SOAT1 ,Sterol O-Acyltransferase ,Lipidology - Abstract
Background This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD). Methods DNA methylation levels of the candidate genes FLOT1, FLOT2 and SOAT1 were measured in peripheral blood leukocytes (PBLs) from 99 patients diagnosed with CHD and 89 control subjects without CHD. A total of 110 CPG sites around promoter regions of them were examined. Results Compared with groups without CHD, patients with CHD had lower methylation levels of SOAT1 (PP = 0.005). After adjustment of other confounders, methylation levels of SOAT1 were still associated with CHD (P = 0.001, OR = 0.290, 95% CI: 0.150–0.561). Conclusions SOAT1 methylation may be associated with development of CHD. Patients with lower methylation levels in SOAT1 may have increased risks for CHD. Further studies on the specific mechanisms of this relationship are necessary. more...
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- 2019
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31. Prognostic Factors of Cytomegalovirus Infection Associated Retinitis in HIV-Negative Patients: A Retrospective Cohort Study
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Wensheng Li, Zhuyun Qian, Xu Chen, Yong Tao, and Wei Gu
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Visual Acuity ,Human immunodeficiency virus (HIV) ,Congenital cytomegalovirus infection ,Cytomegalovirus ,Eye Infections, Viral ,Retinitis ,Aqueous humor ,HIV Antibodies ,medicine.disease_cause ,Antiviral Agents ,Retina ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Child ,Ganciclovir ,Retrospective Studies ,030203 arthritis & rheumatology ,business.industry ,HIV ,virus diseases ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Cytomegalovirus infection ,Ophthalmology ,Cytomegalovirus Retinitis ,DNA, Viral ,Intravitreal Injections ,030221 ophthalmology & optometry ,Female ,Cytomegalovirus retinitis ,business ,Follow-Up Studies - Abstract
Purpose: To summarize the prognostic factors of cytomegalovirus (CMV) retinitis (CMVR) in HIV-negative patients treated with multiple intravitreal injections (IVs) of ganciclovir.Methods: A retrosp... more...
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- 2019
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32. Active tunable terahertz resonators based on hybrid vanadium oxide metasurface
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Zhi-Yong Tao, Huan Liu, Lin Li, Ya-Xian Fan, and Hong-Ge Chen
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Phase transition ,Materials science ,business.industry ,Terahertz radiation ,Graphene ,Physics::Optics ,Metamaterial ,02 engineering and technology ,Low frequency ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,law.invention ,010309 optics ,Resonator ,Optics ,Semiconductor ,law ,Electric field ,0103 physical sciences ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,0210 nano-technology ,business - Abstract
Hybrid terahertz (THz) metamaterial resonators have exhibited superior reconfigurable resonant response enabled by active materials, such as liquid crystals, graphene, and semiconductors. However, the tunable range of constitutive parameters of materials is still limited, which leads to the low modulation depth of THz devices. Unlike other phase change materials, vanadium dioxide (VO2) exhibits an insulator-to-metal transition characteristic and the conductivity can be increased by 4–5 orders of magnitude under external stimulus including electric fields, optical, and thermal pumps. Here, we propose an active tunable THz resonator based on a hybrid VO2 metasurface for thermal control. The simulated results show that by external thermal stimulation, we realize the tuning between the single and double resonant modes. The resonant peak at high frequency disappears while the low frequency peak is enhanced with the increasing temperature. The simulated surface electric fields confirm the physical mechanism of the excellent tunable performance that the L-shaped and cross resonances play a dominant role at the low and high temperature, respectively, due to the VO2 phase transition. Such a hybrid VO2 metasurface resonator with tunable characteristics will greatly promote the practical application of THz functional devices, such as modulators, sensors and filters. more...
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- 2019
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33. Dynamic impact of inflammation-based indices in colorectal cancer patients receiving FOLFOX-based chemotherapy
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Jianming Qiu, Yong Tao, Ningning Jin, Hongshuang Pang, Hongbiao Wu, Danping Yuan, Ningning Wu, Yuepeng Cao, and Dongfang Liu
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0301 basic medicine ,Oncology ,Chemotherapy ,Prognostic factor ,medicine.medical_specialty ,Multivariate analysis ,Receiver operating characteristic ,Proportional hazards model ,business.industry ,Colorectal cancer ,medicine.medical_treatment ,medicine.disease ,body regions ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,FOLFOX ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Neutrophil to lymphocyte ratio ,business ,medicine.drug - Abstract
Background: Inflammatory cellular response is implicated in the pathogenesis of colorectal cancer (CRC). Nevertheless, the dynamic effects of inflammatory index coNLR (neutrophil-to-lymphocyte ratio)-PLR (platelet-to-lymphocyte ratio) during chemotherapy remain elusive. Methods: The baseline clinical data and laboratory parameters of 480 CRC patients who received palliative resection of primary tumors and FOLFOX-based chemotherapy from January 2007 to January 2013 were retrospectively analyzed. Receiver operating characteristic curves were plotted to obtain the predictive NLR and PLR values, and to calculate the coNLR-PLR score. The Kaplan-Meier method was used to estimate the rates of recurrence-free survival (RFS) and overall survival (OS), and the Cox proportional hazards model was employed for analysis. Results: The dynamic cut-off values of NLR during four periods of chemotherapy were 3.029, 2.466, 2.102 and 1.795, respectively, and those of PLR were 216.438, 187.572, 169.027 and 174.368, respectively. A higher coNLR-PLR was significantly associated with lower rates of RFS and OS (P more...
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- 2019
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34. Catalyst-free growth of a Zn2GeO4 nanowire network for high-performance transfer-free solar-blind deep UV detection
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Sai Ma, Ya-Xian Fan, Shuanglong Feng, Yiming Zhao, Haitao Jiang, Zhi-Yong Tao, and Wenqiang Lu
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Materials science ,business.industry ,Band gap ,Nanowire ,Oxide ,Photodetector ,02 engineering and technology ,Chemical vapor deposition ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,Optoelectronics ,Wafer ,Reactive-ion etching ,0210 nano-technology ,business ,Ternary operation - Abstract
Solar-blind deep-ultraviolet (DUV) photodetectors have attracted wide attention because of their extensive military and civil applications. The ternary oxide Zn 2GeO4 is an ideal material with a wide bandgap (Eg = 4.69 eV). In this work, DUV photodetectors based on a ternary Zn2GeO4 nanowire (NW) network were fabricated on SiO2/Si substrates. Reactive ion etching of the SiO2/Si wafer was used to grow the NW network to avoid contamination of the Au catalyst during synthesis of the Zn2GeO4 NW network via high-temperature chemical vapor deposition . Photodetectors based the Zn 2GeO4 NW revealed fast response and recovery times, which is attributed to the unique cross-junction barrier-dominated conductance of the NW network. Results showed that the ternary oxide-based NW network is an ideal building block for nanoscale solar-blind photodetectors with superior performance. more...
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- 2019
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35. Multi-wavelength Q-switched random fiber laser based on stimulated Brillouin scattering and multimodal interference
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Ya-Xian Fan, Jia-Teng Zheng, Zhao-Yun Li, Hai-Yue Pang, and Zhi-Yong Tao
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Multi-mode optical fiber ,Active laser medium ,Materials science ,business.industry ,Optical communication ,Physics::Optics ,Laser ,Interference (wave propagation) ,law.invention ,symbols.namesake ,Optics ,law ,Brillouin scattering ,Fiber laser ,symbols ,Rayleigh scattering ,business - Abstract
We demonstrate a multi-wavelength Q-switched random fiber laser with the erbium-doped fiber as the gain medium and the Rayleigh scattering as the randomly distributed feedback in a 6 km long single-mode fiber. Q-switched pulses and sub-pulses with different repetition frequencies were generated with the pump power as 182 mW by combining the random cavity resonances and the Q-value modulation effect induced by the stimulated Brillouin scattering and nonlinear multimode interference in the graded-index multimode fiber. The pulse repetition rate increased continuously from 79 kHz to 113 kHz, and the corresponding pulse width exponentially decreased with the continuously increasing pump power, and a shortest pulse width of 1.85 μs was obtained. At the same time, a multi-wavelength spectrum with the equally spaced interval and an optical signal-to-noise ratio of ~31 dB was achieved. This laser has the unique properties different from the conventional resonant cavity lasers, which makes it a very promising light source in optical communication, imaging, and sensing applications. more...
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- 2021
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36. Dual-band terahertz biosensor based on metamaterial absorber
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Huan Liu, Zhi-Yong Tao, Hai-Ling He, Ya-Xian Fan, Jing Ma, and Gui-Min Chen
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Materials science ,business.industry ,Terahertz radiation ,Metamaterial absorber ,Miniaturization ,Optoelectronics ,Metamaterial ,Multi-band device ,business ,Absorption (electromagnetic radiation) ,Biosensor ,Refractive index - Abstract
Traditional biological detection methods in practical applications, such as polymerase chain reaction, fluorescence microscopy, flow cytometry and so on, are commonly limited by label needed, high cost, complex operation, low sensitivity. Fortunately, metamaterial-based terahertz (THz) biosensors have shown great potential in label-free, integrated chip and ultra-sensitive sensing due to their advantages in light collection and miniaturization. However, most of THz metamaterial biosensors are based on transmission spectrum measurement, the one-way transmission will lead to the weak interactions between analyte and THz wave, so the sensitivity will be greatly reduced. Here, we proposed a label-free dual-band THz biosensor with ultra-high sensitivity based on metamaterial absorber. The device consists of the asymmetric cross shaped metal metasurface, hollow sensing channel and a back reflector. The simulation results show that the two resonance modes are excited at 0.626 THz and 1.504 THz and the absorptivity is higher than 95%. With the increasing the refractive index of the analyte, the two absorption peaks have obvious red shift. The maximum sensitivities for mode A and mode B are up to 250 GHz/RIU and 630 GHz/RIU, respectively. By simulating the electromagnetic field distribution of the structure, the absorption sensing mechanism is discussed in detail. The proposed THz metamaterial biosensor exhibits promising applications in chemical and biological detection. more...
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- 2021
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37. Detection of Motor Dysfunction With Wearable Sensors in Patients With Idiopathic Rapid Eye Movement Disorder
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Lin Ma, Shu-Ying Liu, Shan-Shan Cen, Yuan Li, Hui Zhang, Chao Han, Zhu-Qin Gu, Wei Mao, Jing-Hong Ma, Yong-Tao Zhou, Er-He Xu, and Piu Chan
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0301 basic medicine ,medicine.medical_specialty ,Motor dysfunction ,Histology ,lcsh:Biotechnology ,Rapid eye movement sleep ,Biomedical Engineering ,STRIDE ,Bioengineering ,gait ,03 medical and health sciences ,0302 clinical medicine ,Gait (human) ,Physical medicine and rehabilitation ,Idiopathic REM sleep behavior disorder ,lcsh:TP248.13-248.65 ,Medicine ,Original Research ,quantitative measurement ,business.industry ,wearable sensors ,Bioengineering and Biotechnology ,Eye movement ,prodromal stage ,Trunk ,030104 developmental biology ,Gait analysis ,business ,Range of motion ,human activities ,030217 neurology & neurosurgery ,Biotechnology - Abstract
Patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) are at high risk for conversion to synucleinopathy and Parkinson disease (PD). This can potentially be monitored by measuring gait characteristics of iRBD patients, although quantitative data are scarce and previous studies have reported inconsistent findings. This study investigated subclinical gait changes in polysomnography-proven iRBD patients compared to healthy controls (HCs) during 3 different walking conditions using wearable motor sensors in order to determine whether gait changes can be detected in iRBD patients that could reflect early symptoms of movement disorder. A total 31 iRBD patients and 20 HCs were asked to walk in a 10-m corridor at their usual pace, their fastest pace, and a normal pace while performing an arithmetic operation (dual-task condition) for 1 min each while using a wearable gait analysis system. General gait measurements including stride length, stride velocity, stride time, gait length asymmetry, and gait variability did not differ between iRBD patients and HCs; however, the patients showed decreases in range of motion (P = 0.004) and peak angular velocity of the trunk (P = 0.001) that were significant in all 3 walking conditions. iRBD patients also had a longer step time before turning compared to HCs (P = 0.035), and the difference between groups remained significant after adjusting for age, sex, and height. The decreased trunk motion while walking and increased step time before turning observed in iRBD may be early manifestations of body rigidity and freezing of gait and are possible prodromal symptoms of PD. more...
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- 2021
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38. Regional anesthetics versus analgesia for stopping the persistent postsurgical pain: A meta‐analysis
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Xifeng Zhang, Yanshu Xu, Chunling Peng, Yong Tao, Qingyang Li, and Li Chen
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Post surgical ,medicine.medical_treatment ,Breast surgery ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Anesthesia, Conduction ,Pregnancy ,medicine ,Humans ,030212 general & internal medicine ,Thoracotomy ,Anesthetics, Local ,Pain, Postoperative ,Cesarean Section ,business.industry ,Postsurgical pain ,General Medicine ,Odds ratio ,Confidence interval ,Regional anesthesia ,Meta-analysis ,Anesthesia ,Female ,Analgesia ,business - Abstract
INTRODUCTION Regional anesthesia might moderate the risk of persistent postsurgical pain, but its effect compared to systemic analgesia is still conflicting. This meta-analysis study was performed to assess the relationship between the efficiency of regional anesthesia versus systemic analgesia in reducing pain persisting longer than 3 months after surgery. METHODS Through a systematic literature search up to August 2020, 31 studies included 2975 subjects who underwent surgery at baseline and reported a total of 1471 subjects using regional anesthesia and 1319 subjects using conventional anesthesia were found recording relationships between efficiency of regional anesthesia versus systemic analgesia in reducing pain persisting longer than 3 months after surgery. Odds ratio (OR) with 95% confidence intervals (CIs) was calculated between regional anesthesia versus systemic analgesia in reducing pain persisting longer than 3 months after surgery using the dichotomous methods with a random or fixed-effect model. RESULTS Number of subjects reporting persistent pain 3 months postsurgery was significantly lower in regional anesthesia compared to systemic analgesia in thoracotomy (OR, 0.44; 95% CI, 0.29-0.65, P more...
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- 2021
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39. An autonomous positioning method for fire robots with multi-source sensors
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Xiang-nan Zhang, Yong-tao Liu, Li Li, Guo-qing Shi, and Ruizhi Sun
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Heading (navigation) ,Computer Networks and Communications ,Computer science ,business.industry ,020206 networking & telecommunications ,020302 automobile design & engineering ,02 engineering and technology ,Positioning technology ,Non-line-of-sight propagation ,0203 mechanical engineering ,Inertial measurement unit ,0202 electrical engineering, electronic engineering, information engineering ,Robot ,Systems design ,Computer vision ,Artificial intelligence ,Electrical and Electronic Engineering ,business ,Encoder ,Inertial navigation system ,Information Systems - Abstract
The present technology, based on laser and visual SLAM navigation and positioning, does not apply to the event of a fire in a room where there is a large amount of smoke, for its increasingly obvious defects. In addition, traditional track deduction technology based on photoelectric encoder has accumulated error, and noise disturbance exists in the INS inertial navigation measurement technology, and the UWB positioning technology is vulnerable to NLOS disturbance caused by site occlusion. To solve the problem of accurate positioning of Autonomous Mobile fire-fighting robot in smoke scenes, the system design is optimized by adopting the following methods: using IMU-assisted residual chi-square criterion to detect whether there is NLOS in UWB, introducing IMU instantaneous compensation positioning data and adopting Chan algorithm fitting of the second multiplication to ensure the stability and accuracy of UWB data; meanwhile, a tight combination model of navigation and positioning is designed: via the improved Kalman filter algorithm, fused with the magnetic encoder track estimation pose, UWB absolute and IMU heading angle pose to realize the accurate positioning of the fire robot in the smoke scene. Finally, the fusion simulation model and algorithm are verified by MATLAB, as it shows, the method has an average positioning accuracy of 98.63% in the X-axis direction, 99.52% in the Y-axis direction, and 97.24% in the heading angle, which solves the inherent physical defects of a single positioning sensor and serves as a reliable and accurate solution for indoor robot positioning. more...
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- 2021
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40. Research on the Cultivation of Pharmaceutical Talents in the Context of Science and Education Integration
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Yan Tian, Gui-Mei Tang, Yong-Tao Wang, and Xiao Wang
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Engineering ,business.industry ,Process (engineering) ,ComputingMilieux_COMPUTERSANDEDUCATION ,Engineering ethics ,Context (language use) ,business - Abstract
This paper mainly focuses on the cultivation of pharmaceutical talents under the background of science and education integration. By analyzing the basic concepts of science and education integration, this paper explores the training principles that should be adhered to in the process of pharmaceutical talents training in colleges and universities. more...
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- 2021
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41. Variation of PPARG Expression in Chemotherapy-Sensitive Patients of Hypopharyngeal Squamous Cell Carcinoma
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Shaolong Cao, Yong Tao, Lizhen Hou, Jugao Fang, Jiaming Chen, Meng Lian, and Xixi Shen
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0301 basic medicine ,Peroxisome proliferator-activated receptor gamma ,Article Subject ,endocrine system diseases ,QH301-705.5 ,medicine.medical_treatment ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Downregulation and upregulation ,Drug Discovery ,Gene expression ,medicine ,Pharmacology (medical) ,Biology (General) ,Receptor ,Gene ,Chemotherapy ,business.industry ,nutritional and metabolic diseases ,Fold change ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,business ,Research Article - Abstract
Our previous study showed that the upregulation of peroxisome proliferator-activated receptor gamma (PPARG) could promote chemosensitivity of hypopharyngeal squamous cell carcinoma (HSCC) in chemotherapeutic treatments. Here, we acquired two more independent expression data of PPARG to validate the expression levels of PPARG in chemotherapy-sensitive patients (CSP) and its individualized variations compared to chemotherapy-non-sensitive patients (CNSP). Our results showed that overall PPARG expression was mildly downregulated ( log fold change = − 0.55 ; p value = 0.42; overexpression in three CSPs and reduced expression in four CSPs), which was not consistent with previous results ( log fold change = 0.50 ; p = 0.22 ; overexpression in nine CSPs and reduced expression in three CSPs). Both studies indicated that PPARG expression variation was significantly associated with the Tumor-Node-Metastasis (TNM) stage ( p = 7.45 e − 7 and 6.50 e − 4 , for the first and second studies, respectively), which was used as one of the predictors of chemosensitivity. The new dataset analysis revealed 51 genes with significant gene expression changes in CSPs ( LFC > 1 or p value < 0.01), and two of them (TMEM45A and RBP1) demonstrated strong coexpression with PPARG ( Pearson correlation coefficient > 0.6 or more...
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- 2021
42. Correlation between SCAP Genetic Polymorphism and Coronary Artery Disease in a Han population in Xinjiang, China
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Yong-Tao Wang, Yi-Tong Ma, Fen Liu, Zhen-Yan Fu, Bang-Dang Chen, Xiao-Dong He, Asiya Abudesimu, Dilare Adi, and Ying-Hong Wang
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Coronary artery disease ,Correlation ,medicine.medical_specialty ,business.industry ,Polymorphism (computer science) ,Internal medicine ,medicine ,Han population ,medicine.disease ,business ,China ,Gastroenterology - Abstract
SREBP cleavage-activating protein (SCAP) plays a vital role in the modulation of cholesterol homeostasis, and cholesterol dysregulation is tightly associated with coronary artery disease (CAD). To investigate the correlation of the genetic polymorphism of SCAP with CAD, we conducted a case-control study of 528 CAD patients (case group) and 483 age- and sex- matched subjects from whom CAD was excluded (control group). Three tagSNPs (rs147215799, rs17079634 and rs59586735) in SCAP gene were genotyped in all participants, the genotype and allele frequencies of which were compared between two groups to determine their associations with CAD. We found rs17079634 showed significant difference in genotype distribution between the case and control group (P=0.016). The difference was most prominent in a dominant model (TT vs. CT + CC, P=0.004). After adjustment for confounding factors, the difference remained statistically significant (OR =1.363, 95% confidence interval [CI]:1.022~1.818, P=0.035). Whereas no significant associations of the other two SNPs with CAD were observed (P=0.393 for rs147215799 and 0.303 for rs59586735, respectively). We drew conclusion that the SCAP genetic polymorphism rs17079634 was associated with CAD. more...
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- 2021
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43. Internal Cylinder Identification Based on Different Transmission of Longitudinal and Shear Ultrasonic Waves
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Huan Liu, Ya-Xian Fan, Wen-Bei Liu, Zhi-Yong Tao, Wen-Bo Yan, and Chengguo Tong
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Shear waves ,Materials science ,Letter ,Acoustics ,education ,lcsh:Chemical technology ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,law.invention ,010309 optics ,law ,0103 physical sciences ,Cylinder ,lcsh:TP1-1185 ,Electrical and Electronic Engineering ,010301 acoustics ,Instrumentation ,business.industry ,elastic waves ,Ultrasound ,Laser ,Atomic and Molecular Physics, and Optics ,Shear (sheet metal) ,defect identification ,Amplitude ,laser ultrasound ,Fizeau fiber interferometer ,Ultrasonic sensor ,business ,Longitudinal wave - Abstract
We have built a Fizeau fiber interferometer to investigate the internal cylindrical defects in an aluminum plate based on laser ultrasonic techniques. The ultrasound is excited in the plate by a Q-switched Nd:YAG laser. When the ultrasonic waves interact with the internal defects, the transmitted amplitudes of longitudinal and shear waves are different. The experimental results show that the difference in transmission amplitudes can be attributed to the high frequency damping of internal cylinders. When the scanning point is close to the internal defect, the longitudinal waves attenuate significantly in the whole defect area, and their amplitude is always smaller than that of shear waves. By comparing the transmitted amplitudes of longitudinal and shear waves at different scanning points, we can achieve a C scan image of the sample to realize the visual inspection of internal defects. Our system exhibits outstanding performance in detecting internal cylinders, which could be used not only in evaluating structure cracks but also in exploring ultrasonic transmission characteristics. more...
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- 2021
44. Disseminated Pulmonary Mucormycosis Involving the Jejunum in an Acute Lymphoblastic Leukemia Patient
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Yong-tao Wang, Lan-lan Wang, Zhi-min Hu, Qin-bin Meng, Yan Feng, Zhong-ju Chen, Yang Yi, and Liang Zou
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Jejunum ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Lymphoblastic Leukemia ,Internal medicine ,Medicine ,business ,Pulmonary mucormycosis ,Gastroenterology - Abstract
Background: Pulmonary mucormycosis and aspergillosis with disseminated mucormycosis involving gastrointestinalin is a very rare but lethal infection leading to extreme mortality. Case presentation: A 51-year-old female was admitted in the hematology clinic following persistent fever. Bone marrow pathology was done on the third day and the common type of acute B-lymphocytic leukemia (B-ALL) with the IKZF1 mutation was diagnosed. IVCP program was prescribed as initial treatment. After five days, broad spectrum antibiotics and voriconazole were started due to febrile neutropenia. Forty-nine days after admission, based on characteristics of the clinical pulmonary symptoms, the feature of the computed tomography (CT) and the morphological profile of the hyphae, we switched the antifungal therapy to intravenous amphotericin B (AmB) with an initial dose of 0.5 mg/kg/d. On day sixty-two, according to the abdominal CT and clinical symptoms, intestinal perforation was diagnosed and emergency surgical management was performed. Histopathology of specimens from the jejunum and ileum showed broad septate fungal hyphae. L-AmB was added to 1.0 mg/kg/d for one week, followed by fever resolution. Considering the relief of symptoms and regression of lesions on imagery, our strategy switched to oral posaconazole 0.8 g/d. The patient was discharged in good condition for continuous therapy with antifungal agents and for follow-up at the outpatient clinic.Conclusions: Direct microscopic testing with calcofluor white is the key to rapid diagnosis of mucormycosis, and early administration of active antifungal agents at optimal doses and complete resection of all infected tissues led to improved therapeutic outcomes. more...
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- 2020
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45. Author response: Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
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Zahra Mohammadi, Abdul Basit, Helena I. S. Nogueira, Soile E. Puhakka, Hongsheng Bi, Ari Voutilainen, Davood Khalili, Bin Zhou, Dermot O'Reilly, Natascia Rinaldo, Paulo A. Lotufo, Bahareh Kheiri, Thein Thein Htay, Simona Giampaoli, Goodarz Danaei, M. Fernanda Lima-Costa, Simona Bo, Peter Schnohr, Jerzy Chudek, Francesco Panza, Ling Yang, Katia Vergetti Bloch, Vincenzo Capuano, Holly E. Syddall, Dong Zhao, Indah Suci Widyahening, Maria Lorenza Muiesan, Leng Huat Foo, Mohsen Azimi-Nezhad, Merete Osler, Laura Torres-Collado, Manu Raj, Adroaldo Cesar Araujo Gaya, Susi Kriemler, Ali Akbar Shayesteh, Aneta Grajda, Anette Varbo, Kazem Mohammad, Leila Beltrami Moreira, Shu Ti Chiou, Iuliia A Rusakova, Jyh Eiin Wong, Torben Jørgensen, Lela Sturua, Lubica Ticha, Hamid Hakimi, Hazzaa M. Al-Hazzaa, Yanina Zócalo, Freda Pitakaka, Savvas C. Savva, Rajeev Gupta, Jennifer Servais, Marie Kunešová, Johanna M. Geleijnse, Elysée Claude Bika Lele, Yannis Manios, Jorge Escobedo-de la Peña, Yufang Bi, Chinh Nguyen Huu, Sibel Gogen, Viviane Cunha Cardoso, Kristine H. Allin, Ana Azevedo, Line Tang Møllehave, Vincent Jr DeGennaro, Novie O. Younger-Coleman, Gretchen A Stevens, Dickman Gareta, Holger Theobald, Anja Schienkiewitz, Bekbolat Zholdin, Janice Luisa Lukrafka, Adela Chirita-Emandi, Ulla Roggenbuck, Kenisha Russell Jonsson, Robespierre Ribeiro, Gabriele Eiben, Eero Kajantie, Sounnia Mediene Benchekor, Fariborz Mansour-Ghanaei, Mary Simon, Prakash C. Gupta, Mohammad Esmaeel Motlagh, Emanuela Gualdi-Russo, María Elena Díaz-Sánchez, Pilar Guallar-Castillón, Bee Koon Poh, Cristina Padez, Azaliia M Tuliakova, Sarah P. Garnett, William R. Tebar, Yingfeng Zheng, Suhad Bahijri, Christina Mavrogianni, Mihaela Vladulescu, Jan A. Staessen, Paula Duarte de Oliveira, Rui Ornelas, Michael Sjöström, Charles Agyemang, Slawomir Koziel, Shohreh Naderimagham, Jari Jokelainen, Stephen T. McGarvey, Patrick Pasquet, Farnam Mohebi, Nader Saki, Aida Pilav, Azim Nejatizadeh, Marianna Noale, Habiba Ben Romdhane, Luís B. Sardinha, Laura Lauria, Jun Hata, Kodanda R Kanala, Gert B. M. Mensink, Nils Lehmann, Elio Riboli, Carolina Tarqui-Mamani, Rodrigo M. Carrillo-Larco, Rosangela Fernandes Lucena Batista, Victoria E Soto-Rojas, Luis Serra-Majem, Martina Müller-Nurasyid, Felipe Vogt Cureau, Lekhraj Rampal, Zhamilya Battakova, Ludmila Sevcikova, Suhaila Abdul Ghaffar, Fikru Tullu, Aung Soe Htet, Angel R. Gonzalez, Annette J. Dobson, Kavumpurathu Raman Thankappan, Hélène Delisle, Francisco J. Félix-Redondo, Ramón Suárez-Medina, Annika Rosengren, Sania Nishtar, Tanja G. M. Vrijkotte, Wolfgang Ahrens, Osvaldo Santos, Maria Cecília Formoso Assunção, Kazi M. Jamil, Stefano Marventano, Wenbin Wei, Norsyamlina Che Abdul Rahim, Shukri F. Mohamed, Bente Sparboe-Nilsen, Soon-Woo Park, Ana Isabel Rito, David Goltzman, W. M. Monique Verschuren, Catterina Ferreccio, Marta Buoncristiano, Ramón Alberto Rascón-Pacheco, Pradeep Joshi, Edward D Janus, Laetitia Huiart, Ala'a Alkerwi, Lorenza Pilotto, Mohannad Al Nsour, Daan Kromhout, Marius B. Bjertness, Oanh T. H. Trinh, Nico Dragano, Angélica Ochoa-Avilés, Ingunn Holden Bergh, Yuki Fujita, Juraci Almeida Cesar, Hajer Aounallah-Skhiri, Maria Dorobantu, Jordi Sunyer, Wolfgang Kratzer, Susanne R. de Rooij, Drude Molbo, Rebecca Goldsmith, Jean Woo, Mohammad El-khateeb, Tiffany K. Gill, Nish Chaturvedi, Benjamin Acosta-Cazares, Erik Lykke Mortensen, Nikhil D. Patel, Francesco Pistelli, Yuan He, Ivana Radic, Yi Zeng, Ilse Khouw, Reynaldo Martorell, Ching-Yu Cheng, Stine Schramm, Hana Shimizu-Furusawa, Jacek Jóźwiak, Radwan Qasrawi, Isti Ilmiati Fujiati, Charles Sossa Jérome, Ben Schöttker, Mikhail Benet, Anastasia Markaki, Christopher T. Cowell, Bharathi Viswanathan, Renata Kuciene, Jose Eugenio Lozano, Pedro J Ortiz, Delphine De Smedt, Elaine M. Murtagh, Kamel Ajlouni, Carlos A. Aguilar-Salinas, Graziella D'Arrigo, Xiangjun Wang, Lars Lind, Macia Enguerran, Marjeta Mišigoj-Duraković, Bo Werner, Jean-Michel Gaspoz, Kyungwon Oh, Seyed Rasoul Zakavi, Daniel Fernández-Bergés, Felix Kaducu, Ramon O. Jimenez, Jonathan E. Shaw, Nipa Rojroongwasinkul, Aicha Soumare, Astrid Petersmann, Tomasz Grodzicki, Parvina Mukhtorova, Eha Nurk, Bhawesh Koirala, Óscar Lopes, Ana Jelakovic, Karolina Milkowska, Magda Gasull, Regina Heidinger-Felso, Marcela González-Gross, Belong Cho, Daphne Mirkopoulou, Salvador Villalpando, Tran Quoc Bao, José Boggia, Daniela Galeone, Josep Redon, Matthias Bopp, Abbas Rezaianzadeh, Dusko Bjelica, Amir Houshang Mehrparvar, Felipe F. Casanueva, Khairil Si-Ramlee, Soheir H Ahmed, Maria Nordendahl, Luciana Zaccagni, Mahboubeh Parsaeian, Rod Jackson, Jorge Motta, Keiu Nelis, Fernando Rigo, Andrzej Pajak, Christa Meisinger, Clara Homs, Namuna Shrestha, Mar Alvarez-Pedrerol, Xun Tang, Johann Willeit, Motahareh Kheradmand, Jean Dallongeville, Jean-Bernard Ruidavets, Anne Tjønneland, Diana A. Santos, Lynne M. Boddy, Jie Hao, David Alejandro González-Chica, Elin Kolle, Jingli Gao, Małgorzata Mossakowska, Isabel O. Oliveira, Giuseppe Grosso, Seongjun Ha, Olfa Saidi, Albina A Fakhretdinova, Oye Gureje, Raluca Pop, Iulia Jurca Simina, Nuno Lunet, Maria Forsner, Peter Bjerregaard, Rachael McLean, Antonio Cabrera de León, Guy De Backer, José A. Casajús, Guang Ning, Emmanuella Magriplis, Laura Censi, Graziella Bruno, Valentina Peterkova, Angelique Chan, Yvonne T. van der Schouw, Charalambos Hadjigeorgiou, Anjani Kumar Jha, Toomas Veidebaum, Thamara Hubler Figueiró, Jana Kratenova, Michelle Cilia, Ivo Rakovac, Bill Stavreski, Ya Xing Wang, Oscar Noboa, Romana Roccaldo, Sara Magnacca, Johan Sundström, Peter Stehle, Tania Lopez, Francis Delpeuch, Julianne Williams, Ellisiv B. Mathiesen, Leanne M. Riley, Claudia M. Hormiga, Joanne Katz, Ekaterina Stoyanova, Heloisa Bettiol, Gabriele Nagel, Alireza Khosravi, Lars Bo Andersen, João Breda, Jørgen Meisfjord, Ahmad Faudzi Yusoff, Marjeta Majer, Robert Beaglehole, Caleb Ochimana, Shynar Abdrakhmanova, George S. Stergiou, Blanca Sandra Ruiz-Betancourt, Leon A. Simons, Eng Joo Tan, Victoria Farrugia Sant'Angelo, Gry Skodje, Maryam Keramati, Liv Elin Torheim, Seppo Koskinen, Assembekov Batyrbek, Jaakko Tuomilehto, Marjo-Riitta Järvelin, Ming-Hui Zhao, Krista Fischer, Tobias F. Rinke de Wit, Agnès Le Port, Reza Homayounfar, James E. Bennett, Yuna He, Matsuda Fumihiko, Qi Sheng You, Angela Spinelli, Scott B. McLean, Shirin Djalalinia, Thet Thet Mu, Yves Martin-Prével, Rafael N. Pichardo, Gailute Bernotiene, Pietro Amedeo Modesti, Frederick C. W. Wu, Chandini Nekkantti, Daniela Rodrigues, Tandi E. Matsha, Mihai Gafencu, Xingwang Ye, Salar Rahimikazerooni, Trevor S. Ferguson, Christophe Tzourio, Marie Zins, Fernando Rodríguez-Artalejo, Xu Ma, Elin Pettersen Sørgjerd, Lourdes Ribas-Barba, Nalan Uysal, Salim Berkinbayev, Enisa Kujundzic, Sari Voutilainen, Iraj Mohebbi, Heiner Boeing, Jorge Mota, Jana Námešná, Maria Tsigga, Zivka Dika, Gulmira Aitmurzaeva, Xu Lin, Valéria Regecová, Herman Schargrodsky, Stevo Popovic, Amelia C. Crampin, Hannu Uusitalo, André Luiz Sena Guimarães, Ali Esmaeili, Catherine Kyobutungi, Virginija Dulskiene, Diego Augusto Santos Silva, David De Ridder, Lizzy M. Brewster, Hashem Jaddou, Eunice Ugel, José Camolas, Azli Baharudin, Idris Guessous, Sok King Ong, Tabara Yasuharu, Ali Ghanbari, Anne W. Taylor, Iraj Nabipour, Justyna Godos, Cyrus Cooper, Bruna Gonçalves Cordeiro da Silva, Gonzalo Valdivia, Gyulli M. Kazakbaeva, Takuro Furusawa, Pawel Kurjata, Diego Vanuzzo, Marvin Cervantes-Loaiza, Karen Morgan, Mostafa Qorbani, Rute Santos, Marika Ferrari, Diego Salmerón, Ida Maria Schmidt, Gao Pei, Abu Am Hanif, Balkish M. Naidu, Maria Wany Louzada Strufaldi, Moesijanti Soekatri, Marcia Scazufca, Katharina Maruszczak, Jacqueline Ramke, Elvis Oa Wambiya, Kairit Mikkel, Napoleón Pérez-Farinós, Natalia Nowak-Szczepanska, Miao Li Chee, Jose Sanchez-Abanto, Rajaa Al-Raddadi, Michel Joffres, Vayia Rarra, Ningli Wang, Charmaine A. Duante, Sheikh Mohammed Shariful Islam, Manoli Garcia-de-la-Hera, Weili Yan, Dong Wook Shin, Rômulo Araújo Fernandes, Ilona Nenko, Sanjib Kumar Sharma, Alfonso Siani, Indrapal I. Meshram, Imelda A. Agdeppa, Ei Ei K. Nang, Ian Rouse, Avula Laxmaiah, Ana M. B. Menezes, Yih Chung Tham, Ebrahim Eftekhar, María José Tormo, Felicia Cañete, Marie Eliasen, Lutgart Braeckman, Dirk Vanderschueren, Genc Burazeri, Kari Kuulasmaa, Jesús Vioque, Marisa K. Sophiea, Agneta Sjöberg, Katarzyna Dereń, Albertino Damasceno, Jochanan Stessman, Stig E. Bojesen, Aline Meirhaeghe, Else Karin Grøholt, Flávio Danni Fuchs, Robert Lundqvist, Frédéric Gottrand, Jeongseon Kim, Helmut Schröder, Joanna Baran, Karina Mary de Paiva, Yousef Khader, Eric Monterrubio-Flores, Aneta Weres, Hans Concin, Damaskini Valvi, Sari Hantunen, Machi Suka, Elena Sacchini, Norbert Amougou, Ursula Kiechl-Kohlendorfer, Edwige Landais, Viktoria Anna Kovacs, Rosemarie Martin, Kenneth James, Amaneh Shayanrad, Grethe S. Tell, Norazizah Ibrahim Wong, Vedrana Sember, Anelise Reis Gaya, Konrad Jamrozik, Thorkild I. A. Sørensen, Martin Neovius, Urho M. Kujala, Nathalie Michels, Marcel Goldberg, Alexandra Cucu, Liliana Dacica, Adelheid Weber, Hermann Pohlabeln, Sandjaja, Jukka T. Salonen, Patricia Varona-Pérez, Tiina Laatikainen, Jolanta Słowikowska-Hilczer, Ana Paula Carlos Cândido, Julie Taylor, Anabela Mota-Pinto, Cora L. Craig, Teresa Shamah-Levy, María Dolores Chirlaque, Mohd Azahadi Omar, Dominique Cottel, Charumathi Sabanayagam, Andrea Gazzinelli, Mieczysław Litwin, Sadaf G. Sepanlou, Adolfo Rubinstein, Abbas Dehghan, Rildo de Souza Wanderley Júnior, Wenhua Zhao, Aleksandra Piwońska, Yong Tao, Bontha V. Babu, Marc J. Gunter, Harunobu Nakamura, Wojciech Drygas, Eiji Oda, Jia Li Duan, Stefan Söderberg, Anthony Kafatos, Lynell V Maniego, Els Clays, Wei-Yen Lim, Marshall K. Tulloch-Reid, Mariachiara Di Cesare, Mattias Johansson, Simona Costanzo, Margot González-León, Matthias Nauck, Henry Völzke, George Luiz Lins Machado-Coelho, Annette Peters, Rajiv T Erasmus, Juan Francisco Miquel, Andrea Gualtieri, Abdul Hamid Zargar, Kaare Christensen, Peter Willeit, Tanja Stocks, Christine Cameron, Samuel C. Dumith, Janina Petkeviciene, Boyd Swinburn, Magdalena Muc, Sabine Schipf, Tajana Zeljkovic Vrkic, Martin Bobak, Damian K Francis, Veronica Mocanu, Karien Stronks, Antonisamy Belavendra, Artur Mazur, Nagalla Balakrishna, Jardena J. Puder, Mehrdad Azmin, Shelly R. McFarlane, Sara Santos Sanz, Yang Yang, Anneke Blokstra, Rafel Ramos, Ertugrul Celikcan, Jody C Miller, Jesús Ibarluzea, Svetlana A. Shalnova, Maria Elisa Zapata, Guansheng Ma, Fereidoun Azizi, Beatriz D'Agord Schaan, Pedro Marques-Vidal, William A. Neal, Ana B. Crujeiras, Zhenyu Zhang, Naser Ahmadi, Abdullatif Husseini, Alun Evans, Jiang He, Edyta Łuszczki, Maria G. Stathopoulou, Alibek Mereke, Mari-Liis Tammesoo, Axel C. Carlsson, Helen Gonçalves, Idowu O Senbanjo, Jim Mann, Rajendra Pradeepa, Juel Jarani, Eva Martos, Eugene Sobngwi, Themistoklis Tzotzas, Vassilis Zafiropulos, Reina Engle-Stone, Atul Trivedi, Hui Cai, Sarah Filippi, Georg Posch, Galina Obreja, Cecily Kelleher, Sareh Eghtesad, Chung T Nguyen, Kay-Tee Khaw, Joseph Cacciottolo, Ana Henriques, Yi-Ting Lin, Anil Poudyal, Liam Smeeth, Kenji Shibuya, Emma Ruiz Moreno, Annamari Lundqvist, Thor Aspelund, Caroline H.D. Fall, Philippe Amouyel, Kristyna Zejglicova, Argyro Karakosta, Piotr Bandosz, Juvenal Soares Dias-da-Costa, Maria Lazo-Porras, Maung Maung Than Htike, Dalia Luksiene, Jutta Stieber, Augusto Di Castelnuovo, Aryeh D. Stein, Lechaba Tshepo, Judith Benedics, Aletta E. Schutte, Jürgen König, Magdalena Korzycka, Grzegorz Sobek, Dimitrios Trichopoulos, Tai Hing Lam, Yn-Tz Sung, Masanori Iwasaki, Elias F. Gudmundsson, Antonio Mistretta, Daniel Lemogoum, Nimmathota Arlappa, Isabelle Herter-Aeberli, Khanh Le Nguyen Bao, Shoichiro Tsugane, Kaosar Afsana, Alireza Sadjadi, Myriam Galfo, Jean Claude Mbanya, Bernardo L. Horta, Marleen E. Hendriks, M. Arfan Ikram, Fadia AlBuhairan, Huashuai Chen, Marzieh Katibeh, Sidsel Graff-Iversen, Sahar Saeedi Moghaddam, Larissa Pruner Marques, Louise Eriksen, Aleksandra Gomula, Ricky Eddie, Maciej Banach, Jost B. Jonas, Andrea R. V. R. Horimoto, Slavica Sović, Charles Mondo, Felix Gutzwiller, Mariana Sbaraini, Aye Aye Sein, Henrike Galenkamp, Jaume Marrugat, Nazan Yardim, Cecilia Björkelund, Luigi Palmieri, Roya Kelishadi, Jie Mi, Nahla Hwalla, Jing Liu, Davide Noto, Panayiotis K. Yiallouros, Kelias P. Msyamboza, Judith Simons, Sofia Malyutina, Michele Monroy-Valle, Andres Metspalu, Lariane M Ono, Rafaela Rosário, Flora A. Ukoli, Efthymios Kapantais, Enzo Manzato, S. Goya Wannamethee, Alison J Price, Gregorio Varela-Moreiras, Ali Reza Safarpour, Erfan Ghasemi, Janine Clarke, René Charles Sylva, Wan Nazaimoon Wan Mohamud, Zhamyila Usupova, Chaoqiang Jiang, Julio Zuñiga Cisneros, Freja B Kampmann, Wei Cheng Lo, Reza Mohammadpourhodki, Kaspar Staub, Mojtaba Farjam, Vincenzo Solfrizzi, Garry L. Jennings, Fabio Galvano, Monika Zuziak, Karin De Ridder, Lucie Viet, Anna Bugge, Mehdi Yaseri, Safiah Md Yusof, Sandra C. Fuchs, Emmanuel Cohen, Snehalatha Chamukuttan, Maria Ruiz-Castell, Karen Sparrenberger, Pedro Plans-Rubio, Wei Zheng, Eldridge Ferrer, Martijn Huisman, Maria Hassapidou, Iris Pigeot, Jakub Stokwiszewski, Domenico Palli, Ewelina Czenczek-Lewandowska, Ramiro Guerrero, Farzad Hadaegh, Han Cg Kemper, Saeid Safiri, Ivan Pećin, Arnaud Chiolero, Niels Møller, Jorge Bezerra, Ulrike Gehring, Iná S. Santos, Dénes Molnár, Muhammad Fadhli Mohd Yusoff, Marie Moitry, Nizal Sarrafzadegan, Jacqueline F. Price, Ranko Stevanovic, Sai Yin Ho, Georg Lappas, Alberto Palloni, Malay K. Mridha, Elaine M. Dennison, Jeonghee Lee, Saeid Eslami, Rahman Shiri, Japhet Killewo, Juergen Breckenkamp, Mathilde Kersting, Y Nikitin, Iqbal Bata, Geetha R Menon, Maria Avdicova, Sanjay Rampal, Antônio Augusto Moura da Silva, Kirsten Mehlig, Chien-An Sun, Ramin Heshmat, Violeta Iotova, Stefaan Demarest, Mette Rasmussen, Dirk De Bacquer, San-Lin You, Suzanne N Morin, Martin Gulliford, Maties Torrent, Luc Dauchet, Fred Paccaud, Paibul Suriyawongpaisal, Sherali Rakhmatulloev, Hyeon Chang Kim, Markku Peltonen, Ruth Frikke-Schmidt, Vera Musil, Ahmad Ali Zainuddin, Angela Chetrit, Dan Zhu, Gowri Mahasampath, Ulrich Keil, Sérgio Viana Peixoto, Haiquan Xu, Helle-Mai Loit, Valérie Deschamps, Ilpo Huhtaniemi, Lijuan Liu, Marialaura Bonaccio, Altan Onat, Rody G. Sy, José María Huerta, Ko Ko Zaw, Akihiro Yoshihara, Peter Ueda, Belgin Ünal, Rachel Dankner, Andrzej Wiecek, Eman Aly, Ruzena Kubinova, Justina Vaitkeviciute, Hanna Tolonen, Priscilla Duboz, Orn Olafsson, Yin Guo, Chiara Donfrancesco, Salim Mohanna, Dusan Grafnetter, Daniel Weghuber, Ali Ahmadi, Rosemary B. Duda, E. Shyong Tai, Louise A. Baur, Nihal Thomas, Prabhdeep Kaur, Norlaila Mustafa, Shariq Rashid Masoodi, Liis Nelis, Badreya Al-Lahou, J. Jaime Miranda, Lèlita Santos, Aroor Bhagyalaxmi, Mohamed Bamoshmoosh, Børge G. Nordestgaard, Jeannette Lee, Ahmad Reza Dorosty, Alain Morejon, Ying-Wei Wang, Jakob Tarp, Rosalba Rojas-Martínez, Luxia Zhang, Bahram Mohajer, Maja Bæksgaard Jørgensen, Jurate Klumbiene, Zhengming Chen, Ambady Ramachandran, Andrea Rodriguez-Martinez, Alisha N. Wade, Suyeon Park, Janne Schurmann Tolstrup, Lucjan Szponar, Krishna Kumar Aryal, Tahir Aris, Mahfuzar Rahman, Dorja Vočanec, Juan P. González-Rivas, Rob M. van Dam, Daniel Bia, Oonagh Markey, Ryutaro Ohtsuka, Kumiko Ohara, Ričardas Radišauskas, Jurate Medzioniene, Tiina Vlasoff, Tania Tello, Suzanne C. Ho, Kodavanti Mallikharjuna Rao, May Soe Aung, Vesselka Duleva, Michael Hobbs, Lutgarde Thijs, Marjolein Visser, Parasmani Dasgupta, Inge Huybrechts, Raimund Erbel, Alice Bonilla-Vargas, Hermann Brenner, Mohammad Reza Fattahi, Jolanda Hyska, Roman Topor-Madry, Ranjit Mohan Anjana, Merike Liivak, Eruke E. Egbagbe, Mathilde Savy, Herculina S. Kruger, Neil Murphy, Vinay Nangia, Cesar G. Victora, Mostafa K. Mohamed, H. Bas Bueno-de-Mesquita, Gabriella Gruden, Marcos André Moura-dos-Santos, Mohammed Rasoul Tarawneh, Maria Teresa Menzano, Francesco Branca, Abdonas Tamosiunas, Elena Bogova, Niveen M E Abu-Rmeileh, Maroje Sorić, Aleksander Giwercman, Elżbieta Dziankowska-Zaborszczyk, Tatjana Hejgaard, Yves Kameli, Margarita Samoutian, Andreia N. Pizarro, Jin Soo Moon, Frank Claessens, Zulfiqar A Bhutta, Frank Tanser, Nor Azwany Yaacob, Vanina Bongard, Gregor Jurak, Johan G. Eriksson, Christina-Paulina Lambrinou, Hanspeter Stamm, Kim Overvad, Yanping Li, Carsten Oliver Schmidt, Thomas Meinertz Dantoft, Wichai Aekplakorn, Anwar Batieha, Eduardo Capuano, Teresa Haugsgjerd, Jeremy M. Jacobs, Paola Russo, Nguyen D Nguyen, Luis Revilla, Hossein Poustchi, Farid Najafi, Giovanni de Gaetano, Wan Mohamad Wan Bebakar, Paul Elliott, Denise Eldemire-Shearer, Angela Döring, Giovanni Viegi, Xiaoguang Yang, María-Elena González-Villalpando, Maria Puiu, Maria Benedetta Donati, Andrew Wong, Tomasz Zdrojewski, Carlos P. Boissonnet, Mohamad Hasnan Ahmad, Mahmudur Rahman, Günther Fink, Marcia Makdisse, Dragana P Jovic, Aline Wagner, Coimbatore Subramaniam Shanthirani, Pascal Bovet, Dong Wook Kim, Tom Wilsgaard, Anders Grøntved, Thirunavukkarasu Sathish, Antonia Trichopoulou, Noushin Mohammadifard, Igor Spiroski, Natasja M. van Schoor, Cláudia S. Minderico, Betina H. Thuesen, Queenie Chan, Ulf Ekelund, Laura A. Rodríguez-Villamizar, Line Lund Kårhus, Cihangir Erem, Amina Barkat, Maria Paula Santos, Fernanda Cunha Soares, Constanta Huidumac Petrescu, Allan G. Hill, Honor Bixby, Benoît Salanave, Joana Carvalho, Maigeng Zhou, Ofra Kalter-Leibovici, Roy A Wong-McClure, Kim F. Michaelsen, Doris Stöckl, Rosalynn Siantar, Jouko Saramies, José R. Banegas, Quang Ngoc La, Uruwan Yamborisut, Parinaz Mehdipour, Farhad Pourfarzi, Sudha Ramachandra Rao, Katsuyasu Kouda, Chien-Jen Chen, Rafael dos Santos Henrique, Martin Nankap, Allan Linneberg, Ronald D. Gregor, Rudolf Kaaks, Maria do Carmo Franco, Marta García-Solano, Beata Gurzkowska, Bahman Cheraghian, Stefaan De Henauw, Daniel Ferrante, Johanna A. Otero, Jamila Abubakar Garba, Antonio Pedro Graça, Sumit Bharadwaj, Shiqi Zhen, Xiu-Hua Guo, Prashant Mathur, Raphael Mendes Ritti-Dias, Kouamelan Doua, Esteban Carmuega, Majid Shirani, Przemyslaw Slusarczyk, Petra Rust, Visnja Djordjic, Farahnaz Joukar, Johanna Gunnlaugsdottir, Leila Houti, Nayu Ikeda, Imperia Brajkovich, Amirabbas Momenan, Erik J. Timmermans, Marcin Rutkowski, Biruta Velika, Joana Araújo, Jostein Steene-Johannessen, Christa L. Lilly, Per Tynelius, Michael Tornaritis, Anne Juolevi, Fatima Zahra Laamiri, Carl Lachat, Kai-Uwe Saum, Espen Bjertness, Ana P. Ortiz, Joel G. R. Roy, Himanshu K. Chaturvedi, Michelle Holdsworth, Niels Wedderkopp, Johan Van der Heyden, Mukharram M. Bikbov, Hsien-Ho Lin, Eva Corpeleijn, Harshpal Singh Sachdev, Mohammad Reza Mirjalili, Maria del Cristo Rodriguez-Perez, Michala Lustigová, Tuyen D Le, Teresa Norat, Hana Zamrazilová, Garry Brian, Tien Yin Wong, Rosa Haghshenas, Clive Osmond, Diego Giulliano Destro Christofaro, Mahmood Moosazadeh, Vilma Irazola, Olli T. Raitakari, Marco Aurélio Peres, Terho Lehtimäki, Shuohua Chen, Dimitrios Papandreou, Robert J. Adams, Sigmund A. Anderssen, Peter T. Katzmarzyk, Luisa M Macieira, Félicité Tchibindat, Lital Keinan Boker, Toshiharu Ninomiya, Morten Sodemann, Jytte Halkjær, Zbigniew Kułaga, Sophie Visvikis-Siest, Farshad Farzadfar, N Capkova, Zumin Shi, Maria Turley, Zbigniew Gaciong, Giovanni Veronesi, Martin McKee, Veikko Salomaa, Gilad Twig, Elisabetta L. Romeo, Peter Kristensen, Grazyna Jasienska, Victor Guillermo Sequera, Mario V. Capanzana, Con Burns, Emanuela Pettenuzzo, Ming-Dong Wang, Jonathan Giovannelli, Stela McLachlan, Ellis Owusu-Dabo, Stefania Toselli, Maria Teresa Anselmo Olinto, Senthil K Vasan, Sara Schramm, Xenophon Theodoridis, Moyses Szklo, Ramfis Nieto-Martínez, Viswanathan Mohan, Guillermo Frontera, Rahul Malhotra, Thomas Ferrao, Dongfeng Gu, Tomas Vega, Hynek Pikhart, Päivi Mäki, Heba Fouad, Vilnis Dzerve, Christina Howitt, Seyed Mohammad Hashemi-Shahri, Jenny M. Kindblom, Marjolijn C. E. Bragt, G. K. Mini, Qian Wang, Liufu Cui, Andrzej Galbarczyk, Sylvain Sebert, Vilmundur Gudnason, Loreto Santa Marina, Kairat Davletov, Afshin Ostovar, Niloofar Peykari, Nicholas J. Wareham, Wilma M. Hopman, Karl-Heinz Jöckel, Jussi Kauhanen, Breige A. McNulty, Alina Kerimkulova, Youcef Laid, Claes Ohlsson, Stefan Kiechl, Alicia Matijasevich, Boban Mugoša, Srinivasan Kannan, Jyrki K. Virtanen, Mohan Deepa, Mangesh S. Pednekar, Shahla AlDhukair, Cynthia M. Pérez, Vera Lanska, Tint Swe Latt, Dominique Hange, João Luiz Bastos, Eliza Markidou Ioannidou, Leticia Hernandez Cadena, Maya Tanrygulyyeva, Reza Malekzadeh, Dimitrios Poulimeneas, Pedro Ordunez, Thomas Waldhör, Ioannis Pagkalos, Carlo M. Barbagallo, Abla M. Sibai, Peter Vollenweider, Asher Fawwad, Emily Sonestedt, Elena Pahomova, Santosh K. Bhargava, Patrick Kolsteren, Aya Mostafa, Fangfang Chen, Flavio Nervi, Imre Janszky, Arvind Pandey, Renata Cifkova, Alexandre C. Pereira, Alejandro Diaz, Alireza Ansari-Moghaddam, Rachakulla Hari Kumar, Jaakko Mursu, Luis A. Moreno, Glen Gironella, Jelena Kos, Tilema Cama, Haakon E. Meyer, Jun Ma, Raphael E. Arku, Ziad Abdeen, Rusidah Selamat, Dianna J. Magliano, Jitendra Jonnagaddala, Konstantinos Gkiouras, Paul Korrovits, Paola Nardone, Paolo Vineis, Kotsedi D Monyeki, Khuong Quynh Long, Alberto Barceló, Camilla T. Damsgaard, Constance Schultsz, Frank J Rühli, Santiago F. Gomez, Tara Coppinger, Muhammad Islam, Pierre Traissac, Eleonora d'Orsi, Irfan Nuhoglu, Rui Providência, Bernard Maire, Leandra Abarca-Gómez, Sinead Brophy, Daniela Pierannunzio, Cristina Taddei, Wen-Harn Pan, Gregor Starc, Abdullah Alkandari, Saeed Dastgiri, Lien Braeckevelt, Gustavo Velasquez-Melendez, Sudhir Kowlessur, Bagher Larijani, Cynthia Robitaille, Mohamed M. Ali, Steiner Krokstad, Noor Ani Ahmad, Anar Dushpanova, Agustinus Soemantri, Susana Sans, Ionela Pascanu, Gwenaëlle Le Coroller, Inger Ariansen, Abhijit Sen, Sergej M. Ostojic, Silvana Donoso, Felix K. Assah, Juan A Rivera, Peter H. Whincup, Oana-Florentina Gheorghe-Fronea, Hanan F. Abdul Rahim, Yadlapalli S. Kusuma, Michael Knoflach, Moein Yoosefi, Cassiano Ricardo Rech, Paul Ferdinand M. Reganit, Tomi-Pekka Tuomainen, Francesco Gianfagna, Stefania Maggi, Mohammad Hossein Somi, Behrooz Hamzeh, Bethlehem D. Solomon, Herman Borghs, Zhanna Kalmatayeva, Heidi Klakk, Akram Pourshams, Naomi S. Levitt, Miquel Porta, Vesna Jureša, Alexander D. Deev, Son Thai Pham, Paula Margozzini, Silvia Bel-Serrat, Dora Romaguera, Monira Alarouj, Winsome R. Parnell, Marloes Cardol, David Faeh, Antonio Bernabe-Ortiz, Giota Touloumi, Maryam Kavousi, Sanja Musić Milanović, Jalila El Ati, Sauli Herrala, Liang Xu, Sirkka Keinänen-Kiukaanniemi, Ian Hambleton, Stefan Savin, Andre Pascal Kengne, R. Krishna Kumar, Kurt Widhalm, Marco M Ferrario, Parisa Amiri, Yi Song, Jianfeng Wu, Jeannette Klimont, Jean Ferrières, Farhad Zamani, Shina Avi, Luis Paulo Gomes Mascarenhas, Aluísio J D Barros, Reecha Sofat, Koen Van Herck, Hoang Van Minh, Enrique Gutiérrez-González, Martine Vrijheid, Susana Cararo Confortin, Antonis Zampelas, Bogdan Wojtyniak, Ausra Petrauskiene, Juha Auvinen, Maryam Sharafkhah, Emanuel Zitt, Majid Ezzati, Young-Ho Khang, Ellina Rakhimova, Magdalena Klimek, Luís Lopes, Erkin M. Mirrakhimov, Maria Lc Iurilli, Günay Can, Mark Woodward, Esther Lopez-Garcia, Mauro Virgílio Gomes de Barros, Ahmed A. Madar, Rainford J. Wilks, Shoaib Afzal, Melanie J. Cowan, Gareth Stratton, Eduardo Salazar Martinez, Sameer Narake, Norie Sawada, Li Juan Wu, Adrian Richter, Licia Iacoviello, Hanno Ulmer, Deepak Amarapurkar, Mohsen Ibrahim, Hamed Pouraram, Massimo Salvetti, Hung-Kwan So, Yonghua Hu, Lars Ängquist, Thi Tuyet-Hanh Tran, Charles Lunogelo, Sabina Zambon, Angelika Schaffrath Rosario, Lauren Lissner, Kamarul Imran Musa, Deepa Weerasekera, Bihungum Bista, Takafumi Ishida, Ekaterina Chikova-Iscener, Mirjam M. Heinen, Tazeen H. Jafar, Semánová Csilla, Raija Korpelainen, Edward W. Gregg, Laura Gutierrez, Victor M. Herrera, Aristides M. Machado-Rodrigues, Fatemeh Malekzadeh, Shouling Wu, Jennifer L. Baker, Clicerio González-Villalpando, Irene G. M. van Valkengoed, Anna Fijałkowska, Meghnath Dhimal, Murat Topbaş, George Moschonis, Robert Eggertsen, Quang Ngoc Nguyen, Janette Walton, Elnaz Faramarzi, Nasheeta Peer, Radka Taxová Braunerová, Harald Geiger, Morteza Shamshirgaran, Lela Shengelia, María Ángeles Dal Re Saavedra, Khem Bahadur Karki, Timothy J. Key, Maria G. Grammatikopoulou, Susana Vale, Bernhard O. Boehm, Songhomitra Panda-Jonas, Iveta Pudule, Elisabete Ramos, Lacramioara Aurelia Brinduse, Paul H. Lee, Terence W O'Neill, Javad Aghazadeh-Attari, Margus Punab, Bojan Jelaković, Eliza Cinteza, Ha Tp Do, and Alison J. Hayes more...
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education.field_of_study ,business.industry ,Population ,Distribution (economics) ,medicine.disease ,Obesity ,Geography ,medicine ,Underweight ,medicine.symptom ,education ,business ,Body mass index ,Demography - Published
- 2020
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46. Relationship Between the Levels of Inflammatory Cytokines in the Aqueous Humor and Cataract in Fuchs Uveitis Syndrome-A Case Control Study
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Hui Wang and Yong Tao
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genetic structures ,business.industry ,Immunology ,Case-control study ,Medicine ,Aqueous humor ,sense organs ,business ,Fuchs uveitis syndrome ,eye diseases ,Proinflammatory cytokine - Abstract
Background This study aims to compare the levels of intraocular cytokines between Fuchs uveitis syndrome (FUS) eyes and the senile cataract eyes. The association between inflammatory cytokine levels and cataract severity in FUS is evaluated to find the possible mechanism of cataract in FUS eyes.Methods A retrospective study of 28 eyes with FUS was performed. Auxiliary examinations were performed, including ophthalmic examinations, laser flare-cell photometry, and levels of inflammatory cytokines in the aqueous humor were measured. The control group included 25 eyes with senile cataract. Data on the aqueous humor inflammatory cytokines were compared between the two groups. The association between the aqueous humor cytokine levels and severity of posterior subcapsular cataract was assessed.Results There were 28 eyes with FUS in 27 patients. Unilateral involvement was noted in 26 patients (96.30%). Stellate keratic precipitates (KPs) were noted in 16 eyes (57.14%). Heterochromia was observed in 21.43% of affected eyes. Posterior subcapsular cataract was observed in 16 of the 28 eyes. Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (PConclusions Expression of VEGF, bFGF, IL-6, IL-8 and IL-10 in the AH of FUS patients was significantly higher than in senile cataract eyes, and the aqueous humor levels of IL-6 and IL-8 were significantly positively associated with the severity of posterior subcapsular cataract. Our results imply that an inflammation mechanism may be involved in the early development of cataract in FUS. more...
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- 2020
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47. Tunable terahertz metasurface resonator based on phase transition of VO2 crosses
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Zhi-Yong Tao, Lin Li, Gui-Min Chen, Jing Ma, Kun Zhang, Ya-Xian Fan, and Huan Liu
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Phase transition ,Resonator ,Range (particle radiation) ,Materials science ,Transmission (telecommunications) ,business.industry ,Terahertz radiation ,Transition temperature ,Phase (waves) ,Optoelectronics ,Insulator (electricity) ,business - Abstract
Based on the insulator to metal transition (IMT) characteristics of vanadium dioxide (VO2), a highly active tunable terahertz (THz) metasurface resonator patterned VO2 cross structures is proposed. The simulation results show that the transmission of the proposed structure at low temperature is higher than 0.7 because of the VO2 in its insulation phase. With the increasing temperature, a strong transmission dip appears at 0.76 THz due to the metal phase of VO2, which indicates the onset of a new resonant mode. The maximum tunable range of transmission for THz wave is 0.06-0.86. Simultaneously, we also demonstrate that the resonant responses of the heating and cooling processes are quite different and the heating process is more sensitive. The transition temperature is close to room temperature and the device can achieve good modulation effect on both TE and TM waves. The TE and TM mode resonances are selective by altering the cross arms, which is almost impossible for other THz devices. So, the resonator can greatly promote practical applications of THz functional devices such as filters, sensors, modulators, and switches. more...
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- 2020
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48. Clinical Characteristics and Aqueous Humor Laboratory Analysis of Chinese Patients With Rubella Virus-Associated and Cytomegalovirus-Associated Fuchs Uveitis Syndrome
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Hui Wang, Weiqiang Yang, Jing Feng, Yanhong Shi, Han Bao, Hao Kang, Xiaofeng Hu, Yinzhang He, and Yong Tao
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medicine.medical_specialty ,Intraocular pressure ,genetic structures ,Congenital cytomegalovirus infection ,Glaucoma ,medicine.disease_cause ,Gastroenterology ,Proinflammatory cytokine ,03 medical and health sciences ,0302 clinical medicine ,anterior uveitis ,Internal medicine ,rubella virus (RV) ,medicine ,Original Research ,lcsh:R5-920 ,business.industry ,Incidence (epidemiology) ,fuchs uveitis syndrome (FUS) ,Rubella virus ,General Medicine ,medicine.disease ,eye diseases ,cytokines ,cytomegalovirus (CMV) ,030221 ophthalmology & optometry ,Etiology ,Medicine ,Differential diagnosis ,business ,lcsh:Medicine (General) ,030217 neurology & neurosurgery - Abstract
Purpose: To describe and compare the clinical characteristics and laboratory analysis results of aqueous humor (AH) in fuchs uveitis syndrome (FUS) patients caused by rubella virus (RV) and cytomegalovirus (CMV).Methods: A retrospective and observation-based study was performed on 32 patients with FUS. Etiologies, clinical characteristics, ocular complications, visual prognoses, inflammatory cytokines, and virus-specific antibodies in AH were compared.Results: Among all the cases involved, 24 had RV FUS and 8 had CMV FUS. The mean age at diagnosis of FUS in the CMV group was older than that of the RV group (P = 0.031). The mean LogMAR best corrected visual acuity (BCVA) at initial presentation and at the final visit were both significantly higher in the CMV FUS group than those in the RV FUS group (P = 0.004, 0.047). The highest intraocular pressure (IOP) was significantly higher in the CMV group (P = 0.040). Consistent with elevated IOP, the CMV FUS patients were significantly more prone to developing glaucoma eventually than the RV FUS patients (P = 0.039). Vitreous opacity was found in 66.7% of the RV patients and 25.0% of the CMV patients (P = 0.038). The gender ratio, initial symptoms, presence and types of keratic precipitates, severity of anterior segment inflammation, iris lesions, and incidence of complicated cataract were similar between the two groups. There was no detectable difference of inflammatory cytokines in AH between RV FUS and CMV FUS.Conclusion: The clinical manifestations and disease prognosis vary between CMV FUS and RV FUS. However, clinical differences are always not obvious enough for differential diagnosis. The laboratory AH analysis is necessary to identify the etiology, determine the therapeutic strategies, and assess the disease prognosis. more...
- Published
- 2020
49. Markedly Elevated Serum Level of T-Helper Cell 17-Related Cytokines/Chemokines in Acute Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis
- Author
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Hongjuan Liu, Nanping Ai, Quangang Xu, Shihui Wei, Yong Tao, Hao Kang, and Hongyang Li
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Chemokine ,medicine.medical_treatment ,chemokines ,lcsh:RC346-429 ,Myelin oligodendrocyte glycoprotein ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Optic neuritis ,CCL11 ,lcsh:Neurology. Diseases of the nervous system ,Original Research ,T helper cell 17 (Th17) ,optic neuritis ,biology ,business.industry ,MOG-IgG ,hemic and immune systems ,medicine.disease ,cytokines ,CXCL1 ,CXCL2 ,030104 developmental biology ,Endocrinology ,Cytokine ,Neurology ,AQP4-IgG ,biology.protein ,Neurology (clinical) ,Antibody ,business ,030217 neurology & neurosurgery - Abstract
Purpose: The purpose of this study was to examine the differences in immunopathogenesis based on the cytokine/chemokine profiles in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-positive and -negative groups. Methods: We measured the levels of T-helper cell 17 (Th17) cell-related cytokines/chemokines in 74 serum samples, which were divided into four groups: healthy control (HC) group (n = 15), idiopathic demyelinating optic neuritis (IDON) group (n = 20), aquaporin 4 (AQP4)-IgG-positive optic neuritis (ON) group (n = 18), and MOG-IgG positive-ON group (n = 21). Serum IL17, IL21, IL28, IL31, CXCL1, CXCL2, CCL2, CCL11, CCL20, and LT-α were detected. Results: The serum of the MOG-IgG-positive ON patients showed an obvious elevation of Th17 cell-related cytokines/chemokines compared with that of all the MOG-IgG-negative ON patients. Serum IL17 and IL21 were significantly higher in the ON patients with MOG-IgG positive than in all the other three groups. The serum levels of IL28, IL31, CXCL1, and CCL11 were higher in the ON patients with MOG-IgG positive than in the HC group and the IDON group. The serum concentration of CCL2, CXCL2, and CCL20 in the MOG-IgG-positive and AQP4-IgG-positive group is higher than that of the HC group. No difference in serum LT-α level was found among the four groups. Adjusted multiple regression analyses showed a positive association of IL17 and IL21 levels with the serum concentration of MOG-IgG in the ON patients. Conclusion: The elevated serum level of Th17 cell-related cytokine/chemokines may play an important role in the pathogenesis of MOG-IgG-positive demyelinating ON. more...
- Published
- 2020
50. Measuring aerosol collection efficiency for the Bladewerx 'New SpeclonTM 5' and the older 'SpeclonTM 5' filter
- Author
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Yong Tao and Murray E. Moore
- Subjects
Optics ,business.industry ,Filter (video) ,Environmental science ,business ,Aerosol - Published
- 2020
- Full Text
- View/download PDF
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