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The article discusses five studies on tumor suppressor p53, published in "Nature." All studies have demonstrated the influence of reducing the activity of tumor suppressor p53 in mouse embryonic fibroblast on the efficiency and kinetics of induced pluripotent stem (iPS) cells. They have show that iPS cells have similar developmental potential as embryonic stem cells. According to the author, the studies have significant implications for research on stem cells, p53 and cancer because they emphasize the function of the p53 pathway. He added that the studies linked p53 with stem cell hypothesis of cancer initiation and maintenance.