1. Reduced field-of-view diffusion-weighted MR imaging for assessing the local extent of uterine cervical cancer.
- Author
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Takeuchi, Mayumi, Matsuzaki, Kenji, Bando, Yoshimi, and Harada, Masafumi
- Subjects
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TRACHELECTOMY , *DIFFUSION magnetic resonance imaging , *CERVICAL cancer , *MAGNETIC resonance imaging , *CERVIX uteri diseases , *THREE-dimensional imaging , *ONCOLOGIC surgery , *RESEARCH , *PREDICTIVE tests , *CANCER invasiveness , *RESEARCH methodology , *RETROSPECTIVE studies , *EVALUATION research , *MEDICAL cooperation , *CANCER , *TUMOR classification , *COMPARATIVE studies , *COMPUTED tomography ,CERVIX uteri tumors - Abstract
Background: Recently, the evaluation of the tumor size and local extension of early-stage uterine cervical cancer on magnetic resonance imaging is important for the accurate clinical staging and to determine the indication of less extensive surgery such as fertility sparing radical trachelectomy. Purpose: To compare the diagnostic ability of reduced field-of-view diffusion-weighted imaging with those of three-dimensional (3D) contrast-enhanced T1-weighted imaging and T2-weighted imaging for assessing the tumor margin delineation and local extent of uterine cervical cancer. Material and Methods: 3T magnetic resonance images, including T2-weighted imaging, reduced field-of-view diffusion-weighted imaging, and 3D contrast-enhanced T1-weighted imaging, in 27 women with surgically proven cervical cancer (19 FIGO stage IB1, 3 IB2, and 5 IIA1) were retrospectively evaluated. Tumor margins and local tumor extent, including the presence of invasion to parametrium and vagina were evaluated on both sagittal and oblique axial (short axis) images; the results were compared with histologically confirmed tumor extension. Results: Reduced field-of-view diffusion-weighted imaging diagnosed the tumor margins, which was more accurate than T2-weighted imaging (P <0.001) and slightly better than 3D contrast-enhanced T1-weighted imaging. Reduced field-of-view diffusion-weighted imaging could define the tumor margins well even in small lesions (≤ 20 mm). Histological examination revealed parametrial invasion in two cases (clinically under-staged) and vaginal invasion in four cases. Reduced field-of-view diffusion-weighted imaging could demonstrate local extension of all lesions, which was more accurate than clinical examination and T2-weighted imaging. Conclusion: Addition of reduced field-of-view diffusion-weighted imaging may improve the staging accuracy of magnetic resonance imaging for cervical cancer in assessing the local tumor extent. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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