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Data on the prevalence of double infection (DI) in HIV individuals are lacking in Spain. To fill this gap, we analyzed the prevalence of DI in a cohort of men who have sex with men (MSM) and examined factors contributing to DI. We selected 81 MSM attending Centro Sanitario Sandoval, a sexually transmitted diseases clinic in Madrid. We obtained by ultra-deep sequencing the proviral sequences in gag and env genes and performed a phylogenetic analysis for the identification of DI. Clinical, behavioral, host, and viral factors were studied for its association with DI. We detected six individuals with DI and one case of superinfection with a global prevalence of 8.6%. The genetic distance among the subtype B viruses in monoinfected individuals (24.4%) was lower than the distance between the two viruses in subtype B DI individuals (29.5%). Individuals with a high number of sexual contacts (>25 partners/year) had an 8.66 times higher risk of DI (p = .017). In this MSM cohort the prevalence of HIV DI was estimated at 8.6%. DI was strongly associated with the number of sexual partners. Because of the pathogenic consequences of HIV DI, this high prevalence should promote public health programs targeted at high-risk population such as MSM for the control of HIV infection and DI. HIV DI should be considered for a better clinical management of these individuals. Work in Centro Nacional de Microbiologia (Instituto de Salud Carlos III) was supported by grant SAF-2016-77894-R from Ministerio de Economia y Competitividad (MINECO, Spain), grant PI 13/02269 from Fondo de Investigación Sanitaria (FIS-Instituto de Salud Carlos III, Spain) and in part by the RIS-RETIC grants RD12/0017/0028 and RD16CIII/0002/0005 funded by the Intituto de Salud Carlos III-European Regional Development Fund. M.P. has a contract of RIS-RETIC RD16CIII/0002/0005. Sí

International audience; Background: Harm reduction (HR) interventions are essential to reduce human immunodeficiency virus (HIV) and hepatitis C virus (HCV) transmission in people who inject drugs (PWID). Preliminary testing of the Individually Tailored Support and Education for Safer Injection (ITSESI) evidence-based educational intervention for PWID was performed in France in 2011. We created the Eurosider project to implement and evaluate ITSESI at a wider European level, with a view to its future pan-European diffusion.Methods: We performed a mixed-methods study involving quantitative (a 6-month before-after study with PWID) and qualitative (focus groups with field workers) components. The study was conducted in 2018-2019 with 307 eligible PWID participating in four existing HR programmes in Bulgaria, Greece, Portugal, and Romania. ITSESI consists in trained field workers observing PWID injection practices and providing an educational exchange. For the present study, PWID participants were allocated to either the control group (i.e., they continued receiving only the current HR services) or the intervention group (i.e., current HR services plus ITSESI). We used the RE-AIM QuEST framework to assess the effectiveness of ITSESI and its acceptability by field workers. Effectiveness was defined as a reduction in both syringe sharing - the highest HIV/HCV transmission risk practice - and in cutaneous abscesses. We used a multivariable mixed logit model to analyse both effectiveness outcomes and to provide adjusted odds ratios (aOR) and 95% confidence intervals (CI). Field workers' acceptability of the intervention was described using a thematic analysis of the qualitative data.Results: Of the 307 PWID, 55% received ITSESI. Syringe sharing and cutaneous abscesses decreased during follow-up in the intervention group (from 25 to 16% and from 27 to 14%, respectively). Reductions were smaller in the control group (from 29 to 24% and from 23 to 18%, respectively). The multivariable analyses confirmed the effect of the intervention on both of these outcomes (aOR [95% CI]: 0.38 [0.17, 0.85]) and (aOR [95% CI]: 0.38 [0.16, 0.90], respectively). Our qualitative data on acceptability showed the feasibility of involving field workers as proactive research partners in making ITSESI more accessible and acceptable across Europe.Conclusions: We demonstrated both the effectiveness of ITSESI in reducing syringe sharing and cutaneous abscesses in four European countries, and a high level of intervention acceptability by field workers. Our findings provide important insights into how ITSESI can be adapted for pan-European implementation.

Background Risk governance involves processes and mechanisms to understand how risk decisions are taken and executed. This concept has gained a reputation over time as being essential for emerging comprehensive management that defines the success of an organization. While guiding documents that explain the use of risk management related to nuclear safety and security are available worldwide, few locally conducted studies have explained risk governance practices in areas where hazard usage is known, such as in radiological emergencies. Objective This paper describes a protocol that was used to determine several factors that influence emergency responders’ perceptions toward radiological risk practices and visualize the risk radiological framework for emergency preparedness and response. Methods A mixed methods study with a convergent design was performed. A qualitative analysis was performed using a case study approach where 6 key informants were purposely sampled for in-depth interview, and a cross-sectional study involving a self-administered questionnaire was conducted among approximately 260 emergency respondents from national regulatory, research, and services organizations. NVivo (version 12, QSR International) was used to analyze the interview transcripts and emerging themes were identified through abductive coding. Simultaneously, multiple logistic regression analysis was used to determine significant predictors that form the equation model. Results The study is still underway. Qualitative findings were based on transcript-coding that informed the relevant thematic analysis, while statistical analyses including multiple logistic regression analysis measured the adjusted odds ratio of significant variables for the equation model. The study is expected to conclude in late 2021. Conclusions Important emerging themes and significant factors that are related to the emergency responders’ perceptions regarding radiological governance practices were determined through the convergent design. This potentially facilitated the development of a plausible radiological risk governance framework. Furthermore, our results will provide key insights that can be used in future studies. International Registered Report Identifier (IRRID) DERR1-10.2196/25877

Aims In France, a non-negligible proportion of opioid-dependent individuals inject morphine sulfate. Although it has not yet been officially approved as an opioid substitution treatment (OST), some physicians can prescribe its use for people in methadone or buprenorphine treatment failure. Longitudinal data from the ANRS-AERLI study, which evaluated an educational intervention for safer injection called AERLI, provided us the opportunity to better characterize the profile, risk practices and needs of people who inject morphine sulfate (MSI), through comparison with other injectors, and to identify correlates of HIV/HCV risk practices in this group. Methods The national multisite ANRS-AERLI study assessed the impact of AERLI offered in volunteer harm reduction (HR) centers (“with intervention”) (n = 113) through comparison with standard HR centers (“without intervention”) (n = 127). All participants were scheduled to be followed up for 12 months and have 3 telephone interviews: at baseline, 6 months and 12 months. We compared MSI (n = 79) with other opioid injectors (n = 161) and then used a mixed logistic model to identify factors associated with HIV/HCV risk practices among MSI. Findings Of the 240 eligible participants, 79 were regular MSI. They were less likely to use cocaine, crack or buprenorphine and to receive OST than other participants. Conversely, MSI were more likely to inject drugs more than three times a day and to report HIV/HCV risk practices. Among MSI, multivariate analysis showed that those receiving morphine sulfate as an OST were less likely to report such practices than other participants (aOR [95%CI] = 0.11 [0.02-0.61]). Conclusion Our results show that while MSI use fewer stimulants, they have more HIV/HCV risk practices than other injectors. However, when MSI are prescribed morphine sulfate as a treatment, these practices tend to decrease. Our findings suggest the importance of increasing access to morphine sulfate as a new OST in France.

Urban livestock keeping in developing cities have an important role in food security and livelihoods but can also pose a significant threat to the environment and health of urban dwellers. The aim of this study was to identify the different livestock systems in Nairobi, their supply chains, and their management and food safety risks. Seven focus group discussions with livestock production officers in charge of each major Nairobi sub-county were conducted. Data were collected on the type of systems existing for each livestock species and their supply chains, disease management, food safety risks, and general husbandry and gender factors. Supply chain flow diagrams and thematic analysis of the data was done. Results of the study show a large variability of livestock keeping in Nairobi. The majority were small scale with

Relations between men who have sex with men (MSM) are power relations between different masculinities. A qualitative study with health professionals assisting MSM looked into HIV prevention in Spain. Barriers were observed in the HIV test at three levels: institutions, social and individual. Deficiencies appeared in public policies: lack of knowledge about MSM realities; lack of tools to assist diversity by health professionals; stigma and prejudice; difficulties to access health. Migration, poverty and vulnerability influence MSM health and the presence of risk practices. We suggest health professionals training in gender transcultural perspective integrated within educative programs to improve MSM’s health. © 2014 The Authors. Published by Elsevier Ltd. Selection and peer-review under responsibility of Encarnacion Soriano, Christine Sleeter and Maria Antonia Casanova.

Article history: Objective: To assess the presence of antibodies to the avian influenza virus H5 subtype in village chickens. Methods: A total of 480 sera samples were obtained from apparently healthy local chickens in four local government areas (LGAs). The sera samples were subjected to the haemagglutination inhibition (HI) test using the H5N2 avian influenza antigen. Results: An overall prevalence of 2.92% with a mean antibody titre of (7.07暲0.73) log2 was obtained. There was a low level of awareness of avian influenza among the rural dwellers, the electronic and print media were the most common source of awareness. Conclusions: This result highlights the important role apparently healthy village chickens may play in virus perpetuation (reservoir) and in the spread of avian influenza to other animals and humans.

ResumenObjetivoDescribir las circunstancias y las consecuencias del consumo de cocaína en el entorno del ejercicio de la prostitución.Material y métodosEstudio cualitativo sobre una muestra de 60 personas, de 18-50 años de edad, que ejercen la prostitución en la calle, apartamentos y clubs de 6 ciudades españolas, mediante entrevista semiestructurada.ResultadosEl alcohol y la cocaína son las principales sustancias de consumo en este contexto. Se trata de consumos ocasionales e instrumentales que permiten a las personas que ejercen la prostitución sobrellevar la actividad que realizan, resistir muchas horas la prestación de prácticas sexuales con diferentes clientes, obtener mayores beneficios económicos y eludir los servicios sexuales. Las consecuencias del consumo por parte de estas personas pueden llevar a la desprotección en las prácticas sexuales y a ser víctimas de agresión o violencia por parte del cliente. Las personas prostituidas desarrollan estrategias de disminución del consumo: reducción de las dosis de consumo, simulación del uso de drogas o selección de los clientes consumidores.ConclusionesEl estudio destaca que los consumos de drogas se encuentran asociados al contexto de realización de los servicios sexuales. Sin embargo, las consecuencias de éstos pueden implicar riesgos para la salud por la desprotección de las prácticas sexuales que demanda el cliente.AbstractObjectiveTo describe the circumstances and consequences of cocaine use in the setting of prostitution.Material and methodWe performed a qualitative study with fieldwork in 6 Spanish cities. Semi-structured interviews were carried out to 60 persons aged between 18 and 50 years old involved in prostitution in different settings: street, flat and brothel.ResultsThe main substances used in prostitution were alcohol and cocaine. Consumption was occasional and instrumental and helped to reduce psychological barriers or inhibition and increase tolerance to long hours of sex work with different clients, thus increasing earnings. Cocaine use was also associated with providing clients with company without having to perform sexual services. Among the consequences of drug use in prostitutes were unprotected sex and a higher risk of violence by clients. Prostitutes developed harm reduction strategies for drug use: dose reduction, simulated drug use, and selection of clients who were users.ConclusionsThis study shows that there is connection between drug use and the provision of sexual services. Drug use can pose a health risk as consumption is associated with unprotected sex.