1. Non-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and Cancer
- Author
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Iman Sahnoune, George A. Calin, Dongmei Chi, Leonard Girnita, Jun-Yan Li, Baoqing Chen, and Steliana Calin
- Subjects
RNA, Untranslated ,Colorectal cancer ,lncRNAs ,Inflammation ,Review ,Biology ,Bioinformatics ,Receptor, IGF Type 1 ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Neoplasms ,Diabetes mellitus ,Gene expression ,microRNA ,Diabetes Mellitus ,medicine ,Humans ,cancer ,Receptor ,030304 developmental biology ,0303 health sciences ,diabetes ,Cancer ,General Medicine ,medicine.disease ,micoRNAs ,3. Good health ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030220 oncology & carcinogenesis ,RNA, Long Noncoding ,medicine.symptom ,IGF-1R ,Signal Transduction - Abstract
The intricate molecular network shared between diabetes mellitus (DM) and cancer has been broadly understood. DM has been associated with several hormone-dependent malignancies, including breast, pancreatic, and colorectal cancer (CRC). Insulin resistance, hyperglycemia, and inflammation are the main pathophysiological mechanisms linking DM to cancer. Non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are widely appreciated as pervasive regulators of gene expression, governing the evolution of metabolic disorders, including DM and cancer. The ways ncRNAs affect the development of DM complicated with cancer have only started to be revealed in recent years. Insulin-like growth factor 1 receptor (IGF-1R) signaling is a master regulator of pathophysiological processes directing DM and cancer. In this review, we briefly summarize a number of well-known miRNAs and lncRNAs that regulate the IGF-1R in DM and cancer, respectively, and further discuss the potential underlying molecular pathogenesis of this disease association.
- Published
- 2019
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