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Background: Cadmium is an established carcinogen. Cadmium exposure resulted in skin carcinogenesis in rats. Furthermore, neurotransmitter-cancer interaction, tissue innervation, and angiogenesis influence cancer prognosis, metastasis, and survival. In this study, we evaluated the anticancer and neuro-protective potentials of MO 11 (isolated from Moringa oleífera leaves) and MS06 (isolated from Musa sapientum suckers) against in-vivo Cadmium Chloride (CdCI2)- induced skin toxicity. Methods: Twenty-four adult male wistar rats were randomly divided into six groups (n = 4). Group 1 was control. Groups 2-4 and 6 received a single intraperitoneal administration of 1.5 mg/kg CdCI2 on Day 1. Thereafter, Groups 3, 4, and 6 were post-treated with 15 mg/kg MO 11,15 mg/kg MO11 + 7 mg/kg MS06, and 3.35 mg/kg Doxorubicin respectively (Days 1-17). Group 5 received an olive oil dose (vehicle) (Days 1-17). Skin histopathology and tissue-enzyme-linked-immunosorbent assays (Tissue-ELISA) of neurotransmitters (Dopamine and Glutamate), biomarkers of myelination (Myelin Basic Protein), drug metabolism and carcinogenesis (Cytochrome-p450), apoptosis (Caspase-3 and p53), proliferation (Ki67), and angiogenesis (sVEGFR) were evaluated in skin homogenates. Data were statistically analyzed using the Mann-Whitney-U test at Z'<0.05. Results: Histopathological analyses revealed normal skin histology (Groups 3 and 4), mild skin histo-alterations (Group 6), and gross skin histopathological alterations (Group 2). Tissue-ELISA analyses showed upregulations of dopamine, Glutamate and Cytochrome-p450, but downregulations of Myelin Basic Protein, Caspase-3, KÍ67, p53, and sVEGFR in groups 3, 4, and 6, compared with group 2. MO 11 and MS06 achieved better anticancer effects than doxorubicin. Conclusion: Overall, MO 11 and MS06 possess histo-protective, neuro-protective, re-myelination, anti-proliferation, anti-angiogenesis, and anti-cancer potentials. [ABSTRACT FROM AUTHOR]

Background: Cadmium (Cd) is an established carcinogen. Cd-induced renotoxicity resulted in oxidative stress, loss of excretory kidney functions, and apoptosis of murine kidney cells. Objectives: This study evaluated renoprotective potentials of MO11 (isolated from Moringa oleifera leaves) and MS06 (isolated from Musa sapientum suckers) against Cd chloride (CdCl2)-induced renotoxicity, renal hyperplasia, and apoptosis in rats. Materials and Methods: Twenty-four adult male Wistar rats (average weight of 155 g) were randomly divided into seven groups (n = 4). Group 1 received physiological saline. Groups 2-4 and 6 received single intraperitoneal (i.p) administration of 1.5 mg/kg body weight of CdCl2 (i.p) (Day 1). Groups 3-4 and 6 were posttreated with 15 mg/kg body weight of MO11, 15 mg/kg body weight of MO11 +7 mg/kg body weight of MS06, and 3.35 mg/kg body weight of doxorubicin, respectively (days: 1-17). Group 5 received only olive oil dose (vehicle), respectively (days: 1-17). Kidney histopathology (hematoxylin and eosin technique) and enzyme-linked immunosorbent assay concentrations of biomarkers of proliferation (Ki67) and apoptosis (p53) in kidney homogenates of rats of Groups 1-6 were evaluated. Results: Histopathological analyses showed normal kidney histology in the rats of Groups 1-6. Posttreatments of CdCl2 -induced renotoxicity with MO11, MO11+MS06, and doxorubicin resulted in downregulations of Ki67 and p53 in Groups 3, 4, and 6 as compared with Group 2. Conclusion: MO11 and MS06 possess renoprotective, anti-proliferation, and anti-apoptosis potentials. [ABSTRACT FROM AUTHOR]