1. Cardiac inositol 1,4,5-trisphosphate receptors.
- Author
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Garcia, M. Iveth and Boehning, Darren
- Subjects
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INOSITOL , *TRIS(2-chloroethyl) phosphate , *CALCIUM channels , *HEART cells , *GENE expression - Abstract
Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP 3 Rs have been associated with regulation of cardiomyocyte function in response to a variety of neurohormonal agonists, including those implicated in cardiac disease. Notably, IP 3 R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II. In this review, we will explore the functional implications of IP 3 R activity in the heart in health and disease. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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