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Purpose Methods and materials Results Conclusion Personal information and conflict of interest References, Purpose: Nipple discharge ( ND ) is one of the most commonly reported complaints related to the breast for which women seek advice from physicians [1]. The vast majority of these reported cases are of benign origin [2]. Clinically, ND can be classified...

Background: Multiple BAP1 negative melanocytic neoplasms are a hallmark of familial cancer susceptibility syndrome caused by BAP1 germline mutation. The syndrome is characterized by increased incidence of renal cell carcinoma, mesothelioma, cholangiocarcinoma, cutaneous and uveal melanoma and some other neoplasms. Methods: We report histomorphologic characteristics of six cutaneous melanocytic neoplasms with loss of BAP1 expression in two members of a family with BAP1- associated cancer susceptibility syndrome. Results: The neoplasms were dermal melanocytic nevi characterized by a proliferation of large epithelioid (spitzoid) melanocytes, and adipocytic metaplasia. Nuclear pseudoinclusions and multinucleated melanocytes were present in most neoplasms. In two of the cases, a nodular melanoma was found associated with a dermal nevus. None of the melanomas recurred or metastasized after 6 and 3 years of follow up. Conclusions: We report two new cases of melanoma arising in a BAP1-deficient melanocytic nevus in the setting of familial tumor predisposition syndrome. Adipocytic metaplasia and nuclear pseudoinclusions may be additional morphologic clues to a BAP1- deficient nevus. It remains to be seen whether these features are more common in familial than sporadic lesions.