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Natural compounds and their derivatives have been identified as valuable sources of therapeutic ingredients for cancer treatment. The naturally occurring phytochemical palmatine (isoquinoline alkaloid) is extracted from plant parts (rhizomes, roots, stems, stem barks, and others) and has protective effects including antioxidant, anti‐inflammatory, and anticancer. This study aims to summarize the anticancer potential of palmatine and its derivatives in the treatment of numerous types of cancer with molecular mechanisms. We also include the pharmacokinetic features, botanical origin, and toxicological characteristics of palmatine and its derivatives. For this, data have been collected from plausible different electronic databases, including PubMed, Google Scholar, PubChem, Science Direct, Web of Science, Scopus, Springer Link, and Wiley Online. The findings demonstrate that palmatine and its derivatives have a protective anticancer effect against a variety of cancers, including breast, colorectal, gastric, ovarian, prostate, pancreatic, skin, hepatocellular cancer, and mammary gland tumors. They provoke their anticancer properties against various cancer cell lines via modifying molecular mechanisms like induction of oxidative stress, cytotoxicity, apoptosis, inhibition of cell invasion and migration, arresting the cell cycle at the S phase, antiproliferative, and antiangiogenic effects. It is suggested that palmatine and its derivatives may be a good option in the development of novel drugs for cancer therapy in the future. [ABSTRACT FROM AUTHOR]

Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well‐being due to its substantial morbidity and death rates worldwide. The potential of plant‐derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti‐inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy. [ABSTRACT FROM AUTHOR]

Ononin is a naturally occurring isoflavone glycoside generally found in various plants like soybeans, legumes, Chinese licorice, Mongolian milkvetch, kudzu, broccoli, and lupine. The compound has exhibited various therapeutic benefits in different laboratory tests. This study aims to evaluate pharmacological effects and biopharmaceutical features based on different clinical and preclinical studies and to assess the underlying mechanisms behind the effects against various deleterious diseases. For this, searching and collection of data were done (up to date as of October 07, 2023) in various reliable electronic databases, including PubMed/Medline, Scopus, Springer Link, ScienceDirect, Wiley Online, Web of Science, and Google Scholar. The findings exhibited beneficial effects against inflammation and a variety of diseases, such as neurodegenerative illnesses (Alzheimer's disease and cerebral I/R), viral and fungal infections (Influenza A and Candida albicans), diabetic nephropathy, osteoarthritis, obesity, and acute myocardial infraction (AMI). These beneficial effects are due to the antioxidant properties of the compound, which are capable of reducing ROS generation and the level of pro-inflammatory markers. The phytochemicals also demonstrated anticancer effects against various cancers, including breast, lung, orthotopic bone tumor, and laryngeal cancers. The compound exerted anticancer effects via cytotoxicity, an apoptotic effect by regulating the Bax/Bcl2 ratio, induction of oxidative stress, inhibition of proliferation, and metastasis through downregulating different cellular pathways such as the EGFR-Erk1/2, PI3K/Akt/mTOR, MEK/ERK, and JNK/ERK/p38 pathways. But the compound has poor oral bioavailability, resulting in low oral efficacy. Therefore, we suggest developing an alternative route and conducting extensive studies to understand the exact molecular mechanism, which will be more reliable for performing the next clinical trials to establish the lead as an efficacious therapeutic agent. [ABSTRACT FROM AUTHOR]