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Your search keyword '"Kharchenko, Sergiy G."' showing total 2 results
Start Over Author "Kharchenko, Sergiy G." Topic calixarenes
2 results on '"Kharchenko, Sergiy G."'

1. Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B.

Author

Trush VV, Kharchenko SG, Tanchuk VY, Kalchenko VI, and Vovk AI

Subjects
Calixarenes chemistry, Catalytic Domain, Enzyme Inhibitors chemistry, Esters chemistry, Humans, Inhibitory Concentration 50, Kinetics, Models, Molecular, Organophosphonates chemistry, Protein Tyrosine Phosphatase, Non-Receptor Type 1 metabolism, Serum Albumin metabolism, Temperature, Calixarenes pharmacology, Enzyme Inhibitors pharmacology, Esters pharmacology, Organophosphonates pharmacology, Protein Tyrosine Phosphatase, Non-Receptor Type 1 antagonists & inhibitors
Abstract

Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.

Published
2015
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2. Phosphorylated Thiacalix[4]arenes.

Author

Drapailo, Andriy B., Kharchenko, Sergiy G., Shishkina, Svitlana V., Shishkin, Oleg V., and Kalchenko, Vitaly I.

Subjects
*PHOSPHORYLATION, *CALIXARENES, *FUNCTIONAL groups, *STEREOCHEMISTRY, *X-ray spectroscopy, *ORGANIC synthesis, *CHEMICAL reactions
Abstract

Thiacalix[4]arenes bearing one, three, or four P=O containing groups at the upper or at the lower rim have been synthesized. Stereochemistry of the compounds was investigated by X-ray method. [ABSTRACT FROM AUTHOR]

Published
2011
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