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Objective: To investigate the effect of desloratadine citrate disodium combined with endoscopic sinus surgery on clinical symptoms and inflammatory response in patients with chronic sinusitis. Methods: 116 patients with chronic sinusitis admitted to our hospital from March 2017 to July 2018 were selected as the research objects. They were divided into traditional group and combined group according to random number table method, 58 cases in each group. The traditional group were treated with endoscopic sinus surgery. The combined group were treated with desloratadine citrate disodium on the basis of endoscopic sinus surgery. The clinical efficacy, symptom visual analogue scale (VAS) scores, clearance function of nasal mucociliary, levels of inflammatory factors and adverse reactions were compared between the two groups. Results: The total effective rate of the combined group were higher than that of the traditional group, and the VAS scores of headache, nasal obstruction, facial pain and olfactory disturbance in the combined group were lower than those in the traditional group (P<0.05). The clearance rate and clearance speed of the two groups after treatment were higher than those before treatment, and the clearance time was shorter than that before treatment (P<0.05). Compared with the traditional group, the clearance rate and clearance speed of the combined group increased and clearance time shortened after treatment (P<0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin-5 (IL-5), interleukin-12 (IL-12) and high-sensitivity C-reactive protein (hs-CRP) in the two groups were lower than those before treatment, and those in the combined group were lower than those in the traditional group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: On the basis of endoscopic sinus surgery, combined use of desloratadine citrate in the treatment of chronic sinusitis patients has a definite effect, effectively alleviating inflammatory response, alleviating the clinical symptoms of patients. [ABSTRACT FROM AUTHOR]