1,561 results on '"Ying Zhao"'
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2. UV light absorbers executing synergistic effects of passivating defects and improving photostability for efficient perovskite photovoltaics
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Xiaodan Zhang, Hao Ling, Peng Wang, Sumin Jiao, Ying Zhao, Wenjing Qi, Xin Zhou, Liming Ding, Khumal Sohail, Guangcai Wang, Jiale Li, Yameng Li, Jingshan Luo, Yuelong Li, and Guofu Hou
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Materials science ,business.industry ,Energy conversion efficiency ,Doping ,Energy Engineering and Power Technology ,medicine.disease_cause ,Fuel Technology ,X-ray photoelectron spectroscopy ,Photovoltaics ,Electrochemistry ,medicine ,Optoelectronics ,Charge carrier ,Irradiation ,business ,Ultraviolet ,Energy (miscellaneous) ,Perovskite (structure) - Abstract
Metal halide perovskite-based solar cells (PSCs) have rapidly-increased power conversion efficiency (PCE) exceeding 25% but poor stability especially under ultraviolet (UV) light. Meanwhile, non-radiative recombination caused by diverse defects in perovskite absorbers and related interfaces is one of the major factors confining further development of PSCs. In this study, we systematically investigate the role of 2-(2-hydroxy-5-methylphenyl)benzotriazole (UVP) additive in perovskite layers. By adjusting the amount of doped UVP, the quality of perovskite absorbers is significantly improved with enlarged grains, longer lifetime and diffusion length of charge carriers. Furthermore, UVP not only reduces defects for less non-radiative recombination, but also matches energy level alignment for efficient interfacial charge extraction. X-ray photoelectron spectroscopy confirms that N-donor of UVP molecule coordinates with undercoordinated Pb2+ on the surface. Interestingly, UVP incorporated in PbI2 protects the perovskite by absorbing UV through the opening and closing of the chelating ring. Eventually, the UVP treated PSCs obtain a champion PCE of 22.46% with remarkably enhanced UV stability, retaining over 90% of initial PCE after 60 mW/cm2 strong UV irradiation for 9 h while the control maintaining only 74%. These results demonstrate a promising strategy fabricating passivated and UV-resistant perovskite materials simultaneously for efficient and stable perovskite photovoltaics.
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- 2022
3. Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR’s cholesterol-decreasing efficacy in patients
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Ying Zhao, Le Sun, Chongming Wu, Ying-Ying Zhang, Baoli Zhu, Yanan Yang, Peng Guo, Fang Zhang, Yuan-Yuan Yang, Wenquan Su, Jiaqi Yu, Sheng-Xian Wu, and Yao-Xian Wang
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Berberine ,medicine.drug_class ,Antibiotics ,Blood lipids ,Hyperlipidemias ,Pharmacology ,Gut flora ,digestive system ,Mice ,chemistry.chemical_compound ,medicine ,Animals ,Humans ,In patient ,Alistipes ,Multidisciplinary ,Bacteria ,biology ,Cholesterol ,business.industry ,Fecal bacteriotherapy ,biology.organism_classification ,Gastrointestinal Microbiome ,chemistry ,business - Abstract
Introduction Gut microbiota has been implicated in the pharmacological activities of many natural products. As an effective hypolipidemic agent, berberine (BBR)’s clinical application is greatly impeded by the obvious inter-individual response variation. To date, little evidence exists on the causality between gut microbes and its therapeutic effects, and the linkage of bacteria alterations to the inter-individual response variation. Objectives This study aims to confirm the causal role of the gut microbiota in BBR’s anti-hyperlipidemic effect and identify key bacteria that can predict its effectiveness. Methods The correlation between gut microbiota and BBR’s inter-individual response variation was studied in hyperlipidemic patients. The causal role of gut microbes in BBR’s anti-hyperlipidemic effects was subsequently assessed by altered administration routes, co-treatment with antibiotics, fecal microbiota transplantation, and metagenomic analysis. Results Three-month clinical study showed that BBR was effectively to decrease serum lipids but displayed an obvious response variation. The cholesterol-lowering but not triglyceride-decreasing effect of BBR was closely related to its modulation on gut microbiota. Interestingly, the baseline levels of Alistipes and Blautia could accurately predict its anti-hypercholesterolemic efficiency in the following treatment. Causality experiments in mice further confirmed that the gut microbiome is both necessary and sufficient to mediate the lipid-lowering effect of BBR. The absence of Blautia substantially abolished BBR's cholesterol-decreasing efficacy. Conclusion The gut microbiota is necessary and sufficient for BBR’s hyperlipidemia-ameliorating effect. The baseline composition of gut microbes can be an effective predictor for its pharmacotherapeutic efficacy, providing a novel way to achieve personalized therapy.
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- 2022
4. Insulin resistance induced by long-term sleep deprivation in rhesus macaques can be attenuated by Bifidobacterium
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Ying Zhao, Yan Shu, Xiong Jia, Si Jin, Chenxing Jian, Zhao Ning, and Zili Zhou
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medicine.medical_specialty ,biology ,Physiology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Insulin ,medicine.medical_treatment ,Gut flora ,Carbohydrate metabolism ,medicine.disease ,biology.organism_classification ,Obesity ,Sleep deprivation ,Insulin resistance ,Endocrinology ,Physiology (medical) ,Internal medicine ,medicine ,Circadian rhythm ,medicine.symptom ,business ,Bifidobacterium - Abstract
Long-term sleep deprivation (SD) is a bad lifestyle habit, especially among specific occupational practitioners, characterized by circadian rhythm misalignment and abnormal sleep/wake cycles. SD is closely associated with an increased risk of metabolic disturbance, particularly obesity and insulin resistance. The incretin hormone, glucagon-like peptide-1 (GLP-1), is a critical insulin release determinant secreted by the intestinal L-cell upon food intake. Besides, the gut microbiota participates in metabolic homeostasis and regulates GLP-1 release in a circadian rhythm manner. As a commonly recognized intestinal probiotic, Bifidobacterium has various clinical indications regarding its curative effect. However, few studies have investigated the effect of Bifidobacterium supplementation on sleep disorders. In the present study, we explored the impact of long-term SD on the endocrine metabolism of rhesus monkeys and determined the effect of Bifidobacterium supplementation on the SD-induced metabolic status. Lipids concentrations, body weight, fast blood glucose, and insulin levels increased after SD. Furthermore, after two months of long-term SD, the intravenous glucose tolerance test (iVGTT) showed that the glucose metabolism was impaired and the insulin sensitivity decreased. Moreover, one month of Bifidobacterium oral administration significantly reduced blood glucose and attenuated insulin resistance in rhesus macaques. Overall, our results suggested that Bifidobacterium might be used to alleviate SD-induced aberrant glucose metabolism and improve insulin resistance. Also, it might help in better understanding the mechanisms governing the beneficial effects of Bifidobacterium.
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- 2022
5. The Relationship Between APOE Gene Polymorphism and In-stent Restenosis After Stenting at the Beginning of the Vertebral Artery
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Rui Chen, Luxia Yan, Yan Chen, Lu Liu, Ying Zhao, Qijin Zhai, Jinqi Liu, Chun Chen, and Liandong Zhao
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Apolipoprotein E ,medicine.medical_specialty ,Vertebral artery ,Constriction, Pathologic ,Coronary Restenosis ,Apolipoproteins E ,Restenosis ,Risk Factors ,Internal medicine ,medicine.artery ,Genotype ,medicine ,Humans ,Risk factor ,Vertebral Artery ,Retrospective Studies ,Computed tomography angiography ,Polymorphism, Genetic ,medicine.diagnostic_test ,business.industry ,Angiography, Digital Subtraction ,Cholesterol, LDL ,Digital subtraction angiography ,medicine.disease ,Cardiology ,Stents ,lipids (amino acids, peptides, and proteins) ,Surgery ,Neurology (clinical) ,Gene polymorphism ,business - Abstract
Objective To retrospectively investigate the relationship between apolipoprotein E (APOE) gene polymorphism and in-stent restenosis (ISR) after stenting at the beginning of the vertebral artery. Methods The study included 155 patients who successfully underwent stenting at the beginning of the vertebral artery and had postoperative digital subtraction angiography or computed tomography angiography. Based on the follow-up results, they were divided into the restenosis (ISR) group and non-restenosis (non-ISR) group. The clinical information and APOE genotypes of both groups were analyzed. A binary logistic regression model was used to analyze independent risk factors for ISR. Results After 1 year of follow-up, 49 (31.6%) patients had ISR and 106 (68.4%) did not. Binary logistic regression analysis showed that serum low-density lipoprotein cholesterol (LDL-C), serum lipoprotein-related phospholipase A2 (Lp-PLA2), and E3/E4 genotype were independent risk factors for ISR after stenting at the beginning of the vertebral artery. In addition, the LDL-C level of patients with the E3/E4 genotype was higher compared to the E3/E3 genotype group (P Conclusions APOE gene polymorphism is associated with ISR, and the E3/E4 genotype is an independent risk factor for ISR after stenting at the beginning of the vertebral artery. Further genetic studies can identify risk genotypes to facilitate the early prediction and identification of high-risk patients with ISR.
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- 2022
6. Oxcarbazepine was associated with risks of newly developed hypothyroxinaemia and impaired central set point of thyroid homeostasis in schizophrenia patients
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Xiangyang Zhang, Wei Hao, Baoqiang Guo, Jinni Chen, Ruiling Zhang, Songyin Gao, Desheng Zhai, Ying Zhao, Ravi Retnakaran, and Shi Wu Wen
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endocrine system ,Pediatrics ,medicine.medical_specialty ,Thyroid Gland ,Oxcarbazepine ,Thyrotropin ,medicine ,Homeostasis ,Humans ,Pharmacology (medical) ,Retrospective Studies ,Pharmacology ,business.industry ,Thyroid ,Retrospective cohort study ,medicine.disease ,Confidence interval ,Thyroxine ,medicine.anatomical_structure ,Hypothyroxinemia ,Schizophrenia ,Relative risk ,business ,medicine.drug ,Diagnosis of schizophrenia - Abstract
Aim Hypothyroxinemia might be easily ignored, due to attention is typically paid to individuals with elevated thyroid stimulating hormone (TSH). In this study, we aimed to evaluate the association of oxcarbazepine use as adjuvant for treatment of schizophrenia with hypothyroxinemia and central set point of thyroid homeostasis. Methods This retrospective cohort study was conducted in the "Second Affiliated Hospital of Xinxiang Medical University". Inpatients with a diagnosis of schizophrenia admitted between January 2016 and October 2019 with normal thyroid function at admission were included. Oxcarbazepine use was the exposure measure. Newly developed hypothyroxinemia was the primary outcome measure and parameters of thyroid homeostasis central set point as measured by "TSH index" and "thyroid feedback quantile-based index (TFQI)" were the secondary outcome measures. Results A total of 1,207 eligible patients were included. The occurrence of hypothyroxinemia in patients who received oxcarbazepine was higher (35/107, 32.7%) than in those patients who did not (152/1099, 13.8%), with adjusted relative risk of 2.24 and 95% confidence interval of 1.57 and 3.17. Oxcarbazepine use was associated with greater reduction in TSH index (adjusted β -0.33 and 95% confidence interval -0.48, -0.19) and TFQI (adjusted β -0.24 and 95% confidence interval -0.31, -0.16). Conclusion Oxcarbazepine use was independently associated with increased risk of developing hypothyroxinemia, and greater reduction in TSH index and TFQI, suggesting that impaired central set point of thyroid homeostasis might be involved in the mechanism of oxcarbazepine induced hypothyroxinemia.
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- 2021
7. Composite electron transport layer for efficient N-I-P type monolithic perovskite/silicon tandem solar cells with high open-circuit voltage
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Dekun Zhang, Renjie Li, Ningyu Ren, Wei Han, Yongliang Chen, Ying Zhao, Xiaodan Zhang, Bingbing Chen, Qian Huang, Pengyang Wang, and Lingling Yan
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Materials science ,Silicon ,Tandem ,Open-circuit voltage ,business.industry ,Energy conversion efficiency ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Tin oxide ,Electron transfer ,Fuel Technology ,chemistry ,Electrochemistry ,Optoelectronics ,business ,Layer (electronics) ,Energy (miscellaneous) ,Perovskite (structure) - Abstract
Perovskite/silicon tandem solar cells (PSTSCs) have exhibited huge technological potential for breaking the Shockley-Queisser limit of single-junction solar cells. The efficiency of P-I-N type PSTSCs has surpassed the single-junction limit, while the performance of N-I-P type PSTSCs is far below the theoretical value. Here, we developed a composite electron transport layer for N-I-P type monolithic PSTSCs with enhanced open-circuit voltage (VOC) and power conversion efficiency (PCE). Lithium chloride (LiCl) was added into the tin oxide (SnO2) precursor solution, which simultaneously passivated the defects and increased the electron injection driving force at the electron transfer layer (ETL)/perovskite interface. Eventually, we achieved monolithic PSTSCs with an efficiency of 25.42% and VOC of 1.92 V, which is the highest PCE and VOC in N-I-P type perovskite/Si tandem devices. This work on interface engineering for improving the PCE of monolithic PSTSCs may bring a new hot point about perovskite-based tandem devices.
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- 2021
8. Expression and Clinical Significance of MPS-1 in Hepatocellular Carcinoma
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Zhenggang Ren, Tongchun Xue, Ningling Ge, Feifei Yuan, Zhi-Ying Zhao, Lan Zhang, and He Jiang
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congenital, hereditary, and neonatal diseases and abnormalities ,business.industry ,nutritional and metabolic diseases ,International Journal of General Medicine ,hepatocellular carcinoma ,General Medicine ,medicine.disease ,digestive system diseases ,ribosomal protein ,Expression (architecture) ,Hepatocellular carcinoma ,Cancer research ,biomarker ,Medicine ,Clinical significance ,prognosis ,MPS-1 ,skin and connective tissue diseases ,business ,Original Research - Abstract
He Jiang, Feifei Yuan, Zhiying Zhao, Tongchun Xue, Ningling Ge, Zhenggang Ren, Lan Zhang Department of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, Peopleâs Republic of ChinaCorrespondence: Lan ZhangDepartment of Hepatic Oncology, Zhongshan Hospital, Liver Cancer Institute and Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, 200032, Peopleâs Republic of ChinaTel +86-021-64041990Fax +86 021-64038472Email zhang.lan@zs-hospital.sh.cnPurpose: Ribosomal protein metallopanstimulin-1 (MPS-1) is implicated in tumorigenesis. However, to date, the underlying role of MPS-1 in the generation, progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. This study aims to investigate the expression of MPS-1 in HCC and its significance for the prognosis of HCC.Methods: The Oncomine and GEPIA databases were used to analyze the expression pattern of MPS-1 in HCC. Immunohistochemical staining was performed on tissue microarrays containing 169 HCC tissue samples to examine the expression of MPS-1. In addition, univariate and multivariate Cox regression analyses and KaplanâMeier analysis were used to verify the correlation between clinicopathological factors in HCC patients and its clinical prognostic significance.Results: MPS-1 was more highly expressed in HCC than in normal tissues, and MPS-1 expression was correlated with serum AFP levels (P = 0.003), liver cirrhosis (P = 0.024), tumor embolus (P = 0.009) and tumor recurrence (P < 0.003). MPS-1 was an independent prognostic factor for the overall survival of HCC (HR, 1.92; 95% CI, 1.01â 3.68), and a higher expression of MPS-1 predicted poorer survival. Furthermore, high expression of MPS-1 indicated a poor prognosis in patients with AFP positivity, cirrhosis or HBsAg positivity.Conclusion: These findings demonstrate that MPS-1 is highly expressed in HCC and serves as an independent prognostic marker, highlighting the potential role of MPS-1 as a novel biomarker and therapeutic target for HCC.Keywords: hepatocellular carcinoma, ribosomal protein, MPS-1, biomarker, prognosis
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- 2021
9. Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7
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Kong Lili, Ying Zhao, Hongyue Wang, Huiyan Cheng, Yan Cui, Chenhao Li, and Li Liu
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diabetic nephropathies ,sulforafan ,Endocrinology, Diabetes and Metabolism ,bone morphogenetic protein 7 ,histone deacetylase 2 ,Pharmacology ,Diseases of the endocrine glands. Clinical endocrinology ,Diabetes Mellitus, Experimental ,Epigenesis, Genetic ,Mice ,chemistry.chemical_compound ,Downregulation and upregulation ,Isothiocyanates ,In vivo ,Fibrosis ,medicine ,Renal fibrosis ,Animals ,Histone deacetylase 2 ,business.industry ,RC648-665 ,Streptozotocin ,medicine.disease ,Up-Regulation ,Basic Research ,chemistry ,Sulfoxides ,Original Article ,Histone deacetylase ,business ,medicine.drug ,Sulforaphane - Abstract
Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity. Bone morphologic protein 7 (BMP-7) has been shown to reduce renal fibrosis induced by transforming growth factor-beta1. The aim of this study was to investigate the epigenetic effect of SFN on BMP-7 expression in diabetes-induced renal fibrosis.Methods: Streptozotocin (STZ)-induced diabetic mice and age-matched controls were subcutaneously injected with SFN or vehicle for 4 months to measure the in vivo effects of SFN on the kidneys. The human renal proximal tubular (HK11) cell line was used to mimic diabetic conditions in vitro. HK11 cells were transfected to over-express HDAC2 and treated with high glucose/palmitate (HG/Pal) to explore the epigenetic modulation of BMP-7 in SFN-mediated protection against HG/Pal-induced renal fibrosis.Results: SFN significantly attenuated diabetes-induced renal fibrosis in vivo. Among all of the HDACs we detected, HDAC2 activity was markedly elevated in the STZ-induced diabetic kidneys and HG/Pal-treated HK11 cells. SFN inhibited the diabetes-induced increase in HDAC2 activity which was associated with histone acetylation and transcriptional activation of the BMP-7 promoter. HDAC2 over-expression reduced BMP-7 expression and abolished the SFN-mediated protection against HG/Pal-induced fibrosis in vitro.Conclusion: Our study demonstrates that the HDAC inhibitor SFN protects against diabetes-induced renal fibrosis through epigenetic up-regulation of BMP-7.
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- 2021
10. Distribution of soil organic carbon and nitrogen under reduced nitrogen application in the Guanzhong plain of China #
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Huili Zhao, Xiao‐Hong Guo, Xiaohong Tian, Bing Song, Ying Zhao, and Nan Wu
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Reduced nitrogen ,chemistry ,business.industry ,Environmental chemistry ,Soil Science ,Distribution (economics) ,Environmental science ,chemistry.chemical_element ,Plant Science ,Soil carbon ,business ,Nitrogen - Published
- 2021
11. W band solid‐state power amplifier for aerospace usage
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Zhonghe Jin, Anxue Zhang, Xiao-Ming Chen, Fei Yang, Jun Li, Heng-Fei Zhao, Ying Zhao, and Hongxi Yu
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Solid state power amplifier ,Materials science ,W band ,business.industry ,General Engineering ,Electrical engineering ,Energy Engineering and Power Technology ,business ,Aerospace ,Software - Published
- 2021
12. Hepatic Arterial Infusion Chemotherapy with Modified FOLFOX as an Alternative Treatment Option in Advanced Hepatocellular Carcinoma Patients with Failed or Unsuitability for Transarterial Chemoembolization
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Yan Wang, Zhenggang Ren, Xin Xu, Yi Chen, Jian-Feng Luo, Zhi-Ying Zhao, Yan-Hong Wang, Lan Zhang, Ning-Ling Ge, Xin Yin, Rongxin Chen, Mao-Pei Chen, and Shu-Jung Hsu
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medicine.medical_specialty ,Abdominal pain ,Carcinoma, Hepatocellular ,Gastroenterology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,FOLFOX ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,Infusions, Intra-Arterial ,Radiology, Nuclear Medicine and imaging ,Chemoembolization, Therapeutic ,Adverse effect ,business.industry ,Liver Neoplasms ,Nomogram ,medicine.disease ,digestive system diseases ,Oxaliplatin ,Treatment Outcome ,Response Evaluation Criteria in Solid Tumors ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Fluorouracil ,medicine.symptom ,business ,medicine.drug - Abstract
This study aimed to assess the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) with modified FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) as an alternative treatment option in advanced hepatocellular carcinoma (HCC) patients with failed or unsuitability for transarterial chemoembolization (TACE). MATERIALS AND METHODS: From September 2018 to January 2020, 87 advanced HCC patients who progressed on TACE or were not eligible for TACE received HAIC treatment with modified FOLFOX. The primary endpoint was overall survival (OS) and secondary endpoints included progression-free survival (PFS), tumor response assessed by Response Evaluation Criteria in Solid Tumors 1.1, and adverse events graded according to CTCAE 5.0. Based on prognostic factors determined by multivariate analysis, a nomogram was developed to predict patient survival.The median OS and PFS were 9.0 months (95%CI 7.6-10.4) and 3.7 months (95%CI 3.1-4.3), respectively. The objective response rate was 13.8%, with a disease control rate of 48.3%. Grade 3 adverse events were observed, such as infection (9.2%), thrombocytopenia (5.7%), hyperbilirubinemia (3.4%), abdominal pain (2.3%) and alanine aminotransferase increase (2.3%). Albumin, AST, and extrahepatic metastasis were incorporated to construct a new nomogram that could stratify patients into three prognostic subgroups, including low-, intermediate-, and high-risk groups, with significant differences in 9-month OS rates (71%, 42% and 6%, respectively; p0.001). The nomogram was better than the Okuda, AJCC, and CLIP staging systems for OS prediction.These findings support the feasibility of HAIC with modified FOLFOX as an alternative treatment strategy for advanced HCC when TACE is ineffective or unsuitable.
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- 2021
13. Design and Evaluation of a Metal-Supported Solid Oxide Fuel Cell Vehicle Power System with Bioethanol Onboard Reforming
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Xiaoqiang Wang, Xiaoying Hu, Ying Zhao, Shuai Ma, and Changqing Dong
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Materials science ,Methane reformer ,business.industry ,General Chemical Engineering ,General Chemistry ,Article ,Anode ,Chemistry ,Electric power system ,Auxiliary power unit ,Biofuel ,Exergy efficiency ,Solid oxide fuel cell ,Process engineering ,business ,QD1-999 ,Electrical efficiency - Abstract
A solid oxide fuel cell (SOFC) has wide stationary and mobile application prospects due to its high efficiency and fuel flexibility. The SOFC system’s performance depends on the reforming option and system design. In this paper, we designed a novel SOFC auxiliary power unit (APU) system with ethanol on-board reforming aiming at vehicle application. The thermodynamic analysis is employed to evaluate the ethanol-fueled SOFC performance of different reforming options with a metal-supported SOFC working at 600 °C and a 0.3 A/cm2 current density. The electrical efficiency of the SOFC can reach a maximum of 50% with ethanol autothermal reforming. Under the optimal reforming option and operating conditions, the conceptual SOFC-APU system design is identified with the trade-off between system efficiency and ethanol flow from the startup and stable operation phase. The results show that the system efficiency of 44.4% can be achieved with a 0.42 g/s ethanol flow at the startup phase. During the stable operation, the electrical efficiency and exergy efficiency of the SOFC-APU system can reach 55.4 and 77.1% with a 70% anode gas recirculation ratio, respectively.
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- 2021
14. Improving upconversion efficiency of NaLuF4:Yb,Er by doping Gd3+ and application for perovskite solar cells
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Xiaodan Zhang, Ying Zhao, and Yanli Ding
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Materials science ,business.industry ,Doping ,Condensed Matter Physics ,Microstructure ,Emission intensity ,Atomic and Molecular Physics, and Optics ,Photon upconversion ,Electronic, Optical and Magnetic Materials ,Ion ,Optoelectronics ,Electrical and Electronic Engineering ,Luminescence ,business ,Excitation ,Perovskite (structure) - Abstract
The use of upconversion (UC) materials is an effective strategy for harvesting the near-infrared (NIR) solar photons in perovskite solar cells. Hexagonal β-NaLuF4:Yb,Er submicron prisms were synthesized by a facile solvothermal method. Gd3+ doping is used to enhance the UC emission intensity. We investigated how the concentration of Gd3+ ions affected the morphological evolution, microstructure, and luminescence performance of NaLuF4:Yb,Er and explored the mechanism for improving luminescence at 980 nm excitation. By incorporating the optimized NaLuF4:Yb,Er,Gd into the perovskite solar cells’ (PSCs) hole transport layer, the short-circuit density (Jsc) of UC-PSCs can be enhanced from 19.31 to 21.77 mA cm−2.
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- 2021
15. Predictive value of gadoxetic acid–enhanced MRI for posthepatectomy liver failure: a systematic review
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Ernesto Sparrelid, Qiang Wang, Torkel B. Brismar, Jiaxing Zhang, Kuansheng Ma, Anrong Wang, and Ying Zhao
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medicine.medical_specialty ,Gadoxetic acid ,medicine.diagnostic_test ,Imaging biomarker ,business.industry ,medicine.medical_treatment ,Liver failure ,Magnetic resonance imaging ,General Medicine ,Cochrane Library ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Liver function ,Hepatectomy ,business ,Neuroradiology ,medicine.drug - Abstract
Objectives Effective and non-invasive biomarkers to predict and avoid posthepatectomy liver failure (PHLF) are urgently needed. This systematic review aims to evaluate the efficacy of gadoxetic acid–enhanced MRI-derived parameters as an imaging biomarker in preoperative prediction of PHLF. Methods A systematic literature search was performed in the databases of PubMed/Medline, Web of Science, Embase, and Cochrane Library up to 11 December 2020. Studies evaluating the incidence of PHLF on patients who underwent hepatectomy with preoperative liver function assessment using gadoxetic acid–enhanced MRI were included. Data was extracted using pre-designed tables. The Quality In Prognostic Studies (QUIPS) tool was adopted to evaluate the risk of bias. Results A total of 15 studies were identified for qualitative synthesis and most studies were marked as low to moderate risk of bias in each domain of QUIPS. The most commonly used parameter was relative liver enhancement or its related parameters. The reported incidence of PHLF ranged from 3.9 to 40%. The predictive sensitivity and specificity of gadoxetic acid–enhanced MRI parameters varied from 75 to 100% and from 54 to 93% in ten reported studies. A majority of the studies revealed that the gadoxetic acid–enhanced MRI parameter was a predictor for PHLF. Conclusions Gadoxetic acid–enhanced MRI showed a high predictive capacity for PHLF and represents a promising imaging biomarker in prediction of PHLF. Multicenter, prospective trials with large sample size and reliable, unified liver function parameters are required to validate the efficacy of individual liver function parameters. Key Points • There is an obvious heterogeneity of the published studies, not only in variance of MRI liver function parameters but also in indication and extent of the liver resection. • Signal intensity (SI)–based parameters derived from gadoxetic acid–enhanced MRI are the commonly used method for PHLF prediction. • Gadoxetic acid–enhanced MRI-derived parameters showed high predictive efficacy for PHLF and can potentially serve as a predictor for the incidence of PHLF.
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- 2021
16. Three-dimensional electronic microfliers inspired by wind-dispersed seeds
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Xinge Yu, Yechan Lee, Yihui Zhang, Chi Hwan Lee, Leonardo P. Chamorro, Sang Min Won, Hokyung Jang, Juyun Kim, Kun Hyuck Lee, Yoonseok Park, Ted S. Chung, Heon Lee, Jiwoong Kim, Yei Hwan Jung, Jin-Tae Kim, Ying Zhao, Cai Tengfei, Zhaoqian Xie, Geumbee Lee, Yongjoon Yu, Bong Hoon Kim, Haiwen Luan, Raudel Avila, Xueju Wang, Yeonha Kim, Woo Jin Jang, Yonggang Huang, Lin Chen, Honglie Song, Seung Yun Heo, Hong-Joon Yoon, Soong Ju Oh, Kan Li, Seung Ho Han, Feng Zhu, Poom Prasopsukh, and John A. Rogers
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education.field_of_study ,Multidisciplinary ,business.industry ,Population ,Aerodynamics ,Wireless ,Fluidics ,Electronics ,Aerospace engineering ,Macro ,business ,education ,Unpowered flight ,Microscale chemistry - Abstract
Large, distributed collections of miniaturized, wireless electronic devices1,2 may form the basis of future systems for environmental monitoring3, population surveillance4, disease management5 and other applications that demand coverage over expansive spatial scales. Aerial schemes to distribute the components for such networks are required, and—inspired by wind-dispersed seeds6—we examined passive structures designed for controlled, unpowered flight across natural environments or city settings. Techniques in mechanically guided assembly of three-dimensional (3D) mesostructures7–9 provide access to miniature, 3D fliers optimized for such purposes, in processes that align with the most sophisticated production techniques for electronic, optoelectronic, microfluidic and microelectromechanical technologies. Here we demonstrate a range of 3D macro-, meso- and microscale fliers produced in this manner, including those that incorporate active electronic and colorimetric payloads. Analytical, computational and experimental studies of the aerodynamics of high-performance structures of this type establish a set of fundamental considerations in bio-inspired design, with a focus on 3D fliers that exhibit controlled rotational kinematics and low terminal velocities. An approach that represents these complex 3D structures as discrete numbers of blades captures the essential physics in simple, analytical scaling forms, validated by computational and experimental results. Battery-free, wireless devices and colorimetric sensors for environmental measurements provide simple examples of a wide spectrum of applications of these unusual concepts. With a design inspired by wind-dispersed seeds, a series of three-dimensional passive fliers at the macro-, meso- and microscale are realized that can bear active electronic payloads.
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- 2021
17. mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens
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Yanping Dai, Xiaobo Cen, Zhen Yang, Min Li, Jie Zhang, Hongbo Wang, Linhong Jiang, Jiamei Zhang, Bin Liu, Xuemei Wan, Rong Chen, Wei Xu, Huaqin Zhang, Yonghai Wang, Hongchun Li, Lin Bai, Yuanyuan Chen, Rui Xu, Ying Zhao, Liang Wang, Haoluo Zhang, Jingwei Tian, Yinglan Zhao, and Xiaojie Wang
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Male ,Lipid accumulation ,media_common.quotation_subject ,Blotting, Western ,Motor Activity ,Pharmacology ,Nucleus accumbens ,Article ,Nucleus Accumbens ,Behavioural sensitization ,Mice ,chemistry.chemical_compound ,Cocaine ,Animals ,Medicine ,Biotinylation ,Pharmacology (medical) ,LY294002 ,Receptors, AMPA ,Internalization ,PI3K/AKT/mTOR pathway ,media_common ,Central Nervous System Sensitization ,business.industry ,Effector ,TOR Serine-Threonine Kinases ,General Medicine ,Mice, Inbred C57BL ,chemistry ,Carrier Proteins ,business ,Intracellular - Abstract
Behavioral sensitization is a progressive increase in locomotor or stereotypic behaviours in response to drugs. It is believed to contribute to the reinforcing properties of drugs and to play an important role in relapse after cessation of drug abuse. However, the mechanism underlying this behaviour remains poorly understood. In this study, we showed that mTOR signaling was activated during the expression of behavioral sensitization to cocaine and that intraperitoneal or intra-nucleus accumbens (NAc) treatment with rapamycin, a specific mTOR inhibitor, attenuated cocaine-induced behavioural sensitization. Cocaine significantly modified brain lipid profiles in the NAc of cocaine-sensitized mice and markedly elevated the levels of phosphatidylinositol-4-monophosphates (PIPs), including PIP, PIP(2,) and PIP(3). The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine. An RNA-sequencing analysis of the downstream effectors of mTOR signalling revealed that cocaine significantly decreased the expression of SynDIG1, a known substrate of mTOR signalling, and decreased the surface expression of GluA2. In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1–GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours. In conclusion, NAc SynDIG1 may play a negative regulatory role in cocaine-induced behavioural sensitization by regulating synaptic surface expression of GluA2.
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- 2021
18. Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling
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Ying Zhao, Yanping Dai, Hongchun Li, Wei Xu, Yonghai Wang, Menglu Li, Yuman He, Haoluo Zhang, Rui Xu, Xiaobo Cen, Xuemei Wan, Linhong Jiang, Haxiaoyu Liu, and Jiamei Zhang
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Male ,Simvastatin ,Physiology ,Male mice ,Craving ,Nucleus accumbens ,Pharmacology ,Extinction, Psychological ,Mice ,Cocaine ,polycyclic compounds ,medicine ,Animals ,cardiovascular diseases ,business.industry ,General Neuroscience ,Brain ,nutritional and metabolic diseases ,General Medicine ,Metabolism ,Extinction (psychology) ,Lipidome ,Conditioned place preference ,Lipidomics ,Conditioning, Operant ,Original Article ,lipids (amino acids, peptides, and proteins) ,medicine.symptom ,business ,medicine.drug - Abstract
Drug-associated reward memories are conducive to intense craving and often trigger relapse. Simvastatin has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive processes is elusive. Here, we used a mass spectrometry-based lipidomic method to evaluate the impact of simvastatin on the mouse brain in a cocaine-induced reinstatement paradigm. We found that simvastatin blocked the reinstatement of cocaine-induced conditioned place preference (CPP) without affecting CPP acquisition. Specifically, only simvastatin administered during extinction prevented cocaine-primed reinstatement. Global lipidome analysis showed that the nucleus accumbens was the region with the greatest degree of change caused by simvastatin. The metabolism of fatty-acids, phospholipids, and triacylglycerol was profoundly affected. Simvastatin reversed most of the effects on phospholipids induced by cocaine. The correlation matrix showed that cocaine and simvastatin significantly reshaped the lipid metabolic pathways in specific brain regions. Furthermore, simvastatin almost reversed all changes in the fatty acyl profile and unsaturation caused by cocaine. In summary, pre-extinction treatment with simvastatin facilitates cocaine extinction and prevents cocaine relapse with brain lipidome remodeling.
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- 2021
19. Improving the Current Spreading by Fe Doping in n-GaN Layer for GaN-Based Ultraviolet Light-Emitting Diodes
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Haoyang Wu, Yue Hao, Jincheng Zhang, Xiaomeng Fan, Huake Su, Hongchang Tao, Jinjuan Du, Ying Zhao, Ruoshi Peng, Ai Lixia, Peixian Li, and Shengrui Xu
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Materials science ,business.industry ,Doping ,Current crowding ,Gallium nitride ,Semiconductor device ,Electronic, Optical and Magnetic Materials ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,Optoelectronics ,Stimulated emission ,Electrical and Electronic Engineering ,business ,Layer (electronics) ,Diode ,Light-emitting diode - Abstract
GaN-based light-emitting diodes (LEDs) grown on the insulating sapphire substrate suffer from a severe current crowding effect. To alleviate the current crowding effect, we demonstrate a current spreading structure for 365-nm ultraviolet LED using Fe doping in n-GaN layer. The surface morphology was studied by atomic force microscope, and the crystal quality was evaluated by high-resolution X-ray diffraction, which shows that a thin insertion layer doped with Fe has less influence on the crystalline quality. Additionally, inserting a Fe-doped layer with appropriate doping concentration enables to induce a barrier in the n-type layer, which contributes to the uniform current distribution. As a result, compared with conventional LED, the light output power obtains a 170.6% enhancement at 100 mA. Furthermore, the uniform optical emission distribution is also achieved by inserting a Fe-doped layer. Finally, the conduction band structures and horizontal hole concentration distributions are calculated by Advanced Physical Models of Semiconductor Devices, which illustrates the mechanism of current spreading.
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- 2021
20. Autophagy in pancreatic cancer
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Congting Guo and Ying Zhao
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business.industry ,Autophagy ,Cell Biology ,General Medicine ,AcademicSubjects/SCI01180 ,medicine.disease ,Pancreatic Neoplasms ,Cell Line, Tumor ,Pancreatic cancer ,Perspective ,Genetics ,Cancer research ,Humans ,Medicine ,business ,Molecular Biology - Published
- 2021
21. Network Pharmacology Approach for Predicting Targets of Zishen Yutai Pills on Premature Ovarian Insufficiency
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Xinyi Chai, Yi-Hui Feng, Yan Ning, Ying Zhao, and Yingyin Chen
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Regulation of gene expression ,Article Subject ,Mechanism (biology) ,business.industry ,Traditional Chinese medicine ,Bioinformatics ,Premature ovarian insufficiency ,Zishen Yutai ,Other systems of medicine ,Complementary and alternative medicine ,MRNA metabolic process ,Medicine ,Signal transduction ,business ,Gene ,RZ201-999 ,Research Article - Abstract
Background and Purpose. Premature ovarian insufficiency (POI) is a serious reproductive disease in females that is characterized by menstrual and ovulation disorders and infertility. The clinical efficacy of complementary and alternative medicine (CAM) has been reported in POI, including compound Chinese medicine. Zishen Yutai Pills (ZSYTP), a well-known patented Chinese medicine, has been widely used for treating POI; however, the pharmacological mechanism and molecular targets of ZSYTP remain unknown. Here, we systematically elucidated the pharmacological mechanism of ZSYTP on POI using a network pharmacology approach and further validated our findings with molecular docking. Methods. A comprehensive strategy based on several Chinese herb databases and chemical compound databases was established to screen active compounds of ZSYTP and predict target genes. For network pharmacological analysis, network construction and gene enrichment analysis were conducted and further verified by molecular docking. Results. A total of 476 target genes of ZSYTP were obtained from 205 active compounds. 13 herbs of ZSYTP overlapped on 8 active compounds based on the compound-target-disease network (C-T network). 20 biological processes and 9 pathways were strongly connected to the targets of ZSYTP in treating POI, including negative regulation of gene expression, mRNA metabolic process, hypoxia-inducible factor 1 (HIF-1) signaling pathway, and gluconeogenesis. Finally, molecular docking was visualized. Conclusion. Intriguingly, the signal pathways and biological processes uncovered in this study implicate inflamm-aging and glucose metabolism as potential pathological mechanisms of POI. The therapeutic effect of ZSYTP could be mediated by regulating glucose metabolism and HIF-1 signal pathway. Collectively, this study sheds light on the therapeutic potential of ZSYTP on POI.
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- 2021
22. Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long‐term prognosis: A retrospective cohort study
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Ping An, Yu Xiong, Jizi Zhou, Ying Zhao, Xiaotian Li, and Xirong Xiao
- Subjects
Pediatrics ,medicine.medical_specialty ,Asymptomatic ,Ultrasonography, Prenatal ,Lesion ,Fetus ,Pregnancy ,Cystic Adenomatoid Malformation of Lung, Congenital ,medicine ,Humans ,Respiratory system ,Retrospective Studies ,Asphyxia ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Respiratory infection ,Congenital pulmonary airway malformation ,Prenatal Care ,Retrospective cohort study ,General Medicine ,medicine.disease ,Female ,medicine.symptom ,business - Abstract
OBJECTIVE To investigate the relationship between mild congenital pulmonary airway malformation (CPAM) and its long-term prognosis in childhood and to explore whether surgery is necessary. METHODS We conducted a retrospective cohort of fetuses with mild CPAM diagnosed prenatally with available long-term outcomes in childhood from 2004 to 2016. The patients were divided into two groups according to the fetal CPAM-to-volume ratio (CVR) of less than 1.0 and 1.0-1.6. The primary outcome was a postnatal composite outcome including CPAM-associated respiratory symptoms and surgical resection of the lesion. The secondary outcomes included neonatal asphyxia, perinatal morbidity and mortality. RESULTS Forty-two fetuses were identified as having CVR
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- 2021
23. The Differential Diagnosis of Double Aortic Arch and Right Aortic Arch with Mirror-Image Branches in the Fetus: A Potential Novel Method
- Author
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Lin Sun, Jiancheng Han, Ying Zhao, Xiaowei Liu, Xiaoyan Gu, Ye Zhang, Jingyi Wang, and Yihua He
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Adult ,Male ,Aortic arch ,medicine.medical_specialty ,Double aortic arch ,Aorta, Thoracic ,Prenatal diagnosis ,Aortic arches ,Ultrasonography, Prenatal ,Diagnosis, Differential ,Young Adult ,Pregnancy ,Internal medicine ,medicine.artery ,Humans ,Medicine ,Cutoff ,Retrospective Studies ,Receiver operating characteristic ,Aortic Arch Syndromes ,business.industry ,Ductus Arteriosus ,medicine.disease ,Vascular Ring ,Cardiac surgery ,medicine.anatomical_structure ,Echocardiography ,Pediatrics, Perinatology and Child Health ,Cardiology ,Female ,Differential diagnosis ,Cardiology and Cardiovascular Medicine ,business - Abstract
The objective of this study was to explore a new method for the differential diagnosis between fetal double aortic arch (DAA) and right aortic arch with mirror-image branches (RAA-MB). Clinical data and prenatal echocardiographic features of the DAA (n = 22) and RAA-MB (n = 65) confirmed by postnatal or autopsy findings were analyzed retrospectively. The angles between the two aortic arches in the DAA group and between the right aortic arch and the mirror branch were measured. The differences between the two groups and differential diagnosis value of the angles were compared and analyzed based on the receiver operating characteristic curve. The proportion of left-sided ductal arteriosus (100%) was higher in the DAA group than that (32.3%) in the RAA-MB group, (P
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- 2021
24. Mirtazapine use may increase the risk of hypothyroxinaemia in patients affected by major depressive disorder
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Mingcan Li, Ruiling Zhang, Desheng Zhai, Yuan Yuan, Ying Zhao, Ravi Retnakaran, Shi Wu Wen, Na Wang, and Wei Hao
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Pharmacology ,Depressive Disorder, Major ,Pediatrics ,medicine.medical_specialty ,business.industry ,Incidence ,Incidence (epidemiology) ,Thyroid ,Confounding ,Mirtazapine ,Retrospective cohort study ,medicine.disease ,medicine.anatomical_structure ,Relative risk ,medicine ,Humans ,Major depressive disorder ,Pharmacology (medical) ,business ,Depression (differential diagnoses) ,Retrospective Studies ,medicine.drug - Abstract
Aims Hypothyroxinaemia could be easily neglected if attention is paid only to patients with elevated thyroid-stimulating hormone. We aimed to assess the association between mirtazapine use and hypothyroxinaemia in patients affected by major depressive disorder. Methods We conducted a retrospective cohort study in the Second Affiliated Hospital of Xinxiang Medical University between January 2016 and December 2018. Patients affected by major depression disorder and admitted to the hospital for treatment during the study period and who had thyroid tests at admission and after treatment were included. Mirtazapine use during hospitalization was the exposure measure and newly developed hypothyroxinaemia was as the primary outcome and structure parameters of thyroid homeostasis were the secondary outcomes of this study. Log-binomial model was used to estimate the association between mirtazapine use and hypothyroxinaemia, after adjusting for potential confounding factors. Results A total of 220 eligible patients were included in the final analysis. The incidence of hypothyroxinaemia in patients who used mirtazapine was higher (37.5%) than those patients who did not use (19.7%). The relative risk of developing hypothyroxinaemia was 1.70 (95% confidence interval: 1.21-2.43) for mirtazapine use, after adjusting for confounding factors. The degree of reduction in thyroid feedback quantile-based index in mirtazapine group was significantly greater than that in nonmirtazapine group. Conclusion Mirtazapine use was associated with the increased risk of developing hypothyroxinaemia. The underlying mechanism may be involved the changed central set point of thyroid homeostasis, in which pituitary was in a possibly impaired sensitivity to the lower level of thyroid hormones.
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- 2021
25. Clinical Outcomes and Prognostic Factors of Salvage Treatment for Local Lymph Node Recurrence After Radical Resection of Oesophageal Carcinoma
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Ying Zhao, Hongxue Ye, Fei Gao, Xiao-Xiang Yin, Liang Gu, Yangchen Liu, and Ye Tian
- Subjects
medicine.medical_specialty ,Univariate analysis ,oesophageal cancer ,Proportional hazards model ,business.industry ,medicine.medical_treatment ,Urology ,Salvage therapy ,lymph node recurrence ,chemoradiotherapy ,Log-rank test ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,Cancer Management and Research ,medicine ,Stage (cooking) ,business ,Lymph node ,Chemoradiotherapy ,Original Research - Abstract
Liang Gu,1,2 Yangchen Liu,2 Hongxue Ye,2 Fei Gao,2 Xiaoxiang Yin,2 Ying Zhao,2 Ye Tian1 1Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Su Zhou, 215004, Jiang Su Province, Peopleâs Republic of China; 2Department of Radiation Oncology, Taixing Peopleâs Hospital, Tai Xing, 225400, Jiang Su Province, Peopleâs Republic of ChinaCorrespondence: Ye TianDepartment of Radiation Oncology, The Second Affiliated Hospital of Soochow University, 1005 Sanxiang Road, Su Zhou, 215004, Jiang Su Province, Peopleâs Republic of ChinaEmail dryetian@126.comBackground: There are no standard therapeutic strategies for local lymph node (LN) recurrence after radical resection of oesophageal squamous cell carcinoma (ESCC), and prognostic risk factors remain controversial. We assessed clinical outcomes and prognostic factors of chemoradiotherapy (CRT) or radiotherapy (RT) for LN recurrence of ESCC after curative resection.Methods: A total of 117 ESCC patients with LN recurrence after radical resection receiving salvage treatment at our hospital were retrospectively reviewed from 2014 to 2017. Overall survival (OS) was estimated using the KaplanâMeier method; clinical characteristics were assessed using the Log rank test in the univariate analysis. Multivariate prognostic analysis was performed using the Cox proportional hazard model.Results: With a median follow-up of 19 months, the 1-, 2- and 3-year OS rates were 75.2%, 40.2% and 27.4%, respectively. The median survival time (MST) was 19.0 months. On univariate analysis for OS, pathological TNM stage, number of LN metastasis, LN maximum (Max) diameter, salvage treatment mode and tumor response were significantly associated with OS (P = 0.0074, P = 0.015, P = 0.0011, P = 0.028, P < 0.000, respectively). On multivariate analysis, tumor response [Response vs No-response hazard ratio (HR), 2.43; 95% confidence interval (CI), 1.53â 3.90, P < 0.000] and LN Max diameter (⤠28 mm vs > 28 mm HR, 2.07; 95% CI, 1.33â 3.32, P = 0.012) were independent prognostic factors.Conclusion: Salvage CRT or RT was safe and effective for treating LN recurrence after radical resection in ESCC. Patients with the small LN Max diameter (⤠28 mm) and obtained response after salvage therapy appeared to achieve long-term OS.Keywords: oesophageal cancer, lymph node recurrence, chemoradiotherapy
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- 2021
26. Effects of guanidinium cations on structural, optoelectronic and photovoltaic properties of perovskites
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Minna Hou, Ying Zhao, Xiaodan Zhang, Ying Tian, Yi Ding, Guofu Hou, Yuzeng Xu, Bo Zhou, Jingshan Luo, and Yan Wu
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Materials science ,Passivation ,business.industry ,Energy Engineering and Power Technology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Grain size ,0104 chemical sciences ,Hysteresis ,Grain growth ,Dipole ,Fuel Technology ,Octahedron ,Phase (matter) ,Electrochemistry ,Optoelectronics ,0210 nano-technology ,business ,Energy (miscellaneous) ,Perovskite (structure) - Abstract
Guanidinium (GA) cations are intentionally introduced in MAPbI3 perovskite by considering its potential capability of stabilizing the material through plenty of hydrogen bonds and mitigating hysteresis because of the zero dipole moment. The configurations of GA cation in film and its effects on structural, optoelectronic and photovoltaic properties of perovskite have been comprehensively studied by systematically modulating the GA ratio. It has been demonstrated that moderate GA cations can effectively passivate the defect surrounding perovskite grains, yielding an enhanced efficiency as high as ~19.2% in a p-i-n type planar solar cells with the GA ratio of 15%. Further increasing the GA ratio deteriorates device performance, as extra GA cations hinder grain growth and thus reduce the grain size, which facilitates the defect generation around the enhanced interface. Moreover, a new two-dimensional (2D) layered perovskite phase that features alternating GA and MA cations in the interlayer space (ACI) appears ultimately, while the ACI phase typically suffers from slow charge transportation across the parallel PbI2 octahedral layers separated by large A-site cations.
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- 2021
27. Low-Temperature Oxide/Metal/Oxide Multilayer Films as Highly Transparent Conductive Electrodes for Optoelectronic Devices
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Chengang Ji, Liu Zhang, Xiufang Yang, Xinghua Cui, Ying Zhao, Yuelong Li, Xinliang Chen, L. Jay Guo, Dong Liu, Guofu Hou, Chengchao Ren, Xin Zhou, Xiaodan Zhang, and Yunlong Zhang
- Subjects
Materials science ,business.industry ,Oxide ,Energy Engineering and Power Technology ,Metal ,chemistry.chemical_compound ,chemistry ,visual_art ,Electrode ,Materials Chemistry ,Electrochemistry ,visual_art.visual_art_medium ,Chemical Engineering (miscellaneous) ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Electrical conductor - Published
- 2021
28. Enhancement of optical characteristic of InGaN/GaN multiple quantum-well structures by self-growing air voids
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Ying Zhao, Yue Hao, Niu Mutong, Shengrui Xu, Ruoshi Peng, Jincheng Zhang, Hongchang Tao, Xiaomeng Fan, Huake Su, and Jinjuan Du
- Subjects
Photoluminescence ,Materials science ,business.industry ,Scanning electron microscope ,Multiple quantum ,General Engineering ,Anisotropic growth ,Stress (mechanics) ,symbols.namesake ,Transmission electron microscopy ,symbols ,Optoelectronics ,Air voids ,General Materials Science ,business ,Raman spectroscopy - Abstract
InGaN/GaN multiple quantum-well (MQW) structures with a wavelength range of green were successfully grown on a c-plane GaN template with SiO2 stripe patterns along the [11-20] and [1-100] directions as a mask. The surface morphologies of both samples were investigated using scanning electron microscopy and demonstrated anisotropic growth characteristics of GaN. The optical characteristics were investigated using Raman spectra and photoluminescence (PL). The InGaN/GaN MQW structure grown on the GaN template with SiO2 stripes along the [1-100] orientation exhibited less stress and higher PL intensity. Transmission electron microscopy results indicated that portions of MQWs were grown on an inclined semipolar plane, and air voids occurred only when the direction of the mask stripe was along the [1-100] orientation. The enhancement of the optical characteristic was due to the air-void structure and inclined semipolar quantum-well sidewalls.
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- 2021
29. A multi-objective optimization algorithm for Bouc–Wen–Baber–Noori model to identify reinforced concrete columns failing in different modes
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De-Cheng Feng, Wael A. Altabey, Chunfeng Wan, Mohammad Noori, Zele Li, and Ying Zhao
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business.industry ,Computer science ,Mechanical Engineering ,020101 civil engineering ,02 engineering and technology ,Structural engineering ,Reinforced concrete ,01 natural sciences ,0201 civil engineering ,0103 physical sciences ,Multi objective optimization algorithm ,General Materials Science ,business ,010301 acoustics - Abstract
Concrete columns are the most important load-bearing components in civil structures. The potential damage in reinforced concrete (RC) columns could be categorized into three different failure modes: flexural shear (FS) failure, flexural-failure (FF), and shear failure (SF). The corresponding hysteresis loops for each mode differ significantly. Therefore, a multi-parameter hysteretic restoring force model is needed to describe the hysteretic energy dissipation phenomenon and behavior. Identification of the optimal parameter values of a multi-parameter hysteresis model of RC columns under different failure modes is essential in the evaluation of structural inelastic seismic performance. In this paper, a multi-objective optimization algorithm called NSGA-II is employed to identify the parameters of Bouc–Wen–Baber–Noori model (BWBN) hysteresis model, this model has been used for describing the response and modelling restoring force behavior in several structural and mechanical engineering systems, that can fully describe the hysteretic restoring force characteristics of RC columns. An objective function for the restoring force is proposed to identify the parameters of BWBN model. In order to ensure the accuracy of identification, based on the sensitivity analysis, the parameters distribution law of RC columns in different failure modes is obtained. Furthermore, the reference values under different failure modes are proposed. The results presented in this paper will significantly reduce the calculation of subsequent identification. Twelve groups of experimental data are randomly selected to verify the feasibility of the above algorithm. It is demonstrated that using the multi-objective optimization algorithm leads to better identification accuracy with minimum prior experience. Performance of the algorithm is verified using simulated and experimental data. The experimental data of the RC columns were collected from the database of the Pacific Earthquake Engineering Research Center.
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- 2021
30. Using shear wave elasticity in normal terminal ileum of a healthy southwest Chinese population: a pilot study of reference elasticity ranges
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Jie-Ying Zhao, Yu-Ting Wu, Ji-Gang Jing, Hua Zhuang, Yuan Luo, Xin Gao, and Yan Zhang
- Subjects
medicine.diagnostic_test ,Correlation coefficient ,business.industry ,030218 nuclear medicine & medical imaging ,Shear (sheet metal) ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Consistency (statistics) ,medicine ,Terminal ileum ,Original Article ,030211 gastroenterology & hepatology ,Radiology, Nuclear Medicine and imaging ,Elastography ,Analysis of variance ,Elasticity (economics) ,Nuclear medicine ,business ,Body mass index ,Mathematics - Abstract
Background Elastography has not been widely applied to the gastrointestinal tract. The bowel wall's normal elasticity values are still unknown and are necessary for studies of gastrointestinal diseases. This study explores the feasibility of using shear wave elastography (SWE) to measure the terminal ileum wall stiffness in healthy subjects and establish the corresponding normal ranges of elasticity values. Methods This observational study recruited 139 healthy adult volunteers from April to July 2020. All examinations were performed in the anterior terminal ileum wall. Shear wave velocity (SWV) and Young's modulus (E) values were measured in the midline on longitudinal sections and replicated different operators' obtained data. Also, bowel wall thickness (BWT) and depth were recorded. Subgroups were classified according to the volunteers' gender, age, body mass index (BMI), BWT, and depth. The intra-class correlation coefficient was calculated to analyze inter- and intra-operator consistency, and independent t-tests and one-way analysis of variance were used to explore the differences in variables. Results The inter- and intra-operator agreements were good to excellent by different operators and in the replicated measurements (intra-operator consistency: 0.963; inter-operator consistency: 0.842). In all volunteers, the mean SWV was 1.08±0.25 m/s, the mean E value was 3.84±1.84 kPa, and the median BWT was 2 mm. SWV and E did not show significant differences according to gender (P=0.589), age (P=0.738), BMI (P=0.678), depth (P=0.375), or BWT (P=0.410). BWT did not show significant differences according to age (P=0.142), BMI (P=0.863), or depth (P=0.368). Conclusions SWE can be used in terminal ileum wall stiffness measurements with good reliability, and the SWE values do not appear to vary significantly according to different physiological factors. The corresponding elasticity ranges of the terminal ileum in normal adults were acquired.
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- 2021
31. Virologic efficacy of tenofovir, lamivudine and dolutegravir as second-line antiretroviral therapy in adults failing a tenofovir-based first-line regimen
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Kaneez Sayed, Rene Goliath, Claire Keene, Rulan Griesel, Gert U. van Zyl, Eric Goemaere, Olina Ngwenya, Graeme Meintjes, Andrew Hill, Ying Zhao, Tracy Flowers, Tali Cassidy, Lubbe Wiesner, Gary Maartens, Zimasa Gcwabe, Charlotte Schutz, Amanda Jackson, and Bryony Simmons
- Subjects
Adult ,0301 basic medicine ,medicine.medical_specialty ,Efavirenz ,Nevirapine ,Anti-HIV Agents ,Pyridones ,Immunology ,HIV Infections ,Emtricitabine ,Piperazines ,South Africa ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Oxazines ,Humans ,Immunology and Allergy ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Tenofovir ,Adverse effect ,business.industry ,virus diseases ,Lamivudine ,Viral Load ,Regimen ,030104 developmental biology ,Infectious Diseases ,chemistry ,Dolutegravir ,HIV-1 ,business ,Heterocyclic Compounds, 3-Ring ,Viral load ,medicine.drug - Abstract
Objective: Recycling tenofovir and lamivudine/emtricitabine (XTC) with dolutegravir would provide a more tolerable, affordable, and scalable second-line regimen than dolutegravir with an optimized nucleoside reverse transcriptase inhibitor (NRTI) backbone. We evaluated efficacy of tenofovir/lamivudine/dolutegravir (TLD) in patients failing first-line tenofovir/XTC/efavirenz or nevirapine. Design: Single arm, prospective, interventional study. Setting: Two primary care clinics in Khayelitsha, South Africa. Participants: Sixty adult patients with two viral loads greater than 1000 copies/ml. Intervention: Participants were switched to TLD with additional dolutegravir (50 mg) for 2 weeks to overcome efavirenz induction. Primary outcome: Proportion achieving viral load less than 50 copies/ml at week 24 using the FDA snapshot algorithm. Results: Baseline median CD4+ cell count was 248 cells/μl, viral load 10 580 copies/ml and 48 of 54 (89%) had resistance (Stanford score ≥15) to one or both of tenofovir and XTC. No participants were lost to follow-up. At week 24, 51 of 60 [85%, 95% confidence interval (CI) 73-93%] were virologically suppressed, six had viral load 50-100 copies/ml, one had viral load 100-1000 copies/ml, one no viral load in window, and one switched because of tenofovir-related adverse event. No integrase mutations were detected in the one participant meeting criteria for resistance testing. Virological suppression was achieved by 29 of 35 (83%, 95% CI 66-93%) with resistance to tenofovir and XTC, 11 of 13 (85%, 95% CI 55-98%) with resistance to XTC, and six of six (100%, 95% CI 54-100%) with resistance to neither. Conclusion: A high proportion of adults switching to second-line TLD achieved virologic suppression despite substantial baseline NRTI resistance and most not suppressed had low-level viraemia (≤100 copies/ml). This suggests recycling tenofovir and XTC with dolutegravir could provide an effective second-line option.
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- 2021
32. Silicon heterojunction-based tandem solar cells: past, status, and future prospects
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Qiaojing Xu, Guofu Hou, Xiaodan Zhang, Chengchao Ren, Li Xingliang, Ying Zhao, Sayantan Mazumdar, Pengyang Wang, Lingling Yan, and Biao Shi
- Subjects
Materials science ,Tandem ,business.industry ,Physics ,QC1-999 ,perovskite/shj tandem solar cell ,shj solar cell ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,electrical and optical performance ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Silicon heterojunction ,Optoelectronics ,iii–v/shj tandem solar cell ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Biotechnology - Abstract
Due to stable and high power conversion efficiency (PCE), it is expected that silicon heterojunction (SHJ) solar cells will dominate the photovoltaic market. So far, the highest PCE of the SHJ-interdigitated back contact (IBC) solar cells has reached 26.7%, approximately approaching the theoretical Shockley–Queisser (SQ) limitation of 29.4%. To break through this limit, multijunction devices consisting of two or three stacked subcells have been developed, which can fully utilize the sunlight by absorbing different parts of the solar spectrum. This article provides a comprehensive overview of current research on SHJ-based tandem solar cells (SHJ-TSCs), including perovskite/SHJ TSCs and III–V/SHJ TSCs. Firstly, we give a brief introduction to the structures of SHJ-TSCs, followed by a discussion of fabrication processes. Afterwards, we focus on various materials and processes that have been explored to optimize the electrical and optical performance. Finally, we highlight the opportunities and challenges of SHJ-TSCs, as well as personal perspectives on the future development directions in this field.
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- 2021
33. Transperineal core-needle biopsy of a rectal subepithelial lesion guided by endorectal ultrasound after contrast-enhanced ultrasound: A case report
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Hua Zhuang, Chun-Yan Lu, Qiong Zhang, Jie-Ying Zhao, Yongyang Yu, Jin Yao, and Yuan Luo
- Subjects
Endoscopic ultrasound ,medicine.medical_specialty ,Uterine fibroids ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,Case report ,medicine ,Stromal tumor ,Vaginal Hemorrhage ,Rectal subepithelial lesion ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Gastroenterology ,Endorectal ultrasound ,General Medicine ,medicine.disease ,Endoscopy ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Transperineal core needle biopsy ,Radiology ,business ,Contrast-enhanced ultrasound - Abstract
Background Rectal subepithelial lesions (SELs) are commonly seen in endoscopic examination, generally manifested as bumps with a smooth surface. Precise preoperative diagnoses for rectal SELs are difficult because abnormal tissues are not easily to be obtained by regular endoscopic forceps biopsy. Traditional guidance modalities of preoperative biopsy, including endoscopic ultrasound, computed tomography, and transabdominal ultrasound, are often unsatisfactory. An updated, safe, and effective biopsy guidance method is required. We herein report a new biopsy guidance modality-endorectal ultrasound (ERUS) combined with contrast-enhanced ultrasound (CEUS). Case summary A 32-year-old woman complained of a mass inside the rectovaginal space for 9 years, which became enlarged within 1 year. A rectal SEL detected by endoscopy was suspected to be a gastrointestinal stromal tumor or exophytic uterine fibroid. Pathological diagnosis was difficult because of unsuccessful transabdominal core needle biopsy with insufficient tissues, as well as vaginal hemorrhage. A second biopsy was suggested after multiple disciplinary treatment discussion, which referred to a transperineal core needle biopsy (CNB) guided by ERUS combined with CEUS. Adequate samples were procured and rectal gastrointestinal stromal tumor was proved to be the pathological diagnosis. Imatinib was recommended for first-line therapy by multiple disciplinary treatment discussion. After the tumor shrunk, resection of the rectal gastrointestinal stromal tumor was performed through the posterior vaginal wall. Adjuvant therapy was applied and no recurrence or metastasis has been found by the last follow-up on December 13, 2019. Conclusion Transperineal CNB guided by ERUS and CEUS is a safe and effective preoperative biopsy of rectal SELs yet with some limitations.
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- 2021
34. An evaluation of a prenatal individualised mixed management intervention addressing breastfeeding outcomes and postpartum depression: A randomised controlled trial
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Qiping Lin, Jing Wang, and Ying Zhao
- Subjects
Postpartum depression ,China ,medicine.medical_specialty ,medicine.medical_treatment ,Breastfeeding ,law.invention ,Depression, Postpartum ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Pregnancy ,law ,Intervention (counseling) ,medicine ,Psychoeducation ,Humans ,Single-Blind Method ,030212 general & internal medicine ,General Nursing ,030504 nursing ,Obstetrics ,business.industry ,Postpartum Period ,General Medicine ,medicine.disease ,Breast Feeding ,Antenatal depression ,Female ,0305 other medical science ,business ,Perinatal Depression - Abstract
AIMS AND OBJECTIVES To determine the effects of an individualised mixed management combined lactation education and psychoeducation intervention on breastfeeding outcomes and postpartum depression (PPD) at 3 and 42 days postpartum. BACKGROUND Pregnant women with antenatal depression are prone to postpartum depression and failure in breastfeeding. DESIGN Eligible women participated in a randomised single-blind controlled trial. Results are reported as per the CONSORT 2010 statement. METHODS Participants were recruited from December 2017-August 2018 at a major teaching hospital located in Shanghai. Primiparous women (n = 182) with an Edinburgh Postnatal Depression Scale score ≥9 were randomly enrolled in the intervention group (n = 91) or the control group (n = 91). The intervention group participated in a 4-session face-to-face mixed management intervention targeting perinatal depression and breastfeeding. The control group received usual care. Breastfeeding and psychological outcomes were measured during the third trimester (≥28 weeks and
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- 2021
35. Randomized Clinical Trial of a Prenatal Breastfeeding and Mental Health Mixed Management Intervention
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Ying Zhao, Qiping Lin, Jing Wang, and Xinli Zhu
- Subjects
Postpartum depression ,medicine.medical_specialty ,Maternal Health ,Breastfeeding ,law.invention ,Depression, Postpartum ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Pregnancy ,law ,medicine ,Humans ,030212 general & internal medicine ,Psychiatry ,Mini-international neuropsychiatric interview ,Breastfeeding promotion ,030219 obstetrics & reproductive medicine ,Management intervention ,business.industry ,Postpartum Period ,Obstetrics and Gynecology ,medicine.disease ,Mental health ,Breast Feeding ,Mental Health ,Edinburgh Postnatal Depression Scale ,Female ,business - Abstract
Background The continuity of maternal depressive symptoms throughout the perinatal period and breastfeeding problems have adverse influences on breastfeeding. Research aim To compare the feeding patterns and breastfeeding experiences, maternal health and mental health, and breastfeeding self-efficacy between women with depressive symptoms who participated in a prenatal individualized mixed management intervention and those who received usual care. Methods Chinese primigravida ( N = 182) with an Edinburgh Postnatal Depression Scale score ≥ 9 in late pregnancy (≥ 28 weeks and < 35 weeks) were randomly assigned to the intervention group ( n = 84) or the control group ( n = 84). Intervention group participants received four sessions of individualized mixed management combining psycho-education and breastfeeding education. Breastfeeding self-efficacy, feeding patterns, maternal depression, and health status were evaluated in both groups. Results Significant differences were noted between the groups in breastfeeding self-efficacy at 42 days postpartum ( p < .05) and feeding patterns at 3 months and 6 months postpartum ( p < .05). Repeated measures analysis of variance showed significant differences in the EPDS scores between groups at three postpartum time points ( p < .05). The intervention group had significantly lower postpartum depression as diagnosed by the MINI ( p < .05). Conclusions A prenatal individualized mixed management intervention holds promise as an effective prevention and health promotion program addressing breastfeeding outcomes and maternal mental health. This RCT was registered (ChiCTR-IOR-17013761) with Chinese Clinical Trial Registry, http://www.chictr.org.cn/enIndex.aspx on 12/7/2017.
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- 2021
36. Upregulation of Matrix Metalloproteinase-9 Protects against Sepsis-Induced Acute Lung Injury via Promoting the Release of Soluble Receptor for Advanced Glycation End Products
- Author
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Yu-Jian Liu, Lai Jiang, Ning Ding, Dun-Feng Xu, Ying Zhao, Yan-Fei Mao, Chu-Fan Xu, Yan Wang, Wen-Wen Dong, Hui Zhang, and Xiao-Yan Zhu
- Subjects
Male ,Aging ,Article Subject ,Acute Lung Injury ,Receptor for Advanced Glycation End Products ,Inflammation ,Punctures ,Lung injury ,medicine.disease_cause ,Biochemistry ,RAGE (receptor) ,Pathogenesis ,Sepsis ,medicine ,Animals ,Cecum ,Ligation ,Lung ,Mice, Inbred ICR ,QH573-671 ,business.industry ,NF-kappa B ,Cell Biology ,General Medicine ,medicine.disease ,Pulmonary edema ,Up-Regulation ,Disease Models, Animal ,medicine.anatomical_structure ,Matrix Metalloproteinase 9 ,Solubility ,Gene Knockdown Techniques ,Cancer research ,medicine.symptom ,Cytology ,business ,Oxidative stress ,Signal Transduction ,Research Article - Abstract
Dysregulation of matrix metalloproteinase- (MMP-) 9 is implicated in the pathogenesis of acute lung injury (ALI). However, it remains controversial whether MMP-9 improves or deteriorates acute lung injury of different etiologies. The receptor for advanced glycation end products (RAGE) plays a critical role in the pathogenesis of acute lung injury. MMPs are known to mediate RAGE shedding and release of soluble RAGE (sRAGE), which can act as a decoy receptor by competitively inhibiting the binding of RAGE ligands to RAGE. Therefore, this study is aimed at clarifying whether and how pulmonary knockdown of MMP-9 affected sepsis-induced acute lung injury as well as the release of sRAGE in a murine cecal ligation and puncture (CLP) model. The analysis of GEO mouse sepsis datasets GSE15379, GSE52474, and GSE60088 revealed that the mRNA expression of MMP-9 was significantly upregulated in septic mouse lung tissues. Elevation of pulmonary MMP-9 mRNA and protein expressions was confirmed in CLP-induced mouse sepsis model. Intratracheal injection of MMP-9 siRNA resulted in an approximately 60% decrease in pulmonary MMP-9 expression. It was found that pulmonary knockdown of MMP-9 significantly increased mortality of sepsis and exacerbated sepsis-associated acute lung injury. Pulmonary MMP-9 knockdown also decreased sRAGE release and enhanced sepsis-induced activation of the RAGE/nuclear factor-κB (NF-κB) signaling pathway, meanwhile aggravating sepsis-induced oxidative stress and inflammation in lung tissues. In addition, administration of recombinant sRAGE protein suppressed the activation of the RAGE/NF-κB signaling pathway and ameliorated pulmonary oxidative stress, inflammation, and lung injury in CLP-induced septic mice. In conclusion, our data indicate that MMP-9-mediated RAGE shedding limits the severity of sepsis-associated pulmonary edema, inflammation, oxidative stress, and lung injury by suppressing the RAGE/NF-κB signaling pathway via the decoy receptor activities of sRAGE. MMP-9-mediated sRAGE production may serve as a self-limiting mechanism to control and resolve excessive inflammation and oxidative stress in the lung during sepsis.
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- 2021
37. Novel GLP-1 analog supaglutide improves glucose homeostasis in diabetic monkeys
- Author
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Yaojing Jiang, Qinghua Wang, Quanquan Zhou, Anran Ma, Minglin Wu, Ying Zhao, Weihong Tao, Wen Zeng, Yinan Liang, Li Zhang, Xiaohang Huang, Zhihong Wang, Anna Shao, Yang Zhenyan, Jia Li, Zunyuan Yang, Qiaoli Cui, and Yijing Liao
- Subjects
Blood Glucose ,Male ,0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Drug Evaluation, Preclinical ,030209 endocrinology & metabolism ,Type 2 diabetes ,03 medical and health sciences ,Subcutaneous injection ,0302 clinical medicine ,Endocrinology ,Pharmacokinetics ,Glucagon-Like Peptide 1 ,Internal medicine ,Diabetes mellitus ,Insulin Secretion ,medicine ,Animals ,Insulin ,Glucose homeostasis ,Kidney ,medicine.diagnostic_test ,business.industry ,Body Weight ,Lipid Metabolism ,medicine.disease ,Macaca mulatta ,030104 developmental biology ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,Lipid profile ,business ,Hormone - Abstract
Glucagon-like peptide 1 (GLP-1) is an insulinotropic hormone and plays an important role in regulating glucose homeostasis. GLP-1 has a short half-life (t1/2 < 2 min) due to degrading enzyme dipeptidyl peptidase-IV and rapid kidney clearance, which limits its clinical application as a therapeutic reagent. We demonstrated recently that supaglutide, a novel GLP-1 mimetic generated by recombinant fusion protein techniques, exerted hypoglycemic and β-cell trophic effects in type 2 diabetes db/db mice. In the present study, we examined supaglutide’s therapeutic efficacy and pharmacokinetics in diabetic rhesus monkeys. We found that a single subcutaneous injection of supaglutide of tested doses transiently and significantly reduced blood glucose levels in a dose-dependent fashion in the diabetic monkeys. During a 4-week intervention period, treatment of supaglutide of weekly dosing dose-dependently decreased fasting and random blood glucose levels. This was associated with significantly declined plasma fructosamine levels. The repeated administration of supaglutide remarkably also decreased body weight in a dose-dependent fashion accompanied by decreased food intake. Intravenous glucose tolerance test results showed that supaglutide improved glucose tolerance. The intervention also showed enhanced glucose-stimulated insulin secretion and improved lipid profile in diabetic rhesus monkeys. These results reveal that supaglutide exerts beneficial effects in regulating blood glucose and lipid homeostasis in diabetic rhesus monkeys.
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- 2021
38. Design of an Intelligent Target Spraying Robot for Processing Hyphantria Cunea Larva Nets
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Ying Zhao, Gao Rongzhi, Changqing Ma, Qun Sun, Zhang Laigang, Dongjie Zhao, and Tian Zhonglai
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Larva ,biology ,Computer science ,business.industry ,General Engineering ,Hyphantria ,Robot ,Computer vision ,Artificial intelligence ,business ,biology.organism_classification - Abstract
Background: The Hyphantria cunea is a worldwide quarantine pest. It has the characteristics of a wide variety of recipes, strong adaptability, wide transmission channels and serious harm, which seriously endanger the sustainable development of the ecological environment. At present, the control methods of the Hyphantria cunea are costly and inefficient. Objective: An intelligent target spraying robot based on machine vision is designed for cleansing Hyphantria cunea larva nets according to the characteristics of the net curtain and the background color. Methodology: The mobile mechanism of the spraying robot is based on a crawler type trolley and the three-dimensional movements are achieved by stepping motor and synchronous belt driving linear guide slider in the horizontal plane, and by the lead screw in the vertical direction. The on-board software controls the hand-eye actuator to scan the target trees with a specific trajectory, and performs image processing to identify the target so as to intelligently spray on the target. Results: The spraying robot can cope with the irregular distribution of Hyphantria cunea larva nets, and can realize the three-dimensional movement of the nozzle, and perform the progressive scanning to identify the larva nets, and the robot controls the nozzle to spray the medicine, thereby realizing the intelligent spraying of the target. Conclusion: Experiments show that accurate target spraying of the robot can be achieved, and the target coverage rate can reach up to 85% of the total larva nets, which greatly improves the spraying efficiency.
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- 2021
39. A Simple and All-Optical Microwave Doppler Frequency Shift and Phase Measurement System Based on Sagnac Loop and I/Q Detection
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Bochao Kang, Yangyu Fan, Wu Zhang, Yongsheng Gao, Chen Yibo, and Ying Zhao
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Physics ,business.industry ,Local oscillator ,020208 electrical & electronic engineering ,Phase (waves) ,02 engineering and technology ,Multiplexer ,Phase detector ,Optics ,Optical Carrier transmission rates ,Wavelength-division multiplexing ,0202 electrical engineering, electronic engineering, information engineering ,Radio frequency ,Electrical and Electronic Engineering ,business ,Instrumentation ,Microwave - Abstract
Microwave measurement system, which acquires the microwave parameters including frequency, phase, and amplitude information, is one of the backbone parts in modern radio frequency (RF) systems. In this article, a simple and novel optical approach is proposed to perform broadband in-phase/quadrature (I/Q) downconverter and is applied in Doppler frequency shift (DFS) and phase measurement. In the proposed approach, a Mach–Zehnder modulator (MZM) is used to modulate both RF and local oscillator (LO) signals. A Sagnac loop structure and optical coupler are used to suppress the optical carrier. A dense wavelength division multiplexer (DWDM) and two photodiodes (PDs) are used to build I/Q channels. The proposed approach has an all-optical structure and no frequency-dependent electronic devices are needed. In the experimental demonstration, the I/Q downconverter achieves low phase imbalance ( $\text {dB}\cdot \text {Hz}^{2/3}$ ) over an ultrawide operating frequency. When DFS measurement is implemented using the I/Q downconverter, the microwave DFS is measured with a maximum measurement error of 8 Hz, and a clear direction can be obtained. When the system is applied for phase detection, the phase shift is successfully estimated with a measurement error of less than 7°.
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- 2021
40. FGF-23 correlates with endocrine and metabolism dysregulation, worse cardiac and renal function, inflammation level, stenosis degree, and independently predicts in-stent restenosis risk in coronary heart disease patients underwent drug-eluting-stent PCI
- Author
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Yang Fu, Xianghua Fu, Xun Wang, Haiyan Wang, Jiayu Zhao, Wei Li, Ying Zhao, Tingting Song, and Yanbo Wang
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Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Time Factors ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Kidney ,Severity of Illness Index ,Ventricular Function, Left ,0302 clinical medicine ,Restenosis ,Prospective Studies ,Ejection fraction ,Drug-Eluting Stents ,Middle Aged ,Cardiac surgery ,Coronary heart disease ,Treatment Outcome ,Drug-eluting stent ,Cardiology ,Female ,Inflammation Mediators ,Cardiology and Cardiovascular Medicine ,Research Article ,In-stent restenosis ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Risk Assessment ,Fibroblast growth factor 23 ,Coronary Restenosis ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Risk factor ,Aged ,business.industry ,Coronary Stenosis ,Percutaneous coronary intervention ,Stent ,medicine.disease ,Fibroblast Growth Factors ,Fibroblast Growth Factor-23 ,Risk factors ,lcsh:RC666-701 ,Conventional PCI ,business ,Energy Metabolism ,Biomarkers - Abstract
Background The present study aimed to assess the correlation of fibroblast growth factor (FGF)-23 expression with clinical characteristics, then further explore its value in predicting 2-year in-stent restenosis (ISR) risk in coronary heart disease (CHD) patients underwent percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Methods In this prospective, single-center, observational study, totally 214 CHD patients treated by PCI with DES were consecutively recruited, and peripheral blood samples were collected prior to PCI with DES for serum samples isolation. Following, FGF-23 level in the serum samples was detected via enzyme linked-immuno-sorbent Assay. The follow-up coronary angiography was performed at 1 year and 2 years after PCI or if suspected ISR symptoms occurred. Results FGF-23 was positively correlated with fasting blood-glucose, insulin resistance, serum creatinine, serum uric acid, LDL-C, high-sensitivity C-reactive protein, cardiac troponin I and N-terminal-proB-type natriuretic peptide, while was negatively associated with HDL-C and left ventricular ejection fraction (all P P P > 0.05). Moreover, FGF-23 level was higher in 2-year ISR patients (n = 38) compared to 2-year non-ISR patients (n = 176) (P Conclusion FGF-23 correlates with endocrine and metabolism dysregulation, worse cardiac and renal function, inflammation level, stenosis degree of target lesion, and serves as an independent risk factor for 2-year ISR risk in CHD patients underwent PCI with DES.
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- 2021
41. Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer
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Guo-bing Zhang, Ping Huang, Zixue Xuan, Hong-ying Zhao, Qiang Ye, Jinying Jiang, Xiao-hong Mao, Ziqi Ye, and Yanfei Shao
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,lcsh:Surgery ,Breast Neoplasms ,Kaplan-Meier Estimate ,Methylation ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Surgical oncology ,Internal medicine ,Diagnosis ,Biomarkers, Tumor ,medicine ,Humans ,Gene ,business.industry ,Research ,Curve analysis ,DNA Patterns ,Patient survival ,lcsh:RD1-811 ,DNA Methylation ,medicine.disease ,Prognosis ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Gene Expression Regulation, Neoplastic ,DNM3 ,ComputingMethodologies_PATTERNRECOGNITION ,030104 developmental biology ,030220 oncology & carcinogenesis ,Surgery ,business ,Biomarkers - Abstract
Background Aberrant DNA methylation is significantly associated with breast cancer. Methods In this study, we aimed to determine novel methylation biomarkers using a bioinformatics analysis approach that could have clinical value for breast cancer diagnosis and prognosis. Firstly, differentially methylated DNA patterns were detected in breast cancer samples by comparing publicly available datasets (GSE72245 and GSE88883). Methylation levels in 7 selected methylation biomarkers were also estimated using the online tool UALCAN. Next, we evaluated the diagnostic value of these selected biomarkers in two independent cohorts, as well as in two mixed cohorts, through ROC curve analysis. Finally, prognostic value of the selected methylation biomarkers was evaluated breast cancer by the Kaplan-Meier plot analysis. Results In this study, a total of 23 significant differentially methylated sites, corresponding to 9 different genes, were identified in breast cancer datasets. Among the 9 identified genes, ADCY4, CPXM1, DNM3, GNG4, MAST1, mir129-2, PRDM14, and ZNF177 were hypermethylated. Importantly, individual value of each selected methylation gene was greater than 0.9, whereas predictive value for all genes combined was 0.9998. We also found the AUC for the combined signature of 7 genes (ADCY4, CPXM1, DNM3, GNG4, MAST1, PRDM14, ZNF177) was 0.9998 [95% CI 0.9994–1], and the AUC for the combined signature of 3 genes (MAST1, PRDM14, and ZNF177) was 0.9991 [95% CI 0.9976–1]. Results from additional validation analyses showed that MAST1, PRDM14, and ZNF177 had high sensitivity, specificity, and accuracy for breast cancer diagnosis. Lastly, patient survival analysis revealed that high expression of ADCY4, CPXM1, DNM3, PRDM14, PRKCB, and ZNF177 were significantly associated with better overall survival. Conclusions Methylation pattern of MAST1, PRDM14, and ZNF177 may represent new diagnostic biomarkers for breast cancer, while methylation of ADCY4, CPXM1, DNM3, PRDM14, PRKCB, and ZNF177 may hold prognostic potential for breast cancer.
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- 2021
42. Huaier Extract Attenuates Acute Kidney Injury to Chronic Kidney Disease Transition by Inhibiting Endoplasmic Reticulum Stress and Apoptosis via miR-1271 Upregulation
- Author
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Jing-Ying Zhao and Yu-Bin Wu
- Subjects
0301 basic medicine ,Article Subject ,Renal function ,Apoptosis ,Complex Mixtures ,CHOP ,Pharmacology ,urologic and male genital diseases ,General Biochemistry, Genetics and Molecular Biology ,Cell Line ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Fibrosis ,medicine ,Animals ,Humans ,Endoplasmic Reticulum Chaperone BiP ,Heat-Shock Proteins ,Trametes ,General Immunology and Microbiology ,urogenital system ,business.industry ,Endoplasmic reticulum ,Acute kidney injury ,General Medicine ,Acute Kidney Injury ,Endoplasmic Reticulum Stress ,medicine.disease ,female genital diseases and pregnancy complications ,Up-Regulation ,Mice, Inbred C57BL ,MicroRNAs ,030104 developmental biology ,Gene Expression Regulation ,030220 oncology & carcinogenesis ,Disease Progression ,Kidney Failure, Chronic ,Medicine ,business ,Transcription Factor CHOP ,Research Article ,Kidney disease - Abstract
Endoplasmic reticulum stress (ERS) is strongly associated with acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Huaier extract (HE) protects against kidney injury; albeit, the underlying mechanism is unknown. We hypothesized that HE reduces kidney injury by inhibiting ERS. In this study, using an AKI-CKD mouse model of ischemia-reperfusion injury (IRI), we evaluated the effect of HE on AKI-CKD transition. We also explored the underlying molecular mechanisms in this animal model and in the HK-2 human kidney cell line. The results showed that HE treatment improved the renal function, demonstrated by a significant decrease in serum creatinine levels after IRI. HE appreciably reduced the degree of kidney injury and fibrosis and restored the expression of the microRNA miR-1271 after IRI. Furthermore, HE reduced the expression of ERS markers glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) and inhibited apoptosis in the IRI group. This in vivo effect was supported by in vitro results in which HE inhibited apoptosis and decreased the expression of CHOP and GRP78 induced by ERS. We demonstrated that CHOP is a target of miR-1271. In conclusion, HE reduces kidney injury, probably by inhibiting apoptosis and decreasing the expression of GRP78 and CHOP via miR-1271 upregulation.
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- 2020
43. Performance Promotion through Dual-Interface Engineering of CuSCN Layers in Planar Perovskite Solar Cells
- Author
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Xiaodan Zhang, Ying Zhao, Minna Hou, Ying Tian, Yan Wu, Guofu Hou, Yuzeng Xu, and Yi Ding
- Subjects
General Energy ,Interface engineering ,Materials science ,Planar ,business.industry ,Energy conversion efficiency ,Optoelectronics ,Degradation (geology) ,Physical and Theoretical Chemistry ,business ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Perovskite (structure) - Abstract
Although perovskite solar cells (PSCs) with organic hole-transporting layers (HTLs) have demonstrated the certified power conversion efficiency (PCE) over 25%. Unavoidable performance degradation i...
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- 2020
44. SNX29, a new susceptibility gene shared with major mental disorders in Han Chinese population
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Robert Stewart, Yongyong Shi, Jia Wei Shen, Raja Amjad Waheed Khan, Zhuo Wang, Zhijian Song, Jianhua Chen, Xue Min Jian, Dun Pan, Lin He, Si Ying Xiang, Juan Zhou, Ying Zhao, Zu Jia Wen, Yifeng Xu, Ning Ning Li, and Zhiqiang Li
- Subjects
China ,medicine.medical_specialty ,Han chinese ,Bipolar Disorder ,Susceptibility gene ,Polymorphism, Single Nucleotide ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,mental disorders ,medicine ,Humans ,Genetic Predisposition to Disease ,Bipolar disorder ,Psychiatry ,Sorting Nexins ,Biological Psychiatry ,Depressive Disorder, Major ,business.industry ,Mental Disorders ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Schizophrenia ,Case-Control Studies ,Major depressive disorder ,business - Abstract
Environmental and genetic factors play important roles in the development of schizophrenia (SCZ), bipolar disorder (BPD) or major depressive disorder (MDD). Some risk loci are identified with shared genetic effects on major psychiatric disorders. To investigate whetherWe focussed on 11 single-nucleotide polymorphisms (SNPs) harbouringWe found that rs3743592 was significantly associated with MDD and rs6498263 with BPD in both allele and genotype distributions. Before correction, rs3743592 showed allelic and genotypic significance with SCZ, rs6498263 showed allelic significance with SCZ. WGCNA identified top 10 modules of co-expressed genes. Gene Ontology (GO) and pathway analysis were used to examine the functions of SNX29, which revealed that SNX29 was involved in the regulation of a number of biological processes, such as TGF-beta, ErbB, and Wnt signalling pathway, etc.Our results supported common risk factors in
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- 2020
45. Quantification of Hepatic Fat Fraction in Patients With Nonalcoholic Fatty Liver Disease: Comparison of Multimaterial Decomposition Algorithm and Fat (Water)-Based Material Decomposition Algorithm Using Single-Source Dual-Energy Computed Tomography
- Author
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Qingwei Song, Ying Zhao, Yijun Liu, Tingfan Wu, Qinhe Zhang, Anliang Chen, Ailian Liu, Lizhi Xie, Jingjun Wu, Lu-Han Xie, and Jianying Li
- Subjects
nonalcoholic fatty liver disease ,Adult ,Male ,Radiography ,Contrast Media ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Radiography, Dual-Energy Scanned Projection ,03 medical and health sciences ,0302 clinical medicine ,Nuclear magnetic resonance ,quantitative ,Non-alcoholic Fatty Liver Disease ,fat ,Nonalcoholic fatty liver disease ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Aged ,Retrospective Studies ,Fat fraction ,medicine.diagnostic_test ,business.industry ,Water ,computed tomography ,Dual-Energy Computed Tomography ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,multimaterial decomposition ,Magnetic Resonance Imaging ,Decomposition ,Abdominopelvic Imaging: Gastrointestinal ,Adipose Tissue ,Liver ,Female ,Tomography ,Tomography, X-Ray Computed ,business ,Algorithms ,030217 neurology & neurosurgery - Abstract
Objective The purpose of this study was to evaluate the accuracy of quantifying hepatic fat fraction (HFF) in nonalcoholic fatty liver disease patients with multimaterial decomposition (MMD) and fat (water)-based material decomposition by single-source dual-energy computed tomography. Methods Hepatic fat fractions were quantified by noncontrast (HFFnon-CE) and contrast-enhanced single-source dual-energy computed tomography in arterial phase (HFFAP), portal venous phase (HFFPVP) and equilibrium phase (HFFEP) using MMD in 19 nonalcoholic fatty liver disease patients. The fat concentration was measured on fat (water)-based images. As the standard of reference, magnetic resonance iterative decomposition of water and fat with echo asymmetry and least-squares estimation-iron quantification images were reconstructed to obtain HFF (HFFIDEAL-IQ). Results There was a strong correlation between HFFnon-CE, HFFAP, HFFPVP, HFFEP, fat concentration and HFFIDEAL-IQ (r = 0.943, 0.923, 0.942, 0.952, and 0.726) with HFFs having better correlation with HFFIDEAL-IQ. Hepatic fat fractions did not significantly differ across scanning phases. The HFFs of 3-phase contrast-enhanced computed tomography had a good consistency with HFFnon-CE. Conclusions Hepatic fat fraction using MMD has excellent correlation with that of magnetic resonance imaging, is independent of the computed tomography scanning phases, and may be used as a routine technique for quantitative assessment of HFF.
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- 2020
46. Efficacy of high intensity focused ultrasound treatment for cystic adenomyosis: a report of four cases
- Author
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Cong-Ying Zhao, Chen-Xiao Hou, Cai Tian, Haiyan Li, Zhi-Ming Zhao, Xiao-Jing Zhou, Peng Liu, Yu-Jie Lin, Zhi-Yu Zhao, Min Wang, Ying-Jie Zhou, Ying Liu, and Xiu-Min Li
- Subjects
medicine.medical_specialty ,Uterine fibroids ,medicine.medical_treatment ,Sedation ,Patient satisfaction ,Quality of life ,medicine ,Humans ,Adenomyosis ,Advanced and Specialized Nursing ,Leiomyoma ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Magnetic resonance imaging ,medicine.disease ,High-intensity focused ultrasound ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Quality of Life ,High-Intensity Focused Ultrasound Ablation ,Female ,Radiology ,medicine.symptom ,business - Abstract
Background Cystic adenomyosis is a particular type of adenomyosis, High intensity focused ultrasound (HIFU), as a non-invasive method, has also been used to treat adenomyosis. The purpose of this study was to investigate the efficacy, safety, and feasibility of HIFU for the treatment of cystic adenomyosis. Methods Diagnosis of cystic adenomyosis was obtained through trans-vaginal ultrasound and magnetic resonance imaging (MRI). Ultrasound-guided HIFU ablation was performed under conscious sedation. The patients were evaluated by the comparison of pre-HIFU and post-HIFU imaging, as well as the Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire subscales, consisting of Symptom Severity Score (SSS) and Heath Related Quality of Life (HRQL). Results HIFU was effective in treating cystic adenomyosis. No complications were observed in the four patients who were successfully treated with HIFU. Compared to preoperative symptoms and patient satisfaction, symptoms at the first follow-up observed significant improvements, with no dysmenorrhea and high health-related quality of life. During the outpatient follow-up of one month, three months, and six months postoperation, the four patients were still without dysmenorrhea and were highly satisfied with the HIFU ablation. Conclusions HIFU, as a non-invasive treatment, supplies a safe and effective possibility for the treatment of cystic adenomyosis.
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- 2020
47. The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer
- Author
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Yiwen Liu, Luoyi Chu, Xiusen Zhang, Ying Zhao, Xiaochen Hu, Xiang Yuan, Di Zhao, Yibo Guo, Desheng Zhai, Dejiu Kong, Lingyun Sun, Chengbiao Lu, Shupei Liu, Jinyu Kong, Feng Ren, and Xurong Hou
- Subjects
0301 basic medicine ,Cancer Research ,Adoptive cell transfer ,Receptor, ErbB-2 ,Antigen presentation ,Breast Neoplasms ,lcsh:RC254-282 ,Immunophenotyping ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Breast cancer ,Immune system ,Antineoplastic Agents, Immunological ,Lymphocytes, Tumor-Infiltrating ,Phagocytosis ,Trastuzumab ,Cell Line, Tumor ,medicine ,Macrophage ,Animals ,Humans ,skin and connective tissue diseases ,Immune Checkpoint Inhibitors ,neoplasms ,Mice, Knockout ,business.industry ,Macrophages ,Antibody-Dependent Cell Cytotoxicity ,Drug Synergism ,ADCP ,HER2+ breast cancer ,V-Set Domain-Containing T-Cell Activation Inhibitor 1 ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Xenograft Model Antitumor Assays ,030104 developmental biology ,B7-H4 ,030220 oncology & carcinogenesis ,Cancer cell ,Humanized mouse ,Cancer research ,Female ,Disease Susceptibility ,business ,medicine.drug - Abstract
Trastuzumab is a humanized mAb used to treat HER2-overexpressing breast cancer; however its mechanisms remain to be fully elucidated. Previous studies suggest a role for immunity in mediating trastuzumab-specific antitumor effects. This study evaluated the role(s) of trastuzumab and other antibodies on macrophage activation and Ab-dependent cell-mediated phagocytosis (ADCP) of HER2+ breast cancer cells in vitro and in vivo. We employed orthotopic implantation of HER2+ murine breast cancer (BC) cells in immunocompetent mouse models, a human HER2+ BC xenograft in an immune humanized mouse model, and human PDXs involving adoptive transfer of autologous macrophages to simulate an endogenous mammary tumor-immune microenvironment. Our study demonstrated that trastuzumab greatly and consistently increased macrophage frequency and tumor-cell phagocytosis, and that concurrent knockdown of B7-H4 by a neutralizing antibody increased immune cell infiltration and promoted an antitumor phenotype. Furthermore, neoadjuvant trastuzumab therapy significantly upregulated B7-H4 in the cancer-infiltrating macrophages of HER2+ BC patients, which predicted poor trastuzumab response. We suggest that strategies to specifically enhance ADCP activity might be critical to overcoming resistance to HER2 mAb therapies by inhibiting tumor growth and potentially enhance antigen presentation. Furthermore, these results advance the understanding of macrophage plasticity by uncovering a dual role for ADCP in macrophages involving elimination of tumors by engulfing cancer cells while causing a concomitant undesired effect by upregulating immunosuppressive checkpoints.
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- 2020
48. Ixazomib-associated cardiovascular adverse events in multiple myeloma: a systematic review and meta-analysis
- Author
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Rui Li, Yi-Wen Ling, Jiankai Zhong, Ying Zhao, and Zhuo-Wen Chen
- Subjects
Boron Compounds ,Oncology ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Glycine ,010501 environmental sciences ,Toxicology ,01 natural sciences ,Ixazomib ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Adverse effect ,Multiple myeloma ,Aged ,0105 earth and related environmental sciences ,Pharmacology ,Chemical Health and Safety ,business.industry ,Public Health, Environmental and Occupational Health ,Treatment options ,General Medicine ,medicine.disease ,chemistry ,Meta-analysis ,Hypertension ,Multiple Myeloma ,business ,030217 neurology & neurosurgery - Abstract
Prolonged survival and expanded treatment options in myeloma patients have led to adverse events associated with treatment getting increased attention. This systematic review and meta-analysis aimed to determine the incidence of ixazomib-associated cardiovascular adverse events (CVAEs) and to compare the rates of ixazomib-associated CVAEs and related therapies. CVAEs were defined as heart failure, hypertension, ischemia, and arrhythmia. All-grade and high-grade CVAEs and study characteristics were recorded. A total of 266 potentially relevant articles were identified, and 246 were excluded after review. Twenty studies of 1715 patients with multiple myeloma were thus considered in this study. The estimated rates of all-grade and high-grade ixazomib associated CVAEs were 11.2 and 3.7%, respectively. Subgroup analysis showed that median age ≥65 years, none phase 1 trial and combination regimen were associated with higher rates of high-grade ixazomib associated CVAEs. Ixazomib was association with increased high-grade CVAEs risk (RR = 1.679, 95% CI: 1.078-2.615
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- 2020
49. Vitamin D levels and busulphan kinetics in patients undergoing hematopoietic stem cell transplantation, a multicenter study
- Author
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Wenyi Zheng, Britt Gustafsson, Martin Höglund, Jonas Mattsson, Fadwa Benkossou, Ibrahim El-Serafi, Carsten Heilmann, Jacek Toporski, Rui He, Kourosh Lotfi, Sandra Oerther, Ahmed T. El-Serafi, Mikael Sundin, Karin Mellgren, Jukka Kanerva, Ying Zhao, and Moustapha Hassan
- Subjects
Transplantation ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Hematology ,Hematopoietic stem cell transplantation ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Multicenter study ,Pharmacokinetics ,hemic and lymphatic diseases ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Vitamin D and neurology ,In patient ,Stem cell ,business ,Prospective cohort study ,030215 immunology - Abstract
Vitamin D (Vit-D), an essential nutrient, interacts with different drugs including chemotherapeutic agents like busulphan, an alkylating agent used for conditioning prior to stem cell transplantation. The correlation between Vit-D plasma levels and busulphan clearance was investigated in an uncontrolled prospective study in patients and mice. Plasma 25(OH)D levels were measured and busulphan pharmacokinetics calculated in 81 patients. Adults received oral busulphan (n = 34) while children received busulphan orally (n = 19) or intravenously (n = 28). Patients received no Vit-D supplementation. To confirm our findings, pharmacokinetics after a single dose of busulphan (oral or intravenous) were evaluated in two groups of mice (n = 60) receiving high or standard-level Vit-D supplementation. Both busulphan clearance (P < 0.0001) and 25(OH)D levels (P = 0.0004) were significantly higher in adults compared to children. A significant negative correlation (P = 0.041) was found between busulphan clearance and 25(OH)D levels in children treated orally. No such correlation was observed in adults or in children receiving intravenous busulphan. In addition, no significant effect of Vit-D levels on busulphan pharmacokinetics in mice regardless of the administration route. In conclusion, 25(OH)D can affect oral busulphan pharmacokinetics in children and its level should be considered when personalizing oral busulphan treatment. Further studies are warranted to confirm the underlying mechanisms.
- Published
- 2020
50. Severely Impaired Renal Function in Unilateral Atherosclerotic Renal Artery Stenosis Indicated by Renal Slow Perfusion
- Author
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Guodong Tang, Jun-Hong Ren, Fucheng Sun, Huiping Zhang, Ying Zhao, Hu Ai, Qi Zhou, Naixin Zheng, Guojian Yang, and Hui Li
- Subjects
medicine.medical_specialty ,Kidney ,medicine.diagnostic_test ,business.industry ,Urology ,Renal function ,General Medicine ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Renal artery stenosis ,medicine.disease ,Scintigraphy ,03 medical and health sciences ,Impaired renal function ,0302 clinical medicine ,medicine.anatomical_structure ,Renal angiography ,030220 oncology & carcinogenesis ,Atherosclerotic renal artery stenosis ,Medicine ,business ,Perfusion - Abstract
Purpose Renal artery stenosis leads to ischemic renal insufficiency, but methods for assessing renal perfusion are limited. This study aimed to evaluate the association between renal slow perfusion and impaired renal function in atherosclerotic renal artery stenosis (ARAS). Patients and Methods A total of 79 consecutive patients with uncontrolled hypertension who underwent renal angiography and renal dynamic scintigraphy for suspected ARAS were enrolled in the retrospective descriptive study. Based on the status of renal artery stenosis and renal perfusion, participants were divided into three groups: the control group (n=26), the unilateral ARAS with renal normal perfusion group (RNP, n=30), and the unilateral ARAS with renal slow perfusion group (RSP, n=23). RSP was defined as renal blush grade (RBG) ≤1, while RBG>1 belonged to RNP. Split renal function (SRF) was achieved from 99mTc-DTPA renal scintigraphy. The value of the difference in split renal function (DSRF) is contralateral SRF minus impaired SRF of paired kidneys in ARAS. We compared the SRF and DSRF between different groups to identify the association between renal slow perfusion and renal impairment in ARAS. Results We analyzed SRF for paired kidneys and found the following: (1) The SRF of the paired kidney was similar in the RNP group (24.3 ± 10.2 mL/min vs 27.5 ± 8.4 mL/min; P = 0.19); however, the impaired SRF was obviously decreased compared with the contralateral SRF in the RSP group (13.5 ± 8.6 mL/min vs 36.7 ± 16.9 mL/min; P < 0.001); and (2) The difference in SRF in the RSP group was significantly higher than that in the control and RNP groups (19.8 ± 11.9 mL/min vs 4.8 ± 8.1 mL/min; 19.8 ± 11.9 mL/min vs 4.6±3.7 mL/min; P < 0.05). Conclusion As an angiographic phenomenon, renal slow perfusion might be an indicator of severely impaired renal function.
- Published
- 2020
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