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Start Over Author "Tian-Xing Zhang" Topic calixarene
2 results on '"Tian-Xing Zhang"'

1. Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent

Author

Tian-Xing Zhang, Juan-Juan Li, Hua-Bin Li, and Dong-Sheng Guo

Subjects
supramolecular chemistry, photodynamic agent, calixarene, fullerene, solubility, Chemistry, QD1-999
Abstract

Fullerene has attracted much attention in biomedical research due to its unique physical and chemical properties. However, the hydrophobic nature of fullerene is limited to deploy in the body, given that the biofluids are mainly water. In this study, a water-soluble supramolecular nanoformulation based on a deep cavitand calixarene (SAC4A) and fullerene is developed to overcome the hydrophobicity of fullerene and is used as a potential photodynamic agent. SAC4A solubilizes fullerene very well with a simple grinding method. The significantly increased water solubility of fullerene enables efficient activation of reactive oxygen species. The host–guest strategy to solubilize fullerene can not only provide a new method to achieve water solubility but also expand the biomedical applications of fullerene.

Published
2021
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2. A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy

Author

Xiaoxue Hou, Jianfeng Liu, Yong Kong, Dong-Sheng Guo, Hua-Bin Li, Muhammad Raza Shah, Fan Huang, Fan Yang, Tian-Xing Zhang, and Yu-Xin Yue

Subjects
photothermal therapy, Chemistry, hypoxia, IR780, Supramolecular chemistry, technology, industry, and agriculture, Medicine (miscellaneous), macromolecular substances, Hypoxia (medical), Photothermal therapy, Theranostic Nanomedicine, supramolecular chemistry, Mice, Photochemotherapy, Cell Line, Tumor, Neoplasms, medicine, Biophysics, Animals, calixarene, medicine.symptom, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Research Paper
Abstract

Photothermal agents (PTAs) based on organic small-molecule dyes emerge as promising theranostic strategy in imaging and photothermal therapy (PTT). However, hydrophobicity, photodegradation, and low signal-to-noise ratio impede their transformation from bench to bedside. In this study, a novel supramolecular PTT formulation by a stimuli-responsive macrocyclic host is prepared to overcome these obstacles of organic small-molecule PTAs. Methods: Sulfonated azocalix[4]arene (SAC4A) was synthesized as a hypoxia-responsive macrocyclic host. Taking IR780 as an example, the supramolecular nanoformulation IR780@SAC4A was constructed by grinding method, and its solubility, photostability, and photothermal conversion were evaluated. The hypoxia tumor-selective imaging and supramolecular PTT of IR780@SAC4A were further evaluated in vitro and in vivo. Results: IR780@SAC4A is capable of enhancing the solubility, photostability, and photothermal conversion of IR780 significantly, which achieve this supramolecular formulation with good imaging-guided PTT efficacy in vitro and in vivo. Conclusions: This study demonstrates that the supramolecular PTT strategy is a promising cancer theranostic method. Moreover, this supramolecular approach is applicative to construct kinds of supramolecular PTAs, opening a general avenue for extending smart PTT formulations.

Published
2021

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