1. Caffeate and piperidine-3-ol derivatives from the stem bark of Cassia sieberiana .
- Author
-
Atontsa BCK, Bitchagno GTM, Mpetga JDS, Wamba BEN, Nayim P, Tchuenguem RT, Ndontsa BL, Koagne RR, Opatz T, Kuete V, and Tane P
- Subjects
- Caffeic Acids isolation & purification, Free Radical Scavengers isolation & purification, Microbial Sensitivity Tests, Phytochemicals isolation & purification, Phytochemicals pharmacology, Piperidines isolation & purification, Plant Bark chemistry, Plant Extracts, Caffeic Acids pharmacology, Cassia chemistry, Free Radical Scavengers pharmacology, Piperidines pharmacology
- Abstract
A new caffeate derivative from the ethanol extract of the stem bark of Cassia sieberiana DC. is described herein along with the known secondary metabolites spectaline ( 2 ), iso -6-cassine ( 3 ), 3- O -methyl- chiro -inositol ( 4 ), monobehenin ( 5 ), octyl nonadecyloate ( 6 ), β -sitosterol ( 7 ), stigmasterol ( 8 ) and sitosterol 3- O - β -D-glucopyranoside ( 9 ). The chemical structures were elucidated by means of various spectroscopic and spectrometric techniques. Extract and isolated compounds were devoid of inhibitory action against the herein selected bacterial strains (MICs > 256 μg/mL) but showed capacities to reduce 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (EC
50 < 3 μg/mL) considerably better than the "gold standard" trolox (EC50 6.47 ± 0.48 μg/mL).- Published
- 2021
- Full Text
- View/download PDF