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Objective: To investigate the effects of pregabalin combined with serratus anterior plane block (SAPB) on sleep quality and serum inflammatory factors in patients after thoracoscopic radical resection of lung cancer. Methods: The collection period of cases was from March 2019 to July 2020. 60 patients who met the requirements after thoracoscopic radical resection of lung cancer were screened and divided into the control group (n=30) and the study group (n= 30). Both groups were given SAPB, followed by intravenous patient-controlled analgesia. The control group was given a placebo. The study group was given pregabalin 150 mg 2 hours before surgery and 75 mg pregabalin on the second day after surgery. The sedative and analgesic effects, sleep quality, serum inflammatory factors, anxiety, vital signs and adverse reactions were compared between the two groups. Results: The visual pain analogue scale (VAS) of the study group was lower than that of the control group at 12 h, 24 h, and 48 h after the operation, and the Ramsay score was higher than that of the control group (P<0.05). The 48h postoperative state-trait anxiety scale (STAI) and Pittsburgh Sleep Quality Index (PSQI) scores of the study group were lower than those of the control group (P<0.05). Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in the study group were lower than those in the control group at 24 h and 48 h after surgery (P<0.05). The heart rate (HR) of the study group was lower than that of the control group at 4 h, 24 h, and 48 h after the operation, and the systolic blood pressure (SBP) and diastolic blood pressure (DBP) were higher than those of the control group (P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Pregabalin combined with SAPB in patients after thoracoscopic radical resection of lung cancer can maintain the patient's vital signs, obtain good analgesic and sedative effects, improve the patient's sleep quality, reduce their anxiety, and reduce serum inflammation. The level of sex factors is safe. [ABSTRACT FROM AUTHOR]